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Search Results: 1 - 10 of 714887 matches for " Campos A.C.L. "
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Custo do transplante hepático no Hospital de Clínicas da Universidade Federal do Paraná
Coelho J.C.U.,Wiederkehr J.C.,Lacerda M.A.,Campos A.C.L.
Revista da Associa??o Médica Brasileira , 1997,
Abstract: OBJETIVO. Determinar o custo do transplante hepático no Hospital de Clínicas da Universidade Federal do Paraná. MéTODO. Os dados do prontuário de 24 pacientes submetidos a 25 transplantes hepáticos foram avaliados do dia da interna o para o transplante hepático até a data da alta hospitalar ou óbito para determinar o número de dias de interna o, o local de interna o, a quantidade de material e medicamentos usados, os exames complementares e procedimentos realizados. Honorários médicos n o foram incluídos no estudo. RESULTADOS. A idade dos pacientes variou de 6 a 56 anos, tendo seis deles menos que 14 anos de idade. Cinco pacientes foram a óbito durante a interna o hospitalar. Retransplante foi realizado em somente um paciente. O custo médio da retirada do fígado do doador foi de US$ 2,783.19. O custo total do transplante hepático variou amplamente entre os pacientes, na dependência de ocorrência de complica es pós-operatórias, do número de dias de interna o hospitalar e da quantidade de transfus o de hemoderivados. O custo total variou de US$ 6,359.84 a US$ 75,434.18, com média de US$ 21,505.53. O item mais caro do transplante hepático foi o custo com a hemoterapia, seguido do custo com medicamentos e diária hospitalar. CONCLUS O. O custo do transplante hepático varia muito entre os pacientes e pode ser realizado no Brasil a um custo inferior ao relatado nos Estados Unidos e na Europa.
Custo do transplante hepático no Hospital de Clínicas da Universidade Federal do Paraná
Coelho, J.C.U.;Wiederkehr, J.C.;Lacerda, M.A.;Campos, A.C.L.;Zeni Neto, C.;Matias, J.E.F.;Campos, G.M.R.;
Revista da Associa??o Médica Brasileira , 1997, DOI: 10.1590/S0104-42301997000100012
Abstract: purpose - to determine the cost of liver transplantation at the clinical hospital of the federal university of parana. methods - the data of 24 patients subjected to 25 liver transplantations were evaluated from the day of hospital admission until the day of discharge to determine the length of hospitalization, quantity of material and medications used, and exams and procedures performed. professional fees were not included in the study. results - the age of the patients varied from 6 to 56 years. six patients were younger than 14 years of age. five patients died during hospitalization. re-transplantation was performed in only one patient. the average cost for liver procurement was us$ 2,783.19. the total cost of the liver transplantation varied, depending on the occurrence of complications, length of hospitalization and the amount of blood products transfused. the total cost varied from us$ 6,359.84 to us$ 75,434.18, with an average of us$ 21,505.53. the most expensive item of the liver transplantation was blood products transfused, followed by medications, and intensive care and room charges. conclusion - the cost of liver transplantation varies among the patients and may be performed in brazil at a cost less than that reported in the united states and europe.
Thalidomide and pentoxifylline block the renal effects of supernatants of macrophages activated with Crotalus durissus cascavella venom
Martins A.M.C.,Nobre A.C.L.,Almeida A.C.,Bezerra G.
Brazilian Journal of Medical and Biological Research , 2004,
Abstract: Because thalidomide and pentoxifylline inhibit the synthesis and release of tumor necrosis factor-alpha (TNF-alpha), we determined the effect of these drugs on the renal damage induced by supernatants of macrophages activated with Crotalus durissus cascavella venom in order to identify the role of TNF-alpha in the process. Rat peritoneal macrophages were collected with RPMI medium and stimulated in vitro with C.d. cascavella venom (10 μg/ml) in the absence and presence of thalidomide (15 μM) or pentoxifylline (500 μM) for 1 h and washed and kept in culture for 2 h. Supernatant (1 ml) was tested on an isolated perfused rat kidney (N = 6 for each group). The first 30 min of each experiment were used as control. The supernatant was added to the perfusion system. All experiments lasted 120 min. The toxic effect of the preparation of venom-stimulated macrophages on renal parameters was determined. At 120 min, thalidomide (Thalid) and pentoxifylline (Ptx) inhibited (P < 0.05) the increase in perfusion pressure caused by the venom (control = 114.0 ± 1.3; venom = 137.1 ± 1.5; Thalid = 121.0 ± 2.5; Ptx = 121.4 ± 4.0 mmHg), renal vascular resistance (control = 4.5 ± 0.2; venom = 7.3 ± 0.6; Thalid = 4.5 ± 0.9; Ptx = 4.8 ± 0.6 mmHg/ml g-1 min-1), urinary flow (control = 0.23 ± 0.001; venom = 0.44 ± 0.01; Thalid = 0.22 ± 0.007; Ptx = 0.21 ± 0.009 ml g-1 min-1), glomerular filtration rate (control = 0.72 ± 0.06; venom = 1.91 ± 0.11; Thalid = 0.75 ± 0.04; Ptx = 0.77 ± 0.05 ml g-1 min-1) and the decrease in percent tubular sodium transport (control = 77.0 ± 0.9; venom = 73.9 ± 0.66; Thalid = 76.6 ± 1.1; Ptx = 81.8 ± 2.0%), percent tubular chloride transport (control = 77.1 ± 1.2; venom = 71.4 ± 1.1; Thalid = 77.6 ± 1.7; Ptx = 76.8 ± 1.2%), and percent tubular potassium transport (control = 72.7 ± 1.1; venom = 63.0 ± 1.1; Thalid = 72.6 ± 1.0; Ptx = 74.8 ± 1.0%), 30 min before and during the stimulation of macrophages with C.d. cascavella venom. These data suggest the participation of TNF-alpha in the renal effects induced by supernatant of macrophages activated with C.d. cascavella venom.
Effects of microcystin-LR in isolated perfused rat kidney
Nobre A.C.L.,Jorge M.C.M.,Menezes D.B.,Fonteles M.C.
Brazilian Journal of Medical and Biological Research , 1999,
Abstract: Microcystin is a hepatotoxic peptide which inhibits protein phosphatase types 1 and 2A. The objective of the present study was to evaluate the physiopathologic effects of microcystin-LR in isolated perfused rat kidney. Adult Wistar rats (N = 5) of both sexes (240-280 g) were utilized. Microcystin-LR (1 μg/ml) was perfused over a period of 120 min, during which samples of urine and perfusate were collected at 10-min intervals to determine the levels of inulin, sodium, potassium and osmolality. We observed a significant increase in urinary flow with a peak effect at 90 min (control (C) = 0.20 ± 0.01 and treated (T) = 0.32 ± 0.01 ml g-1 min-1, P<0.05). At 90 min there was a significant increase in perfusate pressure (C = 129.7 ± 4.81 and T = 175.0 ± 1.15 mmHg) and glomerular filtration rate (C = 0.66 ± 0.07 and T = 1.10 ± 0.04 ml g-1 min-1) and there was a significant reduction in fractional sodium tubular transport at 120 min (C = 78.6 ± 0.98 and T = 73.9 ± 0.95%). Histopathologic analysis of the perfused kidneys showed protein material in the urinary space, suggestive of renal toxicity. These data demonstrate renal vascular, glomerular and urinary effects of microcystin-LR, indicating that microcystin acts directly on the kidney by probable inhibition of protein phosphatases.
Micropropaga??o e aclimatiza??o de geranio (Pelargonium graveolens L.)
Arrigoni-Blank, M.F;Almeida, S.A;Oliveira, A.C.L;Blank, A.F;
Revista Brasileira de Plantas Medicinais , 2011, DOI: 10.1590/S1516-05722011000300004
Abstract: geranium (pelargonium graveolens l.) is a medicinal and aromatic plant native to the south of africa and whose essential oil is widely used by perfume and cosmetic industries, as well as in therapeutics. the effect of luminosity and growth regulators bap and naa on in vitro multiplication was evaluated, together with the use of different substrates on the acclimatization of micropropagated seedlings. the evaluated concentrations were 0, 0.5, 1.0 and 2.0 mg l-1 bap; 0, 0.1 and 0.5 mg l-1 naa; and two luminosity conditions (absence and presence of light), in a 4 x 3 x 2 factorial arrangement. for acclimatization, four substrates were tested: coconut dust + biosafra? (3-12-6) (12 g l-1) + limestone (1 g l-1) (cdbl); coconut dust + biosafra? (3-12-6) (12 g l-1) + limestone (1 g l-1) + vermiculite (1:1) (cdblv 1:1); coconut dust + biosafra? (3-12-6) (12 g l-1) + limestone (1 g l-1) + vermiculite (cdblv 2:1); and vermiculite with weekly addition of ms salts (vs). for p. graveolens micropropagation, the use of 1.3 mg l-1 bap and 0.5 mg l-1 naa is efficient for the direct regeneration of geranium plants, and the dark condition is the most suitable since it provides a larger number of shoots per explant. for the acclimatization of geranium seedlings, the best results were obtained with seedlings acclimatized in the substrate vermiculite with weekly addition of ms salts, followed by the substrate cdblv 1:1.
The anti-adherence effect of Lippia sidoides Cham: extract against microorganisms of dental biofilm Efeito anti-aderente de Lippia sidoides: extrato contra microorganismos do biofilme dental
A.C.L. Albuquerque,M.S.V. Pereira,D.F. Silva,L.F. Pereira
Revista Brasileira de Plantas Medicinais , 2013,
Abstract: Most illnesses affecting the oral cavity are proven to have infectious origin. Several categories of chemical agents have been used in the chemical control of dental biofilm through strategies that aim at reducing bacterial adhesion and inhibiting the growth and the proliferation of microorganisms on the tooth surface. The use of plants in folk medicine and in Dentistry, as well as the spread of successful cases, has led to scientific exploration, resulting in chemical-pharmacological knowledge of thousands of plants. The present study aimed to evaluate the anti-adherence activity of Lippia sidoides Cham., comparing the results with those of 0.12% chlorhexidine by means of an in vitro simulation of dental biofilm. The studied bacterial strains were Streptococcus mutans, Streptococcus sanguinis and Lactobacillus casei, main responsible for the biofilm adherence. The studied extract was effective in inhibiting the adherence of Streptococcus mutans up to a concentration of 1:16, compared to Chlorhexidine. Lippia sidoides Cham extract showed anti-adherence effect on the major microorganisms responsible for dental biofilm consolidation. é fato comprovado que a maior parte das doen as que acometem a cavidade bucal s o de origem infecciosa. Várias categorias de agentes químicos têm sido utilizadas no controle químico do biofilme dental através de estratégias que visam a redu o da ades o bacteriana, a inibi o do crescimento, e a prolifera o dos microrganismos na superfície do dente. A utiliza o das plantas pela medicina popular, seu uso na Odontologia e a divulga o dos êxitos, conduziram a explora o científica resultando no conhecimento químico-farmacológico de milhares de plantas. A presente pesquisa objetivou avaliar a atividade antiaderente da folha da Lippia sidoides Cham. comparando seus resultados com a Clorexidina 0,12%, através de uma simula o, in vitro, do biofilme dental. As linhagens bacterianas utilizadas na pesquisa foram o Streptococcus mutans, Streptococcus sanguinis, e o Lactobacillus casaram, principais responsáveis pela aderência do biofilme. O extrato estudado mostrou-se efetivo na inibi o de aderência das bactérias ensaiadas até uma concentra o de 1:16, sobre o Streptococcus mutans, sendo comparável à Clorexidina. O extrato da Lippia sidoides Cham. demonstrou efeito antiederente, sobre os principais microrganismos responsáveis pela consolida o do biofilme dental.
华北农学报 , 1993, DOI: 10.3321/j.issn:1000-7091.1993.02.021
Abstract: 1990~1991年以出苗期为指标。着重研究了单株幼苗活力对向日葵植株籽粒产量的影响。旨在改进Wade等(1988)提出的向日葵苗期估产数学模型。结果表明。向日葵单株葵盘重量与单株籽粒产量之间呈极显著的回归关系(R2=0.97~0.99),由前者预测后者非常可靠。可作为成熟期测产的参考。在苗期根据向日葵苗情预测收获时的籽粒产量。尽管Wade等模型有效。但加入单株幼苗活力这个因素后。整个多元回归模型的可信度大为提高。原模型中的预测因子仅包括单株面积印株距变异系数时。多元回归方程的决定系数R2为0.25;当模型中再加入单株幼苗活力指标后,R2增加到0.44。而且,单株面积与株距变异系数之间和单株面积与单株幼苗活力之间的互作也达到显著水平。改良模型中影响单株籽粒产量的各因素间,以单株面积和单株幼苗活力最为重要。
Melanose neurocutanea. Relato de caso com melanoma maligno do sistema nervoso central
Juang J.M.,Silva A.C.L.G.,Pires M.C.,Valente Y.S.
Revista da Associa??o Médica Brasileira , 1998,
Abstract: A melanose neurocutanea é uma síndrome rara caracterizada por nevos melanocíticos congênitos gigantes e excessiva melanose da leptomeninge. A síndrome parece representar um erro na morfogênese do neuroectoderma embrionário. Os autores apresentam o caso e necropsia de um paciente masculino de 19 anos que desenvolveu melanoma maligno do sistema nervoso central.
Produ??o de mudas de dois genótipos de alecrim-de-tabuleiro (Lippia gracilis Schauer) em fun??o de fertilizante mineral, calcário, substratos e recipientes
Oliveira, A.C.L;Arrigoni-Blank, M.F;Blank, A.F;Bianchini, F.G;
Revista Brasileira de Plantas Medicinais , 2011, DOI: 10.1590/S1516-05722011000100006
Abstract: commonly known as "alecrim-de-tabuleiro", lippia gracilis schauer (verbenaceae) has moderate antibacterial, antimicrobial and antiseptic activity. this study aimed to evaluate the effect of doses of mineral fertilizer, limestone, substrates and containers on seedling production of two "alecrim-de-tabuleiro" genotypes, using cuttings. in experiment 1, apical cuttings were distributed on expanded polystyrene trays of 128 cells containing coir + sand (1:1), using three replicates of eight cuttings each. experimental design was in randomized blocks, in a 4x2x2 factorial arrangement, i.e. four doses of fertilizer (6-24-12 + micronutrients) (1, 2, 3 and 4 g l-1), two doses of limestone (0 and 1 g l-1) and two genotypes (lgra106 and lgra201). at 35 days after planting, we evaluated survival (%), rooting (%), root length (cm) and root dry matter (mg). in experiment 2, three replicates of eight cuttings each were used. experimental design was in randomized blocks, in a split-plot scheme. in the plots, we tested two containers (expanded polystyrene tray of 128 cells and 110 cm3 tubets). in the subplots, we tested four substrate combinations [coir, coir + sand (1:1), coir + sand (2:1) and coir + sand (3:1)] and two genotypes (lgra106 and lgra201). at 35 days after planting, the same variables of experiment 1 were evaluated, besides shoot length (cm) and shoot dry matter (mg). the use of 1 g l-1 fertilizer without limestone was effective for plant survival and cutting rooting. based on these experiments, the genotype lgra106 is superior to lgra201 as to the evaluated variables and the expanded polystyrene tray is recommended for the production of l. gracilis seedlings through cuttings.
Subacute effects of a maximal exercise bout on endothelium-mediated vasodilation in healthy subjects
Bousquet-Santos, K.;Soares, P.P.S.;Nóbrega, A.C.L.;
Brazilian Journal of Medical and Biological Research , 2005, DOI: 10.1590/S0100-879X2005000400017
Abstract: we evaluated vascular reactivity after a maximal exercise test in order to determine whether the effect of exercise on the circulation persists even after interruption of the exercise. eleven healthy sedentary volunteers (six women, age 28 ± 5 years) were evaluated before and after (10, 60, and 120 min) a maximal exercise test on a treadmill. forearm blood flow (fbf) was measured by venous occlusion plethysmography before and during reactive hyperemia (rh). baseline fbf, analyzed by the area under the curve, increased only at 10 min after exercise (p = 0.01). fbf in response to rh increased both at 10 and 60 min vs baseline (p = 0.004). total excess flow for rh above baseline showed that vascular reactivity was increased up to 60 min after exercise (mean ± sem, before: 526.4 ± 48.8; 10 min: 1053.0 ± 168.2; 60 min: 659.4 ± 44.1 ml 100 ml-1 min-1 . s; p = 0.01 and 0.02, respectively, vs before exercise). the changes in fbf were due to increased vascular conductance since mean arterial blood pressure did not change. in a time control group (n = 5, 34 ± 3 years, three women) that did not exercise, fbf and rh did not change significantly (p = 0.07 and 0.7, respectively). these results suggest that the increased vascular reactivity caused by chronic exercise may result, at least in part, from a summation of the subacute effects of successive exercise bouts.
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