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Search Results: 1 - 10 of 5208 matches for " Carla Rescia "
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Rearreglos de genes de cadenas pesadas de las inmunoglobulinas en las gammapatías monoclonales Immunoglobulin heavy chain gene rearrangements in the monoclonal gammopathies
Andrea Bosaleh,Valeria Denninghoff,Alejandro García,Carla Rescia
Medicina (Buenos Aires) , 2005,
Abstract: Las neoplasias de células plasmáticas resultan de la expansión de un clon de células B que secreta inmunoglobulinas, conocido como componente monoclonal o componente M. Las neoplasias malignas incluyen al mieloma múltiple y la macroglobulinemia de Waldenstr m, y la condición premaligna comprende las gammapatías monoclonales de significado incierto (MGUS). El MGUS presenta un componente monoclonal sin evidencia de mieloma múltiple, macroglobulinemia de Waldenstr m, amiloidosis primaria u otros desórdenes. El diagnóstico se basa en la combinación de características patológicas, radiológicas y clínicas. Aproximadamente el 25% de las gammapatías monoclonales de significado incierto desarrollarán mieloma múltiple, amiloidosis sistémica, macroglobulinemia o enfermedades linfoproliferativas malignas, indicando que sería una condición premielomatosa. El objetivo del presente trabajo es establecer la utilidad clínica de la inmunofenotipificación por citometría de flujo (CF) y la detección de clonalidad por biología molecular. Se estudiaron 32 pacientes, siete con diagnóstico de mieloma múltiple y veinticinco con gammapatía monoclonal en estudio, los cuales fueron divididos en cuatro grupos basados en los datos clínicos y los resultados de CF. En el grupo de pacientes con CF no diagnóstica, se realizó la detección de los rearreglos de los genes de las cadenas pesadas de las inmunoglobulinas mediante reacción en cadena de la polimerasa (PCR), detectándose monoclonalidad en el 59% de los casos. El estudio de los rearreglos de los genes de las cadenas pesadas de las IgH mediante PCR incrementa la sensibilidad de detección de monoclonalidad. Plasma cell neoplasia occurs as a result of the expansion of an immunoglobulin-secreting B-cells clones, known as monoclonal component or M component. Malignant neoplasias include multiple myeloma and Waldenstr m macroglobulinemia, while premalignant conditions comprise monoclonal gammopathies of unknown significance (MGUS). MGUS present a monoclonal component with no signs of multiple myeloma, Waldenstr m macroglobulinemia, primary amyloidosis or other disorders. Pathological, radiological and clinical features are required for the diagnosis. Approximately 25% of patients with MGUS will become multiple myeloma, primary amiloidosis, macroglobulinemia, or other lymphoproliferative disease, which would be a premyelomatous condition. The objective of this study was to determine the clinical implications of immunophenotyping by flow cytometry and of the detection of clonality by molecular biology. A total of 32 patients were studied.
Rearreglos de genes de cadenas pesadas de las inmunoglobulinas en las gammapatías monoclonales
Bosaleh,Andrea; Denninghoff,Valeria; García,Alejandro; Rescia,Carla; Avagnina,Alejandra; Elsner,Boris;
Medicina (Buenos Aires) , 2005,
Abstract: plasma cell neoplasia occurs as a result of the expansion of an immunoglobulin-secreting b-cells clones, known as monoclonal component or m component. malignant neoplasias include multiple myeloma and waldenstr?m macroglobulinemia, while premalignant conditions comprise monoclonal gammopathies of unknown significance (mgus). mgus present a monoclonal component with no signs of multiple myeloma, waldenstr?m macroglobulinemia, primary amyloidosis or other disorders. pathological, radiological and clinical features are required for the diagnosis. approximately 25% of patients with mgus will become multiple myeloma, primary amiloidosis, macroglobulinemia, or other lymphoproliferative disease, which would be a premyelomatous condition. the objective of this study was to determine the clinical implications of immunophenotyping by flow cytometry and of the detection of clonality by molecular biology. a total of 32 patients were studied. seven of them were diagnosed with multiple myeloma, and 25 with monoclonal gammopathy under study. these 32 patients were divided into four groups, based on their clinical data and flow cytometry outcome. in patients with non-diagnostic flow cytometry detection of immunoglobulin heavy chain gene rearrangements by pcr was performed, and monoclonality was found in 59% of the cases. the study of immunoglobulin heavy chain gene rearrangements by molecular biology allows a more sensitive detection of clonality.
Linfoma del manto vs. Leucemia linfática crónica atípica: Utilización de inmunohistoquímica, citometría de flujo y biología molecular para su correcta tipificación
Gómez Pescie,Mariana; Denninghoff,Valeria; García,Alejandro; Rescia,Carla; Avagnina,Alejandra; Elsner,Boris;
Medicina (Buenos Aires) , 2005,
Abstract: the differential diagnosis of certain b cd5+ lymphoproliferative processes, such as mantle cell lymphoma (mcl) and atypical chronic lymphocytic leukemia (acll), is difficult. the aim of this study was to correlate morphological findings, cyclin d1 (cd1) detection by immunohistochemistry (ihc) and immunophenotype by flow cytometry (fc) with the results obtained by molecular biology in this type of neoplasias. we analyzed 20 samples classified as b cd5+ lymphoproliferative processes by fc. pcr was used for t(11;14) bcl-1/igh determination. histopathological and ihc studies for cd1 were done in 14 cases. twelve cases were diagnosed as mcl, with positive cd1 in 5 (5/9), five as acll and three as b lymphoproliferative process. pcr revealed t(11;14) in 6/12 mcl and negative results in the other groups (0/8). molecular biology evidenced translocation in 4/5 mcl positive for cd1 with ihc. the presence of translocation could be demonstrated by ihc and pcr in 7/12 mcl: 4 with both techniques, 2 with pcr alone, and 1 with ihc alone. these findings show a significant association between cd1 by ihc and bcl-1/igh gene detection by pcr, which implies that both techniques are complementary for mcl typing.
Linfoma del manto vs. Leucemia linfática crónica atípica: Utilización de inmunohistoquímica, citometría de flujo y biología molecular para su correcta tipificación Mantle cell lymphoma vs. atypical chronic lymphocytic leukemia: Use of immunohistochemistry, flow cytometry and molecular biology for their adequate typing
Mariana Gómez Pescie,Valeria Denninghoff,Alejandro García,Carla Rescia
Medicina (Buenos Aires) , 2005,
Abstract: Algunos procesos linfoproliferativos B CD5+ son de difícil diagnóstico diferencial como es el caso del linfoma del manto (LM) y la leucemia linfocítica crónica atípica (LLCA). El motivo del presente estudio fue correlacionar los hallazgos morfológicos, la detección de ciclina D1 (cD1) por inmunohistoquímica (IHQ) y el inmunofenotipo por citometría de flujo (CF) con los resultados obtenidos por biología molecular en este tipo de neoplasias. Se estudiaron 20 muestras clasificadas como procesos linfoproliferativos B CD5+ por CF. Se realizó la determinación de t(11;14) bcl-1/IgH por PCR. El estudio histopatológico e IHQ para cD1 se efectuó en 14 casos. Doce casos fueron diagnosticados como LM, con cD1 positiva en 5 (5/9); cinco como LLCA y tres como proceso linfoproliferativo B. Con PCR se observó t(11;14) en 6/12 LM y negatividad en los restantes grupos (0/8). Se pudo demostrar la presencia de traslocación en 7/12 LM mediante IHQ Y PCR: 4 con ambas técnicas, 2 con PCR exclusivamente y 1 con IHQ, evidenciando una alta asociación entre cD1 por IHQ y la detección del gen bcl-1/IgH por PCR, ambas técnicas complementarias en la tipificación de LM. The differential diagnosis of certain B CD5+ lymphoproliferative processes, such as mantle cell lymphoma (MCL) and atypical chronic lymphocytic leukemia (ACLL), is difficult. The aim of this study was to correlate morphological findings, cyclin D1 (cD1) detection by immunohistochemistry (IHC) and immunophenotype by flow cytometry (FC) with the results obtained by molecular biology in this type of neoplasias. We analyzed 20 samples classified as B CD5+ lymphoproliferative processes by FC. PCR was used for t(11;14) bcl-1/IgH determination. Histopathological and IHC studies for cD1 were done in 14 cases. Twelve cases were diagnosed as MCL, with positive cD1 in 5 (5/9), five as ACLL and three as B lymphoproliferative process. PCR revealed t(11;14) in 6/12 MCL and negative results in the other groups (0/8). Molecular biology evidenced translocation in 4/5 MCL positive for cD1 with IHC. The presence of translocation could be demonstrated by IHC and PCR in 7/12 MCL: 4 with both techniques, 2 with PCR alone, and 1 with IHC alone. These findings show a significant association between cD1 by IHC and bcl-1/IgH gene detection by PCR, which implies that both techniques are complementary for MCL typing.
Reactivación del sistema socioecológico ganadero de Picos de Europa (norte de Espa a)
A. J. Rescia,S. G. Fungairi?o,J. W. Dover
Ecosistemas , 2010,
Abstract: La resiliencia del sistema socioecológico (SSE) de Picos de Europa está amenazada por los cambios en la forma tradicional de explotación ganadera que agudiza la vulnerabilidad económica de la población local y por el éxodo hacia zonas urbanas acompa adas de una homogenización del paisaje. Se realizó una serie de encuestas-entrevistas con el fin de analizar la capacidad de la población para influir y ser influida por la dinámica de los cambios de usos del territorio y su percepción de los cambios ya ocurridos. Se apreció un conflicto de intereses entre los componentes del SSE y se plantearon probables tendencias de evolución del territorio integrando parámetros históricos, culturales y ambientales bajo diferentes políticas de gestión. La recuperación y la persistencia del SSE con niveles aceptables de productividad y de diversidad biológica y espacial serían viables con una gestión adaptativa y con una participación activa de la población local en la toma de decisiones. La continuidad en el tiempo del paisaje tradicional sostenido por la ganadería extensiva mantendría a su vez el desarrollo del turismo, actividad que constituye actualmente uno de los pilares de la economía local.
Inter-Network Resource Sharing in IEEE 802.22 Networks  [PDF]
Carla Passiatore, Pietro Camarda
Communications and Network (CN) , 2012, DOI: 10.4236/cn.2012.42015
Abstract: IEEE 802.22 is the first worldwide standard for Cognitive Networks (CNs) that exploits unused spectrum of the television broadcast service. An IEEE 802.22 network is also called Wireless Regional Area Network (WRAN). An open issue in cognitive 802.22 networks is represented by the resource distribution among WRANs. In this paper a protocol for radio resource management for CNs in a multichannel environment is presented and analysed. In particular, the contribution of this work is a resource sharing method to schedule the WRAN access to the available channels in a community made by two o more coexisting WRANs. The method adapts to the continuous changes of the spectrum availability due to necessity of vacating a channel in case of the incumbent primary users. Moreover, the introduced allocation scheme allows to divide the available band in a proportional way to the cognitive user spectrum demands, taking into account the issue of spatial diversity, i.e. the case where the channel coverage area is not uniform. The effectiveness of the proposed multichannel scheme is proved through simulations. The results compared favorably with other methods already known in literature and show that the proposed algorithm optimize the spectral efficiency, keeping high fairness as demonstrated computing the Jain’s index.
Energy and Sustainability in Museums. The Plant Refurbishment of the Medieval Building of Palagio di Parte Guelfa in Florence  [PDF]
Carla Balocco, Enrico Marmonti
Open Journal of Energy Efficiency (OJEE) , 2012, DOI: 10.4236/ojee.2012.13004
Abstract: This paper presents a performance-based design of a HVAC plant and controller system of the “Palagio di Parte Guelfa” Palace, a medieval building converted into a museum in the city of Firenze. Transient simulations to evaluate the internal microclimate conditions during the year for the building and the different system plant were carried out. A comparison between the indoor microclimatic parameters obtained and the values suggested by the standards on protection and conservation of historical works of art, suggested a non-invasive and reversible plant system solution. The MuseumofHistorical Footballbuilding portion is the case study. The proposed plant, a constant air flow system coupled with radiant panels dry mounted above the existing flooring, was simulated throughout the year under transient conditions to evaluate its energy performance. This solution ensures indoor temperature and humidity values suitable for the conservation of works of art and visitor comfort. It is an example of a possible course of action for a plant refurbishment in a historic building converted into a museum, located in climatic regions characterized by high thermal and solar loads. The present paper concerns the study of an integrated and reversible architectural-plant solution proposed: reversibility of the proposed system is understood as the possibility for the present conditions being easily restored.
Apoptosis in TMJ Disc Diseases  [PDF]
Giuseppe Musumeci, Carla Loreto
Open Journal of Apoptosis (OJApo) , 2013, DOI: 10.4236/ojapo.2013.24007
Abstract: Apoptosis in TMJ Disc Diseases
Challenges of Effective Collaboration in a Virtual Learning Environment among Undergraduate Students  [PDF]
Russell Butson, Carla Thomson
Creative Education (CE) , 2014, DOI: 10.4236/ce.2014.516162
Abstract: Web-based technology has influenced the way we perceive and use computer devices. One effect of the increasing variety of online web services has been a move away from “personal” computing toward networked or “social” computing. In this paper we discussed a research project which explored the potential in using a purpose-built social-networked environment to support learning in undergraduate education. In particular, we were interested in which tools would be adopted and the collaborative manner which would be used. A prototype web-based networked environment was built that allowed each student a personal space with their profile, access to resources and a group-project work space. The network incorporated a people-centric paradigm that integrated networking across a range of collaborative tools to support course activities. The system embraced an “open” philosophy where all students and staff were linked to all members and work- group areas. Each work-group area consisted of a number of web-based tools that included a group wiki, group blog, file repository, weblink tool, discussion area, and calendar. The site allowed for both synchronized and asynchronized communication via messaging and chat facilities. The results showed that students did not work collaboratively and struggled to use the web-based tools to advance their learning. Further investigation revealed that students preferred individual offline approaches to the more demanding processes required in a collaborative online environment.
Modelling infection spreading control in a hospital isolation room  [PDF]
Carla Balocco, Pietro Liò
Journal of Biomedical Science and Engineering (JBiSE) , 2010, DOI: 10.4236/jbise.2010.37089
Abstract: This paper investigates the airflow patterns connected to different cough conditions, the effects of these arrangements on the regions of droplet fallout and dilution time of virus diffusion of coughed gas. We focus on some of the physical processes that occur in a double bed hospital isolation room, investigating the effect of the ventilation system on the spread of particles in air. A cough model was carried out and used for the numerical simulation of virus diffusion inside an existent isolation room. Transient simulations of air pattern diffusion and air velocity field, provided by the existing typical HVAC primary air system designed for infectious patients, were performed using CFD. A multiphysics approach, combined Convection-Conduction, Incompressible Navier-Stokes models on non-isothermal air flow and Convection-Diffusion, was used. Simulations results highlighted that the flow field and velocity distribution induced by the high turbulence air inlet diffuser combined with the air return diffusers produce wide recirculation zones near the wall and partial stagnation areas near the ceiling and between the two beds, but lower particle concentration in the room and their shorter spreading distance. This type of analysis is certainly cost effective to identify all the air recirculation zones which can harbour lingering pathogens.
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