oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2019 ( 589 )

2018 ( 819 )

2017 ( 758 )

2016 ( 1114 )

Custom range...

Search Results: 1 - 10 of 466185 matches for " Caridad Margarita García Pe?a "
All listed articles are free for downloading (OA Articles)
Page 1 /466185
Display every page Item
Validación de los métodos analíticos para el control de la calidad y el estudio de estabilidad del colirio de idoxiuridina 0,1 %
García Pea,Caridad Margarita; Martínez Espinosa,Vivian;
Revista Cubana de Farmacia , 2005,
Abstract: two analytical methods were validated by ultraviolet chromatography and high performance liquid chromatography for the quality control and stability study, respectively, in the idoxuridine 0.1 % eye drops. in the validation, there were evaluated the parameters of specificity for these ends, system lineality, exactness and accuracy, which was expressed in its 2 forms: repeatability and intermediate precision. the analytical methods proved to be specific, lineal, precise and exact in the interval of the studied concentrations.
Validación de los métodos analíticos para el control de la calidad y el estudio de estabilidad del colirio de idoxiuridina 0,1 % Validation of the analytical methods for the quality control and the stability study of idoxuridine 0.1 % eye drops
Caridad Margarita García Pea,Vivian Martínez Espinosa
Revista Cubana de Farmacia , 2005,
Abstract: Se validaron 2 métodos analíticos por espectrofotometría ultravioleta y por cromatografía líquida de alta resolución para el control de la calidad y el estudio de estabilidad, respectivamente, en el colirio de idoxiuridina 0,1 %. En la validación se evaluaron los parámetros de especificidad para estos fines, linealidad del sistema, exactitud y precisión expresada en sus 2 formas: repetibilidad y precisión intermedia. Los métodos analíticos resultaron ser específicos, lineales, precisos, exactos en el intervalo de concentraciones estudiadas. Two analytical methods were validated by ultraviolet chromatography and high performance liquid chromatography for the quality control and stability study, respectively, in the idoxuridine 0.1 % eye drops. In the validation, there were evaluated the parameters of specificity for these ends, system lineality, exactness and accuracy, which was expressed in its 2 forms: repeatability and intermediate precision. The analytical methods proved to be specific, lineal, precise and exact in the interval of the studied concentrations.
Desarrollo de un método analítico para el control de la calidad del colirio de pilocarpina 2 % Development of a analytical method for quality control of 2 % Pilocarpine eyedrops
Martha Botet García,Caridad Margarita García Pea,Jacqueline Aylema Romero,Caridad Rodríguez
Revista Cubana de Farmacia , 2007,
Abstract: Se desarrolló y validó un método analítico alternativo para el control de la calidad del colirio de pilocarpina por espectrofotometría ultravioleta, ya que este método resulta más rápido, sencillo y económico. Además, se validó el método analítico reportado para el estudio de estabilidad por cromatografía líquida de alta resolución. Ambos métodos se compararon estadísticamente y resultaron específicos, lineales, precisos y exactos en el rango de concentraciones estudiadas. A alternating and analytical method was developed and validated for quality control of Pilocarpine eyedrops by UV spectrophotometry, since this method is more fast, simple, and cheap. Also, for stability study by high performance liquid chromatography, reported analytical method was validated. Both methods were statistically compared, and were specific, linear, accurate, and in the rank of study concentrations.
Desarrollo de un método analítico para el control de la calidad del colirio de pilocarpina 2 %
Botet García,Martha; García Pea,Caridad Margarita; Aylema Romero,Jacqueline; Rodríguez,Caridad; Martínez Espinosa,Vivian;
Revista Cubana de Farmacia , 2007,
Abstract: a alternating and analytical method was developed and validated for quality control of pilocarpine eyedrops by uv spectrophotometry, since this method is more fast, simple, and cheap. also, for stability study by high performance liquid chromatography, reported analytical method was validated. both methods were statistically compared, and were specific, linear, accurate, and in the rank of study concentrations.
Desarrollo y validación de un método analítico aplicable al control de la calidad del picosulfato de sodio gotas orales
Herrera Santi,María Teresa; García Pea,Caridad Margarita; Méndez Jorrín,Gladys;
Revista Cubana de Farmacia , 2008,
Abstract: an analytical, easy and economic method applicable to the quality control of sodium picosulphate oral drops 0.75 % was developed and validated. the parameters of specificity, lineality, exactness and precision were evaluated. the results attained by parameters analyzed in the validation of the method were within the established limits. the applied analytical method proved to be lineal, precise, specific and exact in the range of the studied concentrations.
Desarrollo y validación de un método analítico aplicable al control de la calidad del picosulfato de sodio gotas orales Development and validation of an analytical method applicable to the quality control of sodium picosulphate oral drops
María Teresa Herrera Santi,Caridad Margarita García Pea,Gladys Méndez Jorrín
Revista Cubana de Farmacia , 2008,
Abstract: Se desarrolló y validó un método analítico, fácil y económico, aplicable al control de la calidad del picosulfato de sodio 0,75 %, gotas orales. Se evaluaron los parámetros de especificidad, linealidad, exactitud y precisión. Los resultados obtenidos mediante los parámetros analizados en la validación del método se encontraron dentro de los límites establecidos. El método analítico desarrollado resultó lineal, preciso, específico y exacto en el rango de concentraciones estudiadas. An analytical, easy and economic method applicable to the quality control of sodium picosulphate oral drops 0.75 % was developed and validated. The parameters of specificity, lineality, exactness and precision were evaluated. The results attained by parameters analyzed in the validation of the method were within the established limits. The applied analytical method proved to be lineal, precise, specific and exact in the range of the studied concentrations.
Estabilidad de una formulación de zidovudina solución oral 1 mg/mL
García Pea,Caridad Margarita; Morales Lacarrere,Iván; Martínez Espinosa,Vivian;
Revista Cubana de Farmacia , 2011,
Abstract: the carrying out of a high-performance liquid chromatography analytical method was assessed; applicable to stability study of oral solution zidovudine (1 mg/ml) was made. the analytical method was linear, precise, specific and exact in the study concentrations. the stability study of oral solution zidovudine (1 mg/ml) was conducted determining expiring date. the shelf life study was conducted over 24 months at room temperature; whereas that of accelerated stability was conducted with the product under wet and temperature conditions; analysis was carried out over three months. formula met quality specifications described in pharmacopeia. results from the shelf life study demonstrated that product keeps the parameters determining its quality during that time and in accelerated studies there was not significant product degradation. under above mentioned conditions two years were established as expiring date.
Estudio de estabilidad de tabletas de risperidona 3 mg
García Pea,Caridad Margarita; Iraizoz Barrios,Antonio; Martínez Espinosa,Vivian;
Revista Cubana de Farmacia , 2010,
Abstract: stability study was conducted of 3 mg risperidone tablets determining its caducity date and using the shelf life methods and of accelerated stability by high-performance liquid chromatography validated in drug development and research center. the shelf life study was developed during 24 months at room temperature; whereas the accelerated stability study was performed subjecting the product to light, humidity and temperature influence. the 3 mg risperidone tablets formula fulfilled the quality specifications described in pharmacopeia. results from shelf life study after 24 months show that the product maintains the parameters determining its quality during that time and in accelerated studies product degradation was noted. under conditions signaled 2 years was established as the expiry date.
Evaluación comparativa de la liberación in vitro de risperidona 3 mg producida en Cuba contra Risperdal?
García Pea,Caridad Margarita; Iraizoz Barrios,Antonio; Martínez Espinosa,Vivian;
Revista Cubana de Farmacia , 2010,
Abstract: the 3 mg risperidone tablets dissolution profiles, a generic drug produced in cuba and the risperidal? (janssen-cilag s.a. labs) were compared to demonstrate its similarity. also, we compared some dissolution means at different ph to assess a potential bio-exoneration. to quantify the active principle, a previously validated high-performance liquid chromatography was used. the comparison was conducted on the base of differentiation and similarity factors. results demonstrated that there weren't differences en release profiles for tablets produced in cuba and of innovative product, as well as for the different dissolution means at ph used.
Validación de un método cromatográfico para la cuantificación de latanoprost 50 μg/mL en el colirio de producción nacional Validation of a chromatographic method for quantitation of 50 μg/mL Latanoprost in a Cuban eye drops
Caridad Margarita García Pea,Vivian Martínez Espinosa,Ania González Cortezón
Revista Cubana de Farmacia , 2012,
Abstract: Introducción: el latanoprost está indicado para el tratamiento de la presión intraocular elevada en pacientes con hipertensión ocular o glaucoma de ángulo abierto. Objetivo: desarrollar y validar un método analítico por cromatografía líquida de alta resolución, aplicable al control de la calidad del latanoprost 50 μg/mL, colirio. Métodos: para cuantificar el principio activo en el producto terminado, la separación se realizó a través de una columna cromatográfica Altima C-18 (10 μm) (250 × 4 mm), con detección ultravioleta a 205 nm, empleando una fase móvil compuesta por acetonitrilo-buffer fosfato pH 4,5 (650:350) y la cuantificación de este frente a una muestra de referencia con el método del estándar externo. Resultados: los resultados de los parámetros evaluados en la validación del método se encontraron dentro de los límites establecidos. Conclusiones: el método analítico desarrollado y validado por cromatografía líquida de alta resolución para el control de la calidad del colirio de latanoprost 50 μg/mL, resultó específico, lineal, exacto y preciso en el rango de concentraciones estudiadas, por lo que puede emplearse de manera confiable y segura. Introduction: Latanoprost is indicated to treat high intraocular pressure in patients suffering from ocular hypertension or from open angle glaucoma. Objective: to develop and to validate a high performance liquid chromatography-based analytical method for quality control of 50 μg/mL Latanoprost eye drops. Methods: to quantify the active principle of the final product, the separation was performed through Altima C-18 chromatographic column (10 μm) (250 × 4 mm), with ultraviolet detection at 205 nm, and a mobile phase made up of acetonitryle-phosphate buffer of pH= 4.5 (650:350). The quantification of the principle against a reference sample was carried out with the external standard method. Results: the results of the evaluated parameters in the validation of the method were found to be within the set limits. Conclusions: the developed and validated high performance liquid chromatography-based analytical method for the quality control of 50 μg/mL Latanoprost eye drops proved to be specific, linear, exact and precise within the range of the studied concentrations; therefore, it may be safely and reliably used.
Page 1 /466185
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.