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Search Results: 1 - 10 of 13582 matches for " Carmen Parra Cid "
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Síntesis y evaluación del efecto ansiolítico de un nuevo derivado pirimido[1,6-a]pirimidínico
Alejandro Mu?oz Zurita,Jesús Sandoval Ramírez,Luis Emilio Espinoza Moreno,Carmen Parra Cid
Revista de la Sociedad Química de México , 2003,
Abstract: Se describe la síntesis de la (E)-9-estirilcarboxamido-6,8- dioxo-7-propil-1,3,4,6,7,8-hexahidro-2H-pirimido[1,6-a]pirimidina (9) a partir de 6-aminouracilo (4) utilizando una vía de síntesis quimio- y regioselectiva; además se reporta el estudio fármaco-biológico de 9 utilizando el modelo experimental ansiolítico del laberinto elevado en cruz. Adicionalmente, se presenta la relación dosis efecto de 9 sobre la actividad locomotora empleando el modelo de campo cerrado en ratas macho Wistar; la cual concluye que al administrar crónicamente diferentes dosis de 9 se genera un efecto ansiolítico importante y una disminución de la actividad locomotora.
Efecto de la (E)-3-butil-8-estiri1-1-propilxantina sobre la asimetría motora en rata
Alejandro Mu?oz Zurita,Jesús Sandoval Ramírez,Carmen Parra Cid,Daniel Limón Pérez de León
Revista de la Sociedad Química de México , 2002,
Abstract: Se describe la síntesis de la (E)-3-butil-8-estiri1-1-propilxantina (A15Bu) a partir de 6-aminouracilo (6) y un estudio biológico con el modelo experimental antiparkinsoniano de conducta de giro, en ratas de cepa Wistar. Al administrar el compuesto A15Bu en ratas lesionadas con 6-hidroxidopamina (6-OHDA) en la sustancia nigra pars compacta la asimetría motora se redujo en un 75 %.
Motor Effects of 1,3-Disubstituted 8-Styrylxanthines as A1 and A2 Adenosine-Receptor Antagonists in Rats  [PDF]
Ilhuicamina Daniel Limón-Pérez de León, María del Carmen Parra-Cid, Alejandro Mu?oz-Zurita, Saúl Alejandro Merino-Contreras, Sara Montiel-Smith, Socorro Meza-Reyes, Gerardo Ramírez-Mejía, Jesús Sandoval-Ramírez
Pharmacology & Pharmacy (PP) , 2013, DOI: 10.4236/pp.2013.43044
Abstract:

A series of 1,3-substituted 8-styrylxanthines (11a-d) was synthesized, under chemo- and regioselective conditions, in a good overall yield. The compounds showed affinity towards both A1 and A2A-adenosine receptors by radioligand binding by means of in vitro assays. The (E)-3-ethyl-1-propyl-8-styrylxanthine (11a) showed the greatest affinity towards the A2A receptor, whereas (E)-3-pentyl-1-propyl-8-styrylxanthine (11d) showed the greatest affinity for the A1 receptor. When the 8-styrylxanthines 11a (A15Et) and 11c (A15Bu) were administrated in rats, which were previously injured with 6-hydroxydopamine at the substantia nigra pars compacta (SNc), the turning behavior decreased 50%. Based on these results we propose to A15Et as a potential compound to treat some symptoms of Parkinson’s disease.

Lesión de médula espinal y medicina regenerativa
Estrada-Mondaca,Sandino; Carreón-Rodríguez,Alfonso; Parra-Cid,María del Carmen; León,Clemente Ibarra-Ponce de; Velasquillo-Martínez,Cristina; Vacanti,Charles A.; Belkind-Gerson,Jaime;
Salud Pública de México , 2007, DOI: 10.1590/S0036-36342007000600011
Abstract: spinal cord injury (sci) is a trauma problem striking mainly working age adults, therefore affecting society beyond the victim?s family circle. most of the victims of sci will never recover; therapy for this type of injury consists basically on spinal cord support and stabilization. with the discovery of stem cells (sc), sci treatment has been given another chance. stem cells are responsible for tissue renewal throughout the individual?s life, as well as tissue repair when needed. from the therapeutic point of view, the most appealing sc are those capable of generating a variety of tissues, those easily harvested, and finally, those ethically unquestioned. this article summarizes some studies carried with sc of various origins and their application to sci treatment.
La controversia de los agrocombustibles, una propuesta didáctica para las Ciencias para el Mundo Contemporáneo
María Escudero,Carmen Cid,Ricardo Escudero
Revista Eureka sobre Ense?anza y Divulgación de las Ciencias , 2009,
Abstract: Presentamos una propuesta didáctica para llevar a cabo en la nueva materia Ciencias para el Mundo Contemporáneo (CMC). Elegimos un tema actual y controvertido, como es el caso de los agrocombustibles (mal llamados biocombustibles) y lo abordamos de un modo que se convierta en algo atractivo para los alumnos, haciéndoles conocer a la vez los fundamentos científicos del problema.
H. pylori and mitochondrial changes in epithelial cells: The role of oxidative stress
Calvino-Fernández,M.; Parra-Cid,T.;
Revista Espa?ola de Enfermedades Digestivas , 2010, DOI: 10.4321/S1130-01082010000100006
Abstract: infection with h. pylori plays a role in the pathogenesis of gastritis, peptic ulcer, gastric carcinoma, and gastric lymphoma, but mechanisms leading to the various clinical manifestations remain obscure and are the primary focus of research in this field. proliferation and apoptosis are essential in the maintenance of gastric tissue homeostasis, and changes seen in their balance may condition gastric mucosal changes during infection. thus, excessive apoptosis or proliferation inhibition will result in cell mass loss, which is observed in gastric ulcers. on the other hand, accelerated epithelial cell turnover is characteristic of carcinogenic mucosas. there is also scientific evidence that demonstrates an association between h. pylori infection and exacerbated synthesis of free radicals, the latter being well known as a primary cause of cell death. a thorough review of the literature and the results of our experimental research lead to conclude that h. pylori-induced oxidative stress activates the intrinsic pathway of apoptosis. structural and functional changes caused by this process on mitochondrial organelles lie at the origin of gastric mucosal toxicity, and lead to the development of the various manifestations associated with this infection. based on these data we suggest that therapy with antioxidants should prove beneficial for the clinical management of patients with h. pylori infection.
H. pylori and mitochondrial changes in epithelial cells: The role of oxidative stress H. pylori y alteraciones mitocondriales en células epiteliales: Relación con estrés oxidativo
M. Calvino-Fernández,T. Parra-Cid
Revista Espa?ola de Enfermedades Digestivas , 2010,
Abstract: Infection with H. pylori plays a role in the pathogenesis of gastritis, peptic ulcer, gastric carcinoma, and gastric lymphoma, but mechanisms leading to the various clinical manifestations remain obscure and are the primary focus of research in this field. Proliferation and apoptosis are essential in the maintenance of gastric tissue homeostasis, and changes seen in their balance may condition gastric mucosal changes during infection. Thus, excessive apoptosis or proliferation inhibition will result in cell mass loss, which is observed in gastric ulcers. On the other hand, accelerated epithelial cell turnover is characteristic of carcinogenic mucosas. There is also scientific evidence that demonstrates an association between H. pylori infection and exacerbated synthesis of free radicals, the latter being well known as a primary cause of cell death. A thorough review of the literature and the results of our experimental research lead to conclude that H. pylori-induced oxidative stress activates the intrinsic pathway of apoptosis. Structural and functional changes caused by this process on mitochondrial organelles lie at the origin of gastric mucosal toxicity, and lead to the development of the various manifestations associated with this infection. Based on these data we suggest that therapy with antioxidants should prove beneficial for the clinical management of patients with H. pylori infection.
Percepción del riesgo en relación con capacidades de autoprotección y autogestión, como elementos relevantes en la reducción de la vulnerabilidad en la ciudad de La Serena
Cid Ortiz,Guillermo; Castro Correa,Carmen; Rugiero de Souza,Vanessa;
Revista INVI , 2012, DOI: 10.4067/S0718-83582012000200004
Abstract: the conception of risk and its terminology, as well as its disciplinary approach, have changed over time. different approaches derived from natural, applied and social sciences have not yet prepared a solid and consistent theory of risk, thus hampering an effective management that facilitates the estimation and intervention of risk from a multidisciplinary perspective. likewise, risk cannot be seen only from an objective point of view when it comes to reducing its impact given the different interpretations and perspectives of different social actors. social perception of risk is one of the relevant factors in the natural risks field, since it incorporates these subjectivities, thus finding more realistic solutions in case of disaster. this paper evaluates this component in the case of la serena, located in the coquimbo region, through its relation with socioeconomic level, self-protection factors and self-management capacity in the face of a tsunami hazard caused by seismic activity in a country like chile, regarded as the most seismically active place in the world due to its location in the subduction and sliding zone between the nazca and south american plates. it is observed a clear segregation of socioeconomic strata in the districts of la compa?ía alta and intendencia, the most vulnerable areas. the results of this research indicate that risk perception is related to social aspects, thus verifying the social nature of risk.
Ecomicrobiology and microbial assimilative capacity of the oligotrophic Andean Lake Laja, Chile
KARRASCH,BERNHARD; WOELFL,STEFAN; URRUTIA,ROBERTO; GONZáLEZ,JENNY; VALDOVINOS,CLAUDIO; CID,HERNáN; PARRA,OSCAR;
Revista chilena de historia natural , 2011, DOI: 10.4067/S0716-078X2011000300010
Abstract: a strong socio-economic development pressure in south chile will more and more cause an impact to the present lakes and rivers. nevertheless, our knowledge concerning the ecological structure and the microbial self-purification capabilities of these lacustrine water bodies is scant but essential for a future sustainable development of land and water use. we studied lake laja, a lake already heavily impacted by water diversions for hydropower generation and irrigation. typical for the andean region lake laja is an oligotrophic water body, limited by nitrogen nutrients. only very low chlorophyll a and particulate organic carbon (poc) concentrations and a small abundance and biomass of bacteria (mainly ultramicrobacteria) and heterotrophic flagellates were encountered. weak trophic interrelations were derived from a high bacteria-to-heterotrophic flagellate ratio. for the ten investigated extracellular enzymes (alkaline phosphatase, leucine, arginine-, glycine and tyrosine-aminopeptidase, α-, β-d-glucosidase, α-, β-d-galactosidase, n-acetyl-β-d-glucosaminidase), with the exception of α-d-glucosidase, a broad range of organic matter degradation activities was proven. probably, due to the n-limitation, organic nitrogen hydrolysing extracellular enzymes reached activities on average of 45 % compared to other studies in oligotrophic waters. the possible effect of n-limitation on extracellular enzyme activities was more pronounced by cell specific extracellular enzymatic activity rates, which exceeded those of other oligotrophic water bodies on average by factor 2. the overall activities of all microbial extracellular enzymes studied proved to be dominated by the dissolved free external enzymes (up to 98 %) over the ectoenzymes which are associated with particulate organic matter (bacterial cell walls, particles, and aggregates). it is concluded that future socio-economic changes, dealing with watershed human intervention (accelerating inorganic and organic loads) as well a
Dolor torácico crónico
Cid,J.; Andrés,J. de; Díaz,L.; Parra,M.; Leal,F.;
Revista de la Sociedad Espa?ola del Dolor , 2005,
Abstract: thoracic pain is one of the main causes of consultation in primary health care. first of all, ischemic heart disease must be ruled out as the specifictreatment thet they require. thoracic pain also causes concern and anxiety to patients due to the information available to them, so thet suspicion of angina pectoris or heart attack can worsen their symptomatology and determine the couse of the disease. thoracic pain can have a visceral, central or parietal origin, be referred to structures outsid the thorax or even have a psychological orgin. in addition, sympathetic innervation plays an essebtial role in this type of pain. the diagnosis is based on a correct history and an apropriate physical examination including imagin and other tests. a significant proportion of these conditions result from musculoskeletal pain due to the complex anatomical structure of the thoracic cavity. thoracic pain can also have a neuropathic component, since the thorax is the origin of a great number of post-herpectic neuralgias. finally, pain can have a visceral, lung, esophageal or cadiac orgin. the tratment includes several therapeutic ptions, such as pharmacology, revascularization or neuromodulaation.
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