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Search Results: 1 - 10 of 219733 matches for " C. Volpe "
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New treatment options in the management of hypertension: appraising the potential role of azilsartan medoxomil
Volpe M, Savoia C
Integrated Blood Pressure Control , 2012, DOI: http://dx.doi.org/10.2147/IBPC.S13784
Abstract: reatment options in the management of hypertension: appraising the potential role of azilsartan medoxomil Review (3825) Total Article Views Authors: Volpe M, Savoia C Published Date March 2012 Volume 2012:5 Pages 19 - 25 DOI: http://dx.doi.org/10.2147/IBPC.S13784 Received: 27 December 2011 Accepted: 17 February 2012 Published: 12 March 2012 Massimo Volpe1,2, Carmine Savoia1 1Division of Cardiology, Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Rome Italy; 2IRCCS Neuromed, Pozzilli (Is), Italy Abstract: Renin–angiotensin–system (RAS) activation plays a key role in the development of hypertension and cardiovascular disease. Drugs that antagonize the RAS (angiotensin-converting enzyme [ACE] inhibitors and angiotensin receptor blockers [ARBs]) have proven clinical efficacy in reducing blood pressure values and cardiovascular morbidity and mortality. ACE inhibitors partially inhibit plasma ACE, and angiotensin II generation. Thus, ARBs, which block selectively type 1 angiotensin II receptor (AT1R), have been developed and used in the clinical management of hypertension and cardiovascular disease. Experimental and clinical trials with ARBs indicate that this class of drug represents an effective, safe and well tolerated therapeutic option for the prevention and care of hypertension, even though there is no proven superiority as compared to ACE inhibitors except for the better tolerability. Most ARBs may not completely inhibit the AT1R at the approved clinical doses. Azilsartan medoxomil is a newly approved ARB for the management of hypertension. This ARB induces a potent and long-lasting antihypertensive effect and may have cardioprotective properties. This article reviews the current evidence on the clinical effectiveness of azilsartan in hypertension.
Neutrino beams as a probe of the nuclear isospin and spin-isospin excitations
Lazauskas, R.;Volpe, C.
High Energy Physics - Phenomenology , 2007, DOI: 10.1016/j.nuclphysa.2007.06.005
Abstract: We explore the possibility of performing nuclear structure studies using low energy neutrino beams. In particular, low energy beta-beams and conventional sources (muon decay-at-rest) are considered. We present results on the total charged-current as well as flux-averaged cross sections associated to electron (anti)-neutrino scattering on oxygen, iron, molybdenum and lead, as typical examples. It is shown that by using neutrinos from low energy beta-beams, information on forbidden states, in particular the spin-dipole, could be extracted.
New treatment options in the management of hypertension: appraising the potential role of azilsartan medoxomil
Volpe M,Savoia C
Integrated Blood Pressure Control , 2012,
Abstract: Massimo Volpe1,2, Carmine Savoia11Division of Cardiology, Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Rome Italy; 2IRCCS Neuromed, Pozzilli (Is), ItalyAbstract: Renin–angiotensin–system (RAS) activation plays a key role in the development of hypertension and cardiovascular disease. Drugs that antagonize the RAS (angiotensin-converting enzyme [ACE] inhibitors and angiotensin receptor blockers [ARBs]) have proven clinical efficacy in reducing blood pressure values and cardiovascular morbidity and mortality. ACE inhibitors partially inhibit plasma ACE, and angiotensin II generation. Thus, ARBs, which block selectively type 1 angiotensin II receptor (AT1R), have been developed and used in the clinical management of hypertension and cardiovascular disease. Experimental and clinical trials with ARBs indicate that this class of drug represents an effective, safe and well tolerated therapeutic option for the prevention and care of hypertension, even though there is no proven superiority as compared to ACE inhibitors except for the better tolerability. Most ARBs may not completely inhibit the AT1R at the approved clinical doses. Azilsartan medoxomil is a newly approved ARB for the management of hypertension. This ARB induces a potent and long-lasting antihypertensive effect and may have cardioprotective properties. This article reviews the current evidence on the clinical effectiveness of azilsartan in hypertension.Keywords: RAS, sartan, hypertension, cardiovascular protection
Low energy neutrino scattering measurements at future Spallation Source facilities
R. Lazauskas,C. Volpe
Physics , 2010, DOI: 10.1088/0954-3899/37/12/125101
Abstract: In the future several Spallation Source facilities will be available worldwide. Spallation Sources produce large amount of neutrinos from decay-at-rest muons and thus can be well adapted to accommodate state-of-the-art neutrino experiments. In this paper low energy neutrino scattering experiments that can be performed at such facilities are reviewed. Estimation of expected event rates are given for several nuclei, electrons and protons at a detector located close to the source. A neutrino program at Spallation Sources comprises neutrino-nucleus cross section measurements relevant for neutrino and core-collapse supernova physics, electroweak tests and lepton-flavor violation searches.
Supernova Relic Electron Neutrinos and anti-Neutrinos in future Large-scale Observatories
C. Volpe,J. Welzel
Physics , 2007,
Abstract: We investigate the signal from supernova relic neutrinos in future large scale observatories, such as MEMPHYS (UNO, Hyper-K), LENA and GLACIER, at present under study. We discuss that complementary information might be gained from the observation of supernova relic electron anti-neutrinos and neutrinos using the scattering on protons on one hand, and on nuclei such as oxygen, carbon or argon on the other hand. When determining the relic neutrino fluxes we also include, for the first time, the coupling of the neutrino magnetic moment to magnetic fields within the core-collapse supernova. We present numerical results on both the relic electron neutrino and anti-neutrino fluxes and on the number of events for electron neutrinos on carbon, oxygen and argon, as well as electron anti-neutrinos on protons, for various oscillation scenarios. The observation of supernova relic neutrinos might provide us with unique information on core-collapse supernova explosions, on the star formation history and on neutrino properties, that still remain unknown.
Charmonium production in relativistic proton-nucleus collisions : What will we learn from the negative x_F region ?
D. Koudela,C. Volpe
Physics , 2003, DOI: 10.1103/PhysRevC.69.054904
Abstract: We study the nuclear medium effects on the $c\bar{c}$ time evolution and charmonium production, in a relativistic proton-nucleus collision. In particular, we focus on the fragmentation region of the nucleus where the formation length of the charmonium mesons is shorter than the size of the nucleus. Little is known on the nuclear effects in this region. We use a quantum-mechanical model which includes a realistic potential for the $c\bar{c}$ system and an imaginary potential to describe the collisions of the $c\bar{c}$ with the nucleons. The imaginary potential introduces a transition amplitude among the charmonium states and produces an interference pattern on the charmonium survival probability, which is particulartly important for $\psi'$. Our results on the suppression factors are compared with data from the NA50 and E866/NuSea Collaborations. Predictions are given for the suppression of $J/\psi,~\psi',~\chi_c$ as a function of the nuclear mass and in the negative $x_F$ region, where data will be available soon.
The size of two-body weakly bound objects : short versus long range potentials
R. Lombard,C. Volpe
Physics , 2001, DOI: 10.1103/PhysRevLett.88.190402
Abstract: The variation of the size of two-body objects is investigated, as the separation energy approaches zero, with both long range potentials and short range potentials having a repulsive core. It is shown that long range potentials can also give rise to very extended systems. The asymptotic laws derived for states with angular momentum l=1,2 differ from the ones obtained with short range potentials. The sensitivity of the asymptotic laws on the shape and length of short range potentials defined by two and three parameters is studied. These ideas as well as the transition from the short to the long range regime for the l=0 case are illustrated using the Kratzer potential.
The bubble-universe and a physico-chemical analogy of the cosmological constant
C. Della Volpe
Physics , 2012,
Abstract: An analogy is developed between the bubble universe model and the Young-Laplace equation obtaining an analogic equation and commenting some numerical results produced by its application. The results, even if based on a simple analogy, appear quite intriguing and very close to the experimentally estimated or calculated values. Some conceptual and numerical limitations of such an analogic approach are also indicated.
Short versus long range interactions and the size of two-body weakly bound objects
R. J. Lombard,C. Volpe
Physics , 2003,
Abstract: Very weakly bound systems may manifest intriguing "universal" properties, independent of the specific interaction which keeps the system bound. An interesting example is given by relations between the size of the system and the separation energy, or scaling laws. So far, scaling laws have been investigated for short-range and long-range (repulsive) potentials. We report here on scaling laws for weakly bound two-body systems valid for a larger class of potentials, i.e. short-range potentials having a repulsive core and long-range attractive potentials. We emphasize analogies and differences between the short- and the long-range case. In particular, we show that the emergence of halos is a threshold phenomenon which can arise when the system is bound not only by short-range interactions but also by long-range ones, and this for any value of the orbital angular momentum $\ell$. These results enlarge the image of halo systems we are accustomed to.
On the asymmetry of Gamow-Teller beta-decay rates in mirror nuclei in relation with second-class currents
N. A. Smirnova,C. Volpe
Physics , 2002, DOI: 10.1016/S0375-9474(02)01392-1
Abstract: The theoretical evaluation of major nuclear structure effects on the asymmetry of allowed Gamow-Teller beta-decay rates in light mirror nuclei is presented. The calculations are performed within the shell model, using empirical isospin-nonconserving interaction and realistic Woods-Saxon radial wave functions. The revised treatment of p-shell nuclei is supplemented by systematic calculations for sd-shell nuclei and compared to experimental asymmetries when available. The results are important in connection with the possible existence of second-class currents in the weak interaction.
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