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Search Results: 1 - 10 of 10322 matches for " Carmen Galani Berado "
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“Sometimes It’s Difficult to Have a Normal Life”: Results from a Qualitative Study Exploring Caregiver Burden in Schizophrenia
Adam Gater,Diana Rofail,Chloe Tolley,Chris Marshall,Linda Abetz-Webb,Steven H. Zarit,Carmen Galani Berado
Schizophrenia Research and Treatment , 2014, DOI: 10.1155/2014/368215
Abstract: Objectives. As a disease typified by early onset and chronic disease course, caring for a person with schizophrenia may have a significant impact on caregivers’ lives. This study aimed to investigate the subjective experiences of caregivers of people with schizophrenia as a means of understanding “caregiver burden” in this population. Methods. Face-to-face qualitative interviews were conducted with a diverse sample of 19 US-English speaking caregivers of people with schizophrenia (who were at least moderately ill). Interview transcripts were analyzed using grounded theory methods and findings used to inform the development of a preliminary conceptual model outlining caregivers’ experiences. Results. Findings support assertions that people with schizophrenia were largely dependent upon caregivers for the provision of care and caregivers subsequently reported lacking time for themselves and their other responsibilities (e.g., family and work). Caregiver burden frequently manifested as detriments in physical (e.g., fatigue, sickness) and emotional well-being (e.g., depression and anxiety). Conclusions. Caring for a person with schizophrenia has a significant impact on the lives of informal (unpaid) caregivers and alleviating caregiver burden is critical for managing individual and societal costs. Future research should concentrate on establishing reliable and valid means of assessing burden among caregivers of persons with schizophrenia to inform the development and evaluation of interventions for reducing this burden. 1. Introduction Over the past 50 years, as evidenced by the closure of mental hospitals and advent of community-based care, there has been transition of care for schizophrenia patients from formal hospital-based healthcare systems to outpatient and community services. The financial burden (in terms of direct and indirect costs) of community-dwelling patients with schizophrenia is high with estimated annual costs in the US of $23 billion [1]. It is estimated that 50–90% of people with chronic psychiatric illness live with their families or friends [2, 3] and informal caregivers (i.e., “a person who has significant responsibility for managing the well-being of a person diagnosed with schizophrenia in an unpaid capacity”) [4] provide an important service by reducing need for formal care and burden upon healthcare systems [5]. This is true not just of schizophrenia but also of other medical conditions such as stroke [6], cancer [7] and dementia [8], with estimates in 2011 suggesting that the economic value of all informal caregivers’ unpaid
An Investigation of Hand-Drawn Representations of Rivers by Fifth-Grade Students in Greek Elementary Schools
Apostolia Galani,Ageliki Rokka
ISRN Education , 2014, DOI: 10.1155/2014/548365
Abstract: This paper is part of a wider study and reflects an attempt to explore the cognitive representations that Greek pupils in the 5th grade of elementary school have, as they emerge from the freehand drawing of rivers. An attempt was made to explore the extent to which the cognitive representation skills of school pupils are associated with real images of space and the extent to which intervention by the teacher who presents the structure of a river emphasizing on how it is formed can contribute to an improvement in the drawings made. Two groups of pupils ( , ) took part in this study. They were taught one of two parallel lesson plans, to create representations relating to the concept of river. This was followed by an analysis of the drawings and the pre- and postteaching interviews ( /group). The results indicate that pupils perceive the differences between reality and how it is conveyed in images, and they reproduce stereotypical models of rivers presented in schoolbooks without using complex structures to represent them. In addition, it was clear how encouraging use of children’s mental maps can be not only in revising existing teaching theories but also in building new ones. 1. Introduction Although several studies have been conducted concerning school pupils’ ideas about the concept of “river” and how teachers can investigate those ideas, there is a wide range of research methodologies available which teachers could use to deepen school pupils’ thoughts and ideas on the topic [1]. One research methodology which is not widespread but which provides valuable information involves exploring school pupils’ ideas through the drawings they make. Hayes et al. [2] have shown that in science-related classes which include depictive models, pupils “are happy to convey the concepts as images.” Conveying concepts through drawings is also a useful, alternative form of expression for children who have difficulty in expressing their ideas verbally [3]. Some pupils more easily convey concepts through drawings rather than through written descriptions. Drawings can be used by teachers in various activities in order to explore pupils’ understanding of the Science. In the educational sector, this is not the first time that such an approach has been attempted. Studies by Goodnow and Levine [4], Glenn et al. [5], and Dove [6] all examined drawings by pupils that featured rivers. The images created by school pupils were investigated, as was the question of how pupils oriented the river on the page. The conclusion was that pupils usually tend to draw the river from left to
Anaplastic Large Cell Lymphoma, ALK-Negative Presenting in the Rectum: A Case Report and Review of the Literature  [PDF]
Komal Galani, Suryakanth R. Gurudu, Longwen Chen, Katalin Kelemen
Open Journal of Pathology (OJPathology) , 2013, DOI: 10.4236/ojpathology.2013.31007
Abstract:

ALK-negative anaplastic large cell lymphoma (ALCL, ALK-) is a CD30+ T-cell neoplasm composed of large lymphoid cells with abundant cytoplasm and pleomorphic nuclei that lacks expression of ALK protein. We describe a case of ALCL, ALK-with primary involvement of the rectum in a 37 year old man, where the original diagnosis was established based on a colonoscopic biopsy. T-cell lymphomas are rare in the colorectal area and besides ALCL, their differential diagnosis includes enteropathic T-cell lymphoma, peripheral T-cell lymphoma, not otherwise specified, NK/T cell lymphoma, or NK-cell enteropathy. In addition, syncytial variant of classical Hodgkin lymphoma or a pleomorphic CD30-positive diffuse large B-cell lymphoma should also be ruled out. We discuss pitfalls of the differential diagnosis and review the literature of anaplastic large cell lymphoma in the gastrointestinal tract. Correct diagnosis of ALCL in the colon is important to avoid a colorectal surgery for an assumed adenocarcinoma, and to open the possibility for lymphoma-directed chemotherapy.

EFFECT OF POLYHERBAL PREPARATION ON THIOACETAMIDE INDUCED LIVER DAMAGE AND HEPATIC ENCEPHALOPATHY IN RATS
Dhorajiya Mehul C,Galani Varsha J
International Research Journal of Pharmacy , 2012,
Abstract: To evaluate the hepatoprotective activity of polyherbal preparation on thioacetamide (TAA) induced liver damage and hepatic encephalopathy in rats. Effect of 14 days treatment of polyherbal extract (PHE) (300 mg/kg and 600 mg/kg, p.o) was evaluated against thioacetamide (TAA) (200 mg/kg X 2, i.p.) induced liver damage and hepatic encephalopathy in rats. Serum ALT, AST, ALP, GGT, bilirubin and liver histological changes were assessed in control and PHE treated rats. The effect of PHE against hepatic encephalopathy was evaluated by the assessment of blood ammonia level, motor and cognitive activity and brain neurotransmitters such as dopamine, noradrenaline, serotonine and GABA in rats. Pretreatment with PHE significantly reduced liver enzymes level in blood as compared to TAA treated animals. PHE prevents the TAA induced elevation of ammonia level in blood. Pretreatment with PHE had significant protection against TAA induced changes in brain neurotransmitters level and impairment of motor and cognitive function. Histology of the liver sections confirmed that PHE prevented hepatic damage induced by TAA showing the presence of normal hepatocytes, absence of necrosis and fatty infiltration. The behavioral, biochemical and histological results indicated the protective effect of PHE against TAA induced liver damage and hepatic encephalopathy in rats.
Inflammatory Myofibroblastic Tumor of the Urinary Bladder—A Case Report with Review of Literature  [PDF]
Mahesh Deshmukh, Radhika Pagey, Komal S. Galani, Prasanna Joshi, Amol Bitey, Mrunmayi Kotwal
Open Journal of Pathology (OJPathology) , 2014, DOI: 10.4236/ojpathology.2014.44023
Abstract: Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm with unknown malignant potential that has been described in most organ systems. We herein present a case of a young female who presented with macroscopic hematuria. An IMT of the urinary bladder which was not suspected after clinical, radiological and surgical work-up was diagnosed microscopically and confirmed by immunohistochemistry. A close clinical follow-up is recommended because of the unknown biological behavior of this tumor. A brief review of literature is also presented here.
A Rare Case of an Inflammatory Myofibroblastic Tumor in a Middle-Aged Female
Lamprini Kosma,Lubna Khaldi,Panagiota Galani,Dimitrios Mytas,Sofia Lafoyianni
Case Reports in Oncological Medicine , 2012, DOI: 10.1155/2012/148053
Abstract: Inflammatory myofibroblastic tumors (IMTs) are distinct entities with specific characteristics immunohistochemically and molecularly. They are regarded as “intermediate malignancy” tumors of unknown etiology. We report a case of a 64-years-old woman with a fever and abdominal discomfort for 3 months; a computer tomography was performed indicating gastrointestinal stromal tumor. Histologically the lesion proved to be IMT of the abdomen.
RIVAROXABAN: AN ORAL DIRECT INHIBITOR OF FACTOR X-A
Mehta Hiren R,Patel Paresh B,Galani Varsha J
International Research Journal of Pharmacy , 2011,
Abstract: Venous thrombo embolism (VTE), which includes deep vein thrombosis and pulmonary embolism, is a major cause of morbidity and mortality in patients undergoing major orthopaedic surgery, and routine thrombo prophylaxis has been the standard of care over the last 20 years. Currently available options for the prevention of venous thrombo embolism in major orthopedic surgery include low-molecular-weight heparins, vitamin K antagonists and, more recently, the synthetic pentasaccharide fondaparinux. Although effective, these drugs have several limitations, and new oral antithrombotics offering predictable, effective and safe anticoagulation are strongly needed. This overview focuses on the most advanced oral direct inhibitors of factor Xa, rivaroxaban.Rivaroxaban, an oral oxazolidinone-based anticoagulant, is a potent, selective direct inhibitor of factor Xa that is used in the prevention of venous thrombo embolism in adult patients after total hip replacement (THR) or total knee replacement (TKR) surgery. In four large, clinical trials, oral rivaroxaban was more effective than subcutaneous enoxaparin in preventing postoperative VTE in patients undergoing total hip replacement or total knee replacement surgery. Notably, the superior efficacy of rivaroxaban was achieved with a low but not significant increase in the incidence of major bleeding episodes. In addition, preliminary pharma co-economic analyses in several countries indicate that rivaroxaban is a cost-effective treatment strategy versus enoxaparin. Although the position of rivaroxaban relative to other therapies remains to be fully determined, it is an effective emerging option for the prevention of venous thrombo embolism following total hip replacement and total knee replacement.
FACTORS AFFECTING PHARMACOKINETIC DISPOSITION OF DRUGS
Mehta Hiren R,Patel Paresh B,Galani Varsha J
International Research Journal of Pharmacy , 2011,
Abstract: Absorption of drugs from the gastrointestinal tract is a complex process the variability of which is influenced by many physicochemical and physiologic factors. The two most important physicochemical factors that affect both the extent and the rate of absorption are lipophilicity and solubility. The rate and extent of absorption are governed by the solubility, permeability and stability of the drug, with solubility being a pH-dependent parameter for weak acids and bases. The gastrointestinal tract can be viewed as discrete sections with a variety of differential local pH environments ranging from the acidic stomach to the more basic small intestine. The multiple peaking, double peaking or secondary peaking phenomena can occur in the disposition of a variety of xenobiotics during drug development (the pre-clinical phase) and in subsequent clinical studies and use. The physicochemical and physiological mechanisms underlying the occurrence of this phenomenon are often multi factorial and include but are not limited to solubility-limited absorption, modified-release formulations, complexation, enterohepatic recirculation, gastric emptying and the intestinal transit time, site-specific absorption, gastric secretion-enteral reabsorption. Double peak absorption has been described with several orally administered drugs such as cimetidine furosemide, piroxicam, ranitidine, talinolol, alprazolam and phenazopyridine.
A Rare Case of an Inflammatory Myofibroblastic Tumor in a Middle-Aged Female
Lamprini Kosma,Lubna Khaldi,Panagiota Galani,Dimitrios Mytas,Sofia Lafoyianni
Case Reports in Oncological Medicine , 2012, DOI: 10.1155/2012/148053
Abstract: Inflammatory myofibroblastic tumors (IMTs) are distinct entities with specific characteristics immunohistochemically and molecularly. They are regarded as “intermediate malignancy” tumors of unknown etiology. We report a case of a 64-years-old woman with a fever and abdominal discomfort for 3 months; a computer tomography was performed indicating gastrointestinal stromal tumor. Histologically the lesion proved to be IMT of the abdomen. 1. Introduction Inflammatory myofibroblastic tumors (IMTs) are relatively uncommon neoplasms. They mainly involve the lungs of children, without sex predilection, whereas, extra-pulmonary locations are manifested mostly in the viscera with a slight predominance in females [1]. Their etiology remains unknown, whereas their true origin has been widely debated regarding its neoplastic or postinflammatory nature. In the past, confusion has been presented in the literature between those tumors and wide spectrum of lesions under the term “inflammatory pseudotumors” because of their overlapping morphology. Usually IMTs are composed of myofibroblastic cells admixed with inflammatory cells [2]. The differential diagnosis includes a variety of neoplastic and reactive lesions. At present, surgery is the principal treatment [3]. Herein we report the case of a middle-aged Caucasian female with a soft tissue mass in the abdomen. A combination of clinical history, biochemical findings, and imaging features raised the suspicion of gastrointestinal stromal tumor (GIST) as initial diagnosis. However the histopathological appearance and the immunohistochemical analysis elucidated any ambiguity concerning the diagnosis of IMT. Complete surgical excision was considered sufficient and followup imperative. 2. Case Report A 64-year-old woman was referred to our hospital due to worsening fatigue, low-grade fever, and mild upper abdominal discomfort persisting for the last three months. She also reported a weight loss of about 5?kg over the last six months. During patient’s hospitalization, afternoon episodes of fever with concomitant diaphoresis were registered. On physical examination a palpable mass was revealed in the left upper quadrant of the abdomen. Blood analysis showed a severe hypo-micro-anemia (HCT: 18.2%, HGB: 5.4?g/dL, MCV: 53.4?Fl, MCH: 15.8?pg, and MCHC: 29.6?g/dL) and thrombocytosis (PLT: 705 × 103/μL). The white blood cell (WBC) was normal. On admission laboratory tests revealed highly distorted inflammatory markers: C-reactive protein (CRP) value was 170?mg/dL and erythrocyte sedimentation rate (ESR) was 120?mm/h. Thereafter the
A Framework for Managing Evolving Information Resources on the Data Web
Marios Meimaris,George Papastefanatos,Christos Pateritsas,Theodora Galani,Yannis Stavrakas
Computer Science , 2015,
Abstract: The web of data has brought forth the need to preserve and sustain evolving information within linked datasets; however, a basic requirement of data preservation is the maintenance of the datasets' structural characteristics as well. As open data are often found using different and/or heterogeneous data models and schemata from one source to another, there is a need to reconcile these mismatches and provide common denominations of interpretation on a multitude of levels, in order to be able to preserve and manage the evolution of the generated resources. In this paper, we present a linked data approach for the preservation and archiving of open heterogeneous datasets that evolve through time, at both the structural and the semantic layer. We first propose a set of re-quirements for modelling evolving linked datasets. We then proceed on concep-tualizing a modelling framework for evolving entities and place these in a 2x2 model space that consists of the semantic and the temporal dimensions.
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