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Search Results: 1 - 10 of 11547 matches for " Cao Haixia "
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Potentiation of Scutellarin on Human Tongue Carcinoma Xenograft by Low-Intensity Ultrasound
Haixia Li, Haixia Fan, Zhu Wang, Jinhua Zheng, Wenwu Cao
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0059473
Abstract: Scutellarin 7-O-β-d-glucuronide (scutellarin) has shown great potential as a chemotherapeutic agent for cancer treatment, but only at high dosage. Here we investigate the possibility of using low intensity ultrasound to reduce the scutellarin dosage. Ultrasound intensities of 1.0 W/cm2 and 0.05 W/cm2 were used for in vivo and in vitro experiments, respectively, and a very low dosage of scutellarin (15 nM) was used. Tumor-bearing Balb/c mice and SAS human-tongue squamous carcinoma cell suspensions were used for the in vivo and in vitro experiments, respectively. Each kind of subjects was divided into control, ultrasound-alone, scutellarin-alone, and combined ultrasound-scutellarin treatment groups. Only the combined treatment showed strong anticancer effects. In the in vivo case, the combined treatment significantly delayed tumor growth, initiated cellular chromatin changes (including a decrease in the number of cytoplasmic organelles and fragmentation of condensed nuclear chromatin), inhibited tumor angiogenesis and lymphangiogenesis, stopped cancer-cell proliferation, decreased MMP-2 and MMP-9 expression levels and caused cancer-cell apoptosis. In the in vitro case, the combined treatment produced cancer cell-shape irregularity in a manner seriously fractured microvilli, inhibited cancer-cell migratory and invasion activities, and induced cancer-cell apoptosis. Because the combined treatment did not increase intracellular ROS production, scutellarin is not a sonosensitizer so that the anticancer effect is not through sonodynamic therapy. Low-intensity ultrasound is merely increasing the permeability of scutellarin into cancer cells. Based on our results, one may perform localized chemotherapy using much reduced dosage of the drug with the help of low intensity ultrasound, which will greatly minimize side effects.
A Facile Procedure for the Generation of Dichlorocarbene from the Reaction of Carbon Tetrachloride and Magnesium using Ultrasonic Irradiation
Haixia Lin,Mingfa Yang,Peigang Huang,Weiguo Cao
Molecules , 2003, DOI: 10.3390/80800608
Abstract: An improved method for the generation of dichlorocarbene was developed that utilizes ultrasound in the reaction of carbon tetrachloride with magnesium. High yields of gem-dichlorocyclopropane derivatives can be obtained in the presence of olefins by this method.
Capacity-Optimized Access Scheduling Control for Heterogeneous MANETs with MIMO Links  [PDF]
Haixia Cui, Wanmei Feng
Communications and Network (CN) , 2017, DOI: 10.4236/cn.2017.92009
Abstract: Multiple-input and multiple-output (MIMO) technique can significantly improve transmission reliability and bandwidth efficiency in wireless networks. However, many upper layer aspects of MIMO links, especially in mobile networks with heterogeneous antennas and strong interference environments, need further investigation. In this paper, we study its impact on medium access and network capacity. Since MIMO links can enhance physical layer capacity and co-channel interference suppression that affects network access scheduling directly, we develop a capacity-optimized access scheduling control (COASC) scheme for mobile ad hoc networks (MANETs) with MIMO links. We formulate the distributed scheduling taking the key of optimization into design to improve the network capacity and transmission reliability. Simulation results are presented to show the effectiveness of the proposed scheme.
Relationship between structure and function ofJWA in the modulation of cell differentiation
Xia Wei,Zhou Jianwei,Cao Haixia,Zou Changping,Wang Chengya,Shen Qun,Lu Hua
Chinese Science Bulletin , 2001, DOI: 10.1007/BF02901133
Abstract: To elucidate the structure characteristic, regulation of expression and the potential function ofJWA— a novel retinoic acid responsible and cytoskeleton associate gene, a ratJWA homologue gene and a 621-bpJWA promoter fragment were cloned and analyzed. Using reverse transcription-polymerase chain reaction (RT-PCR),JWA mRNA expression in NIH3T3, K562 and human primary acute promyelocytic leukaemia (APL) cells have been investigated after treatment with all trans retinoic acid (ATRA), N-4-hydroxyphenyl-retinamide (4HPR), arsenic trioxide (As2O3), Phorbol-12-myristate-13-acetate (TPA) and dimethyl sulfoxide (DMSO). The results showed that there is a complete TPA responsive element (TRE) existed in the promoter ofJWA at 437 to 443 bp; ratJWA homologue gene showed that there are four nucleotides different from humanJWA within coding region. After treatment with TPA, an uneven pattern ofJWA transcription existed in different cell lines, suggesting that even TPA induces cell differentiation in different cell lines, and it may be referred to different signal pathways. In ATRA pretreated APL cells, all the above chemicals induce cellular differentiation and down regulateJWA transcriptionin vitro. This suggests that pretreatment of ATRA on APL cells seems a precondition for turning onJWA involved signal pathway.
Role of JWA in acute promyelocytic leukemia cell differentiation and apoptosis triggered by retinoic acid, 12-tetradecanoylphorbol-13-acetate and arsenic trioxide
Haixia Cao,Wei Xia,Qun Shen,Hua Lu,Jian Ye,Aiping Li,Changping Zou,Jianwei Zhou
Chinese Science Bulletin , 2002, DOI: 10.1360/02tb9188
Abstract: JWA, a cytoskeleton associated gene, was primarily found to be regulated by all trans-retinoic acid (ATRA), 13 cis-retinoic acid (13 cis-RA) and 12-tetradecanoylphorbol-13-acetate (TPA). Our previous data showed that JWA might be involved in both cellular differentiation and apoptosis induced by several chemicals. In this study, we addressed the possible mechanism of JWA in the regulation of cell differentiation and apoptosis in NB4, a human acute promyelocytic leukemia cell line. CD11b/CD33 expression and cell cycle were analyzed for detecting of cell differentiation and apoptosis. Both reverse-transcription polymerase chain reaction (RT-PCR) and Western blot assays were used for understanding the expressions of JWA. The results showed that under the indicated concentrations ATRA (10 6 mol/L) and AS2O3 (10 6 mol/L) induced cell differentiation and apoptosis separately; while both 4HPR (10 6 mol/L) and TPA (10 7 mol/L) showed dual-directional effects on NB4 cells, they not only trigger cells’ differentiation but also induce cells apoptosis at the same time. All chemicals up-regulated JWA expression whatever they trigger cells either differentiation or apoptosis; however, it seems that the chemicals have no effect on PML/RARα in the treated NB4 cells. Anti-sense JWA oligonucleotide could partially block the ability of TPA in inducing cell differentiation and apoptosis via direct signal pathway. Interestingly, a high molecular weight JWA protein (JWAF) was identified only in de novo primary APL cells and it was also responsible for ATRA treatment. It raises questions of whether the JWAF is a novel APL specific marker and, how it was involved in the known mechanism of APL.
Exosomes: Decreased Sensitivity of Lung Cancer A549 Cells to Cisplatin
Xia Xiao, Shaorong Yu, Shuchun Li, Jianzhong Wu, Rong Ma, Haixia Cao, Yanliang Zhu, Jifeng Feng
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0089534
Abstract: Exosomes are small extracellular membrane vesicles of endocytic origin released by many cells that could be found in most body fluids. The main functions of exosomes are cellular communication and cellular waste clean-up. This study was conducted to determine the involvement of exosomes in the regulation of sensitivity of the lung cancer cell line A549 to cisplatin (DDP). When DDP was added to A549 cells, exosomes secretion was strengthened. Addition of the secreted exosomes to other A549 cells increased the resistance of these A549 cells to DDP. Upon exposure of A549 to DDP, the expression levels of several miRNAs and mRNAs reportedly associated with DDP sensitivity changed significantly in exosomes; these changes may mediate the resistance of A549 cells to DDP. Exosomes released by A549 cells during DDP exposure decreased the sensitivity of other A549 cells to DDP, which may be mediated by miRNAs and mRNAs exchange by exosomes via cell-to-cell communication. Although the detailed mechanism of resistance remains unclear, we believed that inhibition of exosomes formation and release might present a novel strategy for lung cancer treatment in the future.
Detection of SNPs in the Cathepsin D Gene and Their Association with Yolk Traits in Chickens
Qian Sheng, Dingguo Cao, Yan Zhou, Qiuxia Lei, Haixia Han, Fuwei Li, Yan Lu, Cunfang Wang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056656
Abstract: CTSD (Cathepsin D) is a key enzyme in yolk formation, and it primarily affects egg yolk weight and egg weight. However, recent research has mostly focused on the genomic structure of the CTSD gene and the enzyme’s role in pathology, and less is known about the enzyme’s functions in chickens. In this paper, the correlations between CTSD polymorphisms and egg quality traits were analyzed in local Shandong chicken breeds. CTSD polymorphisms were investigated by PCR-SSCP (polymerase chain reaction single strand conformation polymorphism) and sequencing analysis. Two variants were found to be associated with egg quality traits. One variant (2614T>C), located in exon 3, was novel. Another variant (5274G>T), located in intron 4, was previously referred to as rs16469410. Overall, our results indicated that CTSD would be a useful candidate gene in selection programs for improving yolk traits.
{2,2′-[4-Chloro-5-methyl-o-phenylenebis(nitrilomethylidyne)]diphenolato}nickel(II)
Haixia Wang
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810046088
Abstract: In the title complex, [Ni(C21H15ClN2O2)], the NiII ion is coordinated by two N and two O atoms from the tetradentate Schiff base ligand in a distorted square geometry. The crystal packing exhibits short intermolecular Ni...Ni distances of 3.273 (3) .
2-(5,6-Dibromo-7-methyl-3H-imidazo[4,5-b]pyridin-2-yl)phenol
Haixia Wang
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810045277
Abstract: In the title compound, C13H9Br2N3O, the molecular skeleton, influenced by an intramolecular O—H...N hydrogen bond, is roughly planar, with a mean deviation of 0.033 . In the crystal, intermolecular N—H...O hydrogen bonds link the molecules into chains propagating in [100]. Weak intermolecular π–π interactions [centroid–centroid distances = 3.760 (3) and 3.723 (3) ] further consolidate the packing.
Research on the Innovation of MICE Education Model
Haixia Guo
Education Research Frontier , 2012,
Abstract: Recently, there are more demands for MICE talents with the rapid development of MICE economy. But the situation of MICE education can't meet the needs of the MICE talents, thus it restricts the development of competition ability of MICE industry. Therefore, developing exhibition education and creating newer exhibition education model are essential way to raise the competitiveness of MICE industry. We should combine theory teaching with practice teaching, combine education with training, combine doctor education, postgraduate education, bachelor education with vocational and technical education, combine MICE education with MICE research, and combine domestic education with abroad education to create newer exhibition education model and raise MICE talent international competitiveness.
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