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INTOXICACION POR HERBICIDA Y EL USO DE LA TIAMINA. UN ESTUDIO EXPERIMENTAL
Pérez-Pérez Elizabeth,Calderón de Cabrera Lourdes,Rodríguez-Malaver Antonio,Dmitrieva Natalia
Salud, Arte y Cuidado , 2012,
Abstract: Pesticide poisoning, accidental or intentional self-poisoning is a signi cant problem in many parts of the developing world. Paraquat is a compound that has been widely used as a non-selective contact herbicide since 1962. Ingestion of paraquat is a signi cant method ofself-poisoning in parts of Asia, Paci c islands, and Caribbean. Ingestion of large amounts is considered to be uniformly fatal, resulting in death from multi-organ; however, in smaller quantities, paraquat is speci cally taken up into and accumulates in the lung, and the redox cycling and free radical generation triggers a eutrophil-mediated in ammatory response in the lungs which initiates an irreversible brotic process that kills the majority of patientswithin several weeks. In this work, was studied the ability of thiamine to protect against Paraquat (PQ)-induced mortality and oxidative damage in rat liver. The medial lethal dose (LD50) for PQ was 32 mg/kg of body weight within 48 h. When thiamine (100 mg/kg) wasadministrated to PQ-treated rats, mortality was not observed. However, thiamine at 200 mg/kg did not modify mortality. For the oxidative stress study, the liver was obtained 24 h after Q-treatment and thiobarbituric acid reactive ubstances (TBARS) were measured.PQ induced a signi cant increase in TBARS levels and thiamine prevented this increase
Determinación de los efectos de la N-acetilcisteína y metionina en cerebelo de ratas intoxicadas con plomo Determination of the N-acetylcysteine and methionine effectsin the cerebellum of rats intoxicated with lead.
Lourdes Calderón-Cabrera,María Gabriela Durán-Galetta,Ingo Garcia,Douglas Galetta
Investigación Clínica , 2008,
Abstract: Se realizó un ensayo terapéutico para determinar los efectos de la N-Acetilcisteína (NAC), Metionina (MET) y la combinación NAC + MET sobre los niveles sanguíneos de Plomo (Pb), los niveles de malondialdehido(MDA) y actividad de catalasas (CAT) en el cerebelo de ratas intoxicadas con 0,5 y 2 μg/g de acetato de Pb. Se sometieron a prueba 198 ratas Wistar macho con peso promedio de 240 g divididas en cinco grupos. En el Grupo 1 Control, se determinaron niveles basales, el Grupo 2 corresponde a las ratas intoxicadas, los grupos restantes una vez intoxicados recibieron tratamiento de la forma siguiente Grupo 3 NAC, Grupo 4 MET, Grupo 5 NAC + MET. Los resultados mostraron que la NAC disminuye los niveles de plomo en sangre en un 35% y 38% con dosis de intoxicación de 0,5 μg/g y 2 μg/g de acetato de Pb respectivamente. Esta disminución no fue estadísticamente significativa; sin embargo, hubo una disminución del MDA en cerebelo en 56% con la dosis de 0, 5μg/g de Pb y de 75% con la dosis de 2μg/g. La CAT en cerebelo aumentó su actividad en 62% y 71% con las dosis de Pb estudiadas, siendo esta diferencia estadísticamente significativa (p < 0,0001) en relación al grupo intoxicado. La MET tuvo un efecto similar a la NAC aunque fue menor, no obstante cuando se combinan la NAC + MET mostraron un efecto quelante significativo observándose 45% y 51% de disminución de los niveles de Pb con las dosis de intoxicación administradas (p < 0,001) así como disminución del MDA y aumento de la actividad de CAT en el cerebelo de ratas expuestas al Pb. En esta investigación se puede concluir que la combinación de NAC + MET tiene efectos beneficiosos sobre los parámetros aquí estudiados en intoxicación aguda por Pb. A therapeutic essay was done to determine the effects of N-Acetylcysteine (NAC), Methionine (MET) and the NAC + MET combination on the lead (Pb) blood levels, the malondialdehide (MDA) and catalase activity (CAT) in cerebellum of rats treated with 0.5 and 2 μg/g of Pb acetate. One hundred ninety eight male Wistar rats with an average weight of 240 g were subjected to a test, divided into five groups. Group 1 was the control group where basal levels were determined; Group 2 was the treated group; the rest of the groups once treated received the following: Group 3 NAC, Group 4 MET, Group 5 NAC + MET. The results showed that NAC lowers blood lead levels by 35% and 38% with intoxication doses of 0.5 μg/g and 2 μg/g of Pb acetate respectively. This decrease was not statistically significant; however, there was a 56% decrease of MDA in the cerebellum with a dose of 0.5 μg/g
Determinación de los efectos de la N-acetilcisteína y metionina en cerebelo de ratas intoxicadas con plomo
Calderón-Cabrera,Lourdes; Durán-Galetta,María Gabriela; Garcia,Ingo; Galetta,Douglas; Lacruz,Luis; Naranjo,Raquel; Pérez,Beatriz; Ferreira,Elizabeth;
Investigación Clínica , 2008,
Abstract: a therapeutic essay was done to determine the effects of n-acetylcysteine (nac), methionine (met) and the nac + met combination on the lead (pb) blood levels, the malondialdehide (mda) and catalase activity (cat) in cerebellum of rats treated with 0.5 and 2 μg/g of pb acetate. one hundred ninety eight male wistar rats with an average weight of 240 g were subjected to a test, divided into five groups. group 1 was the control group where basal levels were determined; group 2 was the treated group; the rest of the groups once treated received the following: group 3 nac, group 4 met, group 5 nac + met. the results showed that nac lowers blood lead levels by 35% and 38% with intoxication doses of 0.5 μg/g and 2 μg/g of pb acetate respectively. this decrease was not statistically significant; however, there was a 56% decrease of mda in the cerebellum with a dose of 0.5 μg/g of pb and of 75% with 2 μg/g; cat activity increased in the cerebellum by 62% and 71% with the studied pb doses, making this a statistically significant difference (p < 0.0001) in relation to the intoxication group. met has a similar effect to nac, even though it was less strong; anyhow, when nac + met are combined a quelant effect is shown, with a statistically significant 45% and 51% reduction in the pb levels with the doses administered (p < 0.001); mda decreased and cat activity increased in the cerebellum. in this research we can conclude that nac+met when combined, have a beneficial effect on the studied parameters during acute pb treatment.
Eficacia del tratamiento homeopático en la estomatitis subprótesis
Nápoles González,Isidro de Jesús; Barciela Calderón,Julio; Cabrera Caballero,Nereyda; Puig Capote,Elizabeth;
Revista Archivo M??dico de Camag??ey , 2008,
Abstract: fundamento: la estomatitis subprotésica es una afección que produce cambios inflamatorios intrabucales, restringidos a la mucosa que cubre una prótesis dental. objetivo: determinar la eficacia de la homeopatía en el tratamiento de la estomatitis subprótesis. método: se realizó un ensayo clínico fase ii (exploración terapéutica), abierto en el policlínico ?ignacio agramonte? entre enero y octubre de 2007, en pacientes mayores de 20 a?os, de ambos sexos, portadores de estomatitis subprótesis. para la selección de estos pacientes se tuvieron en cuenta los criterios de diagnóstico, inclusión y exclusión. la muestra para el estudio quedó constituida por 35 pacientes que cumplieron con los criterios descritos anteriormente. resultados: esta afección prevaleció en el grupo de edades de más de 60 a?os con 13 pacientes, de los cuales 10 pertenecieron al sexo femenino (28,57%), y el masculino en el grupo de 50 a 59 a?os con seis enfermos (17,14 %). al relacionar el tiempo de curación y el grado de la lesión se encontró que dentro de los primeros 14 días de tratamiento la mayoría de los pacientes se curaron. el 100% de los pacientes del grado i se curó y los del grado ii lo lograron en el 95,83%. de forma general el 97,13 % de los pacientes eliminó la estomatitis subprótesis. conclusiones: prevaleció el sexo femenino, el grupo de edades más afectado fue el de más de 60 a?os. se comprobó que la homeopatía es eficaz en el tratamiento de la estomatitis subprótesis.
Impacto del libre flujo de capitales en la intermediación bancaria en el Perú: 1988-1997 Impacto del libre flujo de capitales en la intermediación bancaria en el Perú: 1988-1997
Lourdes Coll Calderón
Revista Economía , 1998,
Abstract: The inflow of capitals into Latin America during the 1990s attracted by more favorable economic indicators, such as a growing product and inflation under control, has allowed for the expansion in the volume of funds handled by the banking system, risking a deterioration of the quality of bank assets. This article examines the measures taken to control this problem in Peru, as well as in other countries in the region, in order to compare their results. We also make a review of the new bank supervision norms, and an analysis of the risk that has not yet been covered with the application of the Basel norms. La afluencia de los capitales hacia América Latina en la década del noventa, atraídos por los indicadores más favorables de las variables fundamentales de crecimiento del producto y control de la inflación, ha permitido la expansión del volumen de fondos a ser intermediados, con lo cual se ha puesto en riesgo la calidad de los activos bancarios. El artículo examina las medidas que se han tomado para controlar el efecto de los flujos de capital en el crédito interno del Perú, y se contrasta estos resultados con los de otros países de la región; asimismo, se hace una revisión de las nuevas formas de supervisión implementadas a raíz del cambio de régimen. Se analiza también los riesgos que todavía no están cubiertos con la aplicación de las normas internacionales de Basilea.
Impacto de las políticas del FMI en la economía de los países miembros que adoptaron sus programas
Lourdes Coll Calderón
Revista Economía , 1985,
Abstract: El artículo no presenta resumen
Maize Prolamins Could Induce a Gluten-Like Cellular Immune Response in Some Celiac Disease Patients
Juan P. Ortiz-Sánchez,Francisco Cabrera-Chávez,Ana M. Calderón de la Barca
Nutrients , 2013, DOI: 10.3390/nu5104174
Abstract: Celiac disease (CD) is an autoimmune-mediated enteropathy triggered by dietary gluten in genetically prone individuals. The current treatment for CD is a strict lifelong gluten-free diet. However, in some CD patients following a strict gluten-free diet, the symptoms do not remit. These cases may be refractory CD or due to gluten contamination; however, the lack of response could be related to other dietary ingredients, such as maize, which is one of the most common alternatives to wheat used in the gluten-free diet. In some CD patients, as a rare event, peptides from maize prolamins could induce a celiac-like immune response by similar or alternative pathogenic mechanisms to those used by wheat gluten peptides. This is supported by several shared features between wheat and maize prolamins and by some experimental results. Given that gluten peptides induce an immune response of the intestinal mucosa both in vivo and in vitro, peptides from maize prolamins could also be tested to determine whether they also induce a cellular immune response. Hypothetically, maize prolamins could be harmful for a very limited subgroup of CD patients, especially those that are non-responsive, and if it is confirmed, they should follow, in addition to a gluten-free, a maize-free diet.
Comportamiento de la gingivitis ulceronecrotizante aguda: Departamento de estomatología de Conuco Viejo
Blanco Berta,Lourdes; Alfonso Calderón,Ernesto;
Revista M??dica Electr?3nica , 2010,
Abstract: we carried out a transversal prospective descriptive observational study with the objective of determining the behavior of acute ultranecrotizing gingivitis, in 37 15 to 50 years-old patients, who visited the stomatologic service of conuco viejo, municipality of garcía, in the period from january to december 2009. the studied patients were characterized according to sociodemographic variables and the present risk facts were identified, and also the level of knowledge on buccal dental health. a thorough clinic examination was made and the patients applied an inquiry of knowledge on buccal health. we found that 15-20 years-old adolescents and 21-25 years-old young adults were the most affected patients, with 32,44 % and 29,73 % respectively. the female genre, with 62,16 %, and the high school scholarship with 40,55 % showed the highest percentages. among the local risk facts, the highest percents corresponded to chronic gingivitis, with 75,67 %, while stress represented the highest percent among general risk facts, with 59,45 %. as the result of the enquiry, the knowledge of 54,05 % of the studied patients were evaluated as unsatisfactory.
La enfermedad de dengue en colaboradores cubanos en el estado de Nueva Esparta: A?o 2007
Alfonso Calderón,Ernesto; Blanco Berta,Lourdes;
Revista M??dica Electr?3nica , 2010,
Abstract: we carried out a retrospective observational descriptive study among cuban collaborators in nueva esparta state, bolivarian republic of venezuela, affected by dengue disease during the period from january to december 2007. we studied 38 collaborators fulfilling the inclusion and exclusion criteria, analyzing variables that allowed characterizing the cases according to age, genre, race, presentation form, mission to whom they pertained, clinical manifestation and risk facts. female sex with 57,68 % and 27-32 years-old age group with 23,68 % presented the highest percentages. white people and collaborators from the medical mission were the most affected, with 50 % and 78,95 % respectively. the most common clinical manifestations were fever, headache, myalgias and arthralgias. among the risk facts, the highest percents corresponded to the non usage of individual protection media, the presence of aedes aegypti mosquitoes, water storage, the existence of micro dumps, and also the detection of focuses in the houses of ill collaborators.
Comportamiento de la gingivitis ulceronecrotizante aguda: Departamento de estomatología de Conuco Viejo Behavior of acute ultranecrotizing gingivitis at the stomatologic: Department of Conuco Viejo
Lourdes Blanco Berta,Ernesto Alfonso Calderón
Revista M??dica Electr?3nica , 2010,
Abstract: Se realizó un estudio observacional descriptivo prospectivo de corte transversal, con el objetivo de determinar el comportamiento de la gingivitis ulceronecrotizante aguda, en 37 pacientes entre 15 y 50 a os de edad, quienes acudieron al servicio de estomatología de Conuco Viejo, municipio García, en el período comprendido de enero a diciembre de 2009. Se caracterizaron a los pacientes estudiados según variables sociodemográficas, y se identificó los factores de riesgo presentes, así como el nivel de conocimientos sobre salud bucodental. Se les realizó un examen clínico minucioso y se le aplicó una encuesta de conocimiento de salud bucal. Se encontró que los adolescentes de 15-20 a os y adultos jóvenes de 21-26 a os fueron los más afectados, con un 32,44 % y 29,73 %, respectivamente. El sexo femenino, con un 62,16 %, el nivel educacional secundaria básica con 40,55 % fueron los de mayor porcentaje. Dentro de lo factores de riesgo, los mayores por cientos correspondieron a la gingivitis crónica en los locales, con un 75,67 %, mientras que el estrés en los generales, con 59,45 %. Al aplicarse la encuesta de conocimientos un 54,05 % de los pacientes estudiados fue evaluado de mal. We carried out a transversal prospective descriptive observational study with the objective of determining the behavior of acute ultranecrotizing gingivitis, in 37 15 to 50 years-old patients, who visited the Stomatologic Service of Conuco Viejo, municipality of García, in the period from January to December 2009. The studied patients were characterized according to sociodemographic variables and the present risk facts were identified, and also the level of knowledge on buccal dental health. A thorough clinic examination was made and the patients applied an inquiry of knowledge on buccal health. We found that 15-20 years-old adolescents and 21-25 years-old young adults were the most affected patients, with 32,44 % and 29,73 % respectively. The female genre, with 62,16 %, and the high school scholarship with 40,55 % showed the highest percentages. Among the local risk facts, the highest percents corresponded to chronic gingivitis, with 75,67 %, while stress represented the highest percent among general risk facts, with 59,45 %. As the result of the enquiry, the knowledge of 54,05 % of the studied patients were evaluated as unsatisfactory.
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