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Search Results: 1 - 10 of 72798 matches for " CALDAS MARIA LEONOR "
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Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis
Eduard Baquero,Wiston Qui?ones,Wellman Ribon,Maria Leonor Caldas,Ladys Sarmiento,Fernando Echeverri
Tuberculosis Research and Treatment , 2011, DOI: 10.1155/2011/986409
Abstract: Tuberculosis (TB) is an important disease that causes thousands of deaths around the world. Resistance against antitubercular available drugs has been reported; so, research on new effective antimycobacterial molecules is needed. Antimycobacterial activity of three lignans and two synthetic hydrazones was assessed against Mycobacterium tuberculosis H37Rv by antimycobacterial microdilution assay (TEMA). An oxadiazoline (AC451) and a lignan (ethoxycubebin) were the most active compounds (MIC 6.09 and 62.4?μM, resp.). Several changes in mycolic acid profile of treated bacteria were detected with both compounds by mass spectrometry analysis. Additionally, the level of reduction of mycolic acids in ethoxycubebin treatment was correlated to disruption in bacterial morphology. 1. Introduction Approximately 33% of the human population is infected with Mycobacterium tuberculosis, and every day 4,200 people die of tuberculosis around the world. Several facts have been considered as main factors for pandemic progress [1]. Antituberculosis drugs were discovered more than 40 years ago, [2, 3] resistant strains have emerged due to lengthy treatments, and latent and persistent infections have spread all over the world as population migration has increased. In addition and as it has been described recently, “HIV/AIDS continues to fuel tuberculosis epidemic, especially in Africa” [4]. Under these circumstances, there is an urgent need to search for new antimycobacterial substances to be used as templates for drug development so that the current situation of the disease can be tackled. Moreover, studies on the mechanism of action of new molecules can be useful to design more effective antimycobacterial compounds. Species of Mycobacterium and related genus synthesize mycolic acids (MAs), which are important lipid components of the cell wall (CW), are related to the protection of M. tuberculosis against dehydration, chemical injury, host immune system, and entry of hydrophilic antibiotics [5]. Therefore, MAs metabolism is an important target for Mycobacterium growth inhibition, for example, isoniazid is a first line antitubercular drug that inhibits MAs biosynthesis [6]. In this paper, we report the antimycobacterial activity of three lignans and two oxadiazoline derivatives against M. tuberculosis H37Rv analyzed by mass spectrometry and transmission electronic microscopy to assess the effect of the most active molecules on MAs biosynthesis and the ultrastructural changes of this pathogen. 2. Materials and Methods 2.1. Plant Material and Compounds Leaves of Virola flexuosa
COMPARACIóN HISTOLóGICA Y MORFOMéTRICA ENTRE EL OJO DE Eremophilus mutisii (TRICHOMYCTERIDAE) Y EL DE Oncorhynchus mykiss (SALMONIDAE)
TOVAR BOHóRQUEZ MARIO OSWALDO,CONTRERAS BRAVO LUISA FERNANDA,CALDAS MARIA LEONOR,RODRIGUEZ CAICEDO DANIEL
Acta Biológica Colombiana , 2008,
Abstract: La visión es de importancia variable dependiendo de la relación de los peces con su hábitat, siendo clave en algunas especies y secundaria en otras. El objetivo de este estudio fue realizar una comparación entre el ojo de capitán de la sabana y trucha arco iris. La primera, nativa del altiplano cundiboyacence. La segunda es una especie introducida al país y con alta importancia en la piscicultura. Se obtuvieron cortes de ojo a 5 μm de espesor en ambas especies. Las dos presentan la estructura ocular típica de teleósteos conformada por una retina con ocho capas y dos membranas, células fotorreceptoras (conos y bastones), así como los otros tipos de células neuronales características (bipolares, horizontales, amacrinas y ganglionares), y un cristalino casi esférico. La trucha presenta cartílago en la esclerótica y en capitán de la sabana está ausente. El espesor promedio de las estructuras en capitán de la sabana es: retina de 183,5 +/-41,2 μm, córnea de 20,6 +/-5,4 μm e iris de 31,2 +/-6,4 μm; trucha arco iris presentó una retina de 389,5 +/-65,2 μm, una córnea de 300,4 +/-101,8 μm y un iris de 41,2 +/-13,7 μm. Los resultados obtenidos en este estudio muestran diferencias en el espesor de la retina, cornea, esclerótica, tama o relativo del ojo y diámetro horizontal del cristalino; para los cuales trucha arco iris presenta un valor mayor. Estas diferencias posiblemente se relacionan con diferencias en sensibilidad y resolución visual entre las dos especies y podrían reflejar adaptaciones del sistema visual al medio.
COMPARACIóN HISTOLóGICA Y MORFOMéTRICA ENTRE EL OJO DE Eremophilus mutisii (TRICHOMYCTERIDAE) Y EL DE Oncorhynchus mykiss (SALMONIDAE)
TOVAR BOHóRQUEZ,MARIO OSWALDO; CONTRERAS BRAVO,LUISA FERNANDA; CALDAS,MARIA LEONOR; RODRíGUEZ CAICEDO,DANIEL; HURTADO GIRALDO,HERNáN;
Acta Biológica Colombiana , 2008,
Abstract: the importance of vision in fishes varies depending on their relationship to their habitat, being crucial for some species, and secondary for other species. the main goal of this work was to make a comparison between the eyes of capitán de la sabana and rainbow trout. the first one, from the cundiboyacense highlands, and the second one, a foreign species introduced in our country, very important as a cultured organism. histological 5 μm thickness eye sections were obtained. both species do present the typical teleosteal eye structure with an 8 layers retina, photoreceptor cells (cones and rods), as well as different types of neurons (bipolar, horizontal, amacrine, and ganglionic cells ), and an almost spherical lens. rainbow trout has cartilage in the sclerotica, while capitán de la sabana does not present this tissue. mean thickness of the structures in capitán de la sabana are: retina 183.5 41.2 μm, cornea 20.6 5.4 μm and iris 31.2 6.4 μm; mean thickness in rainbow trout are: retina 389.5 65.2 μm, cornea 300.4 101.8 μm, and iris 41.2 13.7 μm. our results shows thickness differences in retina, cornea, sclerotica, relative eye size, lenses diameter, being larger for rainbow trout. these differences are probably related to differences in sensibility and visual resolution between the species, and do reflect visual system adaptations to different environments.
A arte da fuga: Os mecanismos da liquidez The Art of Fugue: The Mechanisms of Liquidity L’art de la fugue: les mécanismes de la liquidité
José Maria Castro Caldas
Revista Crítica de Ciências Sociais , 2012, DOI: 10.4000/rccs.617
Abstract: A ideia de “liquidez” enquanto característica da fase actual da modernidade, presente na obra mais recente de Zygmunt Bauman, convida a uma leitura cruzada entre este autor e Keynes. Quer em Bauman, quer em Keynes, a liquidez aplica-se a rela es que podem ser facilmente revertidas, ou revertidas a baixo custo, e a sistemas que, sendo caracterizados pela precariedade dos la os que unem os seus elementos constituintes, tendem a ser, eles próprios, instáveis e precários. Em ambos os autores, a liquidez e a especula o surgem como respostas racionais à incerteza e, ao mesmo tempo, como estratégias individuais que contribuem para o aumento do risco sistémico. As duas abordagens s o complementares e coerentes. A leitura cruzada sugere a existência de mecanismos da liquidez transversais a diferentes domínios institucionais cuja identifica o é aqui ensaiada. The idea of ‘liquidity’ as a feature of the ongoing phase of modernity, to be found in the most recent work of Zygmunt Bauman, invites a cross-reading of this author and Keynes. Both in Bauman and in Keynes, liquidity is linked to relations which can easily be reverted, or reverted at a low cost, and to systems which, characterised by the precariousness of bonds linking its constituting elements, tend, themselves, to be unstable and precarious. In both authors, liquidity and speculation appear as rational responses to uncertainty, and, at the same time, as individual strategies contributing to increased systemic risk. Both approaches are complementary and consistent. Cross-reading suggests the existence of liquidity mechanisms which are transversal to different institutional domains, identification of which is here essayed. L’idée de liquidité en tant que caractéristique de la phase actuelle de la modernité, présente dans l’ouvre la plus récente de Zygmunt Bauman, suscite une lecture croisée entre cet auteur et Keynes. Soit chez Bauman, soit chez Keynes, la liquidité s’applique à des relations qui peuvent être facilement réversibles, ou réversibles à bas prix, et à des systèmes qui, étant caractérisés par la précarité des liens unissant leurs éléments constitutifs, tendent à être, eux-mêmes, instables et précaires. Chez les deux auteurs, la liquidité et la spéculation surgissent comme réponses rationnelles à l’incertitude et, en même temps, comme stratégies individuelles qui contribuent à l’augmentation du risque systémique. Les deux approches sont complémentaires et cohérentes. Leur lecture croisée suggère l’existence de mécanismes de liquidité transversaux dans les différents domaines institutionnels
Pesquisas em psicoterapia: se??es especiais de periódico (1981 a 1994)
Enéas, Maria Leonor Espinosa;
Psicologia: Teoria e Pesquisa , 2008, DOI: 10.1590/S0102-37722008000100013
Abstract: the article presents psychotherapy researches and it intends to offer a qualitative view of the field development and tendencies. it analyses nine special sections about this issue, published from 1981 to 1994, in a journal of the american psychological association (apa), which is considered the top in psychotherapy research. it verifies the emphasis on scientific evidences searching and the articulation of research and clinical practice. the article also observes a great production in this period of time and a progress in this field, especially in single-case methodology. the core questionings still challenge the researchers.
Pesquisas em psicoterapia: se??es especiais de periódico (1995 a 2005)
Enéas, Maria Leonor Espinosa;
Psicologia: Teoria e Pesquisa , 2007, DOI: 10.1590/S0102-37722007000300013
Abstract: the article presents psychotherapy research to complete a qualitative view of the tendencies in this field. seven special sections about this issue published between 1995 and 2005 in an important journal of the american psychological association (apa) are analyzed. it verifies that the great emphases in the field - the search for scientific evidence and the combination of the research and clinical practice - are still the focus of the discussions, mainly the debate about the controlled clinical essays. less intensive production in the period but more objective conditions to a possible approach between the researchers and the clinicians are observed. there are still challenges, now searching new directions.key words: identification; psychoanalysis; metapsychology.
História da forma??o de professores
Tanuri, Leonor Maria;
Revista Brasileira de Educa??o , 2000, DOI: 10.1590/S1413-24782000000200005
Abstract: this paper deals with the history of the brazilian training college for elementary school teachers from the viewpoint of state educational policy and having as sources historiographical works on elementary school teacher's training colleges of several states. founded in 19th. century those institutions initially showed a rather modest feature of elementary schools themselves with emphasis on the content to be taught. with time, however, they progressively incorporated a didatic-pedagogical content. new school movement ideas influenced them decisively changing the emphasis of their curricula to the "sciences of education". the article examines questions related to: consolidation and expansion of that college, evolution of its general and curricular organization which has reached the secondary level from the 1930's onwards until the national education law 9.394/96 when a higher education level was required to elementary teachers.
História da forma o de professores
Leonor Maria Tanuri
Revista Brasileira de Educa??o , 2000,
Abstract: This paper deals with the history of the Brazilian training college for elementary school teachers from the viewpoint of State educational policy and having as sources historiographical works on elementary school teacher s training colleges of several States. Founded in 19th. century those institutions initially showed a rather modest feature of elementary schools themselves with emphasis on the content to be taught. With time, however, they progressively incorporated a didatic-pedagogical content. New School movement ideas influenced them decisively changing the emphasis of their curricula to the sciences of education . The article examines questions related to: consolidation and expansion of that College, evolution of its general and curricular organization which has reached the secondary level from the 1930 s onwards until the National Education Law 9.394/96 when a higher education level was required to elementary teachers.
Organiza es n o governamentais: espa os de imbrica o de "políticas de piedade" e "políticas de justi a"?
Maria Leonor Sampaio
Revista Organiza??es em Contexto , 2006,
Abstract: N o fazendo incidir a nossa reflex o sobre um certo tipo de voluntariado cuja perspectiva é mais planetária e cujas ac es visam o refor o de outros movimentos congéneres de alcance internacional defendendo causas mais universais, neste pequeno estudo iniciaremos t o só uma abordagem das diferentes formas do trabalho que o Terceiro Sector em Portugal tem vindo a adquirir e que a nosso ver ultrapassam o altruísmo humanitário e aquilo a que Scheler chamou de piedade (SCHELER, 1967). Porque, se o espectáculo do sofrimento (ARENDT, 1967) daqueles que sofrem à distancia (Boltanski, 1993), pode estimular uma prática de piedade por parte daqueles que observam esse sofrimento, mas n o o vivenciam, que dizer das raz es que levam à integra o formal em organiza es que se dedicam a outro tipo de actividades ainda que voluntárias? Haverá uma motiva o transversal a todas as ONGs, desde aquelas que se aplicam na defesa do património arquitectónico, na defesa da cultura nacional ou local, na limpeza de praias e matas, em práticas voluntárias junto de animais, no apoio e/ou visita a doentes, a presos etc.? Inseridos num ritmo da mudan a característico da modernidade (GIDDENS, 1992), em que o individualismo se constrói na reflex o crítica e se pretende livre (SINGLY, 2003), que regimes justificativos de ac o (BOLTANSKI, 2001) subjazem à forma o e/ou ades o a este tipo de organiza es? Com base em que estratégias individuais se faz a passagem para um comprometimento colectivo?
Functional Vegetable-Based Sausages for Consumption by Children  [PDF]
Solange Burri, Isabel Tato, Maria Leonor Nunes, Rui Morais
Food and Nutrition Sciences (FNS) , 2011, DOI: 10.4236/fns.2011.25072
Abstract: The dislike food preferences that children registered regarding vegetables and fish compromise the exposure to those iodine sources and may contribute to cause a nutritional deficiency in this micronutrient, causing serious damage of the brain and the central nervous system. Functional foods are becoming well-established in the market, focused on by an adult consumer more interested in healthy eating habits but without the motivation to optimize natural food preparation or to promote a wide variety of food in their diet. This article presents evidence of a new functional product concept, 100% vegetable, fermented soya based and salted by a red algae, that was approved by 900 parents who chose the sensorial features: distinctive aroma (57.9%), soft texture (38.4%), sausage shape (21%) and attractive color (77.9%). Three different varieties were developed: carrot (50% w/w), sugar-beet (50% w/w) and tomato (40% w/w) mini sausages, with tofu (20% w/w) and 0.8 % (w/w) of seaweed, reflecting trends that the younger consumer demands. The sensorial tests performed, after quality control assays, received very satisfactory acceptance by the potential buyer.
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