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Search Results: 1 - 10 of 29371 matches for " Carvalho-Filho "
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Individualized treatment of chronic hepatitis C with pegylated interferon and ribavirin
Roberto J Carvalho-Filho, Olav Dalgard
Pharmacogenomics and Personalized Medicine , 2010, DOI: http://dx.doi.org/10.2147/PGPM.S4461
Abstract: dividualized treatment of chronic hepatitis C with pegylated interferon and ribavirin Review (4445) Total Article Views Authors: Roberto J Carvalho-Filho, Olav Dalgard Published Date March 2010 Volume 2010:3 Pages 1 - 13 DOI: http://dx.doi.org/10.2147/PGPM.S4461 Roberto J Carvalho-Filho1, Olav Dalgard2 1Division of Gastroenterology, Hepatitis Section, Federal University of S o Paulo, S o Paulo, Brazil; 2Department of Medicine, Rikshospitalet, Oslo, Norway Abstract: Chronic infection with hepatitis C virus (HCV) is a major public health problem, with perhaps 180 million people infected worldwide. A significant proportion of these will eventually develop clinical complications, such as cirrhosis, liver decompensation and hepatocellular carcinoma. Sustained virological response (SVR) to antiviral therapy is associated with improvement in liver histology and survival free of liver-related complications. Great effort has been made to improve SVR rate by adapting the duration of therapy according to HCV genotype and to on-treatment response. Rapid virological response (RVR, undetectable HCV RNA at week 4) usually has a high positive predictive value for achieving SVR and early virological response (EVR, ≥ 2 log reduction or undetectable HCV RNA at week 12) exhibits a high negative predictive value for non-response. Individualized approach can improve cost-effectiveness of HCV antiviral therapy by reducing side effects and the costs of therapy associated with unnecessary exposure to treatment and through extending therapy for those with unfavorable features. This article summarizes recent data on strategies of individualized treatment in na ve patients with mono-infection by the different HCV genotypes. The management of common side effects, the impact of HCV infection on health-related quality of life and the potential applications of host genomics in HCV therapy are also briefly discussed.
Individualized treatment of chronic hepatitis C with pegylated interferon and ribavirin
Roberto J Carvalho-Filho,Olav Dalgard
Pharmacogenomics and Personalized Medicine , 2010,
Abstract: Roberto J Carvalho-Filho1, Olav Dalgard21Division of Gastroenterology, Hepatitis Section, Federal University of S o Paulo, S o Paulo, Brazil; 2Department of Medicine, Rikshospitalet, Oslo, NorwayAbstract: Chronic infection with hepatitis C virus (HCV) is a major public health problem, with perhaps 180 million people infected worldwide. A significant proportion of these will eventually develop clinical complications, such as cirrhosis, liver decompensation and hepatocellular carcinoma. Sustained virological response (SVR) to antiviral therapy is associated with improvement in liver histology and survival free of liver-related complications. Great effort has been made to improve SVR rate by adapting the duration of therapy according to HCV genotype and to on-treatment response. Rapid virological response (RVR, undetectable HCV RNA at week 4) usually has a high positive predictive value for achieving SVR and early virological response (EVR, ≥ 2 log reduction or undetectable HCV RNA at week 12) exhibits a high negative predictive value for non-response. Individualized approach can improve cost-effectiveness of HCV antiviral therapy by reducing side effects and the costs of therapy associated with unnecessary exposure to treatment and through extending therapy for those with unfavorable features. This article summarizes recent data on strategies of individualized treatment in na ve patients with mono-infection by the different HCV genotypes. The management of common side effects, the impact of HCV infection on health-related quality of life and the potential applications of host genomics in HCV therapy are also briefly discussed.Keywords: hepatitis C, pegylated interferon, individualized treatment, genotype, genomics
Life History of Aricoris propitia (Lepidoptera: Riodinidae)—A Myrmecophilous Butterfly Obligately Associated with Fire Ants
Lucas A. Kaminski,Fernando S. Carvalho-Filho
Psyche , 2012, DOI: 10.1155/2012/126876
Abstract: The immature stages of Aricoris propitia (Stichel) are described and illustrated for the first time, using both light and scanning electron microscopy. Females oviposit in at least seven host-plant families, always in the presence of fire ants (Solenopsis saevissima (Smith) complex), without being attacked by them. Larvae are tended by ants during all larval and pupal stages. From the fourth instar on, larvae feed at night and rest during the day inside underground shelters constructed by ants on the host plant roots, and where pupation occurs. Several observed features, including ant-mediated oviposition, persistent ant attendance throughout all instars, and high spatiotemporal fidelity indicate that A. propitia is a myrmecophile obligately associated with fire ants. We propose A. propitia as an extraordinary model for studies on ant-butterfly evolutionary history in the Neotropics.
Neriidae (Diptera: Schizophora) of the Brazilian Amazon: new records of genera and species, and key to species
Carvalho-Filho, Fernando S.;Esposito, Maria C.;
Neotropical Entomology , 2008, DOI: 10.1590/S1519-566X2008000100008
Abstract: the present study brings together survey data from collection in several localities in the brazilian amazon and specimens from the entomological collection of museu paraense emílio goeldi (mpeg-belém). the flies were collected over organic decomposing matter (bananas and bovine meat) baits. the genus odontoloxozus enderlein, with the species odontoloxozus peruanus hennig, is recorded from brazil for the first time. the species glyphidops (glyphidops) flavipes (widemann), g. (oncopsia) flavifrons (bigot), g.(o.) durus (cresson) and g. (o.) dipsar (hennig) are new occurrences for brazil. the species g. (o.)carrerai aczél and n. plurivittatus bigot are new occurrences from brazilian amazon. a key to brazilian amazon species is provided.
Redescription of Pseudopomyzella flava Hennig (Diptera: Cypselosomatidae) and the first record from Brazil
Carvalho-Filho, Fernando da Silva;Esposito, Maria Cristina;
Biota Neotropica , 2011, DOI: 10.1590/S1676-06032011000100020
Abstract: cypselosomatidae is composed of cypselosomatinae and pseudopomyzinae, including 11 extant genera. only the genus rhinopomyzella hennig (pseudopomyzinae) has been previously recorded from brazil, represented by two species from santa catarina. the genus pseudopomyzella hennig is comprised of a single species, pseudopomyzella flava hennig, previously found only in peru and ecuador. here, we report p. flava for the first time from brazil (pará) and redescribe the species based on the specimens collected.
The Effect of High Carbohydrate Consumption on Glucose Levels and Antibody Production in Nonobese Diabetic Mice  [PDF]
Tonicley Alexandre da Silva, Caio José de Carvalho-Filho, Elizabeth de Sousa Barcelos Barroqueiro, Deysianne Costa das Chagas, Flá via Raquel Fernandes Nascimento, Rosane Nassar Meireles Guerra
Food and Nutrition Sciences (FNS) , 2016, DOI: 10.4236/fns.2016.710086
Abstract: The aim of this study was to evaluate the effect of chronic treatment with diets rich in carbohydrates on the IgM and IgG antibody production and the seric glucose concentration in diabetes. Nonobese diabetic (NOD) mice received, ad libitum, by oral route, the diet consisting of an aqueous extract (20 mg/mL) of the following flours: babassu mesocarp, manioc, corn or rice, during 120 days. The diet intake was monitored throughout this period. At the end, the weight variation, blood glucose, serum IgG and IgM antibody and IgM anti-insulin titers, were determined. The babassu and manioc flour extracts altered Purina chow intake and these animals also presented a significant increase in body weight. In contrast, treatment with rice flour resulted in a significant weight loss. Moderate to severe hyperglycemia was observed in the groups receiving rice and manioc, whereas treatment with babassu mesocarp flour and cornmeal resulted in hypoglycemia. The extracts did not alter the IgG concentration. On the other hand, the cornmeal extract caused a marked reduction in both total IgM and anti-insulin IgM antibody production. Although babassu mesocarp flour, cornmeal and manioc flour caused important variations in the parameters studied, only treatment with the rice flour extract anticipated the onset of diabetes in male mice genetically predisposed to the disease.
Translational research into gut microbiota: new horizons in obesity treatment
Tsukumo, Daniela M.;Carvalho, Bruno M.;Carvalho-Filho, Marco A.;Saad, Mário J. A.;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2009, DOI: 10.1590/S0004-27302009000200004
Abstract: obesity is a pandemic which has been rapidly developing for three decades. when a population is submitted to the same nutritional stress, some individuals are less susceptible to diet-induced weight gain and hyperglycemia. this observation suggests that other mechanisms are involved which are not directly related to the human genome. the human gut contains an immense number of microorganisms, collectively known as the microbiota. evidence that gut microbiota composition can differ between obese and lean humans has led to the speculation that gut microbiota can participate in the pathophysiology of obesity. different mechanisms have been proposed to explain the link between gut flora and obesity. the first mechanism consists in the role of the gut microbiota to increase energy extraction from indigestible dietary polysaccharides. the second, consists in the role of gut flora to modulate plasma lipopolysaccharide levels which triggers chronic low-grade inflammation leading to obesity and diabetes. a third mechanism proposes that gut microbiota may induce regulation of host genes that modulate how energy is expended and stored. however, further studies are needed to clarify a number of issues related to the relationship between the gut microbiota and obesity.
Hypercalcemia in a patient with disseminated paracoccidioidomycosis: a case report
Rafael Almeida, Loureno Cezana, Daniela Tsukumo, Marco de Carvalho-Filho, Mário Saad
Journal of Medical Case Reports , 2008, DOI: 10.1186/1752-1947-2-262
Abstract: We report the case of a 22-year-old man in whom disseminated infection with paracoccidioidomycosis was associated with hypercalcemia. The patient had a high normal serum level of 1,25-dihydroxyvitamin D and a suppressed parathyroid hormone value, an indication that the hypercalcemia was not mediated by parathyroid hormone and might be associated with 1,25-dihydroxyvitamin D.The episode resolved readily with administration of corticosteroids, an outcome suggesting that this is an effective treatment of hypercalcemia of this origin. On follow-up, while receiving antifungal therapy for P. brasiliensis the patient's calcium values remained normal.Hypercalcemia is well described in various granulomatous disorders, such as sarcoidosis, tuberculosis, berylliosis, leprosy and fungal infections. Among the fungal diseases, disseminated candidiasis, histoplasmosis, cryptococcosis and coccidioidomycosis have rarely been implicated as causes of hypercalcemia [1-5]. In this report we describe a patient in whom hypercalcemia was associated with disseminated infection with Paracoccidioides brasiliensis and a high normal serum level of 1,25-dihydroxyvitamin D.The patient, a 22-year-old male agriculturalist was admitted to our hospital in November 2006 with asthenia, weight loss, fever, diffuse enlargement of cervical lymph nodes and enlarged liver and spleen. The patient's temperature was 38.5°C and his blood pressure was 120/80 mmHg with a pulse of 96 beats per minute.Initial laboratory studies included an erythrocyte sedimentation rate of 89 mm/hour, serum hemoglobin of 11.4 g/dl, white blood cell count of 13,690/mm3 (27% eosinophils), serum albumin of 2.4 g/dl, normal serum urea, creatinine, sodium and potassium. On admission, the patient had a total serum calcium level of 10.4 mg/dl (normal range 8.4 to 9.7 mg/dl; ~12 mg/dl when corrected for albumin), ionized calcium of 1.46 mmol/l (normal range 1.15 to 1.29 mmol/l) and phosphorus of 4.9 mg/dl (normal range 2.7 to 4.5 mg/dl). A
Diversidade de Calliphoridae (Insecta: Diptera) na base de extra??o petrolífera da Bacia do Rio Urucu, na Amaz?nia brasileira
Esposito, Maria Cristina;Sousa, José Roberto Pereira de;Carvalho-Filho, Fernando da Silva;
Acta Amazonica , 2010, DOI: 10.1590/S0044-59672010000300018
Abstract: the diversity and abundance of blow flies in three environments (anthropic gaps, tree-fall gaps, and primary "terra firme" forest) of porto urucu/am were evaluated in annual collects realized in 2004, 2005, and 2006. during these three years were collected 2,121 specimens belonging to 14 species. the most abundant species were chloroprocta idioidea (robineau- desvoidy), eumesembrinella randa (walker), and hemilucilia semidiaphana (rondani). primary forests and tree-fall gaps enviroments, showed higher blow flies abundance than anthropic gaps, with diversity and equitability index higher than anthropic gaps, when the dominance value was high.
Hemocromatose hereditária: relato de caso e revis?o da literatura
SOUZA, Aécio Flávio Meirelles de;CARVALHO-FILHO, Roberto J.;CHEBLI, Júlio Fonseca;
Arquivos de Gastroenterologia , 2001, DOI: 10.1590/S0004-28032001000300010
Abstract: background ? hfe-associated hemochromatosis is one of the most common inherited liver disease in caucasian populations and refers to the association of increased iron stores with tissue damage (e.g., cirrhosis, diabetes, cardiomyopathy), which is progressive when diagnosis and treatment are delayed. aims - description of a case of hereditary hemochromatosis in an asymptomatic 44-years-old patient, whose diagnosis was made through casual identification of abnormal iron markers. we will also present a brief review of the literature about the topic. conclusions - hereditary hemochromatosis is an ideal disease for primary prevention since the disease can be detected well before serious complications develop. this intervention has been shown to prevent the manifestations of the disease, altering its natural history.
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