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Search Results: 1 - 10 of 378647 matches for " Carlos Andrés; Casals "
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Decay of linkage disequilibrium within genes across HGDP-CEPH human samples: most population isolates do not show increased LD
Elena Bosch, Hafid Laayouni, Carlos Morcillo-Suarez, Ferran Casals, Andrés Moreno-Estrada, Anna Ferrer-Admetlla, Michelle Gardner, Araceli Rosa, Arcadi Navarro, David Comas, Jan Graffelman, Francesc Calafell, Jaume Bertranpetit
BMC Genomics , 2009, DOI: 10.1186/1471-2164-10-338
Abstract: Although the average r2 was found to be significantly different both between and within continental regions, a much higher proportion of r2 variance could be attributed to differences between continental regions (2.8% vs. 0.5%, respectively). Similarly, while the proportion of SNP pairs with r2 > 0.8 was significantly different across continents for all distance classes, it was generally much more homogenous within continents, except in the case of Africa and the Americas. The only isolated populations with consistently higher LD in all distance classes with respect to their continent are the Kalash (Central South Asia) and the Surui (America). Moreover, isolated populations showed only slightly higher proportions of SNP pairs with r2 > 0.8 per gene region than non-isolated populations in the same continent. Thus, the number of SNPs in isolated populations that need to be genotyped may be only slightly less than in non-isolates.The "isolated population" label by itself does not guarantee a greater genotyping efficiency in association studies, and properties other than increased linkage disequilibrium may make these populations interesting in genetic epidemiology.Linkage disequilibrium (LD) is the non-random association between allele frequencies at two loci. Recombination rate variation is the main determinant of LD [1,2]. It has been shown that recombination is extremely heterogeneous along the genome, even at short distances, which creates intricate LD patterns. LD is also shaped by demographic forces and natural selection, and has become a tool used to infer population history [3-5] and selection [6-9]. Genome- and population-related factors, then, explain why linkage disequilibrium levels vary dramatically across the genome and among some populations. The extent of LD in non-Africans is higher than in Africans [10-12], reflecting the origin and spread of modern humans from Africa, although the difference in LD between Africans and non-Africans varies greatly acr
Validación de la Lista de Chequeo de Psicopatía-Revisada (PCL-R) en población carcelaria masculina de Colombia *
García Valencia,Jenny; Arango Viana,Juan Carlos; Correa Rico,Oscar; Pérez González,Andrés Felipe; Agudelo,Víctor Hugo; Mejía Mosquera,Carlos Andrés; Casals,Sergi; López Calle,Gabriel Jaime; Pati？o López,Juan David; Palacio Acosta,Carlos Alberto;
Revista Colombiana de Psiquiatría , 2008,
Abstract: introduction: psychopathy is characterized by a pattern of constant affective deficit and lack of respect for other people's rights and social norms. the psychopathy check-list revised (pcl-r) is an instrument of measurement composed of 20 items and it is one of the most used in psychopathy and antisocial personality disorder research. objective: to validate the pcl-r in colombian male inmates. methods: two translations into spanish and two back-translations for each of the items were done. the instruction manual was also translated into spanish and back-translated. face validity was assessed by a group of experts. content validity was examined as well as internal consistency, test-retest and inter-rater reproducibility. results: in the factor analysis for the content validity, four domains were found which explained 61.1% of the variance. the internal consistency was high (cronbach's alpha=0.94). similarly, the test-retest and inter-rater reproducibility were icc=0.83, 95% ci: 0.68-0.91 and icc=0.83, 95% ci: 0.86-0.96, respectively. conclusions: the spanish version of the pcl-r for colombian male jail inmates shows good psychometric properties.
ENCRUCIJADA Y CONFLICTO. URBANIZACIóN, CONSERVACIóN Y RURALIDAD EN LOS CERROS ORIENTALES DE BOGOTá
MEZA,CARLOS ANDRéS;
Revista Colombiana de Antropología , 2008,
Abstract: the article explores the eastern mountains of bogotá as a complex of territoriality regimes and socio-historical heterogeneous and conflicting experiences through time. the teusacá river basin is the micro regional context in the transition between bogotá city and the eastern plains. it serves as a case study to identify overlapping and conflicting territorialities associated with nature conservation, urban expansion and rural life. the analysis of the construction of different territorial regimes during the last century allows a glimpse at the dilemmas and conflicts that characterize the eastern mountains of bogotá in this new century
Síndrome metabólico: definición, historia, criterios
Pineda,Carlos Andrés;
Colombia Médica , 2008,
Abstract: the metabolic syndrome is a set of risk factors for diabetes mellitus type 2 and cardiovascular disease, characterized by the presence of resistance to the insulin and compensating hiperinsulinemia associate to alterations of the metabolism of carbohydrates and lipids, elevated arterial blood pressure, and obesity. a revision in medline was made, and gave as a result 6366 entrances for ？metabolic syndrome？. in the beginnings of the xx century, associations of risk factors were described. in 1988, reaven observed that several risk factors (dislipidemia, hypertension, hyperglicemia) tended to be together. this set was named syndrome x. the name metabolic syndrome like diagnostic entity with defined criteria was introduced by the who in 1998. the prevalence of the metabolic syndrome varies according to some factors such as gender, age, ethnic group, but it is located between 15% to a 40%, being greater in the population of hispanic origin. several criteria for the metabolic syndrome diagnosis exist. the most known it is of atp iii, in this case, three factors must be present: high abdominal perimeter (>102 cm in men and >88 cm in women), tg >150 mg/dl, hdl under (men >40 mg/dl y women hdl >0 mg/dl), ta >130/85 mm hg, glycemia >110 mg/dl including diabetes mellitus.other factors also considered are: thrombogenesis, inflammation, uric acid, stress, cigarette, sedentariness, age, ethnic origin, acantosis nigricans, polycystic ovary syndrome, microalbuminuria, primary hypothyroidism, use of protease inhibitors for patients with hiv, endogenous or exogenous excess of glucocorticoids.
Guías preventivas por ciclo vital individual en Colombia
Pineda,Carlos Andrés;
Colombia Médica , 2006,
Abstract: the preventive guides are condensations of the different interventions in health promotion and disease prevention that are made to take part of the population？s interventions. they contain council strategies, screening and specific measures of protection. it is mentioned the characteristics of screening test. it presents the preventive guides by each individual vital cycle as far as council measures, specific protection and screening. thus, a concrete guide offers itself on the interventions to carry out preventive consultations with the patients in colombia.
(Com)partiendo el secreto, entre la ley y la ficción (la literatura y lo político en el pensamiento de Jacques Derrida)
Manrique,Carlos Andrés;
Revista de Estudios Sociales , 2010,
Abstract: to understand derrida's conception of the relationship between literature and politics, one needs to begin with his reflection on the connection between the production of meaning in language, on the one hand, and the demarcation of borders in socio-political space, on the other. for derrida, literature is a specific kind of writing that, by intensifying the limits of meaning, suspends or de-stabilizes the socio-political borders erected by all institutional normativity. this article reflects on the mutual entanglement, thus emphasized by derrida, between a certain idea of "literature" and a certain idea of "democracy." what is at stake here is the possibility of configuring the political community by other means. this possibility implies the challenge of re-thinking the exercise of freedom and the affirmation of an unrestricted universality, no longer in the transparency of a fully-accountable subject or in the space of intelligibility of discursive rationality, as we are used to thinking about them. but rather, it is a freedom associated with an irreducible opacity of the subject, and a universality associated with an instance of excess (the "secret'), which dislocates the structure of discursive meaning. by pointing out suggestive points of convergence between several late kantian texts and some works by derrida on the apophatic writing of medieval mysticism, the article attempts to show how derrida's meditation on the political function of literature prompts us to question and de-stabilize the opposition between "enlightenment" and "mysticism", and a series of dichotomies tied the latter that have become dogmatic in our understanding of politics.
Sector externo: clave del desempe o económico en el cuatrienio Uribe
Carlos Andrés Giraldo
Perfil de Coyuntura Económica , 2006,
Abstract: en el último cuatrienio, el entorno internacional ha sido un factor determinante del mejor desempe o económico de la economía colombiana. El desempe o de economías como la estadounidense y China, grandes consumidoras de energéticos y materias primas, favoreció la demanda y cotización de los commodities, lo que benefició el saldo en la cuenta corriente de la economía. Además, la amplia liquidez mundial impulsó el flujo de capitales hacia los mercados emergentes, incidiendo la reducción del costo de financiamiento público y privado. El desempe o futuro de la economía a mostrar se ales de cambio. Por un lado, la tendencia creciente que han mostrado las tasas de interés internacionales puede disminuir el dinamismo de la economía mundial, a la vez que presiona las tasas internas al alza. Por otro lado, los precios de los commodities se encuentran en niveles históricamente altos, lo cual podría interpretarse como que, en caso de no suceder un hecho atípico, no hay buena probabilidad de aumentos sustanciales en los próximos meses.
Rese a de "Cine, recetas y símbolos" de Jerónimo Rivera Betancur
Carlos Andrés Arango
Palabra Clave , 2010,
Abstract:
Margarita Serje (coordinadora). Desarrollo y conflicto. Territorios, recursos y paisajes en la historia oculta de proyectos y políticas
Meza Carlos Andrés
Maguaré , 2011,
Abstract: Margarita Serje (coordinadora). Desarrollo y conflicto. Territorios, recursos y paisajes en la historia oculta de proyectos y políticas. Bogotá: Universidad de los Andes, 2010. 296 páginas.
Aproximación teórica al debate por el reconocimiento político, jurídico y social del sector LGTBIQ
Carlos Andrés Duque
Revista CS , 2008,
Abstract: La discriminación que históricamente han padecido las orientaciones y expresiones sexuales diferentes a las heterosexuales ha venido perdiendo legitimidad durante las últimas décadas. Esto no significa, sin embargo, que exista unanimidad sobre la base teórica y discursiva desde la cual se deben reivindicar los derechos de personas gays, lesbianas y transexuales, entre oras. Este atículo revisa críticamente tres paradigmas políticos que abordan este problema: la política liberal, la política de la diferencia y la política de la transformación cultural. Finalmente, presenta la propuesta teórica de Nancy Fraser de abordar la falta de reconocimiento como un problema de subordinación de estatus, la cual es complementada con la propuesta de construcción de la democracia radical de Chantal Mouffe.
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