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Search Results: 1 - 10 of 48 matches for " Capparis sepiaria "
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Antidiabetic activity of the ethanol extract of Capparis sepiaria L leaves
Selvamani P,Latha S,Elayaraja K,Babu P
Indian Journal of Pharmaceutical Sciences , 2008,
Abstract: Capparis sepiaria L, a profusely branched hedge plant, is used in Indian traditional medicine. Capparis sepiaria leaves were extracted with ethanol and concentrated to dryness. The LD 50 value was determined as 894.43 mg/kg body weight by acute toxicity study. The ethanol extract was investigated for possible hypoglycemic effect produced by single oral administration at various dose levels 100, 200 and 300 mg/kg in the streptozotocin induced diabetic rats and compared against normal saline control and the standard glibenclamide. A maximum fall of plasma glucose level 9.40%; 13.57%; 15.25% and 18.80% was observed after 12 h of treatment when administered with ethanol extract of Capparis sepiaria at 100, 200 and 300 mg/kg, and glibenclamide 10 mg/kg dose, respectively. The findings from the study suggest that the Capparis sepiaria leaves may be prescribed as an adjunct to traditional formulation and drug treatment for controlling diabetes mellitus.
ANTITUMOR ACTIVITY OF CAPPARIS SEPIARIA ON EHRLICH ASCITES CARCINOMA IN MICE
Y VenuGopal,Ravindranath A,Kalpana G,Prabhaker Reddy.V
International Journal of Biomedical Research , 2013, DOI: 10.7439/ijbr.v2i4.103
Abstract: The methanol extract of Capparis Sepiaria (Capparaceae) bark (MECS) were evaluated for antitumor activity against Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. The extract was administered at the doses of 200, and 400 mg/kg body weight per day for 14 days after 24 h of tumor inoculation. After the last dose and 18 h fasting, the mice were sacrificed. The present study deals with the effect of MECS on the growth of transplantable murine tumor, life span of EAC-bearing hosts and hematological profile MECS caused significant (P < 0.01) decrease in tumor volume, packed cell volume, and viable cell count; and it prolonged the life span of EAC-tumor bearing mice. Hematological profile converted to more or less normal levels in extract-treated mice. The results indicate that MECS exhibited significant antitumor activity in EAC-bearing mice.
ANTITUMOR ACTIVITY OF CAPPARIS SEPIARIA ON EHRLICH ASCITES CARCINOMA IN MICE
Y VenuGopal,Ravindranath A,Kalpana G,Prabhaker Reddy.V
International Journal of Biomedical Research , 2011, DOI: 10.7439/ijbr.v2i4.103
Abstract: The methanol extract of Capparis Sepiaria (Capparaceae) bark (MECS) were evaluated for antitumor activity against Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. The extract was administered at the doses of 200, and 400 mg/kg body weight per day for 14 days after 24 h of tumor inoculation. After the last dose and 18 h fasting, the mice were sacrificed. The present study deals with the effect of MECS on the growth of transplantable murine tumor, life span of EAC-bearing hosts and hematological profile MECS caused significant (P < 0.01) decrease in tumor volume, packed cell volume, and viable cell count; and it prolonged the life span of EAC-tumor bearing mice. Hematological profile converted to more or less normal levels in extract-treated mice. The results indicate that MECS exhibited significant antitumor activity in EAC-bearing mice.
Phytochemical Screening and Toxicity Studies on the Leaves of Capparis sepiaria Linn. (Capparidaceae)
P. Rajesh,,S. Latha,,P. Selvamani,,V. Rajesh Kannan
Journal of Basic and Clinical Pharmacy , 2010,
Abstract: Capparis sepiaria Linn. (Family: Capparidaceae) is a rare indigenous in South India but has widespread distribution in many tropical and sub-tropical countries. The present study intended with various phytochemical screening and toxicity studies were carried out on the leaves of the Capparis sepiaria. Preliminary phytochemical evaluation of the ethanolic extract of revealed that the presence of reducing sugar, flavonoids, steroids, tannins, glycosides, alkaloids, gums, resins, amino acids, proteins and anthraquinones. The toxicity studies were performed as acute, sub-acute and chronic toxicity determined the LD50 value of 300-5000 mg/kg body weight 4-6 weeks. The results of the various phytochemical tests indicated that the plant to be rich in various biologically active compounds which could serve as potential source of the crude drugs and in addition the plant is not toxic to the experimental model
EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF CAPPARIS SEPIARIA LEAVES
R. Thirumalaikumaran,Uma Maheswara Reddy
International Journal of Biomedical Research , 2011, DOI: 10.7439/ijbr.v2i3.93
Abstract: The effect of the ethanolic extract of the leaves of capparis sepiaria Linn was studied against carbon tetrachloride induced hepatotoxicity in Wister rats. Significant hepatoprotective effects were obtained liver damage induced by carbon tetrachloride as evident from decreased serum levels of glutamate pyruvate transaminase (SGPT),glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (SAKP) and bilirubin (SB) in the capparis sepiaria (CS) treated groups (100,200 mg/kg), compared to the intoxicated controls. The hepatoprotective effect was further confirmed by histopathalogical studies of the liver, which showed improved architecture, absence of nuclear pycnosis, hepatocyte congestion and necrosis, when compared with the liver of the toxin group of animals. capparis sepiaria (CS) extract also showed significant free radical scavenging activity in vitro. Thus the present study provides a scientific rationale for the traditional use of this plant in the management of liver disorders.
EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF CAPPARIS SEPIARIA LEAVES
R. Thirumalaikumaran,Uma Maheswara Reddy
International Journal of Biomedical Research , 2013, DOI: 10.7439/ijbr.v2i3.93
Abstract: The effect of the ethanolic extract of the leaves of capparis sepiaria Linn was studied against carbon tetrachloride induced hepatotoxicity in Wister rats. Significant hepatoprotective effects were obtained liver damage induced by carbon tetrachloride as evident from decreased serum levels of glutamate pyruvate transaminase (SGPT),glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (SAKP) and bilirubin (SB) in the capparis sepiaria (CS) treated groups (100,200 mg/kg), compared to the intoxicated controls. The hepatoprotective effect was further confirmed by histopathalogical studies of the liver, which showed improved architecture, absence of nuclear pycnosis, hepatocyte congestion and necrosis, when compared with the liver of the toxin group of animals. capparis sepiaria (CS) extract also showed significant free radical scavenging activity in vitro. Thus the present study provides a scientific rationale for the traditional use of this plant in the management of liver disorders.
Evaluation of hypolipidaemic activity of Capparis decidua
Neelkamal chahlia
International Journal of Biomedical Science , 2009,
Abstract: Background: The effect of various extracts (50% ethanolic) of Capparis decidua on lipid profile of streptozotocin diabetic rats was studied. Procedure: The extract was administered to the diabetic models for 30days. Findings: The extract produced a significant (p<0.05) dose-dependent decrease in the levels of total cholesterol (TC), Triacylglycerol (TG), low-density lipoprotein-cholesterol (LDL cholesterol), with a significant increase in the level High-density lipoprotein-cholesterol (HDL-C). Conclusion: The extracts of Capparis decidua< prove to have a hypolipidemic potential.
Antihyperglycemic, antioxidant and hypolipidemic effect of Capparis aphylla stem extract in streptozotocin induced diabetic rats
KS Dangi
Biology and Medicine , 2010,
Abstract: Capparis aphylla, a xerophytic plant, has been used in traditional Indian medicine for treating diabetes andcardiovascular disease. The methanol extracts and active fraction from stem of C. aphylla administered todiabetic rats and blood glucose, antioxidant level, lipid, urea and creatinine level were assayed. The single oraldosing(300mg/kg b.wt) of methanol extract and active fraction(30mg/kg b.wt) from stem part of C. aphyllasignificantly reduced blood glucose levels in normal and diabetic rats (p<0.01) during oral glucose tolerance test.While total plasma cholesterol, triglycerides, VLDL and LDL levels were significantly (p<0.01) reduced, serumHDL was elevated by 116% after 7 days of active fraction oral administration in diabetic rats. Active fractiontreatment lead to significant (p<0.01) increase in GSH and decreased MDA level in liver, heart and kidney ofdiabetic rat. Finding supported the traditional use of C. aphylla in the treatment of diabetes and cardiovasculardisease.
Stachydrine and Volatile Isothiocyanates from the Unripe Fruit of Capparis spinosa L.
SULEIMAN AFSHARYPUOR AMIR AREFIAN JAZY
DARU : Journal of Pharmaceutical Sciences , 1999,
Abstract: The alkaloid stachydrine of the unripe fruit as well as other parts of Capparis spinosa var. mucronifolia was extracted by 80% methanol, purified by column chromatography and identified by 'H NMR and IR spectroscopic methods. Volatile isothiocyanates were prepared by hydro-distillation of the autolyzed plant material and studied by GC and GC/MS methods.The volatile oil of the unriupe fruit was composed mainly of methyl isothiocyanate (39.2%), isopropyl isothio-cyanate(21.4%), and sec-butyl isothiocyanate (6.4%).
Capparis L. Subgénero Calanthea DC. En Venezuela
Ruiz-Zapata,Thirza;
Ernstia , 2006,
Abstract: calanthea was designated as a section of capparis by de candolle in 1824 and raised to subgeneric status by eichler in 1865. with the objective knowing the species of capparis subgenus calanthea present in venezuela a revision of the taxonomic literature and specimens from different national and foreign herbaria was undertaken, and species were observed in their habitats as well. three species were registered: c. pulcherrima jacq., c. stenosepala urb.and c. detonsa triana et planch.; they have disjunct distributions and live in different habitats. the first two grow in thorny xerophytic thickets, and the last in montane evergreen forests. in venezuela, c. pulcherrima is known only from lara state, at 600-700 m, and in colombia from the type locality and neighboring areas. c. stenosepala is an endemic of venezuela and registered in anzoátegui, sucre, and nueva esparta states, from sea level to 500 m, and c. detonsa is present in amazonas, bolívar, barinas and táchira states, at elevations of 600-1300 m; the last species has the broadest distribution, since it is also present in brazil, colombia, ecuador, peru and bolivia. for each species illustrations and a distribution map are included.
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