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Search Results: 1 - 10 of 144346 matches for " Cali F. Bartholomeusz "
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Neurocognitive and Social Cognitive Approaches for Improving Functional Outcome in Early Psychosis: Theoretical Considerations and Current State of Evidence
Cali F. Bartholomeusz,Kelly Allott
Schizophrenia Research and Treatment , 2012, DOI: 10.1155/2012/815315
Abstract: Improving functional outcome, in addition to alleviating psychotic symptoms, is now a major treatment objective in schizophrenia research. Given the large body of evidence suggesting pharmacological treatments generally have minimal effects on indices of functioning, research has turned to psychosocial rehabilitation programs. Among these, neurocognitive and social cognitive interventions are at the forefront of this field and are argued to target core deficits inherent to the schizophrenia illness. However, to date, research trials have primarily focused on chronic schizophrenia populations, neglecting the early psychosis groups who are often as severely impaired in social and occupational functioning. This theoretical paper will outline the rationale for investigating adjunctive cognitive-based interventions in the early phases of psychotic illness, critically examine the current approach strategies used in these interventions, and assess the evidence supporting certain training programs for improving functional outcome in early psychosis. Potential pathways for future research will be discussed.
Neurocognitive and Social Cognitive Approaches for Improving Functional Outcome in Early Psychosis: Theoretical Considerations and Current State of Evidence
Cali F. Bartholomeusz,Kelly Allott
Schizophrenia Research and Treatment , 2012, DOI: 10.1155/2012/815315
Abstract: Improving functional outcome, in addition to alleviating psychotic symptoms, is now a major treatment objective in schizophrenia research. Given the large body of evidence suggesting pharmacological treatments generally have minimal effects on indices of functioning, research has turned to psychosocial rehabilitation programs. Among these, neurocognitive and social cognitive interventions are at the forefront of this field and are argued to target core deficits inherent to the schizophrenia illness. However, to date, research trials have primarily focused on chronic schizophrenia populations, neglecting the early psychosis groups who are often as severely impaired in social and occupational functioning. This theoretical paper will outline the rationale for investigating adjunctive cognitive-based interventions in the early phases of psychotic illness, critically examine the current approach strategies used in these interventions, and assess the evidence supporting certain training programs for improving functional outcome in early psychosis. Potential pathways for future research will be discussed. 1. Introduction The field of schizophrenia research and treatment is in a transitional phase, shifting from a focus on outcomes that are measured by symptomatic remission and basic illness management to an all-encompassing outlook on real-world functional recovery [1, 2]. This is an exciting time for researchers and consumers, as the improvement in social, occupational, and personally challenging activities that impact the individual’s day-to-day living are now primary research objectives. In this research era it is also widely acknowledged that the early phase of a psychotic illness, known as the “critical period,” is the most crucial in terms of limiting or even preventing the development of disability, with maximal levels of disability reached within the first 5 years after illness onset [3]. The first onset of psychosis typically occurs between the age of 18 and 24 [4], although prodromal symptoms are often detectable in the adolescent years [5]. There is a paucity of research that has focused investigation on the “functional” outcome of this early psychosis cohort. A systematic review of 37 early detection/intervention studies in first-episode psychosis (FEP) found that 42% of patients had “good” illness outcomes as opposed to 27% who had “poor” outcomes at an average of 3-year follow-up [6]. However, outcome was predominantly defined by hospital readmission or change in symptom severity, with only 4 of the 37 studies reporting functional recovery.
Neural basis for social cognitive impairment in schizophrenia Bases neurais do comprometimento da cogni o social na esquizofrenia
Hironobu Fujiwara,Cali Bartholomeusz
Jornal Brasileiro de Psiquiatria , 2010, DOI: 10.1590/s0047-20852010000200001
Abstract:
Drainage Bed: A Natural System for WTP Sludge Dewatering and Drying with Different Coagulant Chemicals in Tropical Countries  [PDF]
Marcelo M. Barroso, Cali L. Achon, Renan F. Reis, Jo?o S. Cordeiro
Journal of Water Resource and Protection (JWARP) , 2014, DOI: 10.4236/jwarp.2014.611097
Abstract:

This study seeks to evaluate the mechanisms for dewatering sludge from Water Treatment Plants (WTP) in a natural system that uses nonwoven polyester geotextile blankets named Drainage Bed (DB). Dewatering mechanisms are divided into two stages: Drainage and Drying Phases. For the Drainage Phase, the results showed that the solids content of the Aluminum Sulfate sludge reached 8.9% to 18.3% and the PACl sludge 1.8% to 6.5%, the volume reduction on this phase exceeding 50% and 74%, respectively. The final solids content, after the Drying Phase, was greater than 28%, reaching 90%. In the Drainage Phase the lower the Surface Application Rate—SAR [kg/m2] is, the greater the drainage flow will be. In the Drying Phase, moisture and insolation were key factors in drying sludge. Thus, the Drying Phase in the DB takes special attention for being virtually nonexistent in dewatering technologies in a closed system (confined) without exposure to solar energy. The use of the DB as a natural system for dewatering WTP sludge in tropical countries proved to be a promising alternative, because of its efficient removal of water from sludge coupled with operational simplicity and low costs, provided there is area available.

Cubic Spline Approximation for Weakly Singular Integral Models  [PDF]
Franca Caliò, Elena Marchetti
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.411211
Abstract: In this paper we propose a numerical collocation method to approximate the solution of linear integral mixed Volterra Fredholm equations of the second kind, with particular weakly singular kernels. The collocation method is based on the class of quasi-interpolatory splines on locally uniform mesh. These approximating functions are particularly suitable to tackle on problems with weakly regular solutions. We analyse the convergence problems and we present some numerical results and comparisons to confirm the efficiency of the numerical model.
Correlation of an ex Vivo Model with Clinical Application of an Epigenetic Modifier, Inhibiting Tumor Growth and Metastasis, in Resistant Cholangiocarcinoma—A Case Study  [PDF]
M. A. Nezami, Aron Gould Simon, Geoffrey Bartholomeusz
Journal of Cancer Therapy (JCT) , 2016, DOI: 10.4236/jct.2016.71006
Abstract: Bile duct cancer is a rare form of cancer, with approximately 2000 new cases diagnosed in the United States each year. The prognosis of this disease is very grave, especially in the form of intrahepatic (IHCC), as there is no person with stage four who lives for 5 years, and the average prognosis is less than a year, a majority of patients die in less than 6 months despite all therapies. It is suggested that one of the key elements in the disease progression is the intratumoral hypoxia inducible factor one alfa (HIF-1a) as a regulator of malignant behavior and recently described as a new prognostic indicator of IHCC. (9, 10) HIF is a key regulator under the microenvironmental (terrain) influence, and therefore studies of the cell lines in an in vitro environment where there is no hypoxia, usually fail to translate to a clinical outcome in vivo, unless the cells are transfected by full-length HIF-1alpha (fL HIF-1alpha) and dominant-negative HIF-1alpha (dn HIF-1alpha). To overcome this barrier, an ex vivo model is designed at MD Anderson experimental therapeutics where the patient tumor sample is transferred to the mice and treated with drugs, where the tumor can cross talk with the actual terrain and mimic the human stroma where the HIF can be triggered. Results show significant tumor necrosis on the intrahepatic cholangiocacinoma, only after 5 days of exposure to an experimental compound that is known to suppress hypoxia-induced accumulation of hypoxia-inducible factor-1α (HIF-1α) through inhibiting protein synthesis. (11, 12) Further this is explored in the same actual patient with terminal diagnosis, and proves itself with promising initial response. Here, we review this method and the clinical perspectives, and suggest this method to be studied in larger trials.
ASSOCIA O DA MOET E OPU-PIV NA PRODU O DE EMBRI ES BOVINOS ASSOCIATION OF THE MOET AND OPU-PIV IN THE PRODUCTION OF BOVINE EMBRYOS
Caliê Castilho,Andréa Renesto,Fábio Camara Mustafa,José Otávio Folino Silva
Ciência Animal Brasileira , 2009,
Abstract: Objetivou-se avaliar, em vacas da ra a Nelore, a associa o das biotécnicas MOET e OPU-PIV. Para tanto, foram testadas a superovula o ovariana (SOV), iniciada 48 a 60 horas após a aspira o folicular, em fase aleatória do ciclo estral (OPU1), e a produ o in vitro (PIV) de embri es de oócitos aspirados (OPU2) em diferentes momentos após a aplica o de prostaglandina F2? (PGF2?). As fêmeas (n=23), após a OPU1, receberam implante de progestágeno, e 48 a 60 horas após a OPU iniciou-se a SOV convencional, acrescida da aplica o de 25 mg de LH exógeno para realizar a IA (insemina o artificial) com tempo fixo. No dia da colheita dos embri es, os animais foram separados para testar seis tratamentos, sendo os grupos T(0-144) (n=4), T(48-120) (n=5), T(48-96) (n=4), T(72-96) (n=3), T(96-72) (n=4), T(96-48) (n=3), que variaram de acordo com os momentos da administra o de prostaglandina e da OPU2 após a SOV. Aplicou-se prostaglandina no dia da colheita (dia 0) 0, 48, 72 e 96 horas após, realizando-se a OPU2 144, 96, 72 ou 48 horas após a prostaglandina. Houve diferen a (p<0,05) no número de oócitos recuperados, sendo que a recupera o no T(96-48) foi (p<0,05) menor, comparada ao T(48-96) e T(72-96); a OPU próxima da prostaglandina (48 h após) prejudicou a recupera o de oócitos. Concluiu-se que é possível realizar a associa o das biotécnicas sem prejudicar os índices de produ o, desde que a OPU ocorra após a lise dos CLs presentes nos ovários após a superestimula o, ou seja, a partir de 96 horas após a aplica o de PGF2?, depois, portanto, da colheita de embri es in vivo. PALAVRAS-CHAVES: Aspira o folicular, oócito, embri o, MOET, oócito, Nelore. It has been the aim to value, in Nelore cows, the association of the assisted reproduction MOET e OPU-PIV. For this, it has tested the ovarian superovulation (SOV) 48 to 60 h after the OPU (ovum pick-up) at a random phase of the estral cycle (OPU1) and the in vitro production (PIV) of recovered oocytes embryos (OPU2) in different moments after the prostaglandin F2? (PGF2?) application. The females (n=23) after the OPU1 received progestogen implant and 48 to 60 h after the OPU, then it has began the SOV, with FSH 180 mg / cows in 8 doses, for 4 days. In 6th and 7th applications of FSH, there were administered 500 μg of PGF2? being the implants withdrawn in the 7th dose. After 12 h of the SOV, it was applied 25mg of LH to realize AI (artificial insemination) with fixed time. In the day of the embryos recovery 6 treatments were tested: T (0-144) (n=4), T (48-120) (n=5), T (48-96) (n=4), T (72-96) (n=3), T (96-72) (n=4
Pancolitis with Ischemic Injury as a Complication of Immunosuppressive Treatment in a Patient with Autoimmune Hepatitis: A Case Report
A. Dalbeni,E. Capoferro,L. Bernardoni,P. Capelli,A. Caliò,A. Gabbrielli,F. Capra
Case Reports in Gastrointestinal Medicine , 2012, DOI: 10.1155/2012/698404
Abstract: Ischemic colitis is a serious drug-induced adverse event. There are only few cases of immunosuppression-associated ischemic colitis described in the literature, but none with a pancolitis-like manifestation. We report the case of a 72-year-old female patient who developed a pancolitis with ischemic injury on immunosuppressive treatment with steroids and azathioprine for autoimmune hepatitis. The patient presented with massive rectal bleeding. Colonoscopy confirmed the diagnosis of pancolitis. The results of histological examination indicated drug-induced ischemic colitis involving the entire colon. This is the first case of ischemic pancolitis mimicking an inflammatory bowel disease (IBD) in a patient with immunosuppressive therapy. 1. Background Ischemic colitis is a serious drug-induced adverse event. However, the exclusion of other causes of ischemic colitis, such as hypotension, vascular surgery, and hypercoagulopathy, is crucial before attributing ischemic colitis to drugs [1]. Ischemic colitis is a disease caused by ischemia of the intestinal vessels, which occurs in patients older than 50 years of age and with many vascular comorbidities. It presents with sudden onset of abdominal pain (80% cases), diarrhoea, and hematochezia, but also abdominal distension, leukocytosis, shock, and sepsis. Drugs can cause ischemic colitis by producing vasoconstriction (cocaine, dopamine), decreasing splanchnic flow via systemic hypotension (diuretics, Ace inhibitors), vasculitis (gold compounds), or promotion of thrombosis from hormonal effects (estrogen) [1]. Diagnosis is confirmed by colonoscopy, and the major findings are mucosal bleeding, edema, and longitudinal ulcers [2]. The thickening of the bowel wall detected by ultrasonography and computed tomography are useful as another supportive tests in the diagnosis of ischemic colitis. We describe a case of an elderly woman who developed ischemic colitis during immunosuppressive therapy with steroids and azathioprine. There are only few cases of immunosuppression-associated ischemic colitis described in the literature, but none with a pancolitis-like manifestation. 2. Case Report A 72-year-old woman with a recent diagnosis of type 1 autoimmune hepatitis was admitted to our hospital for a three-day history of lower abdominal pain associated with rectal bleeding. In December 2011, the patient was admitted for the first time to our unit with marked fatigue and blood results suggestive of acute hepatitis (ALT = 1152?IU/L, AST 755?IU/L, total bilirubin 2.95?mg/dL, and directed bilirubin 2.13?mg/dL). Viral markers
Querying Incomplete Data over Extended ER Schemata
Andrea Cali,Davide Martinenghi
Computer Science , 2010,
Abstract: Since Chen's Entity-Relationship (ER) model, conceptual modeling has been playing a fundamental role in relational data design. In this paper we consider an extended ER (EER) model enriched with cardinality constraints, disjointness assertions, and is-a relations among both entities and relationships. In this setting, we consider the case of incomplete data, which is likely to occur, for instance, when data from different sources are integrated. In such a context, we address the problem of providing correct answers to conjunctive queries by reasoning on the schema. Based on previous results about decidability of the problem, we provide a query answering algorithm that performs rewriting of the initial query into a recursive Datalog query encoding the information about the schema. We finally show extensions to more general settings. This paper will appear in the special issue of Theory and Practice of Logic Programming (TPLP) titled Logic Programming in Databases: From Datalog to Semantic-Web Rules.
Adenovirus type 5 E1A-induced apoptosis in COX-2-overexpressing breast cancer cells
Takeshi Sugimoto, Chandra Bartholomeusz, Ana M Tari, Naoto T Ueno
Breast Cancer Research , 2007, DOI: 10.1186/bcr1739
Abstract: We first established the cytotoxicity of celecoxib in two COX-2-overexpressing E1A-transfected breast cancer cell lines (MDA-MB-231 and MDA-MB-435) and in two low-COX-2-expressing E1A-transfected cell lines (MCF-7 (breast cancer) and SKOV3.ip1 (ovarian cancer)). We next tested whether higher sensitivity to celecoxib among these cell lines resulted from increased apoptosis by flow cytometry and western blotting. We further investigated whether suppression of Bcl-2 by celecoxib was involved in the apoptosis resulting from celecoxib treatment, and we explored whether the celecoxib-induced apoptosis in these cells depends on a COX-2 downstream pathway.The two COX-2-overexpressing cell lines MDA-MB-231-E1A and MDA-MB-435-E1A were more sensitive to celecoxib than the corresponding control cells, but the two low-COX-2-expressing cell lines MCF-7-E1A and SKOV3.ip1-E1A were no more sensitive than control cells to celecoxib. Therefore, we used the MDA-MB-231-E1A and MDA-MB-435-E1A cells for all further experiments. In both cell lines, sub-G1 fraction was increased, or cleavage of PARP and caspase-9 were increased after 5 days of exposure to 40 μM celecoxib. However, Bcl-2 was suppressed only in the MDA-MB-435-E1A cells and not in the MDA-MB-231-E1A cells. Restoring Bcl-2 expression in the MDA-MB-435-E1A stable transfectants did not affect their sensitivity to celecoxib. However, adding prostaglandin E2 (PGE2) or PGF2α blunted the sensitivity to celecoxib of both E1A stable transfectants.We speculate that one mechanism by which celecoxib enhances E1A-induced apoptosis in cells that express high levels of COX-2 is through blocking PGE2 or PGF2α.The adenovirus type 5 gene E1A is being developed as a therapeutic agent for breast, head and neck, and ovarian cancer [1-3]. The tumor-suppressive effect of E1A results from its induction of apoptosis, its inhibition of invasion and metastasis, and its suppression of proliferation [4]. Although the mechanism by which E1A induces apoptos
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