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Search Results: 1 - 10 of 45230 matches for " Cai-Mei Zheng "
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Biomarkers in Acute Kidney Injury  [PDF]
Cai-Mei Zheng, Min-Tser Liao, Mei-Yu Lin, Lan Lo, Chia-Chao Wu, Yung-Ho Hsu, Yuh-Feng Lin, Kuo-Cheng Lu
Open Journal of Nephrology (OJNeph) , 2013, DOI: 10.4236/ojneph.2013.31009
Abstract: Acute kidney injury (AKI) is one of the popular topics of discussions due to increasing development of biomarkers recently. The disease progression and prognosis may be determined by these biomarkers detected in blood and urine specimens. Since acute kidney injury is associated with a broad spectrum of disease conditions, prevention and early detection of AKI becomes very important in those clinical settings. Early measurements of AKI biomarkers predict subsequent development of intrinsic AKI, dialysis requirement, duration of intensive care unit stay and finally affect mortality. We, here, discuss the acute kidney injury in different clinical situations and associated natures of biomarkers, which may help us guide to prevent and treat AKI more effectively.
Association of Serum Phosphate and Related Factors in ESRD-Related Vascular Calcification
Cai-Mei Zheng,Kuo-Cheng Lu,Chia-Chao Wu,Yung-Ho Hsu,Yuh-Feng Lin
International Journal of Nephrology , 2011, DOI: 10.4061/2011/939613
Abstract: Vascular calcification is common in ESRD patients and is important in increasing mortality from cardiovascular complications in these patients. Hyperphosphatemia related to chronic kidney disease is increasingly known as major stimulus for vascular calcification. Hyperphosphatemia and vascular calcification become popular discussion among nephrologist environment more than five decades, and many researches have been evolved. Risk factors for calcification are nowadays focused for the therapeutic prevention of vascular calcification with the hope of reducing cardiovascular complications. 1. Introduction Vascular calcification is a kind of extraosseous calcification and is associated with aging physiologically, and a number of disorders including ESRD, diabetes mellitus, and cardiovascular disease pathologically. Multifactorial processes contribute to VC in which derangements in calcium and phosphorus homeostasis plays an important role and becomes popular therapeutic target nowadays. In ESRD patients with vascular calcification, a mixture of intimal and medial calcification has been observed in the effected vessels with dominant medial involvement. The risk of CVD mortality in ESRD patients with vascular calcification is 20 to 30 times higher than that of the general population [1–5]. Although phosphate is important for diverse cellular and physiological functions, impaired renal function with resultant phosphate accumulation with consequent bone and mineral disorders and vascular calcification are major problems among nephrologists. The increased risk of CVD mortality by hyperphosphatemia was partially explained by the predisposition of this population to vascular calcification [6–8]. (Figure 1) Even in early stage CKD, serum phosphorus level disturbances are proved to promote vascular calcification, hypertension, myocardial hypertrophy, and heart failure [9–11]. Current understanding of relationship between phosphorus and those disorders becomes popular in medical field, with the hope of halting or retarding the vascular calcification from the very early status in those patients. Figure 1: Mechanisms of VSMC osteogenesis during vascular calcification in chronic kidney disease. VSMC upregulate expression of transcription factors Osf2/Cbfa1 which were enhanced by ROS, leptin, vitamin D, increased CaxP product, or high PO 4 (Pi) levels induced by Pit-1. VSMC activation occurs in part as a result of the phenotypic switch of VSMCs into osteoblast-like cells. VSMCs that have acquired an osteogenic phenotype express ALP and produce hydroxyapatite crystals.
Use of Sodium Butyrate as an Alternative to Dietary Fiber: Effects on the Embryonic Development and Anti-Oxidative Capacity of Rats
Yan Lin, Zheng-feng Fang, Lian-qiang Che, Sheng-yu Xu, De Wu, Cai-mei Wu, Xiu-qun Wu
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0097838
Abstract: In this study, we evaluated the effect of replacing dietary fiber with sodium butyrate on reproductive performance and antioxidant defense in a high fat diet during pregnancy by using a rat model. Eighty virgin female Sprague Dawley rats were fed one of four diets—(1) control diet (C group), (2) high fat + high fiber diet (HF group), (3) high-fat +5% sodium butyrate diet (SB group), and (4) HF diet + α-cyano-4-hydroxy cinnamic acid (CHC group)—intraperitoneally on days 8, 10, 12, 14, and 16 of gestation. SB and dietary fiber had similar effects on improving fetal number and reducing the abortion rate; however, the anti-oxidant capacity of maternal serum, placenta, and fetus was superior in the HF group than in the SB group. In comparison, CHC injection decreased reproductive performance and antioxidant defense. Both dietary fiber (DF) and SB supplementation had a major but different effect on the expression of anti-oxidant related genes and nutrient transporters genes. In summary, our data indicate that SB and DF showed similar effect on reproductive performance, but SB cannot completely replace the DF towards with respect to redox regulation in high-fat diet; and SB might influence offspring metabolism and health differently to DF.
Certain Inequalities of Multivalent Analytic Functions with Missing Coefficients
Yi-Ling Cang,Cai-Mei Yan
Journal of Complex Analysis , 2013, DOI: 10.1155/2013/512469
Abstract: The purpose of the present paper is to derive the radius of starlikeness for certain p-valent functions with missing coefficients. The results obtained here are sharp. 1. Introduction Let denote the class of functions of the form which are -valent analytic in the open unit disk . A function is said to be -valently starlike of order in if it satisfies For functions and analytic in , we say that is subordinate to in , and we write , if there exists an analytic function in such that Furthermore, if the function is univalent in , then A number of results for -valently starlike functions have been obtained by several authors (see, e.g., [1–7]). In this note, we shall derive the radius of starlikeness for certain -valent functions with missing coefficients. 2. Main Results Our main result is the following. Theorem 1. Let belong to the class and satisfy Then, where , and is the smallest root in of the equation The result is sharp. Proof. From (5), we can write that where is analytic and in . Differentiating both sides of (8) logarithmically, we arrive at Put and ?? . Then, (8) implies that With the help of the Carathéodory inequality: it follows from (10) that where , and From (10), we can see that Thus, we have from (10), (11), and (15) that Since is a even function of , from (13), (14), and (15), we see that Let us now calculate the minimum value of on the closed interval . Noting that (see [8]) and lower bound in (11), we deduce from (18) that where Also, . Suppose that . Then, Hence, by virtue of the mathematical induction, we have for all and . This implies that In view of (20) and (24), we see that when , then Further, it follows from (13), (18), and (25) that where and Note that and . If we let denote the smallest root in of the equation , then (26) yields the desired result (6). To see that the bound is the best possible one, we consider the function It is clear that for , which shows that the bound cannot be increased. Setting , Theorem 1 reduces to the following result which gives the radius of starlikeness for certain -valent analytic functions with missing coefficients. Corollary 2. Let satisfy the condition (5) and . Then, is starlike of order in The result is sharp. Acknowledgment The authors would like to express sincere thanks to the referees for careful reading and suggestions which helped them to improve the paper.
Effect of Calcium and Magnesium on the Photocatalytic Oxidation of Humic Acid in Water over TiO_2

FAN Cai-mei,SUN Yan-ping,

过程工程学报 , 2001,
Abstract: Photocatalytic oxidation of humic acid in water was studied in the presence of calcium and magnesium using TiO2 powder as photocatalyst. The adsorption of humic acid on the photocatalyst was also studied. A cylindrical borosilicon reactor was used as batch photoreactor and a 125 W UV lamp(Emax=365 nm) was used as central light source. The results showed that the photocatalysis is an effective method for removal of humic acid as trihalomethanes precursor in water. The photocatalytic removal rate of humic acid was enhanced in the presence of calcium and magnesium, this may be due to cationic ion bridging between humic acid molecules as well as between humic acid molecule and the surface of titanium dioxide particle, led to the increase of adsorption amount of humic acid on TiO2. The effects of cations concentration and TiO2 dosage on the photocatalytic process were also discussed. Based on the following experimental conditions: HA C0=20 mg/L, Ca2+]=80 mg/L, pH=7, TiO2]=1 mg/ml, 100% color, almost 100% HA concentration and >95% TOC were removed under irradiation 2.5 h.
Zhan-Xian Li,Cai-Mei Ren,Sen Yang,Guang-Jun Yao
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536808035885
Abstract: In the title compound, C13H9NO3, the dihedral angle between the benzene and maleimide rings is 64.1 (2)°. In the crystal structure, molecules interact via C—H...O interactions.
(E)-Methyl 2-chloro-4-dicyclohexylamino-4-oxobut-2-enoate
Cai-Mei Liu,Fu-Ling Xue,Jian-Hua Fu,Zhao-Yang Wang
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811027760
Abstract: In the title compound, C17H26ClNO3, both cyclohexyl rings have chair conformations. In the crystal, molecules are linked by weak intermolecular C—H...O hydrogen bonds.
Dynamic Secret Sharing Scheme Based on Polynomials over Elliptic Curve

YIN Xin-chun,WANG Cai-mei,WANG Yuan-yuan,

计算机应用研究 , 2007,
Abstract: Based on properties of polynomials over elliptic curve,this paper presented a dynamic secret sharing scheme based on polynomials,an improvement of scheme in reference 5] and reduced the communication between CA and participants.Furthermore,this scheme is able to check the validity of the sub-secret keys easily and then avoid cheat from either CA or participants efficiently.Both of their security are based on the intractability of elliptic curve discrete logarithm problem.
Improvement of the Thermostability of Penicillium expansum Lipase by Mutagenesis the Random Mutant Ep8 at K55R

CAI Shao-Li,LIN Jun-Han,WANG Cai-Mei,LIN Lin,

生物工程学报 , 2007,
Abstract: In order to improve the thermostability of the Penicillium expansum Lipase (PEL), the lipase encoding genes was mutated by site-directed mutagenesis. A recombinant vector pAO815-ep8-K55R which contain double mutant genes was constructed by overlap extension PCR using the cDNA of a random-mutant lipase ep8 (a single site mutant) as the template and two special primers were used to generate another mutation site K55R. The recombinant vector was transformed into Pichia pastoris GS115 by electroporation and the recombinant mutant GS-pAO815-ep8- K55R can secret double-mutant lipase PEL-ep8-K55R-GS into the medium when it was induced by Methanol. The yield of the double-mutant lipase is 508 u/mL, which is 81% that of the wild type lipase PEL-GS (627 u/mL) and 55% that of random-mutant PEL-ep8-GS (924 u/mL). The specific activity of double-mutant lipase is 2309.1 u/mg, which is similar to random-mutant lipase PEL-ep8-GS and the wild type lipase PEL-GS. The optimum temperature of the double-mutant lipase is same with the wild type lipase PEL-GS and random-mutant lipase PEL-ep8-GS. While the Tm of the double-mutant lipase is 41.0 degrees C, 2.3 degrees C higher than the wild type lipase PEL-GS and 0.8% higher than the random-mutant lipase PEL-ep8-GS, indicating that the double-mutant lipase PEL-ep8-K55R-GS has higher thermostability.
Improvement of the Thermostability of Penicillium expansum Lipase by Mutagenesis the Random Mutant Ep8 at K55R

CAI Shao-Li,LIN Jun-Han,WANG Cai-Mei,LIN Lin,

微生物学报 , 2007,
Abstract: 利用重叠延伸PCR对扩展青霉脂肪酶(PEL)基因进行体外定点突变,构建了K55R与随机突变体ep8叠加突变的重组质粒pAO815-ep8-K55R。将该质粒电转化引入毕赤酵母(Pichia pastoris)GS115,进行异源表达。实验结果表明:该叠加突变体在毕赤酵母中获得了活性表达,得到表达产物脂肪酶PEL-ep8-K55R-GS。其表达量为508u/mL,分别约为野生型脂肪酶PEL-GS(627u/mL)的81%,随机突变脂肪酶PEL-ep8-GS(924u/mL)的55%;其比活力为2309.1u/mg,与随机突变脂肪酶PEL-ep8-GS和野生型脂肪酶PEL-GS的相仿。叠加突变脂肪酶PEL-ep8-K55R-GS的最适作用温度为37℃,与野生型脂肪酶PEL-GS和随机突变脂肪酶PEL-ep8-GS一致;其Tm值为41.0℃,比野生型脂肪酶PEL-GS提高了2.3℃,比随机突变脂肪酶PEL-ep8-GS提高了0.8℃。表明叠加突变脂肪酶PEL-ep8-K55R-GS的热稳定性有了进一步的提高。
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