OALib Journal期刊

ISSN: 2333-9721



匹配条件: “Cela” ,找到相关结果约51条。
La primària des de la gestió
Jaume Cela
Temps d'Educació , 2000,
Reflexiones de Francisco Ayala sobre el exilio intelectual espa ol
Cela, Julia
Revista de Indias , 1996,
Abstract: Through a discussion of Francisco Ayala′s thinking -a Spanish writer who lived in exile in Argentina in the 1940s- the author analyzes the condition and concept of exile from the point of view of the intellectual who is forced to live and work away from his country, thereby losing contact with the main recipient of his writings: the Spanish public. A través del pensamiento del escritor espa ol Francisco Ayala -exiliado en la Argentina en la década de los a os cuarenta- se analiza el concepto de exilio y exiliado desde la perspectiva del intelectual, que se encuentra obligado a producir fuera de su país, perdiendo así el destinatario principal de su obra: el público espa ol.
Efficacious non-viral methods of reprogramming somatic cells
Elvis Cela
University of Toronto Journal of Undergraduate Life Sciences , 2009,
Abstract: Induced pluripotent stem (iPS) cells have demonstrated considerable potential in ex-vivo genetic manipulation and patient specific cell therapy. Adult somatic or mouse fibroblast cells are reprogrammed to iPS cells via retrovirus mediated transfer of four genes. While this procedure has yielded a high transfection efficiency with stable expression of the transgenes, it is associated with insertional mutagenesis and immunogenic responses. The safety of this method is still questionable given the development of leukemia and adverse immune responses to viral vectors in several gene therapy trials. Advances in non-viral gene delivery systems have been largely overlooked due to their inability to maintain expression for prolonged periods of time. While this is a substantial disadvantage in gene therapy, it represents a lesser concern in iPS therapy where expression of reprogramming factors is required for only eight to twelve days. Recent studies utilizing transposons, the PhiC3 integrase, and episomal vectors have show promising results in their potential utility as reprogramming methods in somatic cells. This paper reviews non-viral methods of gene delivery and discusses their potential benefits along with disadvantages as alternative methods to viral methods of gene transfer. Eliminating the effects of viral gene delivery or substituting it for a safer alternative represents a substantial barrier to overcome in order to significantly speed up introduction of cell based therapies to clinical trials.
Heuristics for the data arrangement problem on regular trees
Eranda Cela,Rostislav Stanek
Mathematics , 2013,
Abstract: The data arrangement problem on regular trees (DAPT) consists in assigning the vertices of a given graph G to the leaves of a d-regular tree T such that the sum of the pairwise distances of all pairs of leaves in T which correspond to edges of G is minimised. Luczak and Noble [6] have shown that this problem is NP-hard for every fixed d larger than or equal to 2. In this paper we propose construction and local search heuristics for the DAPT and introduce a lower bound for this problem. The analysis of the performance of the heuristics is based on two considerations: a) the quality of the solutions produced by the heuristics as compared to the respective lower bounds b) for a special class of instances with known optimal solution we evaluate the gap between the optimal value of the objective function and the objective function value attained by the heuristic solution, respectively.
Influence of Traditional Inoculum and Fermentation Time on the Organoleptic Quality of "Attiéké”  [PDF]
Nimaga Daouda, Tetchi Fabrice Achille, Kakou Cela Abodjo, Nindjin Charlemagne, Amani N’guessan Georges
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.310176
Abstract: To improve the process of “Attiéké” production by the standardization of the traditional inoculums, the effects of inoculums amount (6%, 8%, 10% and 12%) and fermentation time (6, 12 and 18 h) were studied and analyzed for their microbiological and sensory qualities using standard analytical procedures. The microbial analysis showed that Lactobacillus species (9.14 Log cfu/g) as the most important popular microorganism in the paste, followed by enterococci (7.64 Log ufc/g) species, yeasts and moulds (7.30 Log cfu/g) respectively. Sensory analysis revealed significant effects (p < 0.05), of inoculums quantity and fermentation time on the “Attiéké” quality. “Attiéké” obtained with 10% inoculums and after 12 hours of fermentation was identified as the optical inoculums amount and time for “Attiéké” production. The importance of traditional starter inoculums in “Attiéké” processing could be necessary to standardization at small and industrial scale the process of production.
Catálogo de las orquídeas ibéricas y baleares. 1. Aceras R. Br. - Nigritella Rich
Gamarra, Roberto,Galán Cela, Pablo
Anales del Jardín Botánico de Madrid , 2001,
Abstract: A check list of the taxa of the family Orchidaceae found in the Iberian Peninsula and the Balearic Islands is presented in alphabetical order. This section includes the genera from Aceras to Nigritella, down to the rank of variety, but excluding hybrids. We have gathered together the correct names, with their corresponding place of publication, synonyms and indicatio locotypica. Also included are some observations in those genera and species that present nomenclatural and taxonomic problems. Se presenta un catalogo, ordenado alfabéticamente, de los taxones de la familia Orchidaceae incluidos en los géneros Aceras a Nigritella, presentes en la Península Ibérica e Islas Baleares, excluidos los híbridos. Se recogen todos los nombres, hasta el rango varietal, mencionados de dicho ámbito geográfico, con su correspondiente lugar de publicación; por supuesto, los considerados correctos, sus sinónimos e indicatio locotypica. Se incluyen, cuando se estiman oportunas, observaciones de índole nomenclatural y taxonómico
The Management Accounting Practices in Albania in the Context of Globalization
Manjola Naco,Hysen Cela,Petrit Dollani
Contemporary Economics , 2010,
Abstract: The main aim of the paper is to provide relevant findings on the status of management accounting in Albanian Accounting Practices, based on the direct survey with selected companies and individuals (experts on the field). In our analysis we have used as a benchmark the IFAC statement on Management Accounting Concepts and its description of the evolution of management accounting. To achieve our objectives we prepared and provided to a large group of professional accountants (that mainly are dealing with bookkeeping and financial statement preparations) a structured questionnaire, containing several questions on the status of the practices applied in Albania on management accounting. This survey was carried out during the first half of 2009. Findings of this paper are based on the answers given by 300 respondents. These answers point out that management accounting practices in Albania tend not to be complex and sophisticated. Budgeting, product profitability and financial performance measurement remain the central pillars, while other, most contemporary, management accounting techniques are sporadically used. There is also little evidence of management accounting concerned directly with "value creation".
The data arrangement problem on binary trees
Eranda Cela,Joachim Schauer,Rostislav Stanek
Mathematics , 2015,
Abstract: The data arrangement problem on regular trees (DAPT) consists in assigning the vertices of a given graph G, called the guest graph, to the leaves of a d-regular tree T, called the host graph, such that the sum of the pairwise distances of all pairs of leaves in T which correspond to the edges of G is minimised. Luczak and Noble have shown that this problem is NP-hard for every fixed d greater than or equal to 2. In this paper we show that the DAPT remains NP-hard even if the guest graph is a tree, an issue which was posed as an open question in by Luczak and Noble. We deal with a special case of the DAPT where both the guest and the host graph are binary regular trees and provide a 1.015-approximation algorithm for this special case. The solution produced by the algorithm and the corresponding value of the objective function are given in closed form. The analysis of the approximation algorithm involves an auxiliary problem which is interesting on its own, namely the k-balanced partitioning problem (kBPP) for binary regular trees and particular choices of k. We derive a lower bound for the later problem and obtain a lower bound for the original problem by solving hG instances of the k-BPP, where hG is the height of the host graph G.
Two Approaches to the Study of a Controversial Relationship: Cutaneous Photosensitivity and Anti-Ro/SS-A Autoantibodies  [PDF]
Mariela L. Paz, Eliana M. Cela, Alejandro Ferrari, Adrián D. Friedrich, Juliana Leoni, Daniel H. González Maglio
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2014, DOI: 10.4236/ojra.2014.41001
Abstract: Background: Autoantibodies (Aabs) are the hallmark of numerous systemic autoimmune pathologies (SAPs), for instance anti-Ro/SS-A Aabs are usually found in Systemic Lupus Erythematosus (SLE) and Sjogren’s Syndrome. Cutaneous photosensitivity (CP) is found in most forms and subsets of LE and consists of a skin rash as a result of unusual reaction to sunlight. There are many theories which relate specifically the presence of circulating anti-Ro/SS-A Aabs with the CP phenomenon, though there are several studies which are in disagreement. Results: In this study we analyzed the relationship between CP and anti-Ro Aabs by means of two approaches. The first one included an in vitro model where we evaluated by flow cytometry the binding capacity of affinity-purified Aabs to autoantigens relocalized on apoptotic keratinocyte’s surface. We found that there was no relationship between the binding capacity of serum from 10 selected patients or their corresponding purified anti-Ro52 and anti-Ro60 Aabs, and the presence or absence of CP, neither with the SAPs. The in vivo model consisted of Hairless SKH:1 mice which were induced to produce anti-murine Ro52 and/or Ro60 Aabs and were subsequently irradiated with UVB light. We evaluated the skin histology and also the epidermal production of TNF-α. We found no differences between the groups in neither of the parameters evaluated. Conclusions: These results agree with some studies on the role of the Aabs in CP, considering anti-Ro Aabs not as the only responsible for the manifestation; and disagree with many other authors, who believe in the strong association between these two events.
Estrogen aggravates inflammation in Pseudomonas aeruginosa pneumonia in cystic fibrosis mice
Yufa Wang, Elvis Cela, Stéphane Gagnon, Neil B Sweezey
Respiratory Research , 2010, DOI: 10.1186/1465-9921-11-166
Abstract: Exogenous E2 caused adult male CF mice with pneumonia due to a mucoid CF clinical isolate, the P. aeruginosa strain PA508 (PA508), to develop more severe manifestations of inflammation in both lung tissue and in bronchial alveolar lavage (BAL) fluid, with increased total white blood cell counts and differential and absolute cell counts of polymorphonuclear leukocytes (neutrophils). Inflammatory infiltrates and mucin production were increased on histology. Increased lung tissue mRNA levels for IL-23 and IL-17 were accompanied by elevated protein levels of Th17-associated pro-inflammatory mediators in BAL fluid. The burden of PA508 bacteria was increased in lung tissue homogenate and in BAL fluid, and there was a virtual elimination in lung tissue of mRNA for lactoferrin, an antimicrobial peptide active against P. aeruginosa in vitro.Our data show that E2 increases the severity of PA508 pneumonia in adult CF male mice, and suggest two potential mechanisms: enhancement of Th17-regulated inflammation and suppression of innate antibacterial defences. Although this animal model does not recapitulate all aspects of human CF lung disease, our present findings argue for further investigation of the effects of E2 on inflammation and infection with P. aeruginosa in the CF lung.Central to the pathogenesis of cystic fibrosis (CF), inflammation and infection (especially by Pseudomonas aeruginosa (P. aeruginosa)) are mutually reinforcing and eventually lead to respiratory failure, with cor pulmonale as the major cause of death [1,2]. The inflammatory response accounts for the majority of the morbidity and mortality of the disease [3]. Chronic P. aeruginosa within the CF airway is a negative determinant of prognosis [4] and the onset of mucoid P. aeruginosa colonization is associated with subsequent lung function decline [5,6]. The lungs of CF patients infected with P. aeruginosa have increased levels of pro-inflammatory cytokines [7,8] and neutrophils in bronchoalveolar lavage (BA

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