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Search Results: 1 - 10 of 1137 matches for " Casanova Sotolongo "
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Clínica neurológica en pacientes infectados por el virus de la inmunodeficiencia humana en un país de áfrica
Casanova Sotolongo,Pedro; Casanova Carrillo,Carlos;
Revista Cubana de Medicina , 2005,
Abstract: the aids cases are often accompanied with neuropsychiatric disorders. a descriptive and retrospective study was conducted among the patients admitted due to this reason at the central hospital of beira, mozambique from january 1, 1998 to june 30, 1999. a serological investigation was included to determine the presence of hiv infection. the antiretrovirals were not applied in the treatment of these patients. only the sustenance measures were taken mainly for the neurological affection. therefore, the cases considered as aids were subjected to the normal evolution of the disease. of the 210 patients suffering from neurological affections with diagnostic possibilities of contamination because of the virus, 134 (63.8) were seropositive. a significant predominance of males (91, 67.9 %) was observed. headache, vertigo and paresthesias were the most frequent complaints in both study groups. general lethality in seropositive patients with neurological dysfunction was 46.2 % . of the total of 134 patients included in the sample, 36 died in less than the first 2 weeks of admission, accounting for 28.3 % of lethality. it was confirmed that in this aids stage with neurological disorders, the prognosis is very bad, particularly, in individuals that have not been treated with antiretrovirals.
Estudio clínico de pacientes con neuropatía mielo-óptica
Casanova Sotolongo,Pedro; Casanova Carrillo,Pedro;
Revista Cubana de Medicina , 2001,
Abstract: the occurrence of a number of cases with gait disorders, paresthesia and visual disorders was detected in a region of buzi district, sofala province, mozambique. this gave rise to a research study on this phenomenon. sixty patients were studied and applied a detailed questionnaire and a thorough neurological examination aimed at a clinical diagnosis of the disease. it was found as predominant factors: tiredness, weight loss, paresthesia, painful lower limbs and reduced vision. 56.6 % of them showed manifestations suggesting a combined form of peripheral neuropathy with optic nerve affected.clinical evidence of lesions in the central and peripheral nervous systems, and in some cases, the auditory branch of the 8th cranial pair were obtained, being the 21-40 years age group the most affected. the diseases seemed to be related to many factors and the most important of them were the nutritional and toxic factors
Estudio clínico de pacientes con neuropatía mielo-óptica
Pedro Casanova Sotolongo,Pedro Casanova Carrillo
Revista Cubana de Medicina , 2001,
Abstract: Se detectó, en una región del distrito de Buzi, provincia de Sofala, en Mozambique, la aparición de numerosos casos con trastorno de la marcha, parestesias y alteraciones visuales, lo que motivó la investigación de este fenómeno. Se estudiaron 60 pacientes a quienes se les realizó un detallado interrogatorio y un examen neurológico minucioso dirigidos al diagnóstico clínico de la enfermedad. Se encontró que los síntomas predominantes fueron el cansancio, la pérdida de peso, parestesias, dolor en los miembros inferiores y disminución de la visión. En el 56,6 % había manifestaciones que indicaban una forma mixta de neuropatía periférica con toma del nervio óptico. Se obtuvieron evidencias clínicas de lesión de los sistemas nerviosos central y periférico y, en algunos casos, de la rama auditiva del VIII par craneal, con una mayor afectación en el grupo de edad entre 21 y 40 a os. Al parecer, la enfermedad estaba relacionada con factores múltiples: entre los más importantes el nutricional y el tóxico The occurrence of a number of cases with gait disorders, paresthesia and visual disorders was detected in a region of Buzi district, Sofala province, Mozambique. This gave rise to a research study on this phenomenon. Sixty patients were studied and applied a detailed questionnaire and a thorough neurological examination aimed at a clinical diagnosis of the disease. It was found as predominant factors: tiredness, weight loss, paresthesia, painful lower limbs and reduced vision. 56.6 % of them showed manifestations suggesting a combined form of peripheral neuropathy with optic nerve affected.Clinical evidence of lesions in the central and peripheral nervous systems, and in some cases, the auditory branch of the 8th cranial pair were obtained, being the 21-40 years age group the most affected. The diseases seemed to be related to many factors and the most important of them were the nutritional and toxic factors
Clínica neurológica en pacientes infectados por el virus de la inmunodeficiencia humana en un país de áfrica Neurological clinic in HIV patients in an African country
Pedro Casanova Sotolongo,Carlos Casanova Carrillo
Revista Cubana de Medicina , 2005,
Abstract: Los casos de SIDA a menudo se acompa an de trastornos neuropsiquiátricos. Realizamos un estudio descriptivo retrospectivo de los pacientes ingresados por esta causa en el Hospital Central de Beira, Mozambique, en el período comprendido desde el primero de enero de 1998 hasta el 30 de junio de 1999, que incluyó investigación serológica para establecer la presencia de la infección por el virus de la inmunodeficiencia humana. No se contaba con los antirretrovirales aplicados en el tratamiento de estos enfermos, solo se aplicaron medidas de sostén, sobre todo, para la afectación neurológica, por lo que los casos considerados como SIDA estaban sujetos a la evolución natural de la enfermedad. De los 210 sujetos con afecciones neurológicas con posibilidades diagnósticas de contaminación por el virus, 134 (63,8 %) fueron seropositivos con un significativo predominio masculino, 91 (67,9 %). La cefalea, el vértigo y las parestesias fueron las quejas más frecuentes para ambos grupos de estudio. La letalidad general en los pacientes con disfunción neurológica seropositivos fue de 46,2 %. Del total de la muestra de 134 pacientes seropositivos fallecieron, en menos de las 2 primeras semanas del ingreso, 38 (28,3 % de letalidad). Se corroboró que en esta etapa del SIDA con trastornos neurológicos, sobre todo, en sujetos no tratados con antirretrovirales, el pronóstico es muy malo. The AIDS cases are often accompanied with neuropsychiatric disorders. A descriptive and retrospective study was conducted among the patients admitted due to this reason at the Central Hospital of Beira, Mozambique from January 1, 1998 to June 30, 1999. A serological investigation was included to determine the presence of HIV infection. The antiretrovirals were not applied in the treatment of these patients. Only the sustenance measures were taken mainly for the neurological affection. Therefore, the cases considered as AIDS were subjected to the normal evolution of the disease. Of the 210 patients suffering from neurological affections with diagnostic possibilities of contamination because of the virus, 134 (63.8) were seropositive. A significant predominance of males (91, 67.9 %) was observed. Headache, vertigo and paresthesias were the most frequent complaints in both study groups. General lethality in seropositive patients with neurological dysfunction was 46.2 % . Of the total of 134 patients included in the sample, 36 died in less than the first 2 weeks of admission, accounting for 28.3 % of lethality. It was confirmed that in this AIDS stage with neurological disorders, the prognosis i
Enfermedades de la médula espinal en el curso de la infección por el virus de la inmunodeficiencia humana
Casanova Sotolongo,Pedro; Casanova Carrillo,Pedro; Casanova Carrillo,Carlos;
Revista Cubana de Medicina , 2003,
Abstract: on making a review of the neurological complications in aids patients, it was proved that they are diverse, frequent and include opportunistic infections and lymphomas, as well as peripheral neuropathy, myelopathy and dementia related to the acquired immunodeficiency virus (hiv). the spinal cord lesions generally appear at a late stage of the disease and on some occassions they are not noticed by physicians, who are not accostumed to see them. their appareance as a first sign of the disease is very rare. the most common spinal cord affections in these cases are vacuolar myelopahty and myelitis. a close pathological similarity between aids-related myelopathies and the vacuolar myelopathy has been stressed based on the findings on vitamin b12 deficiency that suggest that an abnormality in the metabolism of this vitamin dependent of the transmethylation pathway may be important in the myelopathy genesis in aids. taking into account the possible association between the hiv-1 viral burden in the cerebrospinal fluid and the cognitive disorders, there have been advances in the hypothesis about a similar mechanism with myelopathy, but it has not been possible to establish a correlation of this entity with the viral burden the diagnosis is based on the clinical picture of the spinal cord lesion, mainly on motor disorders with pyramidal signs and sphincteral dysfucntion.a high incidence of paraparesis, paresthesias, spasticity and backache has been stressed. the genesis of myelopathy in this entity is really unknown. the benefits of prophylaxis and of antiretroviral therapy have changed the focus of attention of the neurological diseases in the course of aids.
Toxoplasmosis cerebral durante la infección por el virus de inmunodeficiencia humana
Casanova Sotolongo,Pedro; Casanova Carrillo,Pedro; Casanova Carrillo,Carlos;
Revista Cubana de Medicina , 2002,
Abstract: it is stressed that about one third of the patients with hiv infections have nervous complications that cause considerable morbidity and mortality and that the main neurological manifestations depend on the primary infection due to this virus, to secondary opportunistic infections or to complications of the antiretroviral therapy. any site of the nervous system, be central, peripheral or muscular may be affected during hiv infection. generally, toxoplasmic encephalitis results from the reactivation of an endogenous infection. felines, specially cats, are definitive hosts; the human beign is an accidental host capable of controlling the infection under normal immunity conditions. the toxoplasm infects all the central nervous system difussely from the initial stages. neurotoxoplasmosis together with encephalopathy are some of the most common forms of brain compromise, mainly with clinic of focal dysfunction in hiv-infected patients. the prognosis and survival of these patients depend on the diagnosis and on a timely and efficient treatment. the presumptive diagnosis of toxoplasmic encephalitis is based on the triad of positive toxoplasma serology, characteristic radiography and good response to antitoxoplasmic empiric treatment. although rarely necessary, the definitive diagnosis is based on the proved presence of tg in the biopsy specimen or in the injury aspirate. in the acute infection, it is recommended the combined use of pyrimethamine (daraprim), sulfadiazine and folic acid. the use of pyrimethamine at maintenance doses has been proposed for life.
Deterioro cognitivo en la tercera edad
Casanova Sotolongo,Pedro; Casanova Carrillo,Pedro; Casanova Carrillo,Carlos;
Revista Cubana de Medicina General Integral , 2004,
Abstract: in the normal and pathological aging, amnesic dysfunction is the most common cognitive disorder with detriment to the quality of life, to the capacity for new learning processes, and in the evokation of valuable information. the deterioration of memory associated with age describes a decline of memory without any other cause that explains it. it has been suggested that it is a normal phenomenon in the elderly more than an initial stage of dementia or other disease. the early detection of memory disorders is important as frequent and prodromic signs of the demential syndromes. depression is a risk factor that should always be taken into account. the relative facility of its diagnosis by clinical, neuropsychological and imaging methods, makes it an efficient tool in the hands of the family physicians for the control and classification of the older adult in his communities.
Deterioro cognitivo en la tercera edad Cognitive deterioration at the third age
Pedro Casanova Sotolongo,Pedro Casanova Carrillo,Carlos Casanova Carrillo
Revista Cubana de Medicina General Integral , 2004,
Abstract: Tanto en el envejecimiento normal como en el patológico, la disfunción mnésica es la alteración cognoscitiva más común con detrimento de la calidad de vida y de la capacidad de nuevos aprendizajes y en la evocación de información valiosa. El deterioro de la memoria asociado con la edad describe una declinación en la memoria sin otra causa que lo explique. Se ha sugerido que es un fenómeno normal en los ancianos más que una etapa inicial de una demencia u otra enfermedad. Es importante la detección precoz de los trastornos de memoria como signos frecuentes y prodrómicos de los síndromes demenciales. Un factor de riesgo que debe siempre considerarse es la depresión. La relativa facilidad de su diagnóstico por métodos clínicos, neuropsicológicos y de imagen hace que pueda ser una herramienta eficaz en manos de los médicos de familia, para el control y dispensarización del adulto mayor en sus comunidades. In the normal and pathological aging, amnesic dysfunction is the most common cognitive disorder with detriment to the quality of life, to the capacity for new learning processes, and in the evokation of valuable information. The deterioration of memory associated with age describes a decline of memory without any other cause that explains it. It has been suggested that it is a normal phenomenon in the elderly more than an initial stage of dementia or other disease. The early detection of memory disorders is important as frequent and prodromic signs of the demential syndromes. Depression is a risk factor that should always be taken into account. The relative facility of its diagnosis by clinical, neuropsychological and imaging methods, makes it an efficient tool in the hands of the family physicians for the control and classification of the older adult in his communities.
Enfermedades de la médula espinal en el curso de la infección por el virus de la inmunodeficiencia humana
Pedro Casanova Sotolongo,Pedro Casanova Carrillo,Carlos Casanova Carrillo
Revista Cubana de Medicina , 2003,
Abstract: Se hizo una revisión sobre las complicaciones neurológicas en los pacientes con SIDA, se comprobó que son diversas, frecuentes e incluyen infecciones oportunistas y linfoma, así como neuropatía periférica, mielopatía y demencia relacionadas con el virus de la inmunodeficiencia adquirida (VIH). Las lesiones de la médula espinal aparecen, generalmente, en un estadio tardío de la enfermedad y no pocas veces cursan de modo inadvertido por los facultativos no habituados a su atención. Su aparición como primer signo de la enfermedad es muy rara. Las afecciones medulares más comunes en estos casos son la mielopatía vacuolar y la mielitis. Se ha se alado una estrecha similitud patológica entre las mielopatías asociadas al SIDA y la vacuolar con los hallazgos detectados en la deficiencia de vitamina B12 lo cual ha hecho sugerir que una anormalidad en el metabolismo de esta vitamina dependiente de la vía de la transmetilación pudiera ser importante en la génesis de la mielopatía en el SIDA. Basados en la probable asociación entre la carga viral VIH-1 en el líquido cefalorraquídeo con los trastornos cognitivos se ha avanzado la hipótesis de un mecanismo similar con la mielopatía, pero no se ha podido establecer una correlación de esta entidad con la carga viral. El diagnóstico se establece por el cuadro clínico de lesión de médula espinal, sobre todo de trastornos motores, con signos piramidales y disfunción esfinteriana. Se ha se alado una elevada incidencia de paraparesia, parestesias, espasticidad y dolor de espalda. Se desconoce realmente la génesis de la mielopatía en esta entidad. Los beneficios de la profilaxis y de la terapia antirretroviral han modificado el enfoque de la atención de las enfermedades neurológicas en el curso del SIDA. On making a review of the neurological complications in AIDS patients, it was proved that they are diverse, frequent and include opportunistic infections and lymphomas, as well as peripheral neuropathy, myelopathy and dementia related to the acquired immunodeficiency virus (HIV). The spinal cord lesions generally appear at a late stage of the disease and on some occassions they are not noticed by physicians, who are not accostumed to see them. Their appareance as a first sign of the disease is very rare. The most common spinal cord affections in these cases are vacuolar myelopahty and myelitis. A close pathological similarity between AIDS-related myelopathies and the vacuolar myelopathy has been stressed based on the findings on vitamin B12 deficiency that suggest that an abnormality in the metabolism of this vitamin depende
Toxoplasmosis cerebral durante la infección por el virus de inmunodeficiencia humana
Pedro Casanova Sotolongo,Pedro Casanova Carrillo,Carlos Casanova Carrillo
Revista Cubana de Medicina , 2002,
Abstract: Se se ala que alrededor de un tercio de los pacientes con infecciones por el virus de la inmunodeficiencia humana presentan complicaciones nerviosas que provocan considerable morbilidad y mortalidad y que las principales manifestaciones neurológicas dependen de la infección primaria por ese virus, por infecciones oportunistas secundarias o por complicaciones de la terapia antirretroviral. Cualquier sitio del sistema nervioso, ya sea central, periférico e incluso muscular, puede ser afectado durante la infección por el VIH. La encefalitis por toxoplasma, generalmente, resulta de la reactivación de una infección endógena. Los felinos, en particular los gatos, son huéspedes definitivos; el ser humano es un hospedero accidental, capaz de controlar la infección en condiciones de inmunidad normal. El toxoplasma infecta difusamente a todo el sistema nervioso central desde las etapas iniciales. La neurotoxoplasmosis junto con la encefalopatía, es una de las formas más frecuentes de compromiso cerebral, sobre todo con clínica de disfunción focal en pacientes infectados por el VIH. El pronóstico y la supervivencia de estos pacientes dependen del diagnóstico y tratamiento oportuno y eficaz. El diagnóstico presuntivo de encefalitis toxoplásmica se basa en la tríada de: serología positiva al toxoplasma, radiografía característica y buena respuesta al tratamiento empírico antitoxoplásmico. Aunque raramente necesario, el diagnóstico definitivo se realiza por la presencia demostrada del TG en la muestra de biopsia o en el aspirado de la lesión. En la infección aguda se recomienda el uso combinado de pirimetamina (daraprín), sulfadiacina y ácido fólico. Se ha propuesto el uso de por vida de la pirimetamina en dosis de mantenimiento. It is stressed that about one third of the patients with HIV infections have nervous complications that cause considerable morbidity and mortality and that the main neurological manifestations depend on the primary infection due to this virus, to secondary opportunistic infections or to complications of the antiretroviral therapy. Any site of the nervous system, be central, peripheral or muscular may be affected during HIV infection. Generally, toxoplasmic encephalitis results from the reactivation of an endogenous infection. Felines, specially cats, are definitive hosts; the human beign is an accidental host capable of controlling the infection under normal immunity conditions. The toxoplasm infects all the central nervous system difussely from the initial stages. Neurotoxoplasmosis together with encephalopathy are some of the most common f
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