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Search Results: 1 - 10 of 14121 matches for " Capillary Leak Syndrome "
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The Current Opinions of Capillary Leak Syndrome  [PDF]
Jun Su, Ying Zhang, Wei Hu
Open Journal of Clinical Diagnostics (OJCD) , 2015, DOI: 10.4236/ojcd.2015.51003
Abstract: Capillary Leak Syndrome (CLS) in patients with severe course of disease is more and more common, and the clinical manifestations of CLS include systemic edema, hypoproteinemia, effective circulating blood volume reduction and hemoconcentration. The common pathogenies are sepsis, severe trauma, cardiopulmonary bypass and so on. Clinically, CLS is usually divided into leakage period and recovery period, with different pathophysiologic process, clinical manifestation and treatment in different period respectively. Although there are more treatments, they are not effective treatment measures. There have been so many studies about improvement of endothelial function, macromolecular colloid liquid applications, and continuous blood purification treatment. Systematic understanding of the pathological mechanism, clinical manifestations and staging, diagnosis and treatment of the CLS has a guiding value.
Síndrome do desconforto respiratório agudo comocomplica??o de psoríase pustulosa generalizada
Maehara, Laura de Sena Nogueira;Mariano, Máira Magalh?es;Góis, Aécio Flávio Teixeira de;Padilha, Maria Helena V. Q;Yamada, Sergio;Porro, Adriana Maria;
Anais Brasileiros de Dermatologia , 2011, DOI: 10.1590/S0365-05962011000300026
Abstract: since 1991, eight cases of pulmonary leak capilary syndrome have been described associated with pustular or erythrodermic psoriasis induced or not by the use of acitretin or sirolimus - being one of the cases, fatal. we report the case of a female patient with diagnosed gpp or von zumbusch and multiple hospitalizations due to such condition. at that time, the condition was evolving with pulmonary onset and resolution with corticosteroids. the patient was not using any previously described medication that could precipitate pulmonary condition (methotrexate and acitretin). this is a rare complication associated with psoriasis which has not been described in brazilian patients so far
Distribution characteristics of liquid sequestration in rats with sepsis
Bin LI,Guo-guang MA,Jing-quan LIU,Zhi-Gang ZHANG
Medical Journal of Chinese People's Liberation Army , 2012,
Abstract: Objective To investigate the distribution characteristics of organs with liquid sequestration during fluid resuscitation in rats with sepsis. Methods Fifty male Wistar rats were randomly divided into five groups: control group (n=10), sepsis group (n=10), crystalloid group (n=10), albumin group (n=10), and artificial colloid (HAES) group (n=10). The sepsis model was reproduced by cecal ligation and puncture. The mean arterial pressure was monitored with carotid artery intubation. Twelve hours after fluid infusion by micro-infusion pump via the femoral vein, tissues from the heart, liver, lungs, kidney (right), and small intestine were harvested to observe the pathological changes and calculate the tissue water content. Results The water content of every visceral tissue was higher in the sepsis group than in the control group (P < 0.05); the water content in the heart, liver, and lung tissues was higher in the albumin group than in the crystalloid group (P < 0.05). The water content in both albumin and crystalloid groups was higher than that in the sepsis group (P < 0.05). Moreover, the water content in the heart, liver, and lungs in the HAES group was lower than that in the crystalloid and albumin groups (P < 0.05). Cellular injuries were more severe in the heart, liver, and lungs than in the intestine and kidney in the crystalloid group and albumin group under electron-microscope. Conclusion Liquid sequestration exists mainly in the lungs, heart, and liver of rats with sepsis during fluid resuscitation. The phenomenon is less evident in the kidney and small intestine. Artificial colloid can reduce capillary leak with a good volume expansion effect.
Avalia??o da aprotinina na redu??o da resposta inflamatória sistêmica em crian?as operadas com circula??o extracorpórea
Ferreira, Cesar Augusto;Vicente, Walter Villela de Andrade;Evora, Paulo Roberto Barbosa;Rodrigues, Alfredo José;Klamt, Jyrson Guilherme;Carlotti, Ana Paula de Carvalho Panzeli;Carmona, Fábio;Manso, Paulo Henrique;
Revista Brasileira de Cirurgia Cardiovascular , 2010, DOI: 10.1590/S0102-76382010000100018
Abstract: objective: to assess if the hemostatic high-dose aprotinin is able to reduce the inflammatory process after cardiopulmonary bypass (cpb) in children. methods: a prospective randomized study was performed on children aged 30 days to 4 years who underwent correction of acyanogenic congenital heart disease with cpb and were divided into two groups: control (n=9) and aprotinin (n=10). in the aprotinin group the drug was administered before and during cpb and the systemic inflammatory response and hemostatic and multiorgan dysfunctions were assessed through clinical and biochemical markers. differences were considered to be significant when p<0.05. results: the groups were similar regarding demographic and intraoperative variables, except for a greater hemodilution in the aprotinin group. the drug had no benefit regarding time of mechanical pulmonary ventilation, staying in the postoperative icu and length of hospitalization, or regarding the use of inotropic drugs and renal function. the partial arterial oxygen pressure/ inspired oxygen fraction ratio (pao2/fio2) was significantly reduced 24 h after surgery in the control group. blood loss was similar for both groups. significant leukopenia was observed in the aprotinin group during cpb, followed by leukocytosis. tumor necrosis factor alpha (tnf- α), interleukins (il)-6, il-8, il-10, il-6/il-10 ratio did not differ significantly between groups. the postoperative il-6/il-10 ratio increased significantly in the control group. there were no complications with the use of aprotinin. conclusion: in this study, hemostatic high-dose aprotinin did not minimize the clinical manifestations or serum markers of the inflammatory systemic response.
A single but prolonged and eventually fatal episode of capillary leak syndrome with a diagnosis of a small tumor mass B cell lymphoma
Majorie Schlier,Murielle Rondeau-Lutz,Jean-Christophe Weber
Journal of Advances in Internal Medicine , 2014, DOI: 10.3126/jaim.v3i1.10702
Abstract: The capillary leak syndrome is a rare and serious condition. It is characterized by acute episodes of extravasation of liquids and proteins through the capillary wall to the interstitial space, with generalized edema, hemoconcentration, hypoproteinemia. Most often, capillary leak syndrome is idiopathic. Some cases are associated with neoplastic diseases. We describe a new case of capillary leak syndrome as a paraneoplastic syndrome of a large-B-cell lymphoma. This case is unusual because of the evolution of the capillary leak syndrome during a single but extended and fatal episode. The etiologic diagnosis in this case was particularly difficult to prove because of the small tumour mass. Our case report is thus the fourth reported case of capillary leak syndrome revealing a B-cell lymphoma with a small tumour mass. DOI: http://dx.doi.org/10.3126/jaim.v3i1.10702 ? Journal of Advances in Internal Medicine 2014;03(01):34-37
Eribulin induced capillary leak syndrome in a breast cancer patient

JIA Zhenya
, HU Xichun, FU Fengming, et al

- , 2016, DOI: 10.3969/j.issn.1007-3969.2016.02.015
Herpes simplex virus type 1 and normal protein permeability in the lungs of critically ill patients: a case for low pathogenicity?
Joanne Verheij, AB Johan Groeneveld, Albertus Beishuizen, Arthur van Lingen, Alberdina M Simoons-Smit, Rob Strack van Schijndel
Critical Care , 2004, DOI: 10.1186/cc2850
Abstract: In four critically ill patients with persistent pulmonary infiltrates of unknown origin and isolation of HSV-1 from tracheal aspirate or bronchoalveolar lavage fluid, at 7 (1–11) days after start of mechanical ventilatory support, a pulmonary leak index (PLI) for 67Gallium (67Ga)-transferrin (upper limit of normal 14.1 × 10-3/min) was measured.The PLI ranged between 7.5 and 14.0 × 10-3/min in the study patients. Two patients received a course of acyclovir and all survived.The normal capillary permeability observed in the lungs argues against pathogenicity of HSV-1 in the critically ill, and favors that isolation of the virus reflects reactivation in the course of serious illness and immunodepresssion, rather than primary or superimposed infection in the lungs.In some critically ill patients, herpes simplex virus type 1 (HSV-1) is isolated from the upper or lower respiratory tract [1-15]. On the one hand, immunodepressed patients may be susceptible for transmission and acquisition of viral diseases, but on the other hand viral reactivation may occur and may contribute relatively little to morbidity and mortality. Indeed, reactivation of human herpes virus-6 is common in the critically ill and does not worsen outcome [16,17]. In immunocompetent patients, however, isolation of HSV-1 may be associated with viral pneumonia, even if reactivation rather than primary infection is likely [6,8,18]. Although HSV-1 has been associated with acute respiratory distress syndrome (ARDS) or ventilator-associated pneumonia in the critically ill [1-14], either as primary or superimposed infection, there are only few reports that the virus has elicited an infectious host response, as demonstrated by a rise of serum antibodies, by bronchoscopic airway disease, by "typical" findings on computer tomography of the lungs, or by the presence of giant cells or nuclear inclusion bodies on cytology or biopsy of the lower respiratory tract [3,5,9,10,18]. Indeed, Tuxen et al. observed that prophyl
A Unified Management for Spontaneous CSF Leak  [PDF]
Lobna El Fiky, Ali Kotb, Badr Eldin Mostafa
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2015, DOI: 10.4236/ijohns.2015.42025
Abstract: Background: Spontaneous CSF leak represents less frequent cause of CSF leak, but cases are more difficult to control, with the highest failure rate and recurrence despite adequate repair. The problems in these cases might be related to an underlying undiagnosed associated intracranial hyper-tension. Recognition and long-term treatment of elevated ICP is therefore critical to the successful management of these patients. Objective: To evaluate the CSF pressure in cases of spontaneous CSF rhinorrhea and to describe our same setting combined protocol to the repair of the leak, measurement and management of CSF pressure. Patients and Methods: All patients presenting to Ain Shams University Hospitals, Cairo, Egypt, with spontaneous CSF leak were included prospectively in the study. Clinical and radiologic data were collected to suspect elevated intracranial pressure. After CSF repair, CSF pressure was measured and if found to be more than 20 cmH2O, a lumboperitoneal shunt was used. Results: Twenty-seven cases, 23 women and 4 men, presented with spontaneous CSF leak. 23 patients had BMI above 30. All patients had empty sella syndrome (100%), and a meningoencephalocele was found in 13 cases (48%). CSF pressure ranged from 5 to 39 cmH2O (mean = 28.7). A pressure above 21 cmH2O was found in19 patients (70%) and subsequently had lumboperitoneal shunt in the same setting. No recurrence occurred in this subset of patients with 6 - 60 months follow-up period. Conclusion: A selective and specific same setting protocol can result in a better diagnosis and control of the accompanying elevated ICP in cases of spontaneous CSF leak. It avoids a second operative intervention, and shortens the hospital stay, with an increase in the success rate. In the same time, the smaller number of patients with normal ICP can avoid further drainage.
Pancreas Transplant Salvage by Proximal Loop Ileostomy and Distal Ileostotomy Tube for Duodenal Stump Leak after Enteric Conversion  [PDF]
Monroy-Cuadros Mauricio, Rodriguez-Velez Cesar
Surgical Science (SS) , 2011, DOI: 10.4236/ss.2011.21001
Abstract: After pancreas transplantation, some patients with bladder drainage (BD) of the pancreatic duct will need to be converted to enteric drainage (ED) because of reflux pancreatitis, metabolic acidosis, and urological complications. However, ED is associated with higher rates of duodenal stump leak, intra-abdominal abscess, and peritonitis. In some cases of enteric anastomosis leakage, a primary repair can be attempted, but in more severe cases, graft pancreatectomy is indicated. We report one patient who received a combined kidney and pancreas transplant with BD of exocrine secretions, but who required ED conversion 6 years later because of persistent metabolic acidosis and adverse urological symptoms. However, a significant duodenal leak was discovered 4 days post-operatively. To salvage the transplanted pancreas, we performed a diverting loop ileostomy proximal to the entero-entero anastomosis and the distal section was drained retrogradely with an ileostostomy tube, allowing the area of the leak to heal. Three months later, the ileostomy was reversed without complications, the symptoms that led to the ED conversion resolved, and the kidney and pancreas allografts remain functional 48 months later. We suggest that this might be a method by which transplanted pancreas may be salvaged in the case of leakage after ED conversion.
Ricin and Ricin-Containing Immunotoxins: Insights into Intracellular Transport and Mechanism of action in Vitro
Monika S?omińska-Wojewódzka,Kirsten Sandvig
Antibodies , 2013, DOI: 10.3390/antib2020236
Abstract: Ricin is a type II ribosome inactivating protein (RIP) isolated from castor beans. Its high toxicity classifies it as a possible biological weapon. On the other hand, ricin linked to specific monoclonal antibodies or used in other conjugates has powerful medical applications. Ricin consists of an A-chain (RTA) that damages ribosomes and inhibits protein synthesis, and a B-chain that plays a role in binding and cellular uptake. A number of recent studies have demonstrated that ricin-induced inhibition of protein synthesis is not the only mechanism responsible for cell death. It turns out that ricin is able to induce apoptosis in different cell lines and multiple organs in animals. However, the molecular link between protein synthesis inhibition and ricin-dependent triggering of apoptotic cell death is unclear. This review describes the intracellular transport of ricin and ricin-based immunotoxins and their mechanism of action in different non-malignant and cancer cell lines. Moreover, various ricin-containing immunotoxins, their composition, medical applications and side-effects will be described and discussed. Understanding the mechanism of action of ricin-based immunotoxins will facilitate construction of effectively acting immunotoxins that can be used in the clinic for cancer treatment.
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