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Search Results: 1 - 10 of 87681 matches for " CAI Chen "
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A Case Report of Alendronate Treatment over 20 Years on Osteoporosis and Literature Review  [PDF]
Jinmei Deng, Enjing Chen, Suming Jie, Xiuzhen Cai, Dongmei Cai
Case Reports in Clinical Medicine (CRCM) , 2018, DOI: 10.4236/crcm.2018.76037
Abstract: Osteoporosis is commonly seen in aged people, but not much attention is paid to it. Patient compliance is challenged by many factors, including long-time treatment and high rates of fatality and disability caused by fragility fractures. With age-related changes, the treatment will last for a lifetime. A clinical case of postmenopausal patient who had received incontinuous treatment of alendronate for 20 years was studied in this article. As the level of compliance varied in different treatment phases, the curative outcome of this patient was altered. This study also presented a literature review to discuss the current situation, treatment and compliance of osteoporosis in China and the corresponding influences on bone mineral density (BMD) and prognosis. Hopefully, this study can increase physicians’ awareness of osteoporosis in clinical treatment and its pharmacotherapy and treatment course.
An iterative method for solving a kind of constrained linear matrix equations system
Cai, Jing;Chen, Guoliang;
Computational & Applied Mathematics , 2009, DOI: 10.1590/S1807-03022009000300004
Abstract: in this paper, an iterative method is constructed to solve the following constrained linear matrix equations system: [a1(x),a2(x),... ,ar(x)]=[e1,e2, ... ,er ], x ∈ i={x |x= u(x)}, where ai is a linear operator from cmxn onto cpixqi, ei ∈ cpixqi, i=1 , 2,..., r , and u is a linear self-conjugate involution operator. when the above constrained matrix equations system is consistent, for any initial matrix x0 ∈ i, a solution can be obtained by the proposed iterative method in finite iteration steps in the absence of roundoff errors, and the least frobenius norm solution can be derived when a special kind of initial matrix is chosen. furthermore, the optimal approximation solution to a given matrix can be derived. several numerical examples are given to show the efficiency of the presented iterative method. mathematical subject classification: 15a24, 65d99,65f30.
Systematic investigation of insertional and deletional RNA-DNA differences in the human transcriptome
Chen Cai,Bundschuh Ralf
BMC Genomics , 2012, DOI: 10.1186/1471-2164-13-616
Abstract: Background The genomic information which is transcribed into the primary RNA can be altered by RNA editing at the transcriptional or post-transcriptional level, which provides an effective way to create transcript diversity in an organism. Altering can occur through substitutional RNA editing or via the insertion or deletion of nucleotides relative to the original template. Taking advantage of recent high throughput sequencing technology combined with bioinformatics tools, several groups have recently studied the genome-wide substitutional RNA editing profiles in human. However, while insertional/deletional (indel) RNA editing is well known in several lower species, only very scarce evidence supports the existence of insertional editing events in higher organisms such as human, and no previous work has specifically focused on indel differences between RNA and their matching DNA in human. Here, we provide the first study to examine the possibility of genome-wide indel RNA-DNA differences in one human individual, NA12878, whose RNA and matching genome have been deeply sequenced. Results We apply different computational tools that are capable of identifying indel differences between RNA reads and the matching reference genome and we initially find hundreds of such indel candidates. However, with careful further analysis and filtering, we conclude that all candidates are false-positives created by splice junctions, paralog sequences, diploid alleles, and known genomic indel variations. Conclusions Overall, our study suggests that indel RNA editing events are unlikely to exist broadly in the human transcriptome and emphasizes the necessity of a robust computational filter pipeline to obtain high confidence RNA-DNA difference results when analyzing high throughput sequencing data as suggested in the recent genome-wide RNA editing studies.
Sequential Treatment Reduces the Acute Phases of Adverse Effect of Zoledronic Acid in First Time Users  [PDF]
Jinmei Deng, Dongmei Cai, Suming Jie, Enjing Chen, Xiuzhen Cai, Yanbing Li
Open Journal of Preventive Medicine (OJPM) , 2018, DOI: 10.4236/ojpm.2018.87018
Abstract: Objective: To investigate whether sequential regimen such as traditional anti-reabsorption medications followed by zoledronic acid could reduce the side effects after initiation of zoledronic acid in postmenopausal osteoporosis patients. Methods: A total of 156 postmenopausal osteoporosis patients who presented at our osteoporosis outpatient clinic were enrolled in this study. They were randomly divided into four groups: the control group, alendronate group, calcitonin group, and raloxifene group. All participants were treated with Caltrate 600 mg per day and calcitriol 0.25 ug per day as a baseline treatment, followed by administrating 5 mg/100 mL of zoledronic acid intravenously for one single time three months afterwards. During the abovementioned course of three months, the alendronate group received 70 mg of alendronate sodium orally once a week, the calcitonin group received nasal spray form of salmon calcitonin 10iu daily, the raloxifene group received 60mg of raloxifene orally daily, and the control group received nothing but only the baseline treatment. We tested parameters such as β-cross, blood calcium level, renal function both pre and post zoledronic acid treatment. We also documented those side effects that typically occurred within one week of treatment initiation, which included the proportion, severity, onset time, and duration of the fever, demand for pain medication, severity of bone and joint pain, flu-like symptoms, arrhythmia, blood calcium level, and kidney function impairment. We also evaluated how willing the patients were to receive a second dose of zoledronic acid. Then we did comparative analysis between control group and sequential group. Results: The side effects such as fever, bone and joint pain, flu-like symptoms after zoledronic acid treatment in alendronate group and calcitonin group were all significantly lower than that in control group, while raloxifene group showed no significant difference compared to that in the control group. The proportions of patients who needed NSAIDs in the alendronate group and the calcitonin group were significantly lower than that in control group. However, the raloxifene group showed no significant difference in the NSAIDs demand from that of the control group. The percentages of patients who consented to a second dose of zoledronate therapy in the alendronate, calcitonin and raloxifene groups were significantly higher than that in the control group. Conclusions: Sequential treatment with alendronate sodium or
The Role of Health Education in Improving Patient Compliance with Zoledronic Acid  [PDF]
Suming Jie, Jinmei Deng, Ermei Jie, Enjing Chen, Caixia Lin, Xiuzhen Cai, Dongmei Cai
Open Journal of Nursing (OJN) , 2018, DOI: 10.4236/ojn.2018.810053
Abstract: Objective: To define the role of health education in improving patient compliance with Zoledronic Acid for osteoporosis treatment and management and draw closer attention of patients and physicians to the importance of health education. Methods: A total of 198 postmenopausal patients with osteoporosis who were admitted by the osteoporosis outpatient clinic of our hospital and had the first administration of Zoledronic Acid in 2015 were invited to participate in the follow-up visit that involved questions concerning the frequency of health education and the questionnaire survey on osteoporosis in 2015 and the administration of Zoledronic Acid during the past three years. The patients were divided into five groups according to the frequency of health education to compare the survey results of each group in 2015 and 2018 and investigate the differences in the scores and frequency of administration among the five groups. Results: Among the 198 patients, there were 182 attending the follow-up visit. In terms of the frequency of health education (FREQ = 0, 1, 2, 3, 4), these patients were divided into five groups of 47, 63, 35, 18 and 19 members respectively. After three years of treatment, the questionnaire score of each group was higher than the pre-treatment level and the difference showed statistical significance (p < 0.05, respectively); compared to those who had never received health education (FREQ = 0), the patients who had participated in health education activities at different levels (FREQ = 1, 2, 3, 4) scored significantly higher in the questionnaire survey and increased the frequency of administration of Zoledronic Acid on average; particularly, those who had received health education and Zoledronic Acid treatment twice and above benefited the most. Conclusion: Health education is an effective approach to influence a patient’s knowledge connected to relevant diseases in a positive way and improve patient compliance with Zoledronic Acid treatment. An enhanced health education program can be developed to assist the patients in chronic disease management.
Data-Centric Routing Mechanism Using Hash-Value in Wireless Sensor Network  [PDF]
Xiaomin Zhao, Keji Mao, Shaohua Cai, Qingzhang Chen
Wireless Sensor Network (WSN) , 2010, DOI: 10.4236/wsn.2010.29086
Abstract: Traditional routing protocols as TCP/IP can not be directly used in WSN, so special data-centric routing protocols must be established. The raised data-centric routing protocols can not identify the sensor nodes, because many nodes work under a monitoring task, and the source of data is not so important some times. The sensor node in the network can not judge weather data is come from the some sink node. What’s more, the traditional method use IP to identify sensors in Internet is not suitable for WSN. In this paper, we propose a new naming scheme to identify sensor nodes, which based on a description of sensor node, the description of a sensor node is hashed to a hash value to identify this sensor. The different description generates different identifier. Different from IP schema, this identifier is something about the information of the sensor node. In the above naming scheme, we propose a new data-centric routing mechanism. Finally, the simulation of the routing mechanism is carried out on MATLAB. The result shows our routing mechanism’s predominate increase when network size increase.
Determining the transcriptional regulation pattern of PgTIP1 in transgenic Arabidopsis thaliana by constructing gene  [PDF]
Haiying Chen, Lu Ying, Jing Jin, Qi Li, Weiming Cai
Advances in Bioscience and Biotechnology (ABB) , 2010, DOI: 10.4236/abb.2010.15051
Abstract: The seed size, seed mass, and growth rate of transgenic Arabidopsis plants containing PgTIP1, a ginseng tonoplast aquaporin gene, are significantly higher than those of wild-type Arabidopsis plants. Whole genome expression and bioinformatics analysis, including analysis of co-expression networks and transcription factors (Tfscan), were used to determine the key genes that are activated after the expression of PgTIP1 and the transcription factors that play important roles in the regulation of the genes controlling growth of Arabidopsis thaliana seeds by using transgenic Arabidopsis plants containing PgTIP1. Differential gene analysis showed that transformation of exogenous PgTIP1 to Arabidopsis induced endogenous gene expression changes. Analysis of gene co-expression networks revealed 2 genes, PIP1 (plasma membrane aquaporin 1 gene) and RD26 (responsive to desiccation 26 gene; a NAC transcription factor), that were localized in the core of the networks. Analysis of the transcriptional regulation network of transgenic Arabidopsis plants containing PgTIP1 showed that PIP1 and RD26 were regulated via DNA binding with a finger domain on transcription factor 2 (Dof2). In this study, we demonstrated that Dof2 induces up-regulation of PIP1 and RD26 after transformation with PgTIP1. The results of this study provide a new means for conducting research into and controlling growth of Arabidopsis thaliana seeds.
Design of Omni-Directional Tilt Sensor Based on Machine Vision  [PDF]
Yi-Ping Tang, Cai-Guo Chen
Journal of Sensor Technology (JST) , 2011, DOI: 10.4236/jst.2011.14015
Abstract: This paper presents a new Omni-Directional Tilt Sensor (ODTS), which consists of the LED light, transparent cone-shaped closed container, mercury, camera, embedded systems and so on. The volume of the mercury in the container is equal to half of the container’s. When the detected surface is horizontal, the shape of mercury in the image captured by the camera is a black disc since the mercury is lightproof. When the detected surface tilts, the mercury flows and the mercury surface always maintains horizontally due to the gravity force of the earth. At this time, some area of the transparent cone-shaped closed container is not shaded by mercury and the border of the mercury’s shape in the captured image is a half circle and a half ellipse. Thus there is a translucent crescent-shaped area in the image. With analyzing this area by the specific algorithm based on machine vision, the tilt angle and directional angle can be obtained. The experimental results show that the ODTS proposed has some advantages, such as simple maintenance, high precision, wide range, low cost, real-time, reliability and high visualization.
Modeling of IEEE1588 on OPNET and Analysis of Asymmetric Synchronizing Error in Smart Substation  [PDF]
Jiongcong Chen, Haizhu Wang, Chunchao Hu, Kai Ma, Zexiang Cai
Energy and Power Engineering (EPE) , 2013, DOI: 10.4236/epe.2013.54B103
Abstract:

The IEEE1588 network time synchronization, matched with smart substation information network transmission, is becoming the next generation advanced data synchronization of the smart substation. It is known that the inherent asymmetry error of the network synchronization approach in the smart substation is highlighted, which is concerned particularly. This paper models the synchronization process of the IEEE1588 based on the communication simulation software of OPNET Modeler. Firstly, it builds the models of master-slave clock, IEEE1588 protocol and network synchroniza- tion model, and analyzes the composition and influencing factors of the asymmetry error. Secondly, it quantitatively analyzes the influence of the synchronous asymmetric error of the IEEE1588 affected by the network status differences and the clock synchronization signal transmission path differences. Then its correction method is analyzed, in order to improve the IEEE1588 synchronization reliability and gives the solutions to its application in smart substation.

Analysis of Nonlinear Characteristics of Turbine Governor and Its Impact on Power System Oscillation  [PDF]
Ge Jin, Hanting Yan, Shaoxiang Deng, Xiaomei Chen, Zexiang Cai
Energy and Power Engineering (EPE) , 2013, DOI: 10.4236/epe.2013.54B144
Abstract:

In this paper, the model of turbine governor based on the physical principles is constituted to improve the accuracy of power system dynamic simulation, making the results of simulation consistent with the actual situation. The unit and grid coupling model which reflects the interaction between thermal system of power plant and power system is built using EMTDC/PSCAD. The influence of nonlinear characteristics on the valve opening and the steam turbine mechanical power is also analyzed in this paper. The results of simulation show that the improper setting of parameters reflecting nonlinear characteristics of turbine governor can lead to the cyclical oscillations of the valve opening and the steam turbine mechanical power, and even can lead to the power oscillation persistently. The research achievements in this paper have a certain reference value on exploring the causes of power oscillation from the prime mover.

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