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Search Results: 1 - 10 of 219429 matches for " C. Nagesh "
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Subcutaneous fat necrosis of the newborn mimicking generalized lymphadenopathy
Pai Sanjay,Nagesh Karthik,Radhakrishnan C
Indian Journal of Dermatology, Venereology and Leprology , 2007,
Abstract:
FORMULATION AND EVALUATION OF CLARITHROMYCIN POORLY SOLUBLE DRUG AS MICROEMULSION
Rahul Sutar,Rajashree Masareddy,Nagesh C,Vijaya Joshi
International Research Journal of Pharmacy , 2011,
Abstract: Clarithromycin is well absorbed from the gastro intestinal tract, but its systemic bioavailability is 55% due to first pass metabolism. It undergoes rapid biodegradation to produce the microbiologically active 14-hydroxy metabolite. The design of the novel o/w microemulsion formulation, which enhances the oral bioavailability by raising the solubility of poorly water soluble clarithromycin was studied. Microemulsion were prepared by using oil phase (ethyl oleate and olive oil), diglyceryl monooleate (DGMO-C) lipophilic surfactant, polyoxyethylene 40 hydrogenated castor oil (HCO-40) hydrophilic surfactant, ethanol (co-surfactant), phosphate buffer solution (PBS) pH 6.8 as a aqueous phase and clarithromycin. Prepared formulations were evaluated for size, viscosity, zeta potential, drug content, in vitro release studies & in vivo studies. Average particle size of clarithromycin o/w microemulsion for F1 and F2 was 350-450 nm and 800-900 nm. Results of viscosity, exhibited a simple newtonian flow. Zeta potential of F1 indicates plateau of stability and no agglomerates & F2 o/w microemulsions which indicates plateau of slight stability and few agglomerates. Drug content of the F1 was more than F2 this may be because of increased solubility of drug in the oil (ethyl oleate). The release profile revealed that formulations F1 followed peppas model and F2 higuchi matrix model. The plasma concentration was more in formulation (F1) 47.03 g /mL then (F2) 31.10 g /mL. Hence F1 o/w microemulsion can be a useful formulation, which enhances the oral bioavailability by increasing the solubility of poorly water soluble drug clarithromycin.
SUSTAINED RELEASE DEVICE CONTAINING ORNIDAZOLE FOR PERIODONTITIS
M. Shankraiah,C. Nagesh.,J. S. Venkatesh,M. Lakshmi Narsu.
International Research Journal of Pharmacy , 2011,
Abstract: The purpose of this study was to develop a sustained release device containing ornidazole for insertion within periodontal pockets. Cast films of ethyl cellulose with dibutyl phthalate as plasticizer, containing ornidazole were prepared. The films were evaluated for thickness, folding endurance, weight variation, content uniformity, tensile strength and in vitro antibacterial activity. In vitro release of ornidazole from the film was measured using UV spectrophotometer. The release data obtained were subjected for release kinetics study. The study revealed that drug release was found to be diffusion controlled with sustained release of ornidazole over a period of nine days within the periodontal pocket.
Prevalence & Prescription: Prescribing Practices of Clozapine in Australia between 2005 & 2010
Shae-Leigh C. Vella,Nagesh B. Pai
Online Journal of Health & Allied Sciences , 2012,
Abstract: Clozapine is an anti-psychotic used to treat refractory schizophrenia. This study reviews the rates of clozapine prescription for refractory schizophrenia in a region of Australia and compares the prescribing patterns to the estimated prevalence rates of refractory schizophrenia in the region. Utilising a pharmacoepidemiological approach; the results indicated that only 8.4% of the individuals estimated to be suffering from refractory schizophrenia in the region were prescribed clozapine between 2005 and 2010, with only 4.1% continuing clozapine to the conclusion of the study. In conclusion it is evident that clozapine is widely under-prescribed in this area of Australia.
Psychosocial and Biological Factors Contributing to Body Weight Gain in Schizophrenia
Shae-Leigh C. Vella,Nagesh B. Pai
Online Journal of Health & Allied Sciences , 2011,
Abstract: Overweight and obesity are frequently reported to be a significant issue in schizophrenia resulting in the inherent complications of these disorders. Body weight gain also commonly results from treatment with the most tolerable and efficacious pharmacological treatments, second-generation antipsychotics. However there are numerous other factors that contribute to increased body mass in individuals with schizophrenia prior to the initiation of treatment. With prior research indicating that individuals with schizophrenia have higher rates of overweight and obesity before treatment. Therefore this article provides a review of pertinent issues associated with body weight gain in schizophrenia in an attempt to delineate the impact of both the disease and treatment upon body weight gain. The results of the review indicate that body weight gain in schizophrenia occurs from both psychosocial and biological factors that are further compounded by antipsychotic treatment. The article concludes with recommendations for future research.
A Qualitative Analysis of Medical Students Views of Their First Psychiatry Rotation
Nagesh B. Pai,Shae-Leigh C. Vella,Kerry Dawes
Online Journal of Health & Allied Sciences , 2012,
Abstract: Objective: The importance of student’s perspectives in informing curricula and pedagogy has long been recognised. However, student’s perspectives are rarely reported in the academic literature. Therefore this study explores and reports on medical student’s perspectives of their first psychiatry clinical rotation in a ‘new’ era medical school in Australia. Method: Seventy-three graduate entry medical students completed a semi-structured questionnaire about their experiences during a mental health rotation. The responses were analysed and coded into thematic categories. Results: The following thematic categories were evident; staff, breadth of experience, attitudes towards mental health, course materials and structure, and professional development. Conclusion: The results are discussed in the context of the current academic recommendations for the teaching of psychiatry and behavioural science to medical students. Although the use of student feedback is recommended by the literature, pragmatically it is rarely utilised and if it is utilised it is not reported in the academic literature. It is recommended that educators embrace the use of student’s perspectives to evaluate and inform their teaching.
Role of liquid membrane phenomenon in the anti-bacterial activity of Cefuroxime Sodium
C. Nagesh,M. M. Shankaraiah,J. S. Venkatesh
Journal of Basic and Clinical Pharmacy , 2010,
Abstract: The role of liquid membrane phenomenon has been studied in the anti bacterial activity of cephalosporins i.e. Cefuroxime sodium. In our earlier publication [1] it was reported that hydraulic permeability data obtained to demonstrate the existence of liquid membrane in series with supporting membrane generated by Cefuroxime sodium. Transport of selected permeants (glucose, PABA, glycine, and ions like Mg++, NH4+, PO4-, Ca++, Na+, K+ and Cl-) through liquid membrane generated by Cefuroxime sodium in series with supporting membrane has been studied. The results indicated that the liquid membrane generated by Cefuroxime sodium inhibit the transport of various essential bio-molecules and permeants in to the cell. This modification in permeability of different permeants in the presence of the liquid membranes is likely to play significant role in the biological actions of Cefuroxime sodium. The anti-bacterial activity of Cefuroxime sodium further confirmed that the generation of liquid membrane by Cefuroxime sodium is also contributing for the antibacterial activity of them.
Distributed Cut Detection in Wireless Sensor Networks
K. R. Lokesh,C.Nagesh,P.Namratha
International Journal of Technological Exploration and Learning , 2013,
Abstract: A wireless sensor network consists of spatially distributed autonomous sensors to physical or environmental conditions, such as temperature, sound, pressure, etc. and to cooperatively pass their data through the network to main location. When the data transmission between one node to another, there is some of the nodes in the network are failed, because of above mentioned issues. So, the data will not be transferred to the destination. Because of these failures of nodes the network is divided into multiple parts. The ability to detect the cuts by using the source node and disconnected node of a wireless sensor network will lead to the increase in the lifetime of network. The Distributed Cut Detection (DCD) algorithm proposed here enables every node of wireless sensor network to detect Disconnected from Source events if they occur. Second, it enables a subset of nodes that experience CCOS events to detect them and find the approximate location of the cut in the form of a list of active nodes that lie at the boundary of the cut. The advantage of DCD algorithm is that convergence rate of the iterative scheme is quite fast and independent of the size and structure of network.
Shear-Controlled Gold Mineralization of G. R. Halli Area of Chitradurga Schist Belt, Dharwar Craton: Insights from Fluid Inclusion Study  [PDF]
Govindappa Gopalakrishna, Mohamed Shareef, Poorigali Chowdaiah Nagesh
Open Journal of Geology (OJG) , 2018, DOI: 10.4236/ojg.2018.87039
Abstract: Gold mineralization at G. R. Halli is located along the Central shear zone of Chitradurga schist belt, extending from west of Gonur, through east of G. R. Halli and C. K. Halli to east of Honnemardi, roughly parallel to stratigraphic units. The NNW-SSE trending shear zone has a width of 0.5 to 1.5 km shows extensive carbonatization of metabasalts and the associated lithologies confined to NNW-WNW trending arcuate brittle-ductile zone. The sheared and silicified contact zones between carbonaceous argillite and schistose metabasalt form the potential sites for localization of mineralization. The gold is associated with sulphides mainly pyrite, arsenopyrite, galena, sphalerite, minor chalcopyrite. Textural relationship indicates two stage sulphide mineral assemblages co-relatable with two stage fluid ascents having temperature of homogenization between 125°C and 256°C. It is a typical epigenetic lode gold system, which got affected by later deformation.
FORMULATION AND EVALUATION OF MATRIX TYPE TRANSDERMAL SYSTEM OF LISINOPRIL DIHYDRATE
Suchetha Reddy Aleti,Aman Kant,R.Nagendra Rao,Nagesh.C
International Research Journal of Pharmacy , 2011,
Abstract: Lisinopril is a drug of class angiotensin converting enzyme (ACE) inhibitor that is primarily used in treatment of hypertension, congestive heart failure, heart attacks and also in preventing renal and retinal complications of diabetes. If it is given orally, there may be severe hepatic first pass metabolism as a result there is reduction in the bioavailability (6-60%). In order to increase the bioavailability of the lisinopril, transdermal films were formulated using different polymer combinations such as hydrophilic (hydroxy propyl methyl cellulose: poly vinyl pyrrolidone) and combination of lipophillic- hydrophilic polymers (ethyl cellulose: poly vinyl pyrrolidone) in different ratios. The prepared films were evaluated for thickness, folding endurance, drug content uniformity, tensile strength, percent moisture uptake, percent moisture loss, in-vitro skin permeation study. In-vitro drug release study through sigma membrane indicated that hydrophilic polymer combinations have shown greater drug release than the hydrophilic-lipophillic polymer combinations. By fitting the data into zero order, first order and Higuchi model, it was concluded that drug release from matrix films followed Higuchi model and the mechanism of release was diffusion mediated.
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