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Search Results: 1 - 10 of 143 matches for " Catia Trubiani "
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A model-driven approach to broaden the detection of software performance antipatterns at runtime
Antinisca Di Marco,Catia Trubiani
Computer Science , 2014, DOI: 10.4204/EPTCS.147.6
Abstract: Performance antipatterns document bad design patterns that have negative influence on system performance. In our previous work we formalized such antipatterns as logical predicates that predicate on four views: (i) the static view that captures the software elements (e.g. classes, components) and the static relationships among them; (ii) the dynamic view that represents the interaction (e.g. messages) that occurs between the software entities elements to provide the system functionalities; (iii) the deployment view that describes the hardware elements (e.g. processing nodes) and the mapping of the software entities onto the hardware platform; (iv) the performance view that collects specific performance indices. In this paper we present a lightweight infrastructure that is able to detect performance antipatterns at runtime through monitoring. The proposed approach precalculates such predicates and identifies antipatterns whose static, dynamic and deployment sub-predicates are validated by the current system configuration and brings at runtime the verification of performance sub-predicates. The proposed infrastructure leverages model-driven techniques to generate probes for monitoring the performance sub-predicates and detecting antipatterns at runtime.
Male circumcision as strategy for HIV prevention and sexually transmitted diseases: the potential role of traditional birth attendants in neonatal male circumcision
Dini,Catia;
Annali dell'Istituto Superiore di Sanità , 2010, DOI: 10.4415/ANN_10_04_02
Abstract: in developing countries, it would be advisable to give priority to human immunodeficiency virus (hiv) prevention strategies, because of the high mortality caused by the rapid spread of the pandemic. furthermore, hiv prevention could contribute to the mitigation of tuberculosis (tb) propagation, which is tightly correlated to acquired immune deficiency syndrome (aids). as demonstrated, male circumcision (mc) confers protection against hiv and sexually transmitted diseases (std). the suggested strategy considers the neonatal mc advantageous, since it is safer, feasible, culturally more acceptable and less costly than adult mc. this approach is based on the assumption that, if newborn males are circumcised, within the next 15-20 years the sexually active population will be almost entirely circumcised and, consequently, the hiv transmission will be reduced. the employment of retrained traditional birth attendants is considered in order to implement the mc after the child birth and to facilitate its acceptance in those contexts where it is not traditionally performed.
Convergence rates for Bayesian density estimation of infinite-dimensional exponential families
Catia Scricciolo
Mathematics , 2007, DOI: 10.1214/009053606000000911
Abstract: We study the rate of convergence of posterior distributions in density estimation problems for log-densities in periodic Sobolev classes characterized by a smoothness parameter p. The posterior expected density provides a nonparametric estimation procedure attaining the optimal minimax rate of convergence under Hellinger loss if the posterior distribution achieves the optimal rate over certain uniformity classes. A prior on the density class of interest is induced by a prior on the coefficients of the trigonometric series expansion of the log-density. We show that when p is known, the posterior distribution of a Gaussian prior achieves the optimal rate provided the prior variances die off sufficiently rapidly. For a mixture of normal distributions, the mixing weights on the dimension of the exponential family are assumed to be bounded below by an exponentially decreasing sequence. To avoid the use of infinite bases, we develop priors that cut off the series at a sample-size-dependent truncation point. When the degree of smoothness is unknown, a finite mixture of normal priors indexed by the smoothness parameter, which is also assigned a prior, produces the best rate. A rate-adaptive estimator is derived.
Empirical Bayes conditional density estimation
Catia Scricciolo
Statistics , 2015,
Abstract: The problem of nonparametric estimation of the conditional density of a response, given a vector of explanatory variables, is classical and of prominent importance in many prediction problems since the conditional density provides a more comprehensive description of the association between the response and the predictor than, for instance, does the regression function. The problem has applications across different fields like economy, actuarial sciences and medicine. We investigate empirical Bayes estimation of conditional densities establishing that an automatic data-driven selection of the prior hyper-parameters in infinite mixtures of Gaussian kernels, with predictor-dependent mixing weights, can lead to estimators whose performance is on par with that of frequentist estimators in being minimax-optimal (up to logarithmic factors) rate adaptive over classes of locally H\"older smooth conditional densities and in performing an adaptive dimension reduction if the response is independent of (some of) the explanatory variables which, containing no information about the response, are irrelevant to the purpose of estimating its conditional density.
Adaptive Bayesian density estimation using Pitman-Yor or normalized inverse-Gaussian process kernel mixtures
Catia Scricciolo
Statistics , 2012,
Abstract: We consider Bayesian nonparametric density estimation using a Pitman-Yor or a normalized inverse-Gaussian process kernel mixture as the prior distribution for a density. The procedure is studied from a frequentist perspective. Using the stick-breaking representation of the Pitman-Yor process or the expression of the finite-dimensional distributions for the normalized-inverse Gaussian process, we prove that, when the data are replicates from an infinitely smooth density, the posterior distribution concentrates on any shrinking $L^p$-norm ball, $1\leq p\leq\infty$, around the sampling density at a \emph{nearly parametric} rate, up to a logarithmic factor. The resulting hierarchical Bayesian procedure, with a fixed prior, is thus shown to be adaptive to the infinite degree of smoothness of the sampling density.
Bayesian adaptation
Catia Scricciolo
Statistics , 2014,
Abstract: In the need for low assumption inferential methods in infinite-dimensional settings, Bayesian adaptive estimation via a prior distribution that does not depend on the regularity of the function to be estimated nor on the sample size is valuable. We elucidate relationships among the main approaches followed to design priors for minimax-optimal rate-adaptive estimation meanwhile shedding light on the underlying ideas.
Specialized multi-disciplinary heart failure clinics in Ontario, Canada: an environmental scan
Wijeysundera Harindra C,Trubiani Gina,Abrahamyan Lusine,Mitsakakis Nicholas
BMC Health Services Research , 2012, DOI: 10.1186/1472-6963-12-236
Abstract: Background Multi-disciplinary heart failure (HF) clinics have been shown to improve outcomes for HF patients in randomized clinical trials. However, it is unclear how widely available specialized HF clinics are in Ontario. Also, the service models of current clinics have not been described. It is therefore uncertain whether the efficacy of HF clinics in trials is generalizable to the HF clinics currently operating in the province. Methods As part of a comprehensive evaluation of HF clinics in Ontario, we performed an environmental scan to identify all HF clinics operating in 2010. A semi-structured interview was conducted to understand the scope of practice. The intensity and complexity of care offered were quantified through the use of a validated instrument, and clinics were categorized as high, medium or low intensity clinics. Results We identified 34 clinics with 143 HF physicians. We found substantial regional disparity in access to care across the province. The majority of HF physicians were cardiologists (81%), with 81% of the clinics physically based in hospitals, of which 26% were academic centers. There was a substantial range in the complexity of services offered, most notably in the intensity of education and medication management services offered. All the clinics focused on ambulatory care, with only one having an in-patient focus. None of the HF clinics had a home-based component to care. Conclusions Multiple HF clinics are currently operating in Ontario with a wide spectrum of care models. Further work is necessary to understand which components lead to improved patient outcomes.
Functional assay, expression of growth factors and proteins modulating bone-arrangement in human osteoblasts seeded on an anorganic bovine bone biomaterial
O Trubiani,S Fulle,T Traini,M Paludi
European Cells and Materials (ECM) , 2010,
Abstract: The basic aspects of bone tissue engineering include chemical composition and geometry of the scaffold design, because it is very important to improve not only cell attachment and growth but especially osteodifferentiation, bone tissue formation, and vascularization. Geistlich Bio-Oss (GBO) is a xenograft consisting of deproteinized, sterilized bovine bone, chemically and physically identical to the mineral phase of human bone.In this study, we investigated the growth behaviour and the ability to form focal adhesions on the substrate, using vinculin, a cytoskeletal protein, as a marker. Moreover, the expression of bone specific proteins and growth factors such as type I collagen, osteopontin, bone sialoprotein, bone morphogenetic protein-2 (BMP-2), BMP-7 and de novo synthesis of osteocalcin in normal human osteoblasts (NHOst) seeded on xenogenic GBO were evaluated. Our observations suggest that after four weeks of culture in differentiation medium, the NHOst showed a high affinity for the three dimensional biomaterial; in fact, cellular proliferation, migration and colonization were clearly evident. The osteogenic differentiation process, as demonstrated by morphological, histochemical, energy dispersive X-ray microanalysis and biochemical analysis was mostly obvious in the NHOst grown on three-dimensional inorganic bovine bone biomaterial. Functional studies displayed a clear and significant response to calcitonin when the cells were differentiated. In addition, the presence of the biomaterial improved the response, suggesting that it could drive the differentiation of these cells towards a more differentiated osteogenic phenotype. These results encourage us to consider GBO an adequate biocompatible three-dimensional biomaterial, indicating its potential use for the development of tissue-engineering techniques.
The potential role of vitamin D for prevention and treatment of tuberculosis and infectious diseases
Dini,Catia; Bianchi,Antonio;
Annali dell'Istituto Superiore di Sanità , 2012, DOI: 10.4415/ANN_12_03_13
Abstract: introduction: vitamin d deficiency (vdd) is a common condition among several populations in the world. vdd is associated with higher incidence of immune system disorders and faster progression of some infectious diseases. vitamin d is known to be of physiological importance, it is considered an essential micronutrient for the bone health and plays a beneficial role in the prevention and/or treatment of a number of chronic diseases. vitamin d has a complex action on the immune system. results: evidence that vitamin d protects against tuberculosis has been supported by in vitro, epidemiological and some preliminary clinical studies. vitamin d has a potential effect on hiv (human immunodeficiency virus) and plays a crucial role in the defence against respiratory infections. conclusions: vitamin d supplementation could be a low-cost, practical method to protect groups of people with high incidence of those diseases. public health education should stress the need for adequate dietary intake of vitamin d in those vulnerable groups.
"Plantar pro gasto": a importancia do autoconsumo entre famílias de agricultores do Rio Grande do Sul
Grisa, Catia;Schneider, Sergio;
Revista de Economia e Sociologia Rural , 2008, DOI: 10.1590/S0103-20032008000200008
Abstract: the article discusses the value and importance of the self-consumption production in the social reproduction of the family units and it characterizes the food self-consumed. the paper used the research "family farm, local development and pluriactivity" (ufrgs/ ufpel/cnpq-2003) that propitiated the formation of a database with information on the dynamics of the family farm in four areas different from the geography of the rio grande do sul, your sources and types of income, among these the self-consumption. to bring this debate means to retake a theme little discussed until then, and that, although marginalized or considered without importance, it develops important role as income non monetary, strengthens the food security and it penetrates spheres of the sociability and social identity. besides the introduction, is presented the role of the self-consumption in the family farm, the calculation of the self-consumption production, discussion of the objectives and results, and final considerations. the results demonstrate that the self-consumption production is an appealing strategy for the family units and it differs in agreement with the dynamics of the family farm. it differentiates this expresses in relative values (%) and in the number of establishments belonging to differentiated strata of self-consumption, and a little in the types of foods produced for this end, being observed a homogeneity of the alimentary habits.
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