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Search Results: 1 - 10 of 486772 matches for " C.; Espinosa Borrás "
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Grupos de Apoyo Nutricional en un entorno hospitalario: La experiencia cubana Nutritional support groups at a hospital setting: The Cuban experience
S. Santana Porbén,J. Barreto Penié,C. Martínez González,A. Espinosa Borrás
Nutrición Hospitalaria , 2007,
Abstract: En este trabajo se presentan los resultados de 8 a os de trabajo ininterrumpido de un Grupo de Apoyo Nutricional (GAN) dentro de un hospital de tercer nivel de la ciudad de La Habana (CUBA). Los resultados se refieren al desempe o del Grupo en los 3 dominios de la actuación médica, por un lado, y el despliegue de un Programa de Intervención Alimentaria, Nutrimental y Metabólica (PRINUMA) de alcance institucional, por el otro. La labor asistencial ha servido para demostrar la factibilidad de los esquemas de intervención conducidos bajo la premisa del uso primordial de la vía enteral, y los beneficios que resultan de su observación en casos seleccionados. La labor docente ha sido siempre una prioridad del trabajo del Grupo, y ha permitido exponer a los grupos básicos de trabajo de la institución a ideas novedosas y nuevos modos de hacer, a fin de desterrar las prácticas indeseables que puedan atentar contra el estado nutricional del paciente, y que muchas veces están sustentadas en mitos, dogmas y sofismas. La labor investigativa ha sido un perfecto complemento del desempe o del Grupo en los 2 dominios anteriores, y ha hecho posible la incorporación de temas de apoyo nutricional y Nutrición Artificial en la carpeta de investigaciones de la institución. La labor médica del GAN se ha acompa ado de una intensa actividad de despliegue del PRINUMA para dar respuesta a los retos que traen consigo el reconocimiento de la desnutrición asociada a las enfermedades como un problema institucional de salud. Las pautas adoptadas en este artículo para el reporte de las actividades del Grupo pueden convertirse en una plataforma metodológica que facilite la evaluación por terceras partes. The results achieved by a Nutritional Support Group (NSG) operating within a tertiary-level hospital in the city of Havana (CUBA) for the last 8 years are presented in this work. Results relate to the performance of the Group in the three domains of medical care, on one hand, and the inception of a Metabolic, Nutritional and Feeding Intervention Program (PRINUMA) of institutional reach, on the other. Nutritional assistance has served the purpose of demonstrating the feasibility of intervention schemes conducted under the premise of the use of the enteral route as first choice, and the benefits observed in selected cases. Teaching has always been a priority of the Group, as a tool to expose the institution's medical care teams to new ideas and novel ways of acting, in order to eliminate those undesirable practices attempting against the patient's nutriture that have arisen most of the tim
Grupos de Apoyo Nutricional en un entorno hospitalario: La experiencia cubana
Santana Porbén,S.; Barreto Penié,J.; Martínez González,C.; Espinosa Borrás,A.; Morales Hernández,L.;
Nutrición Hospitalaria , 2007,
Abstract: the results achieved by a nutritional support group (nsg) operating within a tertiary-level hospital in the city of havana (cuba) for the last 8 years are presented in this work. results relate to the performance of the group in the three domains of medical care, on one hand, and the inception of a metabolic, nutritional and feeding intervention program (prinuma) of institutional reach, on the other. nutritional assistance has served the purpose of demonstrating the feasibility of intervention schemes conducted under the premise of the use of the enteral route as first choice, and the benefits observed in selected cases. teaching has always been a priority of the group, as a tool to expose the institution's medical care teams to new ideas and novel ways of acting, in order to eliminate those undesirable practices attempting against the patient's nutriture that have arisen most of the times from myths, fallacies and dogmas. research has been a perfect complemment of the group's performance in the two previous domains, making possible the incorporation of nutritional support and artificial nutrition issues into the institution's r&d portfolio. gan's medical workup has been accompannied by the deployment of the prinuma, in order to respond to the challenges brought about by the recognition of disease-associated-malnutrition as an institutional health problem. the guidelines followed in this article for reporting the group's activities can become a methodological platform for the purpose of assessment by third parties.
Estado nutricional de los pacientes con insuficiencia renal crónica atendidos en el programa de Hemodiálisis del Hospital Clínico-Quirúrgico "Hermanos Ameijeiras"
Ordó?ez Pérez,V.; Barranco Hernández,E.; Guerra Bustillo,G.; Barreto Penié,J.; Santana Porbén,S.; Espinosa Borrás,A.; Martínez González,C.; Anías Martínez,A.;
Nutrición Hospitalaria , 2007,
Abstract: introduction: heterogeneity of malnutrition rates associated with end-stage renal disease (esrd) under haemodialysis (hd) points towards differing performances of the used indicators. objectives: to identify those indicators that better describe the nutritional state of the patient with esrd under hd. setting: program of haemodialysis, service of nephrology, "hermanos ameijeiras" hospital (havana city, cuba). methods: twenty-eight patients were recruited. hospital admissions between december 2001-december 2002 were recorded. the condition of the patient (alive/deceased) after one year of observation was registered. the subjective global assessment (sga) form was administered to each patient. the nutritional profile included: height, weight, mid-arm circumference (mac), triceps skinfold (tsf), albumin and total lymphocyte count (tlc). nutritional status as described by means of albumin and mac was correlated with sga score, the ocurrence of hospital admissions and the final condition of the patient. results: malnutrition rates were as follows (albumin < 35 g/l): 42.9%; (mac < cut-off value): 60.7%; [(mac < cut-off value) and/or (albumin < 35)]: 71.4%; (sga score = at risk/malnourished): 42.9%. sga score was an independent predictor of the ocurrence of admissions [or = 14.14; ci 95%: 1.5-137.3] and mortality [or = 21.0; ci 95%: 2.9-151.4]. serum albumin was an independent predictor of the patient's mortality [or = 21.0; ci 95%: 2.9-151.4]. the [(mac < cut-off value) and/or (albumin < 35)] rule failed to predict patient's morbimortality. seventy-seven point eight percent of patients with +60 years-old died during the year of observation [or = 13.2; ic 95%: 1.9-89.5]. conclusions: increased mortality associated with diminished values of albumin and mac justifies the fostering of nutritional intervention aimed to preserve lean tissues.
Expression of the Gene Encoding Secretor Type Galactoside 2 α Fucosyltransferase (FUT2) and CD44 Marker in Urogenital Tumors  [PDF]
M. A. Ensinck, N. Lebensohn, S. García Borrás, L. Racca, C. Cotorruelo, C. Biondi
Open Journal of Genetics (OJGen) , 2016, DOI: 10.4236/ojgen.2016.64011
Abstract: The aim of this work was to investigate the FUT2 gene, the secretor status and the expression of CD44 protein in epithelial cells obtain from saliva and urine samples from patients with urogenital tumours. We studied 104 subjects. Half of them had urogenital tumours, while the other half was the healthy control group. We determined the secretor status in saliva with the haemagglutination inhibition technique. We analyzed the FUT2 polymorphism by allele specific oligonucleotide–polymerase chain reaction (ASO-PCR) with specific primers for the G428 allele and the wild type allele of FUT2 gene. We found higher intensity of urogenital disease in the non-secretor group (OR = 3.44). In contrast with the healthy population, 51.6% of the patients with potential malignant urogenital lesions and cancerous lesions were non-secretors. We also investigate by confocal microscopy, the expression of CD44 protein in epithelial cells obtained from urine samples from these patients. The results obtained also showed fluorescence corresponding to the presence of CD44 protein in samples from patients diagnosed with cancer. Our study suggests that the lack of wild type FUT2 gene and a nonsecretor status appear to be an associated risk marker for the development of urogenital tumors. Several mechanisms, based on the properties of CD44 as the major hyaluronan CD44 in cell carcinomas receptor, have been proposed to explain the role of elevated CD44 expression during tumour development and progression. CD44 might be a good candidate as a predictor of prognosis in this group of cancers.
Shock cardiogénico asociado a un programa nutricional inapropiado: síndrome de realimentación Cardiogenic shock associated with an inappropriate nutritional programme: re-feeding syndrome
C. Campos-Ferrer,M. Cervera-Montes,A. Romero,S. Borrás
Nutrición Hospitalaria , 2004,
Abstract: Se han comunicado situaciones de paro cardíaco en pacientes con desnutrición proteico-calórica en los que se iniciaba aporte de nutrientes de manera incontrolada. El reconocimiento de la asociación entre el aporte de alimentos en estas circunstancias y los eventos clínicos graves, generalmente trastornos del ritmo cardíaco, llevó a describirlo como "síndrome de realimentación". Presentamos un caso de influencia respiratoria aguda grave y shock cardiogénico en una paciente de 44 a os con desnutrición proteico-calórica grave asociado al inicio de un soporte nutricional hiperproteico. El tratamiento con drogas inotrópicas-vasoactivas y diuréticos junto con un programa nutricional progresivo consiguió la reversión completa de la insuficiencia cardíaca y del síndome endocrino-metabólico concomitante. Situations of cardiac arrest have been reported in under-nourished patients with protein and calorie deficits when the provision of nutrients was initiated in an uncontrolled manner. The recognition of the association between the provision of food in these circumstances and the serious clinical consequences, generally heartbeat disorders, has led this condition to be described as "re-feeding syndrome". The case presented here is of severe acute respiratory failure and cardiogenic shock in a 44-year-old female patient with severe protein and calorie malnutrition associated with the start of hyperproteic nutritional support. Treatment with inotropic-vasoactive drugs and diuretics together with a progressive nutritional programme brought about the complete reversal of her heart failure and the concomitant endocrine-metabolic syndrome.
Using Expression Profiling to Understand the Effects of Chronic Cadmium Exposure on MCF-7 Breast Cancer Cells
Zelmina Lubovac-Pilav, Daniel M. Borràs, Esmeralda Ponce, Maggie C. Louie
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0084646
Abstract: Cadmium is a metalloestrogen known to activate the estrogen receptor and promote breast cancer cell growth. Previous studies have implicated cadmium in the development of more malignant tumors; however the molecular mechanisms behind this cadmium-induced malignancy remain elusive. Using clonal cell lines derived from exposing breast cancer cells to cadmium for over 6 months (MCF-7-Cd4, -Cd6, -Cd7, -Cd8 and -Cd12), this study aims to identify gene expression signatures associated with chronic cadmium exposure. Our results demonstrate that prolonged cadmium exposure does not merely result in the deregulation of genes but actually leads to a distinctive expression profile. The genes deregulated in cadmium-exposed cells are involved in multiple biological processes (i.e. cell growth, apoptosis, etc.) and molecular functions (i.e. cadmium/metal ion binding, transcription factor activity, etc.). Hierarchical clustering demonstrates that the five clonal cadmium cell lines share a common gene expression signature of breast cancer associated genes, clearly differentiating control cells from cadmium exposed cells. The results presented in this study offer insights into the cellular and molecular impacts of cadmium on breast cancer and emphasize the importance of studying chronic cadmium exposure as one possible mechanism of promoting breast cancer progression.
EL PLANO, LOS ESCENARIOS Y LA PUESTA EN ESCENA ETNOGRáFICA. UNA CONVERSACIóN CON JOANNE RAPPAPORT Y CéSAR ABADíA
César Tapias,Nicolás Espinosa
Tabula Rasa , 2010,
Abstract:
Shock cardiogénico asociado a un programa nutricional inapropiado: síndrome de realimentación
Campos-Ferrer,C.; Cervera-Montes,M.; Romero,A.; Borrás,S.; Gómez,E.; Ricart,C.;
Nutrición Hospitalaria , 2004,
Abstract: situations of cardiac arrest have been reported in under-nourished patients with protein and calorie deficits when the provision of nutrients was initiated in an uncontrolled manner. the recognition of the association between the provision of food in these circumstances and the serious clinical consequences, generally heartbeat disorders, has led this condition to be described as "re-feeding syndrome". the case presented here is of severe acute respiratory failure and cardiogenic shock in a 44-year-old female patient with severe protein and calorie malnutrition associated with the start of hyperproteic nutritional support. treatment with inotropic-vasoactive drugs and diuretics together with a progressive nutritional programme brought about the complete reversal of her heart failure and the concomitant endocrine-metabolic syndrome.
Reactive oxidation products promote secondary organic aerosol formation from green leaf volatiles
J. F. Hamilton, A. C. Lewis, T. J. Carey, J. C. Wenger, E. Borrás i Garcia,A. Mu oz
Atmospheric Chemistry and Physics (ACP) & Discussions (ACPD) , 2009,
Abstract: Green leaf volatiles (GLVs) are an important group of chemicals released by vegetation which have emission fluxes that can be significantly increased when plants are damaged or stressed. A series of simulation chamber experiments has been conducted at the European Photoreactor in Valencia, Spain, to investigate secondary organic aerosol (SOA) formation from the atmospheric oxidation of the major GLVs cis-3-hexenylacetate and cis-3-hexen-1-ol. Liquid chromatography-ion trap mass spectrometry was used to identify chemical species present in the SOA. Cis-3-hexen-1-ol proved to be a more efficient SOA precursor due to the high reactivity of its first generation oxidation product, 3-hydroxypropanal, which can hydrate and undergo further reactions with other aldehydes resulting in SOA dominated by higher molecular weight oligomers. The lower SOA yields produced from cis-3-hexenylacetate are attributed to the acetate functionality, which inhibits oligomer formation in the particle phase. Based on observed SOA yields and best estimates of global emissions, these compounds may be calculated to be a substantial unidentified global source of SOA, contributing 1–5 TgC yr 1, equivalent to around a third of that predicted from isoprene. Molecular characterization of the SOA, combined with organic mechanistic information, has provided evidence that the formation of organic aerosols from GLVs is closely related to the reactivity of their first generation atmospheric oxidation products, and indicates that this may be a simple parameter that could be used in assessing the aerosol formation potential for other unstudied organic compounds in the atmosphere.
Overexposure of radiation therapy patients in Panama: problem recognition and follow-up measures
Borrás,Cari;
Revista Panamericana de Salud Pública , 2006, DOI: 10.1590/S1020-49892006000800014
Abstract: this report summarizes and analyzes the responses of various organizations that provided assistance to the national oncology institute (instituto oncológico nacional, ion) of panama following the overexposure of 28 radiation therapy patients at the ion in late 2000 and early 2001. the report also looks at the long-term measures that were adopted at the ion in response to the overexposure incident, as well as implications that the incident has for other cancer treatment centers worldwide. in march 2001, the director of the ion was notified of serious overreactions in patients undergoing radiation therapy for cancer treatment. of the 478 patients treated for pelvic cancers between august 2000 and march 2001, 3 of them had died, possibly from an overdose of radiation. in response, the government of panama invited international experts to carry out a full investigation of the situation. medical physicists from the pan american health organization (paho) were among those invited. they ascertained that 56 patients treated with partially blocked teletherapy fields for cancers of the uterine cervix, endometrium, prostate, or rectum, had had their treatment times calculated using a computerized treatment planning system. paho's medical physicists calculated the absorbed doses received by the patients and found that, of these 56 patients, only 11 had been treated with acceptable errors of ±5%. the doses received by 28 of the 56 patients had errors ranging from +10 to +105%. these are the patients identified by ion physicists as overexposed. twenty-three of the 28 overexposed patients had died by september 2005, with at least 18 of the deaths being from radiation effects, mostly rectal complications. the clinical, psychological, and legal consequences of the overexposures crippled cancer treatments in panama and prompted paho to assess radiation oncology practices in the countries of latin american and the caribbean. ion clinicians evaluated the outcome of 125 non-overexposed
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