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Search Results: 1 - 10 of 78285 matches for " CHEN SHENGCHANG "
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Effects of Dietary Protein on Ruminal Fermentation, Nitrogen Utilization and Crude Protein Maintenance in Growing Thai-indigenous Beef Cattle Fed Rice Straw as Roughage
Shengchang Chen,Pramote Paengkoum,Xianlin Xia,Pongchan Na-Lumpang
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2010.2396.2400
Abstract: Six male growing Thai-indigenous beef cattle with Body Weight (BW) of 154±13.18 kg were randomly assigned in replicated 3x3 Latin square design and fed with differences levels Crude Protein (CP) Total Mixed Ratio (TMR) diets. Crude Protein (CP) levels in diets were 4, 7% and 10% base on Dry Matter (DM), respectively. Dry Matter Intake (DMI) increased iinearly (p<0.01) with increasing crude protein concentration. There was not significantly different (p>0.05) digestibility of DM, Organic Matter (OM), Acid Detergent Fiber (ADF) and Neutral Detergent Fiber (NDF). Ruminal ammonia nitrogen (NH3-N) concentration increased (p<0.01) with increasing CP level. Rumen pH, total VFA, acetate, propionate and butyrate were not affected by CP levels (p>0.05). Nitrogen (N) intake, urinary N excretion, N digestibility, N retention (g day-1) and N retention (Percentage of N intake) increased linearly with increasing dietary CP levels (p<0.05) and was affected significantly (p<0.01) by diet of CP levels, respectively. However, the fecal N excretion was not affected (p>0.05) by dietary CP levels. The CP for maintenance requirement in growing Thai-indigenous beef cattle was 3.54 g kg-1 BW0.75 which was estimated by using linear regression of N retention and N intake.


地球物理学报 , 2003,
Abstract: 提出了一套基于平面波分解的波动方程叠前地震数据深度偏移方法.通过对共炮点道集和共偏移距道集地震数据的平面波分解,分别得到适用于单平方根波场外推方程和双平方根波场外推方程的共ps(炮点坐标平面波参数)平面波道集和共ph(偏移距坐标平面波参数)平面波道集.在对共炮点道集和共偏移距道集地震数据的平面波分解时,不需要进行通常意义下的τ-p变换计算.通过对共ps平面波道集和共ph平面波道集的偏移效果对比,我们认为在速度弱横向变化介质中,两种平面波道集偏移方法的效果相当,但对于速度强横向变化介质,共ps平面波道集偏移方法的效果要优于共ph平面波道集偏移方法.在计算效率方面,共ps平面波道集偏移方法与共ph平面波道集偏移方法基本相同.
A Novel PEGylated Liposome-Encapsulated SANT75 Suppresses Tumor Growth through Inhibiting Hedgehog Signaling Pathway
Yike Yuan, Yuwei Zhao, Shengchang Xin, Ni Wu, Jiaolin Wen, Song Li, Lijuan Chen, Yuquan Wei, Hanshuo Yang, Shuo Lin
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0060266
Abstract: The Hedgehog (Hh) pathway inhibitors have shown great promise in cancer therapeutics. SANT75, a novel compound we previously designed to specially inhibit the Smoothened (SMO) protein in the Hh pathway, has greater inhibitory potency than many of commonly used Hh inhibitors. However, preclinical studies of SANT75 revealed water insolubility and acute toxicity. To overcome these limitations, we developed a liposomal formulation of SANT75 and investigated its antitumor efficacy in vitro and in vivo. We encapsulated SANT75 into PEGylated liposome and the mean particle size distribution and zeta-potential (ZP) of liposomes were optimized. Using the Shh-light2 cell and Gli-GFP or Flk-GFP transgenic reporter zebrafish, we confirmed that liposome-encapsulated SANT75 inhibited Hh activity with similar potency as the original SANT75. SANT75 encapsulated into liposome exerted strong tumor growth-inhibiting effects in vitro and in vivo. In addition, the liposomal SANT75 therapy efficiently improved the survival time of tumor-bearing mice without obvious systemic toxicity. The pathological morphology and immunohistochemistry staining revealed that liposomal SANT75 induced tumor cell apoptosis, inhibited tumor angiogenesis as assessed by CD31 and down-regulated the expression of Hh target protein Gli-1 in tumor tissues. Our findings suggest that liposomal formulated SANT75 has improved solubility and bioavailability and should be further developed as a drug candidate for treating tumors with abnormally high Hh activity.
Changes in Carbon Pool and Stand Structure of a Native Subtropical Mangrove Forest after Inter-Planting with Exotic Species Sonneratia apetala
Weizhi Lu, Shengchang Yang, Luzhen Chen, Wenqing Wang, Xiaona Du, Canmou Wang, Yan Ma, Guangxuan Lin, Guanghui Lin
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0091238
Abstract: In this study, we compared stand structure, biomass and soil carbon pools, and litterfall production between a mixed mangrove forest consisting of Aegiceras corniculatum inter-planted with the exotic Sonneratia apetala and a native monospecific forest dominated by A. corniculatum in the intertidal area of Zhanjiang, Guangdong Province, southeast China. The goal of this study was to test the hypothesis that inter-planting fast growing exotic mangrove S. apetala into subtropical native mangrove forests will significantly increase C sequestration. Although the tree heights and basal diameters of S. apetala were significantly higher than those of A. corniculatum, the density of the 12-year-old S. apetala trees in the mixed forest was much smaller than that of A. corniculatum in the monospecific forest. In contrast to several previous studies on S. apetala forests planted directly on mangrove-free mudflats, the mixed mangrove forest showed no significant difference in either standing biomass or soil carbon pools from the native monospecific mangrove forest (p = 0.294 and 0.073, respectively) twelve years after inter-planting with S. apetala. Moreover, carbon cycling was likely speeded up after inter-planting S. apetala due to higher litterfall input and lower C/N ratio. Thus, inter-planting fast-growing S. apetala into native mangrove forest is not an effective way to increase carbon sequestration in this subtropical mangrove forest. Given that exotic plant species may exert negative impact on native mangrove species and related epifauna, this fast-growing mangrove species is not suitable for mangrove plantation projects aiming mainly at enhancing carbon sequestration.
Controlling topological entanglement in engineered protein hydrogels with a variety of thiol coupling chemistries
Shengchang Tang,Bradley D. Olsen
Frontiers in Chemistry , 2014, DOI: 10.3389/fchem.2014.00023
Abstract: Topological entanglements between polymer chains are achieved in associating protein hydrogels through the synthesis of high molecular weight proteins via chain extension using a variety of thiol coupling chemistries, including disulfide formation, thiol-maleimide, thiol-bromomaleimide and thiol-ene. Coupling of cysteines via disulfide formation results in the most pronounced entanglement effect in hydrogels, while other chemistries provide versatile means of changing the extent of entanglement, achieving faster chain extension, and providing a facile method of controlling the network hierarchy and incorporating stimuli responsivities. The addition of trifunctional coupling agents causes incomplete crosslinking and introduces branching architecture to the protein molecules. The high-frequency plateau modulus and the entanglement plateau modulus can be tuned by changing the ratio of difunctional chain extender to the trifunctional branching unit. Therefore, these chain extension reactions show promise in delicately controlling the relaxation and mechanical properties of engineered protein hydrogels in ways that complement their design through genetic engineering.
Critical wind speed study on a single-layer car running in strong wind areas

ZHOU Xisai
, LIU Tanghong, CHEN Zhengwei, ZOU Xiang, GE Shengchang

- , 2016,
Abstract: 采用基于k-ε方程的湍流数值模拟方法,研究单层客车在不同路堤、桥梁以及路堑运行时的气动性能,得到气动力系数与侧滑角之间的关系;根据车辆倾覆稳定性计算模型,得到不同高度路堤、桥梁以及不同深度路堑条件下车速和临界倾覆风速关系。研究结果表明:列车在路堤上运行时,气动力系数总体上随侧滑角的增大而增大,在侧滑角为15°~70°之间变化较为明显,之后变化缓慢;临界倾覆风速随着路堤高度的增加先增高后降低,其拐点在车速为120 km/h的位置;桥梁高度越高,临界倾覆风速越低;路堑深度越深,临界倾覆风速越高;车速相对较低时,相同高度条件下,车辆在路堤上的临界倾覆风速大于在桥梁上的临界倾覆风速,当车速超过分界车速时,车辆在桥梁上的临界倾覆风速大于在路堤上的临界倾覆风速。
Numerical simulation method based on k-εturbulence equations was used to study the aerodynamic performance of a single-layer car running on different embankments, bridges and cuttings. The relationship between the aerodynamic coefficients and the slip angle was gotten. According to the vehicle stability calculation model,the relationship between running speed and critical overturning wind speed was also gotten under the conditions of different heights of embankments, bridges and different depths of cuttings. Results show that: When the single-layer car runs on embankment, the aerodynamic coefficients generally increase with the increase of slip angle. The aerodynamic coefficients change obviously when the slip angle is from 15° to 70°, then they change slowly. The critical overturning wind speed increases with the increase of embankment height first, and then decreases. The inflection point of vehicle speed is found to be about 120 km/h. The critical overturning wind speed decreases with the increase of bridge height, and it increases with the increase of cutting depth. At relatively low speed, the vehicle critical overturning wind speed on the embankment is greater than that on the bridge at the same height. When the speed of vehicle exceeds the boundary speed, the vehicle critical overturning wind speed on a bridge is greater than that on the embankment
Disruption of LRRK2 Does Not Cause Specific Loss of Dopaminergic Neurons in Zebrafish
Guiqi Ren,Shengchang Xin,Song Li,Hanbing Zhong,Shuo Lin
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0020630
Abstract: Mutations in LRRK2 are genetically linked to Parkinson's disease (PD) but its normal biological function is largely unknown. Sheng et al. recently reported that deletion of the WD40 domain of LRRK2 in zebrafish specifically causes PD-like loss of neurons and behavior defect. However, our similar early study and recent confirming experiments using the same reagents reported by Sheng et al. failed to reproduce the phenotype of the loss of dopaminergic neurons, although the mRNA of LRRK2 was molecularly disrupted. Our study suggests that function of LRRK2 and its usefulness to generate zebrafish PD model needs further evaluation.
Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors
Chao Che,Song Li,Bo Yang,Shengchang Xin
Beilstein Journal of Organic Chemistry , 2012, DOI: 10.3762/bjoc.8.94
Abstract: Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure–activity relationship of this important class of hedgehog-pathway inhibitors.
Effects of Gradient Photoperiod and Temperature on Energy Metabolism and Body Composition in Tupaia belangeri chinensis
Zhu, Wanlong,Yang, Shengchang,Zhang, Lin,Wang, Zheng-kun
Journal of Stress Physiology & Biochemistry , 2013,
Abstract: In order to explore the adaptive changes in energy metabolism and body composition in response to a gradual reduction in both ambient temperature and photoperiod, male adult tree shrews Tupaia belangeri chinensis were raised under the conditions of 30 oC and 12L:12D photoperiod (control group). The treatment group was changed from 25 oC and 16L:8D photoperiod to 5 oC and 8L:16D photoperiod (treatment group) over a period of four weeks and then maintained at those conditions for a further 4 weeks. Changes in body mass, resting metabolic rates (RMR),energy intake, and wet and dry mass of organs and tissues were measured at the end of the acclimation. Body mass in treatment tree shrews was higher than control. RMR showed significant differences between groups. No significant differences were detected in dry matter intake, energy intake, and digestible energy intake in control tree shrews during the whole acclimation period, while these parameters were significantly increased within treatment tree shrews at the end of acclimation, and were significantly higher than those in control tree shrews. Small intestine and stomach dry mass, as well as the wet mass of small intestine, heart, lung, liver and kidney were significantly higher in treatment groups than in controls, but no significant differences were found in the mass of other organs and tissues. These results suggest that increasing body mass and energy intake, together with adjusting the mass of some organs and tissues, are important physiological changes in tree shrews to adapt the changing environmental conditions.
Anti-Aging Effect of Adipose-Derived Stem Cells in a Mouse Model of Skin Aging Induced by D-Galactose
Shengchang Zhang, Ziqing Dong, Zhangsong Peng, Feng Lu
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0097573
Abstract: Introduction Glycation products accumulate during aging of slowly renewing tissue, including skin, and are suggested as an important mechanism underlying the skin aging process. Adipose-derived cells are widely used in the clinic to treat ischemic diseases and enhance wound healing. Interestingly, adipose-derived stem cells (ASCs) are also effective in anti-aging therapy, although the mechanism underlying their effects remains unknown. The purpose of the present study was to examine the anti-aging effect of ASCs in a D-galactose-induced aging animal model and to clarify the underlying mechanism. Materials and Methods Six-week-old nude mice were subcutaneously injected with D-gal daily for 8 weeks. Two weeks after completion of treatment, mice were randomized to receive subcutaneous injections of 106 green fluorescent protein (GFP)-expressing ASCs, aminoguanidine (AG) or phosphate-buffered saline (PBS). Control mice received no treatment. We examined tissue histology and determined the activity of senescence-associated molecular markers such as superoxide dismutase (SOD) and malondialdehyde (MDA). Results Transplanted ASCs were detectable for 14 days and their GFP signal disappeared at day 28 after injection. ASCs inhibited advanced glycation end product (AGE) levels in our animal model as well as increased the SOD level and decreased the MDA level, all of which act to reverse the aging phenotype in a similar way to AG, an inhibitor of AGE formation. Furthermore, ASCs released angiogenic factors in vivo such as vascular endothelial growth factor, suggesting a skin trophic effect. Conclusions These results demonstrate that ASCs may contribute to the regeneration of skin during aging. In addition, the data shows that ASCs provide a functional benefit by glycation suppression, antioxidation, and trophic effects in a mouse model of aging.
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