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Search Results: 1 - 10 of 172056 matches for " Catherine E. Erickson "
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Sustainable Management of Eutrophic Lakes and Reservoirs  [PDF]
Tyler Wagner, Larry E. Erickson
Journal of Environmental Protection (JEP) , 2017, DOI: 10.4236/jep.2017.84032
Abstract: Eutrophication of lakes and reservoirs is a major water quality problem that poses significant environmental, economic and social threats around the world. Monitoring and managing lakes and reservoirs to prevent or limit eutrophication, therefore, has significant value. The literature has been reviewed to study ecological engineering and management methods that have been and can be applied to improve water quality. Ecological engineering has the potential to be utilized to improve the design and operation of lakes and reservoirs through monitoring and active management of biological, chemical and physical components. Phosphorus concentrations can be reduced by effective and sustainable management practices to improve water quality.
Sustainable Management of Algae in Eutrophic Ecosystems  [PDF]
William W. McNeary, Larry E. Erickson
Journal of Environmental Protection (JEP) , 2013, DOI: 10.4236/jep.2013.411A002

The accelerated eutrophication of the world’s freshwater and marine ecosystems is a complex problem that results in decreased productivity, loss of biodiversity, and various economic woes. Controlling algae populations in a eutrophic water body has values in mitigating some of these negative effects. This paper reviews a number of strategies for algae management, with a focus on sustainable practices that have minimal environmental impact. The information in the literature is then used to propose a design for an integrated algae-aquaculture system to be used for the dual purposes of nutrient assimilation and production of fish and algal biomass. Effectiveness of the proposed system and possible revenue streams to offset capital costs are examined; other solutions that utilize the techniques in the literature are also explored.

The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist
Catherine E. Erickson, Rukhsana Gul, Christopher P. Blessing, Jenny Nguyen, Tammy Liu, Lakshmi Pulakat, Murat Bastepe, Edwin K. Jackson, Bradley T. Andresen
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0071980
Abstract: Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes vasodilation by inducing nitric oxide (NO) production. The mechanism via which nebivolol induces NO production remains unknown, resulting in the genesis of much of the controversy regarding the pharmacological action of nebivolol. Carvedilol is another β-blocker that induces NO production. A prominent pharmacological mechanism of carvedilol is biased agonism that is independent of Gαs and involves G protein-coupled receptor kinase (GRK)/β-arrestin signaling with downstream activation of the epidermal growth factor receptor (EGFR) and extracellular signal-regulated kinase (ERK). Due to the pharmacological similarities between nebivolol and carvedilol, we hypothesized that nebivolol is also a GRK/β-arrestin biased agonist. We tested this hypothesis utilizing mouse embryonic fibroblasts (MEFs) that solely express β2-ARs, and HL-1 cardiac myocytes that express β1- and β2-ARs and no detectable β3-ARs. We confirmed previous reports that nebivolol does not significantly alter cAMP levels and thus is not a classical agonist. Moreover, in both cell types, nebivolol induced rapid internalization of β-ARs indicating that nebivolol is also not a classical β-blocker. Furthermore, nebivolol treatment resulted in a time-dependent phosphorylation of ERK that was indistinguishable from carvedilol and similar in duration, but not amplitude, to isoproterenol. Nebivolol-mediated phosphorylation of ERK was sensitive to propranolol (non-selective β-AR-blocker), AG1478 (EGFR inhibitor), indicating that the signaling emanates from β-ARs and involves the EGFR. Furthermore, in MEFs, nebivolol-mediated phosphorylation of ERK was sensitive to pharmacological inhibition of GRK2 as well as siRNA knockdown of β-arrestin 1/2. Additionally, nebivolol induced redistribution of β-arrestin 2 from a diffuse staining pattern into more intense punctate spots. We conclude that nebivolol is a β2-AR, and likely β1-AR, GRK/β-arrestin biased agonist, which suggests that some of the unique clinically beneficial effects of nebivolol may be due to biased agonism at β1- and/or β2-ARs.
The Coiled Coils of Cohesin Are Conserved in Animals, but Not In Yeast
Glenn E. White, Harold P. Erickson
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0004674
Abstract: Background The SMC proteins are involved in DNA repair, chromosome condensation, and sister chromatid cohesion throughout Eukaryota. Long, anti-parallel coiled coils are a prominent feature of SMC proteins, and are thought to serve as spacer rods to provide an elongated structure and to separate domains. We reported recently that the coiled coils of mammalian condensin (SMC2/4) showed moderate sequence divergence (≈10–15%) consistent with their functioning as spacer rods. The coiled coils of mammalian cohesins (SMC1/3), however, were very highly constrained, with amino acid sequence divergence typically <0.5%. These coiled coils are among the most highly conserved mammalian proteins, suggesting that they make extensive contacts over their entire surface. Methodology/Principal Findings Here, we broaden our initial analysis of condensin and cohesin to include additional vertebrate and invertebrate organisms and multiple species of yeast. We found that the coiled coils of SMC1/3 are highly constrained in Drosophila and other insects, and more generally across all animal species. However, in yeast they are no more constrained than the coils of SMC2/4 and Ndc80/Nuf2p, suggesting that they are serving primarily as spacer rods. Conclusions/Significance SMC1/3 functions for sister chromatid cohesion in all species. Since its coiled coils apparently serve only as spacer rods in yeast, it is likely that this is sufficient for sister chromatid cohesion in all species. This suggests an additional function in animals that constrains the sequence of the coiled coils. Several recent studies have demonstrated that cohesin has a role in gene expression in post-mitotic neurons of Drosophila, and other animal cells. Some variants of human Cornelia de Lange Syndrome involve mutations in human SMC1/3. We suggest that the role of cohesin in gene expression may involve intimate contact of the coiled coils of SMC1/3, and impose the constraint on sequence divergence.
Effect of sepsis therapies on health-related quality of life
Sara E Erickson, Greg S Martin
Critical Care , 2008, DOI: 10.1186/cc6215
Abstract: Sepsis affects more than 750,000 patients each year in the United States; it is the 10th leading cause of death and one of the leading causes for admission to the intensive care unit [1-4]. The estimated mortality from sepsis is 20–30%, meaning that approximately 500,000 patients survive their septic episode annually in the United States alone [3,4]. What happens to these sepsis survivors? Are they able to resume their lives and regular activities, or does sepsis have far-reaching effects that extend beyond the hospitalization? Ten years ago, Quartin and colleagues were the first to show that sepsis has long-lasting effects and increases the risk of death up to 5 years after hospitalization for the septic episode [5]. Mounting evidence has since demonstrated that survivors of sepsis have a higher long-term risk of death and a lower health-related quality of life (HRQoL) when compared with the general population [6-8].In 2001, recombinant human activated protein C (rhAPC) was shown to significantly reduce the 28-day mortality in patients with severe sepsis [9]. A subgroup analysis demonstrated that patients who were more severely ill, with multiple organ dysfunction or with Acute Physiology and Chronic Health Evaluation (APACHE) II scores ≥ 25, accrued the greatest benefit from rhAPC, resulting in drug approval focused on these sepsis populations [10]. A subsequent randomized controlled trial that evaluated rhAPC use in patients with severe sepsis and a low risk of death (APACHE II score < 25) found no survival benefit with rhAPC [11]. Given the high cost of rhAPC, the attendant bleeding risk associated with its use, and the lack of clinical trials confirming its efficacy, there continues to be debate and controversy regarding its appropriate use [12].With the increasing emphasis on patient-centered outcomes in clinical trials, we are now more frequently assessing short-term and long-term survival and, at least sometimes, HRQoL. In assessing long-term outcomes among
A model for aperiodicity in earthquakes
B. Erickson, B. Birnir,D. Lavallée
Nonlinear Processes in Geophysics (NPG) , 2008,
Abstract: Conditions under which a single oscillator model coupled with Dieterich-Ruina's rate and state dependent friction exhibits chaotic dynamics is studied. Properties of spring-block models are discussed. The parameter values of the system are explored and the corresponding numerical solutions presented. Bifurcation analysis is performed to determine the bifurcations and stability of stationary solutions and we find that the system undergoes a Hopf bifurcation to a periodic orbit. This periodic orbit then undergoes a period doubling cascade into a strange attractor, recognized as broadband noise in the power spectrum. The implications for earthquakes are discussed.
Managing N Inputs and the Effect on N Losses Following Excretion in Open-Dirt Feedlots in Nebraska
Galen E. Erickson,Terry J. Klopfenstein
The Scientific World Journal , 2001, DOI: 10.1100/tsw.2001.363
Nutritional Methods to Decrease N Losses from Open-Dirt Feedlots in Nebraska
Galen E. Erickson,Terry J. Klopfenstein
The Scientific World Journal , 2001, DOI: 10.1100/tsw.2001.364
Air Quality, Health and Community Action  [PDF]
Larry E. Erickson, Wendy Griswold, Ronaldo G. Maghirang, Brian P. Urbaszewski
Journal of Environmental Protection (JEP) , 2017, DOI: 10.4236/jep.2017.810067
Abstract: Air quality is impacting health in many cities in most countries because of particulate pollution, sulfur dioxide, nitrogen dioxide, and ozone. Very small particulates from engine emissions and coal fired electric power plants enter the lungs and pollute the blood of urban residents leading to a burden of disease with more than 3 million premature deaths per year attributed to outdoor air pollution. Welfare losses including premature deaths associated with air pollution were about $5 trillion in 2013. A global transition to electric vehicles, and the generation of electricity without combustion emissions would improve air quality significantly and reduce greenhouse gas emissions. This transition is in progress in many parts of the world with more than 2 million electric vehicles in service in 2017. Electric bus and electric taxi sales are increasing, and many large cities have multiple programs to improve air quality. When health costs are considered, it is very appropriate for communities to take action to improve air quality and health. This work reviews and reports many positive actions that are in progress in larger cities.
The role of selective cyclooxygenase isoforms in human intestinal smooth muscle cell stimulated prostanoid formation and proliferation
Walter E. Longo,Brian Erickson,Ninder Panesar,John E. Mazuski
Mediators of Inflammation , 1998, DOI: 10.1080/09629359890749
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