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Search Results: 1 - 10 of 14836 matches for " Carmen Navarro "
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Liposomes for Targeted Delivery of Active Agents against Neurodegenerative Diseases (Alzheimer's Disease and Parkinson's Disease)
Carlos Spuch,Carmen Navarro
Journal of Drug Delivery , 2011, DOI: 10.1155/2011/469679
Abstract: Neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease represent a huge unmet medical need. The prevalence of both diseases is increasing, but the efficacy of treatment is still very limited due to various factors including the blood brain barrier (BBB). Drug delivery to the brain remains the major challenge for the treatment of all neurodegenerative diseases because of the numerous protective barriers surrounding the central nervous system. New therapeutic drugs that cross the BBB are critically needed for treatment of many brain diseases. One of the significant factors on neurotherapeutics is the constraint of the blood brain barrier and the drug release kinetics that cause peripheral serious side effects. Contrary to common belief, neurodegenerative and neurological diseases may be multisystemic in nature, and this presents numerous difficulties for their potential treatment. Overall, the aim of this paper is to summarize the last findings and news related to liposome technology in the treatment of neurodegenerative diseases and demonstrate the potential of this technology for the development of novel therapeutics and the possible applications of liposomes in the two most widespread neurodegenerative diseases, Alzheimer's disease and Parkinson's disease.
An update on Helicobacter pylori in pediatrics
Carmen Cofré Navarro
Medwave , 2011,
Sweet and Bitter Tastes Evoked Different Neuronal Activation in the Rostral Portion of the Nucleus of the Solitary Tract of Developing Rats  [PDF]
Lorena Rubio-Navarro, Carmen Torrero, Mirelta Regalado, Manuel Salas
Journal of Behavioral and Brain Science (JBBS) , 2012, DOI: 10.4236/jbbs.2012.23033
Abstract: The impact of the gustatory stimuli on the rostral portion of the nucleus of the solitary tract (rNST) was investigated in developing rats, by using c-fos immunohistochemical staining. Wistar male rats of 5, 15, and 25 days of age were isolated from the mother for 12 h, then stimulated via the intraoral route with quinine, sucrose, or NaCl, and sacrificed 90 min later. The water-stimulated group showed minimal c-fos-like immunoreactivity (FLI) compared with taste-stimulated groups that exhibited different FLI in the rNST at the different ages. At all ages the quinine-stimulated group induced FLI in the medial subfield, while sucrose induced FLI in the lateral subfield of the rNST. The intensity of FLI was highest at P15, and it declined at P25. These findings provide detailed insight into the anatomical basis of rNST activation that is involved in early food intake and the learning capacity of the newborn.
Analysis of the Sensory and Hedonic Impacts of Sweet and Bitter Tastes in Perinatally Underfed Rats  [PDF]
Lorena Rubio-Navarro, Carmen Torrero, Mirelta Regalado, Manuel Salas
Journal of Behavioral and Brain Science (JBBS) , 2014, DOI: 10.4236/jbbs.2014.49041
Abstract: Newborn rats discriminate tastes and generate gustofacial response (GFR) because the neuronal substrate is already operating. The oral application of sucrose or quinine hydrochloride produces a specific GFR. We analyzed the effects of perinatal undernutrition on the GFR development of rats at two cue concentrations. In the undernourished group, pregnant dams received different percentages of a balance diet. After birth, prenatally underfed pups continue the undernourishment by remaining for 12 h with a foster dam, and for 12 h with a nipple-ligated mother. Cues were presented as a single droplet of sucrose, sodium chloride, or quinine at low or high concentrations onto the lips at postnatal days (PDs) 1 and 3, and mouth-opening (MOF) and lip-licking frequencies (LLF) were noted. On PD 1 the undernourished group showed smaller MOF increases in response to low salt and quinine stimuli than the controls but no differences at high concentrations. On PD 3, both low and high concentrations of the sucrose and quinine cues significantly increased the MOF in the underfed compared to the control group. Low but not high salt decreased LLF on PD1 in the underfed compared to the control group. On PD 3 the undernourished pups showed significant increases of LLF with low quinine compared with the control rats, but the reverse was observed with high quinine. These data suggest that perinatal undernutrition affects the development of the sensory and hedonic aspects of taste causing changes in GFR expression.
La ense anza del espa ol con fines específicos en la universidad italiana
María del Carmen Navarro
Panace@ : Revista de Medicina, Lenguaje y Traducción , 2007,
Abstract: En este artículo se exponen los aspectos más relevantes relacionados con la gestión y organización de los cursos de Espa ol con Fines Específicos en la Universidad Italiana. Se profundiza también en los efectos de la Reforma Universitaria italiana sobre la puesta en marcha de nuevos cursos en el ámbito de la mediación lingüística, así como en la importante función desempe ada en ella por el espa ol como lengua de especialidad. Se observa, en este sentido, un aumento relevante de la demanda de cursos centrados en el espa ol especializado, gracias a la aparición de nuevas titulaciones y al reconocimiento creciente de la importancia de la lengua espa ola en el campo de las relaciones internacionales. ---------------------------------------------- The teaching of Spanish as a special language in the Italian University. The article aims to expound the most relevant aspects concerning the management and the organization of courses focused on Spanish as a special language in the Italian university. Moreover, it deals with the effects of the Italian "University Reform" on the start of new courses in the field of linguistic mediation, as well as with the prominent function which Spanish carries out as a special language; indeed, it could be observed a relevant growth of the request of courses centered on the Spanish special language, thanks to several new academic qualifications and the increasing recognition of the importance of the Spanish language in the field of international relations.
Homenaje a Amelia de Irazazábal. Congreso sobre Terminología, Traducción y Comunicación Especializada, Verona (Italia), 11-12 de octubre de 2007
María del Carmen Navarro
Panace@ : Revista de Medicina, Lenguaje y Traducción , 2007,
Diabetes, Inflammation, Proinflammatory Cytokines, and Diabetic Nephropathy
Juan F. Navarro,Carmen Mora
The Scientific World Journal , 2006, DOI: 10.1100/tsw.2006.179
New Insights in the Amyloid-Beta Interaction with Mitochondria
Carlos Spuch,Saida Ortolano,Carmen Navarro
Journal of Aging Research , 2012, DOI: 10.1155/2012/324968
Abstract: Biochemical and morphological alterations of mitochondria may play an important role in the pathogenesis of Alzheimer’s disease (AD). Particularly, mitochondrial dysfunction is a hallmark of amyloid-beta-induced neuronal toxicity in Alzheimer’s disease. The recent emphasis on the intracellular biology of amyloid-beta and its precursor protein (APP) has led researchers to consider the possibility that mitochondria-associated and mitochondrial amyloid-beta may directly cause neurotoxicity. Both proteins are known to localize to mitochondrial membranes, block the transport of nuclear-encoded mitochondrial proteins to mitochondria, interact with mitochondrial proteins, disrupt the electron transport chain, increase reactive oxygen species production, cause mitochondrial damage, and prevent neurons from functioning normally. In this paper, we will outline current knowledge of the intracellular localization of amyloid-beta. Moreover, we summarize evidence from AD postmortem brain as well as animal AD models showing that amyloid-beta triggers mitochondrial dysfunction through a number of pathways such as impairment of oxidative phosphorylation, elevation of reactive oxygen species production, alteration of mitochondrial dynamics, and interaction with mitochondrial proteins. Thus, this paper supports the Alzheimer cascade mitochondrial hypothesis such as the most important early events in this disease, and probably one of the future strategies on the therapy of this neurodegenerative disease. 1. Introduction Each year, over 10 million people globally suffer from neurodegenerative diseases. This figure is expected to grow by 20% over the next decade as the aging population increases and lives longer. This disease group is the fourth biggest killer in the developed world after heart diseases, cancer, and stroke [1]. The most common neurodegenerative diseases are AD, Parkinson disease, Lewy body dementia, frontotemporal dementia, and amyotrophic lateral sclerosis [2]. The most widely recognized is AD, which is among the principal debilitating conditions of the current century. Approximately 24 million people worldwide suffer from dementia, 60% of cases being due to AD, which occurs in 1% of individuals aged 50 to 70 years old and dramatically increases to 50% of those over 70 years old [3]. Dramatically, these numbers are estimated to increase to 15 million in the next 40 years [4]. From the neuropathological point of view, AD is characterized by selective neuronal loss, marked synaptic alteration, morphological mitochondrial abnormalities, and Tau pathology. The
Differences in Architects and Nonarchitects' Perception of Urban Design: An Application of Kansei Engineering Techniques
Carmen Llinares,Antoni Monta?ana,Elena Navarro
Urban Studies Research , 2011, DOI: 10.1155/2011/736307
Abstract: We analyse architects and nonarchitects' emotional assessments of different districts in their own city (Valencia, Spain) by applying Kansei engineering techniques. A field study was carried out on a sample of 140 subjects (70 architects and 70 nonarchitects) who were asked to express their opinions on different areas in the city. The set of emotional impressions used by architects and non-architects to describe their sensations was obtained using differential semantics. The semantic space was described by 9 independent axis which explained 62% of the variability. Then, for each collective the set of impressions which influence the final residential or investment area decision was analysed. This relationship was obtained applying linear regression models. The results showed no significant differences between both groups so that the emotional attributes determining the choice of area were very similar for architects and non-architects. Greater discrepancies were found when the purpose of the choice was investment and not residential. Finally a neighbourhood was semantically profiled to represent and compare both collectives' perceptions. 1. Introduction There are many studies on the differences in architects and nonarchitects’ evaluations [1–13]. Some studies have analysed the categories that both collectives use when assessing buildings. Groat [2], for example, studied the differences in architects and economists’ perceptions and found that while economists classified housing on the basis of type, architects used quality of design, form, style, and historical significance categories. In this regard, in an analysis of two office blocks in Chicago, Devlin [7] observed that whereas nonarchitects tended to give descriptive assessments based on affection, architects provided conceptual, more abstract assessments. Other studies have focused on the different assessments of architectural styles. Gans [1] observed that architects preferred “high” style over “popular”, the style preferred by nonexperts. Subsequently, Devlin and Nasar [6] concluded that this was due to the different emotional assessments which the styles caused in both collectives. For nonexperts the “popular” style was coherent, pleasurable, and clean, signifiers which architects attributed to the “high” style. Fewer works have attempted to identify what specific design elements cause the different assessments. In this regard, Gifford et al. [11] analysed the relationship between the physical characteristics of buildings, the perceptions “attractive” and “pleasurable,” and the subject’s overall
Anomalía morfológica coronal inusual de un incisivo: Diente evaginado anterior
Llena Puy,Mari Carmen; Forner Navarro,Leopoldo;
Medicina Oral, Patología Oral y Cirugía Bucal (Ed. impresa) , 2005,
Abstract: exophytic growth of a portion of the tissue structure is one of the various clinical manifestations of the morphological anomalies that can affect the crown of the anterior teeth. the crown form disorder presented in this paper consists of an asymptomatic bulge on part of the vestibular surface of the tooth, due to enamel and dentine growth, with no radiological evidence of the pulp having extended into the protrusion of mineralised tissues. in this case, it only affects one tooth and is not associated with any other dental morphology or structure disorder, or with any of the syndromes that have been described in association with this anomaly. the term to describe this situation in the anterior teeth is not clearly defined in the relevant literature, which employs various names such as talon cusp, accentuated cingulum (when it affects the lingual or palatal surface) or dens evaginatus (evaginated tooth, evaginated odontome), the term that is always used when it is present in the posterior teeth.
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