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Search Results: 1 - 10 of 219545 matches for " C.; Alberio "
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Education and social inequalities in the urban space: A French example
Marco Alberio
Interventions économiques , 2012,
Abstract: Cet article traite de la relation entre l'éducation et les inégalités au niveau local. Nous allons observer comment l'éducation, à c té de son r le fondamental pour la mobilité sociale, peut aussi être un élément décisif pour la reproduction sociale.Notre point de départ est que les modes de reproduction sociale ont changé au cours des années et pour cette raison, différemment que dans le passé, les mécanismes impliqués sont moins clairs et évidents. Dans cette perspective, l'objectif principal et le défi de cet article est de décrire, à travers une approche qualitative, certains des mécanismes de reproduction sociale des inégalités, qui se déroulent à travers l'éducation en France au niveau local. This article deals with the relationship between education and inequalities at the local level. We will observe how education, next to its role in social mobility, can also be a decisive element of social reproduction.Our starting point is that the modes of social reproduction have changed during the years and for this reason, compared to the past, some of the mechanisms involved are less clear and evident. In this perspective, the main objective and challenge of this article is to outline, through a qualitative approach, some of the mechanisms of social reproduction of inequalities, taking place through education in France at the local level.
Destete precoz y desempe?o reproductivo en vacas tratadas con progesterona intravaginal
Vittone,J.S; Aller,J.F.; Otero,G.; Scena,C.; Alberio,R.H.; Cano,A.;
Archivos de Zootecnia , 2011,
Abstract: the objective of the present study was to determine the effect of early weaning time on the ovulation characteristics and the reproductive efficiency of treated beef cows with an intravaginal progesterone device (div). two experiments were performed utilizing hereford and polled hereford cows. exp. 1: 38 low body condition score cows (bcs; 3.3±0.8, mean±sd, range from 1 to 9) with 57.5±8.8 days postpartum and exp. 2: 35 high bcs (5.4±0.9) cows with 57.5±15.9 days postpartum. on day 0, all cows received an div containing 0.5 g progesterone plus 2 mg of estradiol benzoate i.m. (eb). on day 8, the div was removed and 500 ìg cloprostenol was injected i.m., followed by administration of 1 mg of eb i.m. 24 h later. animals were assigned randomly to each of four treatments:t1) early weaning at 10 days before the div insertion; t2) early weaning the day of the div insertion; t3) early weaning the day of withdrawal div and t4) no early weaning, calves were left with their respective mothers throughout the study period. all cows were fixed-time artificially inseminated 56 h after the div removal. in exp. 1 and 2, follicular dynamics, time and distribution of the ovulation and pregnancy were evaluated by means of transrectal ultrasonography. plasma progesterone concentrations were determined to evaluate the functionality and lifespan of the corpus luteum generated by the induced ovulation. at the time of the div removal, the dominant follicle diameter was larger (p<0.05) in t2 (11.2±2.5 mm) than t3 (7.3±2.0 mm) in cows with low bcs (exp. 1), but did not differ with t1 and t4 (10.3±2.4 and 8.2±2.8, respectively). the t1 and t2 treatments presented a higher (p<0.05) ovulation rate than t3 and t4 (77.8; 88.9; 40 and 40% respectively). pregnancy rate was higher in t2 (77.8%) than in the rest of treatments (t1= 55.6%, t4= 30%, t4= 20%). in exp. 2, no differences were found among treatments for all the evaluated parameters. in non-pregnant cows the corpus luteum had a normal lifespa
Catastrophic Complications of Intravenous Line Flushing with Unfractionated Heparin  [PDF]
Giuseppe Colucci, Maximilian Jahns, Tobias Silzle, Lorenzo Alberio
International Journal of Clinical Medicine (IJCM) , 2012, DOI: 10.4236/ijcm.2012.31007
Abstract: Heparin-induced thrombocytopenia (HIT) is a clinicopathologic syndrome because diagnosis is based on both clinical symptoms and laboratory data. We report a patient with multiple thromboembolic complications after daily flushing of intravenous line with small amounts of unfractionated heparin (UFH). At day 7 bilateral hemorrhagic infarction of the adrenal glands was misdiagnosed as adrenal adenoma. On day 10 thrombocytopenia was noted and the next day a myocardial infarction complicated by a left ventricular thrombus was diagnosed. On day 12, HIT was suspected. The pre-test probability for HIT according to the 4T-score was high (8/8 points) and detection of antibodies directed against the PF4/heparin-complex by particle gel immunoassay (Titer 1:1024) and ELISA (O.D. 2.784) was strongly positive. HIT can be induced by iv-line flushes with UFH. Arterial and venous thrombotic complications can be present before a clear platelet drop can be recognised.
Control reproductivo en vacas de cría mediante progesterona vaginal: Efecto de varios factores sobre la fertilidad
Archivos de medicina veterinaria , 1997, DOI: 10.4067/S0301-732X1997000100007
Abstract: a treatment based on progesterone impregnated vaginal sponges has been used to control breeding in suckled beef cows under grazing conditions. however, fertility has not always been satisfactory. the objective of this trial was to determine whether fertility of treated cows was affected by the following factors: parity and duration of treatment (exp. 1), presence of signs of oestrus at the moment of timed ai and duration of postpartum in anoestrus cows (exp. 2), the time for double timed ai and reduction to a single timed ai (exp. 3). spring-calved suckled angus cows 30 to 90 days (d) postpartum, in good body condition, were used. cows received 10 mg of oestradiol benzoate i.m. and a vaginal sponge containing 2 g of progesterone (esp treatment). exp. 1. parity (primiparous, n=53 vs multiparous, n=83) and duration of esp (8 d, n=72 vs 11 d, n=71) were evaluated. timed artificial inseminations were carried out 48 and 72 hs after sponge removal (ai-t). pregnancy rates at ai-t and accumulated after 30 days of ai (pregnancy rate at day 30 = pregnancy at ai-t and at return to oestrus) were determined. both factors did not interact (p 0.05). esp duration had no effect on pregnancy rate at ai-t and at day 30: 38 vs 42% and 56 vs 61%, 8 vs 11 d respectively (p 0.05). multiparous cows tended to present higher pregnancy rates at ai-t and at day 30: 39 vs 23% and 46 vs 28% (p < 0.1) multiparous vs primiparous respectively. exp. 2. anoestrus multiparous cows (n=124) were treated with esp during 11 d. procedures were similar to those in exp. 1. oestrous rate was 24% and it appeared between 36 and 48 hours after treatment. pregnancy rate at ai-t was 53 and 44% in oestrous cows and non oestrous cows (p 0.05) while pregnancy rate at day 30 was 64 and 60% respectively. in those cows in which exact parturition date was available no different pregnancy rate at ai-t was found when cows were treated between postpartum days 30 to 59 (n=15), 60 to 89 (n=28) or 90 to 145 (n=20): 57, 55.3 an
Modulation of Pluripotency in the Porcine Embryo and iPS Cells
Aida Rodríguez, Cinzia Allegrucci, Ramiro Alberio
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0049079
Abstract: The establishment of the pluripotent ICM during early mammalian development is characterized by the differential expression of the transcription factors NANOG and GATA4/6, indicative of the epiblast and hypoblast, respectively. Differences in the mechanisms regulating the segregation of these lineages have been reported in many species, however little is known about this process in the porcine embryo. The aim of this study was to investigate the signalling pathways participating in the formation of the porcine ICM, and to establish whether their modulation can be used to increase the developmental potential of pluripotent cells. We show that blocking MEK signalling enhances the proportion of NANOG expressing cells in the ICM, but does not prevent the segregation of GATA-4 cells. Interestingly, inhibition of FGF signalling does not alter the segregation of NANOG and GATA-4 cells, but affects the number of ICM cells. This indicates that FGF signalling participates in the formation of the founders of the ICM. Inhibition of MEK signalling combined with GSK3β inhibition and LIF supplementation was used to modulate pluripotency in porcine iPS (piPS) cells. We demonstrate that under these stringent culture conditions piPS cells acquire features of naive pluripotency, characterized by the expression of STELLA and REX1, and increased in vitro germline differentiation capacity. We propose that small molecule inhibitors can be used to increase the homogeneity of induced pluripotent stem cell cultures. These improved culture conditions will pave the way for the generation of germline competent stem cells in this species.
Citrate- vs. acetate-based dialysate in bicarbonate haemodialysis: consequences on haemodynamics, coagulation, acid-base status, and electrolytes
Luca Gabutti, Barbara Lucchini, Claudio Marone, Lorenzo Alberio, Michel Burnier
BMC Nephrology , 2009, DOI: 10.1186/1471-2369-10-7
Abstract: In 25 patients who underwent a total of 375 dialysis sessions, an acetate dialysate (A) was compared with a citrate dialysate with (C+) or without (C) calcium supplementation (0.25 mmol/L) in a randomised single-blind cross-over study. Systemic haemodynamics were evaluated using pulse-wave analysis. Coagulation, acid-base status, calcium balance and dialysis efficiency were assessed using standard biochemical markers.Patients receiving the citrate dialysate had significantly lower systolic blood pressure (BP) (-4.3 mmHg, p < 0.01) and peripheral resistances (PR) (-51 dyne.sec.cm-5, p < 0.001) while stroke volume was not increased. In hypertensive patients there was a substantial reduction in BP (-7.8 mmHg, p < 0.01). With the C+ dialysate the BP gap was less pronounced but the reduction in PR was even greater (-226 dyne.sec.cm-5, p < 0.001). Analyses of the fluctuations in PR and of subjective tolerance suggested improved haemodynamic stability with the citrate dialysate. Furthermore, an increase in pre-dialysis bicarbonate and a decrease in pre-dialysis BUN, post-dialysis phosphate and ionised calcium were noted. Systemic coagulation activation was not influenced by citrate.The positive impact on dialysis efficiency, acid-base status and haemodynamics, as well as the subjective tolerance, together indicate that citrate dialysate can significantly contribute to improving haemodialysis in selected patients.ClinicalTrials.gov NCT00718289A concentrate acidified with citric acid instead of the less physiologic acetic acid has been successfully implemented in the United States for bicarbonate haemodialysis over the past 7 years [1-3]. In contrast to traditional regional citrate anticoagulation, the small amount of citrate used in the acid concentrate (0.8 mmol/L; only about one-fifth of the concentration necessary to achieve anticoagulation [1,4,5]) affects the calcium concentration and the locally enhanced coagulation activation in a limited way, resulting in approximat
Epigenetic reprogramming in the porcine germ line
Sara MW Hyldig, Nicola Croxall, David A Contreras, Preben D Thomsen, Ramiro Alberio
BMC Developmental Biology , 2011, DOI: 10.1186/1471-213x-11-42
Abstract: We regret any inconvenience that this might have caused.
Epigenetic reprogramming in the porcine germ line
Sara MW Hyldig, Nicola Croxall, David A Contreras, Preben D Thomsen, Ramiro Alberio
BMC Developmental Biology , 2011, DOI: 10.1186/1471-213x-11-11
Abstract: Our results show loss of DNA methylation in PGC colonizing the genital ridges. Analysis of IGF2-H19 regulatory region showed a gradual demethylation between E22-E42. In contrast, DMR2 of IGF2R was already demethylated in male PGC by E22. In females, IGF2R demethylation was delayed until E29-31, and was de novo methylated by E42. DNA repeats were gradually demethylated from E25 to E29-31, and became de novo methylated by E42. Analysis of histone marks showed strong H3K27me3 staining in migratory PGC between E15 and E21. In contrast, H3K9me2 signal was low in PGC by E15 and completely erased by E21. Cell cycle analysis of gonadal PGC (E22-31) showed a typical pattern of cycling cells, however, migrating PGC (E17) showed an increased proportion of cells in G2.Our study demonstrates that epigenetic reprogramming occurs in pig migratory and gonadal PGC, and establishes the window of time for the occurrence of these events. Reprogramming of histone H3K9me2 and H3K27me3 detected between E15-E21 precedes the dynamic DNA demethylation at imprinted loci and DNA repeats between E22-E42. Our findings demonstrate that major epigenetic reprogramming in the pig germ line follows the overall dynamics shown in mice, suggesting that epigenetic reprogramming of germ cells is conserved in mammals. A better understanding of the sequential reprogramming of PGC in the pig will facilitate the derivation of embryonic germ cells in this species.Primordial germ cells derived from the epiblast of pre-gastrulating embryos are the founder population of the future gametes. A unique attribute of PGC is the acquisition of totipotency, which is required for the generation of a new organism. Extensive epigenetic reprogramming of PGC underlies the capacity of these cells for acquiring totipotency [1,2]. Genome-wide DNA demethylation in mouse PGC results in the complete erasure of methylation marks in single-copy and imprinted genes, and a moderate reduction in retrotransposons and other repetitive ele
Control de la dinámica folicular ovárica en llamas (Lama glama) en posparto temprano
Cancino,A.K.; Aller,J.F.; Rebuffi,G.; Alberio,R.H.;
Archivos de Zootecnia , 2011,
Abstract: the effect of treatment with medroxiprogesterone acetate (mpa, intravaginal sponge) combined with or without injection of estradiol benzoate (eb) on the patterns of follicular regression, follicular wave emergence and ovulation rate in early postpartum and non-lactating llamas was evaluated. this work was carried out at the experimental station of altitude inta abra pampa (3484 m above sea level). a total of 48 adult females were categorized as lactating (n= 24; 30±4 d postpartum, mean±sd) or non-lactating (n= 24). each one was distributed according to the follicular phase (fp= growing, static or regressing) of dominant follicle (df1) determined by daily ovarian ultrasonography from 3 days before treatment. at day 0, intravaginal sponge (150 mg mpa) was inserted to all llamas for 8 days plus 5 mg mpa (im). half of the females randomly received 2 mg of eb (im). the ovarian response was monitored daily by ultrasonography from day 0 to day 14. at day 12, females having a new dominant follicle >6 mm (df2) were treated with gnrh (8 μg, im) to induce ovulation. blood samples were collected to determine plasma estradiol-17β (from day 0 to day 8) and progesterone (day 14) concentrations to confirm ovulation. factorial design 2 x 2 x 3 (lactational status, treatment with or without eb and follicular phases) was used. there was lactational status by fp interaction on the regression patterns of df1 attributed to greater duration in non-lactating females (6.0 days) than for lactating females (3.5 days) in the follicular static phase. the day (mean±sem) of follicular wave emergence was different (p<0.05) between treatments (with eb= day 6.5±0.6 vs. without eb= day 4.5±0.5). at day 12, the df2 diameter (mean±sem) was affected (p<0.05) by the treatment (with eb= 6.4±0.3 mm vs. without eb= 8.2±0.3 mm) and the lactational status (nonlactating= 8.0±0.4 mm vs. lactating= 6.6±0.3 mm). the total ovulation rate (females with ovulation/ treated females) in eb-treated females (45.8%) was l
Producción in vitro de embriones bovinos: suplementación de los medios de cultivo con suero
Mucci,N; Aller,J F; Kaiser,G G; Hozbor,F; Alberio,R H;
Archivos de medicina veterinaria , 2006, DOI: 10.4067/S0301-732X2006000200002
Abstract: techniques for producing bovine preimplantation embryos by in vitro maturation and fertilization, offers the potential for a large number of embryos at low cost to be used for basic scientific research (embryo development, transgenesis, cloning) or for commercial purposes. embryo culture conditions can influence in vitro embryo development significantly, provoking deviations responsible for low quality compared with in vivo counterparts. in particular, serum supplementation alters both embryo morphology and quality and eliminating serum from the media could be beneficial to produce good quality embryos for cryopreservation and embryo transfer. the objectives of this review are to describe the general aspects of in vitro embryo culture and summerize some hypotheses about the way serum could alter embryo development and quality.
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