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Search Results: 1 - 10 of 10862 matches for " CLAUDIA; MODAK "
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ANTIOXIDANT PROPERTIES OF LIGNANS AND FERULIC ACID FROM THE RESINOUS EXUDATE OF LARREA NITIDA
RENé TORRES,FRANCISCO URBINA,CLAUDIA MORALES,BRENDA MODAK
Journal of the Chilean Chemical Society , 2003,
Abstract: From the resinous exudate of twigs end leaves of Larrea nitida, two lignans nor isoguaiacine 1 and meso-nor-dihydroguaiaretic acid 2 and ferulic acid 3 were isolated. The antioxidant activities of resin and pure compounds were assesed by bleaching of the ABTS derived radical-cation
ANTIOXIDANT PROPERTIES OF LIGNANS AND FERULIC ACID FROM THE RESINOUS EXUDATE OF LARREA NITIDA
TORRES,RENé; URBINA,FRANCISCO; MORALES,CLAUDIA; MODAK,BRENDA; MONACHE,FRANCO DELLE;
Journal of the Chilean Chemical Society , 2003, DOI: 10.4067/S0717-97072003000300012
Abstract: from the resinous exudate of twigs end leaves of larrea nitida, two lignans nor isoguaiacine 1 and meso-nor-dihydroguaiaretic acid 2 and ferulic acid 3 were isolated. the antioxidant activities of resin and pure compounds were assesed by bleaching of the abts derived radical-cation
Emerging treatment options for the treatment of neuroblastoma: potential role of perifosine
Sun W, Modak S
OncoTargets and Therapy , 2012, DOI: http://dx.doi.org/10.2147/OTT.S14578
Abstract: ging treatment options for the treatment of neuroblastoma: potential role of perifosine Review (3437) Total Article Views Authors: Sun W, Modak S Published Date March 2012 Volume 2012:5 Pages 21 - 29 DOI: http://dx.doi.org/10.2147/OTT.S14578 Received: 12 December 2011 Accepted: 29 December 2011 Published: 02 March 2012 Weili Sun1, Shakeel Modak2 1Department of Pediatrics, Keck School of Medicine, University of Southern California, Children's Hospital of Los Angeles, Los Angeles, CA, USA; 2Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA Abstract: Achieving a cure for high-risk neuroblastoma, the most common extracranial solid tumor in children, remains a formidable task despite the recent addition of antibody-mediated anti-GD2 immunotherapy to established multimodality therapy. The PI3K/Akt pathway is a pivotal signaling pathway utilized by a plethora of receptor tyrosine kinases that contribute to the aggressive phenotype of high-risk neuroblastoma. Akt is aberrantly activated in high-risk neuroblastoma and is therefore an attractive therapeutic target. Perifosine is the best-characterized Akt inhibitor in preclinical studies and in clinical trials in adults, although safety in children is not yet confirmed. It is a synthetic third-generation alkylphospholipid with good oral bioavailability and modest side effects. Perifosine targets the lipid-binding PH domain of Akt and inhibits the translocation of Akt to the cell membrane, an essential step for Akt activation. It decreases Akt phosphorylation and increases caspase-dependent apoptosis in neuroblastoma cell lines, inhibits growth of neuroblastoma xenografts, and overcomes RTK/ligand-mediated chemoresistance. It is currently being studied in two Phase I clinical trials in children with recurrent or refractory solid tumors including neuroblastoma. In the single agent trial (ClinicalTrials.gov identifier NCT00776867), maximum tolerated dose has not yet been reached and pharmacokinetic data has been accrued. In the second study (ClinicalTrials.gov identifier NCT01049841), patients are treated with a combination of perifosine and the mTOR-inhibitor temsirolimus based on preclinical data showing synergy of the two agents, and the premise that direct Akt inhibition may overcome Akt activation secondary to mTOR inhibition. Based on results from adult trials, it is unlikely that perifosine alone will produce dramatic therapeutic effects against high-risk neuroblastoma. However, given the recent encouraging early-phase combination therapy results in adults with multiple myeloma and colorectal carcinoma, rational perifosine-containing combination regimens hold promise for neuroblastoma therapy. These will be explored after safety in children is established in Phase I studies.
Ideal on supra topological space
S. Modak,S. Mistry
International Journal of Mathematical Analysis , 2012,
Abstract:
Potential of casein kinase I in digestive cancer screening
Cristina Modak,Jianyuan Chai
World Journal of Gastrointestinal Oncology , 2009,
Abstract: Casein kinase I is a group of ubiquitous Serine/Threonine kinases that have been implicated in both normal cellular functions and several pathological conditions including Alzheimer’ s disease and cancer. Recent findings in colon and pancreatic cancer have brought tremendous attention to these molecules as potential therapeutic targets in treatment of digestive cancers. In this review, we summarize up to date what is known about this family of kinases and their involvement in carcinogenesis and other pathological conditions. Our emphasis is on their implications in digestive cancers and their potential for cancer screening and therapy.
Serum response factor: Look into the gut
Cristina Modak, Jianyuan Chai
World Journal of Gastroenterology , 2010,
Abstract: Serum response factor (SRF) is a transcription factor that regulates many genes involved in cellular activities such as proliferation, migration, differentiation, angiogenesis, and apoptosis. Although it has only been known for about two decades, SRF has been studied extensively. To date, over a thousand SRF studies have been published, but it still remains a hot topic. Due to its critical role in mesoderm-derived tissues, most of the SRF studies focused on muscle structure/function, cardiovascular development/maintenance, and smooth muscle generation/repair. Recently, SRF has received more attention in the digestive field and several important discoveries have been made. This review will summarize what we have learned about SRF in the gastrointestinal tract and provide insights into possible future directions in this area.
( )^{*s} and psi_s operator
S. Modak,S. Mistry
International Journal of Contemporary Mathematical Sciences , 2012,
Abstract:
Emerging treatment options for the treatment of neuroblastoma: potential role of perifosine
Sun W,Modak S
OncoTargets and Therapy , 2012,
Abstract: Weili Sun1, Shakeel Modak21Department of Pediatrics, Keck School of Medicine, University of Southern California, Children's Hospital of Los Angeles, Los Angeles, CA, USA; 2Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, USAAbstract: Achieving a cure for high-risk neuroblastoma, the most common extracranial solid tumor in children, remains a formidable task despite the recent addition of antibody-mediated anti-GD2 immunotherapy to established multimodality therapy. The PI3K/Akt pathway is a pivotal signaling pathway utilized by a plethora of receptor tyrosine kinases that contribute to the aggressive phenotype of high-risk neuroblastoma. Akt is aberrantly activated in high-risk neuroblastoma and is therefore an attractive therapeutic target. Perifosine is the best-characterized Akt inhibitor in preclinical studies and in clinical trials in adults, although safety in children is not yet confirmed. It is a synthetic third-generation alkylphospholipid with good oral bioavailability and modest side effects. Perifosine targets the lipid-binding PH domain of Akt and inhibits the translocation of Akt to the cell membrane, an essential step for Akt activation. It decreases Akt phosphorylation and increases caspase-dependent apoptosis in neuroblastoma cell lines, inhibits growth of neuroblastoma xenografts, and overcomes RTK/ligand-mediated chemoresistance. It is currently being studied in two Phase I clinical trials in children with recurrent or refractory solid tumors including neuroblastoma. In the single agent trial (ClinicalTrials.gov identifier NCT00776867), maximum tolerated dose has not yet been reached and pharmacokinetic data has been accrued. In the second study (ClinicalTrials.gov identifier NCT01049841), patients are treated with a combination of perifosine and the mTOR-inhibitor temsirolimus based on preclinical data showing synergy of the two agents, and the premise that direct Akt inhibition may overcome Akt activation secondary to mTOR inhibition. Based on results from adult trials, it is unlikely that perifosine alone will produce dramatic therapeutic effects against high-risk neuroblastoma. However, given the recent encouraging early-phase combination therapy results in adults with multiple myeloma and colorectal carcinoma, rational perifosine-containing combination regimens hold promise for neuroblastoma therapy. These will be explored after safety in children is established in Phase I studies.Keywords: neuroblastoma, Akt pathway, perifosine
( )^{*p} and psi_p operator
S. Mistry,S. Modak
International Mathematical Forum , 2012,
Abstract:
Prevalence of Violence against Children in Families in Tripura and Its Relationship with Socio-economic Factors
Sibnath Deb,Subhasis Modak
Journal of Injury and Violence Research , 2010,
Abstract: Background: Violence against children is a deep-rooted social problem in India. The problem is also related to economic as well as cultural beliefs and practices. The objective of this study was to ascertain the prevalence and nature of violence experienced by the children in families in Tripura, India and its relationship with socio-economic factors. Methods: A group of 320 children (160 males and 160 females) studying in Class VIII and IX and aged between 14-19 participated in the study after obtaining their informed consent from eight randomly selected English and Bengali medium schools in Agartala, Tripura (India). Data were collected by using a specially designed ‘Semi-structured Questionnaire’. Results: Findings revealed that about 20.9% (67/320), 21.9% (70/230) and 18.1% (58/230) of the children experienced psychological, physical and sexual violence respectively. Male children were more likely to be victims of psychological and physical violence while female children experienced more sexual violence (p=sign). Further analysis of data revealed some relationship between violence against children and nuclear family (p=sign), uncongenial and/or disturbed family environment (p=sign) and dominating, short-tempered and/or aggressive parent personality (p=sign), irrespective of the nature of the violence. Physical violence was found to be more prevalent in high income families (p=sign) while children from the lower income group of families experienced more psychological violence (p=sign). Sexual violence was found to be equally prevalent in all socio-economic groups. The study also clearly indicated that academic performance of violence-experienced children, irrespective of nature of violence and socio-economic groups was poor compared to academic performance of non-violence-experienced children (p=sign). Conclusions: About one-fifth of the children under study did experience violence in Tripura. Findings speak in favor of an intervention program for creating awareness among parents and teachers about the issue of violence against children, targeted at parents when they meet for periodic parent-teachers meetings in the educational institutions.
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