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Search Results: 1 - 10 of 104251 matches for " CQ Zhang "
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Childhood meat eating and inflammatory markers: The Guangzhou Biobank Cohort Study
CM Schooling, CQ Jiang, TH Lam, WS Zhang, KK Cheng, GM Leung
BMC Public Health , 2011, DOI: 10.1186/1471-2458-11-345
Abstract: We used multivariable linear regression in the Guangzhou Biobank Cohort Study phase 3 (2006-8) to examine the adjusted associations of recalled childhood meat eating, <1/week (n = 5,023), about once per week (n = 3,592) and almost daily (n = 1,252), with white blood cell count and its differentials among older (≥50 years) men (n = 2,498) and women (n = 7,369).Adjusted for age, childhood socio-economic position, education and smoking, childhood meat eating had sex-specific associations with white blood cell count and lymphocyte count, but not granulocyte count. Men with childhood meat eating almost daily compared to <1/week had higher white blood cell count (0.33 109/L, 95% confidence interval (CI) 0.10 to 0.56) and higher lymphocyte count (0.16 109/L, 95% CI 0.07 to 0.25). Adjustment for obesity slightly attenuated these associations.If confirmed, this hypothesis implies that economic development and the associated improvements in nutrition at puberty may be less beneficial among men than women; consistent with the widening sex differentials in life expectancy with economic development.In long term industrialized western populations poor childhood conditions are associated with cardiovascular disease [1], although the underlying biological pathway is unclear. Cardiovascular disease may have an inflammatory component [2,3]. Poor childhood conditions are also usually associated with a pro-inflammatory state [4-9]. It is increasingly clear that the social patterning of cardiovascular disease or its risk factors, both traditional and non-traditional, is not universal but epidemiologic stage specific [9-14]. There is often a more marked and longer lasting reversal of the usual social patterning among men than women [9-11] for reasons which have tended to be interpreted mainly in terms of contemporaneous risk factors that differ by sex [11].A factor that countered the generally protective effect of social advantage among men at the early stages of economic development wou
Reverse LISS plating for intertrochanteric Hip Fractures in elderly patients
CQ Zhang, Y Sun, DX Jin, C Yao, SB Chen, BF Zeng
BMC Musculoskeletal Disorders , 2010, DOI: 10.1186/1471-2474-11-166
Abstract: We treated 28 elderly patients with a mean age of 82.3 years. According to the Evens classification, there were 2 Type I fractures, 2 Type II fractures, 3 Type III fractures, 13 Type IV fractures, 6 Type V fractures and 2 Type R fractures. All fractures were treated using the reverse LISS. Radiographic and clinical evidence of functional outcome and complications were evaluated.Mean perioperative blood loss was 92.4 milliliters (range 35 to 245 milliliters), and the mean postoperative hospital stay was 8.7 days (range 3 to 14 days).Complications included one minor wound hematoma. Radiographically, no collapses, screw cutouts, or head penetrations were seen. All surviving patients (28 of 28; 100 percent) had uneventful fracture healing with union achieved by six months in all patients.Use of the Reverse LISS plating for intertrochanteric hip fractures resulted in event-free fracture healing.Hip fractures are a leading cause of death and disability among the elderly. Approximately 50% of hip fractures are intertrochanteric fractures, a large percentage of which are unstable [1,2]. Treatment goals for this patient population include early rehabilitation, restoration of the anatomic alignment of the proximal part of the femur, and maintenance of the fracture reduction [3]. Different approaches have been used to solve this problem, including trochanteric osteotomy techniques, cementing, and different types of fixation devices. Despite improved techniques and devices, failure of fixation is still a problem in unstable intertrochanteric fractures[4].In recent years, the minimally invasive surgical techniques have led to a widespread use of many new implants [5,6]it has been shown that they can reduce operative complications and postoperative morbidity. As such, the present study evaluates the treatment of intertrochanteric hip fractures with the reverse LISS plating system.The present study was reviewed and approved by our institutional review board, and informed consent w
Optimized antimicrobial and antiproliferative activities of titanate nanofibers containing silver
Su YH, Yin ZF, Xin HL, Zhang HQ, Sheng JY, Yang YL, Du J, Ling CQ
International Journal of Nanomedicine , 2011, DOI: http://dx.doi.org/10.2147/IJN.S18765
Abstract: imized antimicrobial and antiproliferative activities of titanate nanofibers containing silver Original Research (4054) Total Article Views Authors: Su YH, Yin ZF, Xin HL, Zhang HQ, Sheng JY, Yang YL, Du J, Ling CQ Published Date August 2011 Volume 2011:6 Pages 1579 - 1586 DOI: http://dx.doi.org/10.2147/IJN.S18765 Yong Hua Su*, Zi Fei Yin*, Hai Liang Xin, Hui Qing Zhang, Jia Yu Sheng, Yan Long Yang, Juan Du, Chang Quan Ling Department of Traditional Chinese Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, People’s Republic of China *These authors contributed equally Abstract: Titanate nanofibers containing silver have been demonstrated through the experiments reported herein to have effective antifungal and antiproliferative activities in the presence of UV light. The titanate nanofibers containing silver can be fabricated by means of ion exchange followed by a topochemical process in an environment suitable for reductive reactions. Excellent antibacterial, antifungal, and antiproliferative activities could be demonstrated by both Ag2Ti5O11 · xH2O and Ag/titanate (UV light irradiation) due to their unique structures and compositions, which have photocatalytic activities to generate reactive oxygen species and capabilities to continuously release the silver ions. Therefore these materials have the potential to produce a membrane for the treatment of superficial malignant tumor, esophageal cancer, or cervical carcinoma. They may also hold utility if incorporated into a coating on stents in moderate and advanced stage esophageal carcinoma or for endoscopic retrograde biliary drainage. These approaches may significantly reduce infections, inhibit tumor growth, and importantly, improve quality of life and prolong survival time for patients with tumors.
Preparation and biodistribution of 188Re-labeled folate conjugated human serum albumin magnetic cisplatin nanoparticles (188Re-folate-CDDP/HSA MNPs) in vivo
Tang QS, Chen DZ, Xue WQ, Xiang JY, Gong YC, Zhang L, Guo CQ
International Journal of Nanomedicine , 2011, DOI: http://dx.doi.org/10.2147/IJN.S24322
Abstract: eparation and biodistribution of 188Re-labeled folate conjugated human serum albumin magnetic cisplatin nanoparticles (188Re-folate-CDDP/HSA MNPs) in vivo Original Research (3306) Total Article Views Authors: Tang QS, Chen DZ, Xue WQ, Xiang JY, Gong YC, Zhang L, Guo CQ Published Date November 2011 Volume 2011:6 Pages 3077 - 3085 DOI: http://dx.doi.org/10.2147/IJN.S24322 Qiu-Sha Tang1,*, Dao-Zhen Chen2,*, Wen-Qun Xue2, Jing-Ying Xiang2, Yong-Chi Gong1, Li Zhang2, Cai-Qin Guo2 1Department of Pathology and Pathophysiology, Medical College, Southeast University, Nanjing, Jiangsu; 2Central Laboratory, Wuxi Hospital for Maternal and Child Health Care, Affiliated Medical School of Nanjin, Wuxi, Jiangsu, China *Authors contributed equally to this work Background: The purpose of this study was to develop intraperitoneal hyperthermic therapy based on magnetic fluid hyperthermia, nanoparticle-wrapped cisplatin chemotherapy, and magnetic particles of albumin. In addition, to combine the multiple-killing effects of hyperthermal targeting therapy, chemotherapy, and radiotherapy, the albumin-nanoparticle surfaces were linked with radionuclide 188Re-labeled folic acid ligand (188Re-folate-CDDP/HSA). Methods: Human serum albumin was labeled with 188Re using the pre-tin method. Reaction time and optimal conditions of labeling were investigated. The particles were intravenously injected into mice, which were sacrificed at different time points. Radioactivity per gram of tissue of percent injected dose (% ID/g) was measured in vital organs. The biodistribution of 188Re-folate-CDDP/HAS magnetic nanoparticles was assessed. Results: Optimal conditions for 188Re-labeled folate-conjugated albumin combined with cisplatin magnetic nanoparticles were: 0.1 mL of sodium gluconate solution (0.3 mol/L), 0.1 mL of concentrated hydrochloric acid with dissolved stannous chloride (10 mg/mL), 0.04 mL of acetic acid buffer solution (pH 5, 0.2 mol/L), 30 mg of folate-conjugated albumin combined with cisplatin magnetic nanoparticles, and 188ReO4 eluent (0.1 mL). The rate of 188Re-folate-CDDP-HSA magnetic nanoparticle formation exceeded 90%, and radiochemical purity exceeded 95%. The overall labeling rate was 83% in calf serum at 37°C. The major uptake tissues were the liver, kidney, intestine, and tumor after the 188Re-folate-CDDP/HSA magnetic nanoparticles were injected into nude mice. Uptake of 188Re-folate-CDDP/HSA magnetic nanoparticles increased gradually after injection, peaked at 8 hours with a value of 8.83 ± 1.71, and slowly decreased over 24 hours in vivo. Conclusion: These results indicate that 188Re-folate-CDDP/HSA magnetic nanoparticles can be used in radionuclide-targeted cancer therapy. Surface-modified albumin nanoparticles with folic acid ligand-labeled radionuclide (188Re) were successfully prepared, laying the foundation for a triple-killing effect of thermotherapy, chemotherapy, and radiation therapy.
Estimated birth weight and adult cardiovascular risk factors in a developing southern Chinese population: a cross sectional study
CM Schooling, CQ Jiang, TH Lam, BJ Cowling, SL Au Yeung, WS Zhang, KK Cheng, GM Leung
BMC Public Health , 2010, DOI: 10.1186/1471-2458-10-270
Abstract: We used published data on birth weight by birth rank from an appropriate population and baseline data from the Guangzhou Biobank Cohort Study phases 2 & 3 (2005-8) to examine the adjusted associations, using instrumental variable analysis, of birth weight with clinically measured cardiovascular risk factors and the metabolic syndrome in older (≥ 50 years) men (n = 5,051) and women (n = 13,907).Estimated birth weight was associated with lower blood pressure (systolic -0.25 mm Hg 95% confidence interval (CI), -0.53 to 0.03 and diastolic -0.33 mm Hg 95% CI -0.48 to -0.18 per standard deviation higher birth weight), but had little association with glucose, lipids, waist-hip ratio, body mass index or the metabolic syndrome, adjusted for age, sex, early environment and number of offspring.Birth weight may impact blood pressure; however associations of birth weight with other cardiovascular risk factors may not be related to foetal exposures, but speculatively could be an historical co-incidence, with corresponding implications for prevention.Lower birth weight is associated with higher risk of cardiovascular diseases (CVD) [1,2], hypertension [3], diabetes [4,5], and perhaps poor lipids in adulthood [6,7], although maternal diabetes in pregnancy and fetal over growth may also be implicated in diabetes [8]. Moreover some of the effects are fairly small, and the underlying causative exposure(s) and mechanism(s) driving the association between lower birth weight and adult cardiovascular diseases are not, as yet, fully understood, possibly because other aspects of fetal development, such as body composition at birth [9], are more important. Maternal adiposity may contribute to higher birth weight [10]. Perhaps because of the difficulty of manipulating birth weight [11], as well as potential ethical problems, almost all the evidence concerning humans comes from observational studies, which may be inherently open to uncontrollable biases. There are many experimental animal stud
In Situ Observation of Growth Behavior and Morphology of Delta-Ferrite as Function of Solidification rate in an AISI304 Stainless Steel

GF Liang,CQ Wan,JC Wu,

金属学报(英文版) , 2006,
New insights about host response to smallpox using microarray data
Gustavo H Esteves, Ana CQ Simoes, Estevao Souza, Rodrigo A Dias, Raydonal Ospina, Thiago M Venancio
BMC Systems Biology , 2007, DOI: 10.1186/1752-0509-1-38
Abstract: We used KEGG pathways annotations to define groups of genes (or modules), and subsequently compared them to macaque survival times. This technique provided additional insights about the host response to this disease, such as increased expression of the cytokines and ECM receptors in the individuals with higher survival times. These results could indicate that these gene groups could influence an effective response from the host to smallpox.Macaques with higher survival times clearly express some specific pathways previously unidentified using regular gene-by-gene approaches. Our work also shows how third party analysis of public datasets can be important to support new hypotheses to relevant biological problems.Large scale gene expression analysis with microarray technology is expanding and generating a large amount of high quality, publicly available data. In the present work we analyzed a dataset derived from monkeys infected by smallpox, published by Rubins et al [1]. Smallpox is a lethal disease that was endemic in many parts of the world until eradicated by a massive immunization program developed by the World Health Organization. Its fatality rate was estimated to be 30%, and the survivors often had disfiguring scars [2].There are serious concerns about the use of smallpox as a bioweapon [3,4]. Recently, some health care workers were vaccinated by the UK government for the analysis of antibody responses [5]. Pox viruses display unique abilities to interfere with the host immune system, producing immune modulators [6] and there are at least 16 viral genes involved in combating the host immune response [7]. The original study's goal was to analyze the evolution of the gene expression of the peripheral blood cells of variola-infected monkeys, so as to clarify the biological processes associated with host-pathogen interactions [1].Among the important results was the absence of a TNF-α/NF-κB-activated transcriptional mechanism during systemic infection, which could
Measuring outcomes in allergic rhinitis: psychometric characteristics of a Spanish version of the congestion quantifier seven-item test (CQ7)
Antonio Valero, Joaquim Mullol, Michael Herdman, Maria-José Rosales, Spanish CQ7 Study Group
Health and Quality of Life Outcomes , 2011, DOI: 10.1186/1477-7525-9-14
Abstract: CQ7 was adapted from English following international guidelines. The instrument was validated in an observational, prospective study in allergic rhinitis patients with NC (N = 166) and a control group without NC (N = 35). Participants completed the CQ7, MOS sleep questionnaire, and a measure of psychological well-being (PGWBI). Clinical data included NC severity rating, acoustic rhinometry, and total symptom score (TSS). Internal consistency was assessed using Cronbach's alpha and test-retest reliability using the intraclass correlation coefficient (ICC). Construct validity was tested by examining correlations with other outcome measures and ability to discriminate between groups classified by NC severity. Sensitivity and specificity were assessed using Area under the Receiver Operating Curve (AUC) and responsiveness over time using effect sizes (ES).Cronbach's alpha for the CQ7 was 0.92, and the ICC was 0.81, indicating good reliability. CQ7 correlated most strongly with the TSS (r = 0.60, p < 0.01), the PGWBI general health dimension (r = 0.56, p < 0.01), and the MOS Sleep scale 'sleep short of breath' dimension (r = 0.49, p < 0.01). Correlations with acoustic rhinometry were generally low. The instrument discriminated well between NC severity groups (ES 0.33-2.07) and AUC was 0.93, indicating excellent sensitivity and specificity. The measure was responsive to change (ES = 1.1) in patients reporting improvement in NC.The Spanish version of the CQ7 is appropriate for detecting, measuring, and monitoring NC in allergic rhinitis patients.Nasal congestion (NC) has been described as one of the most troublesome symptoms for patients with allergic rhinitis (AR) and is associated with poorer sleep, mood, and productivity [1,2]. A new tool to measure patient experience of NC is the Congestion Quantifier Seven-Item test (CQ7) which was developed recently in the United States [3]. The CQ7 was originally developed as a screening tool to identify patients with NC potentially
Gluteus maximus and semitendinosus activation during active prone hip extension exercises
Sakamoto, ACL;Teixeira-Salmela, LF;Rodrigues, de Paula F;Guimar?es, CQ;Faria, CDCM;
Brazilian Journal of Physical Therapy , 2009, DOI: 10.1590/S1413-35552009005000045
Abstract: background: gluteus maximus strengthening exercises are employed in clinical practice as options for the treatment of low back and sacroiliac disorders. however, no studies were found that investigated which were the best exercises to activate this muscle and justify its employment in physical therapy practice. objective: to quantify the electromyographic (emg) activity of the gluteus maximus and semitendinosus muscles during four modalities of therapeutic exercises. methods: thirty-one participants (16 men, 15 women) were selected. the emg activities of the gluteus maximus and semitendinosus was recorded and quantified while the participants performed four modalities of therapeutic exercises, involving active prone hip extension in four positions: knee extension (ke), knee flexion (kf), lateral hip rotation and knee extension (lhrke), and lateral hip rotation and knee flexion (lhr-kf). results: repeated-measures anovas showed that the addition of kf or lhr increased gluteus maximus activity, whereas, ke decreased the activation of this muscle. in contrast, the exercises performed with ke increased semitendinosus activity. conclusions: exercises performed with kf or lhr, or a combination of the two, may be effective choices for gluteus maximus strengthening, however both kf and lhr decreased semitendinosus activity. the exercises performed with ke appeared to be an acceptable choice for semitendinosus activation.
Fatores associados à ades?o ao uso de palmilhas biomecanicas
Guimar?es, CQ;Teixeira-Salmela, LF;Rocha, IC;Bicalho, LI;Sabino, GS;
Brazilian Journal of Physical Therapy , 2006, DOI: 10.1590/S1413-35552006000300004
Abstract: background: the benefits of biomechanical insoles for treating lower limb impairment have been reported. however, in clinical practice, low compliance with the use of such orthoses has been observed, which detracts from the possible benefits. objective: to investigate the factors related to compliance with biomechanical insole use. method: thirty-three subjects (aged 44 ± 14.7 years) for whom biomechanical insoles had been molded took part in this study. a questionnaire asking about the insoles and their use was applied through interviews. the study variables were established from these questions. based on the results obtained, the participants were divided into four groups according to their compliance level: full compliance, partial compliance, irregular compliance and non-compliance. the kruskal-wallis test was utilized to assess differences between these groups regarding the variables investigated. spearman correlation coefficients were utilized to investigate possible relationships between these variables and the compliance. results: among the 33 participants, 15.2% were fully compliant, while 42.4% abandoned the insoles. comparing the four compliance groups in relation to the variables investigated, significant differences were observed regarding insole comfort (p=0.003), improvement attributed to the insoles (p=0.006), and degree of knowledge of the problem (p<0.002). significant correlations (rs=0.58; p<0.001; and rs=0.50; p<0.01) were observed between compliance and the comfort and improvement attributed to the insoles, respectively. conclusion: the findings from this study revealed that the comfort and degree of improvement attributed to the insoles may influence the compliance with the use of these orthoses. these factors are important for the success of the treatment.
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