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Search Results: 1 - 10 of 219572 matches for " C. Giganti "
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Effects of Dragon Boat Training on Cytokine Production and Oxidative Stress in Breast Cancer Patients: A Pilot Study  [PDF]
Ilaria Tresoldi, Calogero Foti, Laura Masuelli, Giovanni Vanni Frajese, Piero Rossi, Andrea Modesti, Roberto Bei, Maria Gabriella Giganti
Open Journal of Immunology (OJI) , 2014, DOI: 10.4236/oji.2014.41004
Abstract: Regular exercise improves physical function and quality of life and reduces fatigue in cancer survivors; these health benefits could be due to the anti-inflammatory effects of exercise. In this study we examined the effects of a whole-body exercise programme and dragon boat paddling on the production of reactive oxygen species (ROMs), antioxidant capacity (BAP) and the circulating levels of several interleukins in breast cancer patients. Thirty four women surgically treated for breast cancer were enrolled in this study: 20 of them usually row dragon boats recreationally while 14 were sedentary. The 16-week training programme consisted of resistance and aerobic exercise, with the addition of dragon boat paddling for the last 8 weeks. Analyses of ROMs, cytokines and BAP were performed before and after 16 weeks of training. Results show a significant decrease in the ROMs value and significantly increased the BAP, IL-6, IL-8 and IL-15 levels. Exercise increased the BAP, IL-6, IL-8 and IL-15 values in the N+ patients, whereas only IL-6 and IL-8 were higher in the N0 patients. We demonstrated that muscle-derived cytokines are released after a training program and that the resulting decreased oxidative stress conditions underline the health-benefiting effects of such activity on breast cancer patients.
Lepidópteros de los bosques nativos del Departamento Aluminé (Neuquén-Argentina): II Contribución
DAPOTO,GRACIELA; GIGANTI,HUMBERTO; GENTILI,MARIO; BONDONI,MARIANO;
Bosque (Valdivia) , 2003, DOI: 10.4067/S0717-92002003000100008
Abstract: the pehuén district is in the sub-antarctic forests of argentina, between 37o 48? s and 40o s, and varies greatly in distance from its border with chile in the east. the area of moquehue represents the climax communities in this district. the presence of the dominant species, araucaria araucana (mol.) koch (araucariaceae), nothofagus dombeyi (mirb.) oerst, n. pumilio (poepp. et endl.) krasser, and n. antarctica (forst. f.) oerst (fagaceae) is their main characteristic. the entomofauna and its relationships with the flora of this area have been studied for several years. this is the second paper describing the lepidoptera of this area. the insect species detailed here are from 14 families, and four of these are recorded for the first time. forty-one species, not previously found in the area, are recorded here for first time, together with novel phenomena for 32 other species relating to collection and flight times, locations, and hosts. of the newly recorded species, 24 are associated with nothofagus species, 13 with other indigenous woody species, eight with exotic woody species, 22 with native herbaceous plants, seven are polyphagous, and the relationships of 22 species are still unknown. two species are associated with a. araucana, the first to be identified since observations began. the presence of ormiscodes schmidtnielseni lemaire (saturniidae) is reported for the first time in argentina.
Primer registro de Hypercompe indecisa (Lepidoptera: Noctuidae: Arctiinae) en perales y álamos en la Patagonia
Dapoto,Graciela; Giganti,Humberto; Bondoni,Mariano; Olave,Anabel;
Revista de la Sociedad Entomol?3gica Argentina , 2010,
Abstract: the alto valle of río negro and neuquén is the main production zone of pomme fruits from argentina. the main pest is cydia pomonella l. (lepidoptera: tortricidae). changes operated in control strategies in the last years have brought changes in the biodiversity of fruit orchards. during the season 2008/09, hypercompe indecisa (walker) (lepidoptera: noctuidae) was detected in a fruit establishment of vista alegre (neuquén) under organic production causing serious damages on fruits and leaves of pear trees and in the leaves of populus spp. hypercompe indecisa is reported for the first time in patagonia and is the first record of this species on populus spp.and pyrus communis l.
Primer registro de Hypercompe indecisa (Lepidoptera: Noctuidae: Arctiinae) en perales y álamos en la Patagonia First record of Hypercompe indecisa (Lepidoptera: Noctuidae: Arctiinae) on pear trees and poplars in Patagonia
Graciela Dapoto,Humberto Giganti,Mariano Bondoni,Anabel Olave
Revista de la Sociedad Entomol?3gica Argentina , 2010,
Abstract: La región del Alto Valle de Río Negro y Neuquén es la zona más importante de producción de frutas de pepita de la Argentina. La principal plaga de estos cultivos es Cydia pomonella L. (Lepidoptera:Tortricidae). Los cambios implementados en las estrategias de control, principalmente la generalización del uso de la Técnica de Confusión Sexual, han causado en los últimos a os cambios en la biodiversidad en esos cultivos. Durante la temporada 2008/09, en un establecimiento frutícola de producción orgánica en Vista Alegre (Neuquén), fue detectada Hypercompe indecisa (Walker) (Lepidoptera: Noctuidae), produciendo graves da os en frutos y hojas de perales y sobre el follaje de Populus spp. Se cita por primera vez H. indecisa para la Patagonia y el primer hallazgo de esta especie sobre Populus spp. y Pyrus communis L. The Alto Valle of Río Negro and Neuquén is the main production zone of pomme fruits from Argentina. The main pest is Cydia pomonella L. (Lepidoptera: Tortricidae). Changes operated in control strategies in the last years have brought changes in the biodiversity of fruit orchards. During the season 2008/09, Hypercompe indecisa (Walker) (Lepidoptera: Noctuidae) was detected in a fruit establishment of Vista Alegre (Neuquén) under organic production causing serious damages on fruits and leaves of pear trees and in the leaves of Populus spp. Hypercompe indecisa is reported for the first time in Patagonia and is the first record of this species on Populus spp.and Pyrus communis L.
Lepidópteros de los bosques nativos del Departamento Aluminé (Neuquén-Argentina): II Contribución Lepidoptera of the Native Forests in the Department of Aluminé (Neuquén-Argentina): 2nd Contribution
GRACIELA DAPOTO,HUMBERTO GIGANTI,MARIO GENTILI,MARIANO BONDONI
Bosque (Valdivia) , 2003,
Abstract: El Distrito del Pehuén se encuentra en los Bosques Subantárticos de la Argentina, entre los 37o 48’ S y 40o S, con un ancho muy variable desde el límite con Chile hacia el Este. El área de Moquehue presenta comunidades clímax de este distrito. Su característica principal es la presencia en forma dominante de Araucaria araucana (Mol.) C. Koch (Araucariaceae), Nothofagus dombeyi (Mirb.) Oerst, N. pumilio (Poepp. et Endl.) Krasser y N. antarctica (Forst. F.) Oerst (Fagaceae). Sobre esta área se está estudiando desde hace varios a os su entomofauna y sus relaciones con la flora. De las contribuciones realizadas, ésta es la segunda referida a Lepidóptera. Los insectos que se detallan se distribuyen en 14 familias, de las cuales cuatro se citan por primera vez. Se mencionan 41 especies no halladas anteriormente en el área así como novedades en relación a época de colecta y de vuelo, localizaciones y hospederos concernientes a otras 32 especies. De las nuevas especies registradas 24 están relacionadas con Nothofagus spp., 13 con otras le osas indígenas, 8 con le osas exóticas, 22 con herbáceas indígenas, 7 son polífagas y de 22 se desconocen todavía sus relaciones. Se encontraron 2 especies relacionadas con A. araucana, las primeras desde el inicio de las observaciones. Se cita por primera vez a Ormiscodes schmidtnielseni Lemaire (Saturniidae) para la Argentina. The Pehuén District is in the sub-Antarctic forests of Argentina, between 37o 48’ S and 40o S, and varies greatly in distance from its border with Chile in the east. The area of Moquehue represents the climax communities in this district. The presence of the dominant species, Araucaria araucana (Mol.) Koch (Araucariaceae), Nothofagus dombeyi (Mirb.) Oerst, N. pumilio (Poepp. et Endl.) Krasser, and N. antarctica (Forst. F.) Oerst (Fagaceae) is their main characteristic. The entomofauna and its relationships with the flora of this area have been studied for several years. This is the second paper describing the Lepidoptera of this area. The insect species detailed here are from 14 families, and four of these are recorded for the first time. Forty-one species, not previously found in the area, are recorded here for first time, together with novel phenomena for 32 other species relating to collection and flight times, locations, and hosts. Of the newly recorded species, 24 are associated with Nothofagus species, 13 with other indigenous woody species, eight with exotic woody species, 22 with native herbaceous plants, seven are polyphagous, and the relationships of 22 species are still unknown. Two species
Solar neutrino detection in a large volume double-phase liquid argon experiment
D. Franco,C. Giganti,P. Agnes,L. Agostino,B. Bottino,S. Davini,S. De Cecco,A. Fan,G. Fiorillo,C. Galbiati,A. M. Goretti,E. V. Hungerford,Al. Ianni,An. Ianni,C. Jollet,L. Marini,C. J. Martoff,A. Meregaglia,L. Pagani,M. Pallavicini,E. Pantic,A. Pocar,A. L. Renshaw,B. Rossi,N. Rossi,Y. Suvorov,G. Testera,A. Tonazzo,H. Wang,S. Zavatarelli
Physics , 2015,
Abstract: The direct search for dark matter WIMP particles through their interaction with nuclei at the "neutrino floor" sensitivity, where neutrino-induced coherent scattering on nuclei starts contributing to the background, requires detectors capable of collecting exposures of the order of 1~ktonne yr free of background resulting from beta and gamma decays and cosmogenic and radiogenic neutrons. The same constraints are required for precision measurements of solar neutrinos elastically scattering on electrons. Two-phase liquid argon time projection chambers (LAr TPCs) are prime candidates for the ambitious program to explore the nature of dark matter. The large target, high scintillation light yield and good spatial resolution in all three cartesian directions concurrently allows a high precision measurement of solar neutrino fluxes. We studied the cosmogenic and radiogenic backgrounds affecting solar neutrino detection in a 300 tonne (100 tonne fiducial) LAr TPC operating at LNGS depth (3,800 meters of water equivalent). Such a detector could measure the CNO neutrino rate with 5 sigma sensitivity, and significantly improve the precision of the 7Be and pep neutrino rates compared to the currently available results from the Borexino organic liquid scintillator detector. Measurements with ~2%, ~10% and ~15% precision for 7Be, pep, and CNO neutrinos, respectively, are possible.
Strengthening Health Systems at Facility-Level: Feasibility of Integrating Antiretroviral Therapy into Primary Health Care Services in Lusaka, Zambia
Stephanie M. Topp,Julien M. Chipukuma,Mark Giganti,Linah K. Mwango,Like M. Chiko,Bushimbwa Tambatamba-Chapula,Chibesa S. Wamulume,Stewart Reid
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0011522
Abstract: HIV care and treatment services are primarily delivered in vertical antiretroviral (ART) clinics in sub-Saharan Africa but there have been concerns over the impact on existing primary health care services. This paper presents results from a feasibility study of a fully integrated model of HIV and non-HIV outpatient services in two urban Lusaka clinics.
Calidad de atención en pacientes diabéticos bajo tratamiento farmacológico
Lombra?a,María A.; Capetta,María E.; Ugarte,Alejandro; Correa,Viviana; Giganti,Jorge; López Saubidet,Cristian; Stryjewski,Martín E.;
Medicina (Buenos Aires) , 2007,
Abstract: diabetes mellitus is a chronic disease with an increasing prevalence. appropriate treatment of the disease and prevention of chronic complications reduce morbidity and mortality in a cost-effective manner. these actions should be measured through the use of validated indicators for quality of care. the goal of this study was to assess the quality of care in diabetic patients under pharmacologic treatment in a private university hospital. a retrospective study was conducted in adult patients who bought insulin or oral hypoglycemic agents during a 3 month period; demographic and clinical data were obtained for 12 consecutive months following the buying period. the study included 305 adult patients; most were males (60%), with type 2 diabetes (95%), and using oral hipoglycemic agents (86%). control of blood pressure was registered in 80%, foot exam in 5%, eye exam in 27%, hba1c blood level in 85%, complete lipid profile in 82%, microalbuminuria in 27% and creatinine clearance in 22% of patients, respectively. mean values were hba1c 7.1(± 1.6)%, and ≤ 7% in 66%, ldl 113 (± 33.6) mg/dl and <100 mg/dl in 30%, bp 136-79 mm hg and < 130-80 mm hg in 46% of patients, respectively. this study emphasizes the need for quality of care assessment through validated indicators and points out the aspects that should be improved within a health care system.
Taking ART to Scale: Determinants of the Cost and Cost-Effectiveness of Antiretroviral Therapy in 45 Clinical Sites in Zambia
Elliot Marseille, Mark J. Giganti, Albert Mwango, Angela Chisembele-Taylor, Lloyd Mulenga, Mead Over, James G. Kahn, Jeffrey S. A. Stringer
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0051993
Abstract: Background We estimated the unit costs and cost-effectiveness of a government ART program in 45 sites in Zambia supported by the Centre for Infectious Disease Research Zambia (CIDRZ). Methods We estimated per person-year costs at the facility level, and support costs incurred above the facility level and used multiple regression to estimate variation in these costs. To estimate ART effectiveness, we compared mortality in this Zambian population to that of a cohort of rural Ugandan HIV patients receiving co-trimoxazole (CTX) prophylaxis. We used micro-costing techniques to estimate incremental unit costs, and calculated cost-effectiveness ratios with a computer model which projected results to 10 years. Results The program cost $69.7 million for 125,436 person-years of ART, or $556 per ART-year. Compared to CTX prophylaxis alone, the program averted 33.3 deaths or 244.5 disability adjusted life-years (DALYs) per 100 person-years of ART. In the base-case analysis, the net cost per DALY averted was $833 compared to CTX alone. More than two-thirds of the variation in average incremental total and on-site cost per patient-year of treatment is explained by eight determinants, including the complexity of the patient-case load, the degree of adherence among the patients, and institutional characteristics including, experience, scale, scope, setting and sector. Conclusions and Significance The 45 sites exhibited substantial variation in unit costs and cost-effectiveness and are in the mid-range of cost-effectiveness when compared to other ART programs studied in southern Africa. Early treatment initiation, large scale, and hospital setting, are associated with statistically significantly lower costs, while others (rural location, private sector) are associated with shifting cost from on- to off-site. This study shows that ART programs can be significantly less costly or more cost-effective when they exploit economies of scale and scope, and initiate patients at higher CD4 counts.
Influence of the Generator in-Growth Time on the Final Radiochemical Purity and Stability of Radiopharmaceuticals
L. Uccelli,A. Boschi,M. Pasquali,A. Duatti,G. Di Domenico,G. Pupillo,J. Esposito,M. Giganti,A. Taibi,M. Gambaccini
Science and Technology of Nuclear Installations , 2013, DOI: 10.1155/2013/379283
Abstract: At Legnaro laboratories of the Italian National Institute for Nuclear Physics (INFN), a feasibility study has started since 2011 related to accelerated-based direct production of by the 100Mo(p,2n) reaction. Both theoretical investigations and some recent preliminary irradiation tests on 100Mo-enriched samples have pointed out that both the / ratio and the specific activity will be basically different in the final accelerator-produced Tc with respect to generator-produced one, which might affect the radiopharmaceutical procedures. The aim of this work was to evaluate the possible impact of different / isomeric ratios on the preparation of different Tc-labeled pharmaceutical kits. A set of measurements with , eluted from a standard 99Mo/ generator, was performed, and results on both radiochemical purity and stability studies (following the standard quality control procedures) are reported for a set of widely used pharmaceuticals (i.e., -Sestamibi, -ECD, -MAG3, -DTPA, -MDP, -HMDP, -nanocolloids, and -DMSA). These pharmaceuticals have been all reconstituted with either the first [ O4]? eluate obtained from a 99Mo/ generator (coming from two different companies) or eluates after 24, 36, 48, and 72 hours from last elution. Results show that the radiochemical purity and stability of these radiopharmaceuticals were not affected up to the value of 11.84 for the / ratio. 1. Introduction 99mTc, with its peculiar physical-chemical properties, still continues to be the most important radionuclide used in diagnostic nuclear medical procedures. In particular, the developments of technetium chemistry have opened new perspectives in the field of diagnostic imaging [1]. More than 80% of the radiopharmaceuticals are currently labeled with this radionuclide [1] by reconstitution with sodium pertechnetate [2–4] [Na99mTcO4] commercial kits containing in lyophilized form the various reagents required for the preparation of each radiopharmaceutical. Its routine applications are ensured by the availability of portable 99Mo/99mTc generators in which 99Mo is bound as molybdate anion to alumina columns. Current global interruptions of 99Mo supply that involved uranium fission of highly enriched 235U targets, aging reactors, and the staggering costs of their maintenance, focused on the search for alternative method of the 99mTc production [5]. One of the possibilities is to replace the reactors with particle accelerators, aiming at a regional production and distribution. At Legnaro laboratories of the Italian National Institute for Nuclear Physics (INFN), a feasibility study
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