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Search Results: 1 - 10 of 215792 matches for " Byung L. Park "
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Characteristics of Eu2+, Dy3+-Doped SrAl2O4 Synthesized by Hydrothermal Reaction and Its Photocatalytic Properties  [PDF]
Byung-Geon Park
Journal of Materials Science and Chemical Engineering (MSCE) , 2018, DOI: 10.4236/msce.2018.62002
Abstract: Eu2+, Dy3+-doped SrAl2O4 was prepared by a hydrothermal reaction through the process of calcination at lower temperature. The physicochemical properties of the SrAl2O4: Eu2+, Dy3+ phosphor were characterized and compared to those of the SrAl2O4: Eu2+, Dy3+ prepared by sol-gel method. The photocatalytic properties of the SrAl2O4: Eu2+, Dy3+ were evaluated in photocatalytic water decomposition for hydrogen production. The SrAl2O4: Eu2+, Dy3+ prepared by hydrothermal reaction exhibited excellent phosphor properties which were similar with that prepared by sol-gel method. Its photocatalytic activity for hydrogen evolution was higher than that of TiO2 photocatalyst.
Effect of Oral Administration of Jerusalem Artichoke Inulin on Reducing Blood Lipid and Glucose in STZ-Induced Diabetic Rats
Park Byung-Sung
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2011.2501.2507
Abstract: This study was carried out to investigate the effect of inulin extracted from Jerusalem artichoke (Helianthus tuberosus) on decrease of blood lipids and blood glucose in STZ-induced diabetic rats. The oral administration of inulin decreased blood lipids and blood glucose, implying the utility of artichoke-extracted inulin as a bioactive material to prevent metabolic diseases related to blood lipids and blood glucose of humans. Twenty four white rats were completely randomly allocated into four treatment groups with six rat per group and inulin was orally administrated to them. The experimental treatment groups were divided into one Normal Control group (NC) and three diabetic groups. The diabetic groups consisted of DC (diabetic control group), DC 50 (diabetic control group+oral administration of inulin, 50 mg kg-1 body weight) and DC 100 (diabetic control group+oral administration of inulin, 100 mg kg-1 body weight). Concerning growth performance, in comparison with the DC group, daily weight gain in the inulin-administered rats increased and recovered to the normal level. The diet intake was significantly low in the inulin-administrated groups (p<0.05) while statistically significant difference in the dietary efficiency between the DC and the inulin-administrated groups and between NC and the inulin-administrated groups was not found. Blood glucose was significantly lowered in the inulin-administrated groups (p<0.05). Compared with DC, the decrease of blood glucose in the inulin-administrated groups was 60.73-63.4% in the 4th week and showed a tendency of gradual recovery. Triacylglycerides in the blood, total cholesterol, LDLC and atherogenic index were significantly decreased by 27.13-32.91, 22.42-23.31, 35.41-38.28 and 49.71-57.11%, respectively in the inulin-administrated groups compared to the DC group. Conversely, HDLC was significantly increased by 24.89-47.20% (p<0.05). The weights of liver, kidney and heart but not the spleen were significantly heavy in the DC group, compared with the inulin-administrated groups (p<0.05).
Influence of Dietary Vegetable Wasps with Fly Pupa on Gastrointestinal Tract Microflora, Carcass Characteristics and Growth Performance in Broiler Chickens
Park Byung-Sung
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2011.2930.2935
Abstract: This study evaluated the effects of the addition of different levels of VWFP (Vegetable Wasps with Fly Pupa) on the growth performance, carcass characteristics and gastrointestinal microorganism populations of broiler chickens. About 400 animals (Ross 308, 1 day old) with an average body weight of 45 g were sorted randomly into 4 treatment groups and 4 repetition groups of 25 animals each. The treatment groups were divided into a control group not fed with VWFP and treatment groups fed with VWFP 2.0, 3.5 and 5.0%. The feeding test lasted 5 weeks separated by the grower period (0-21 days) and the finisher period (22-35 days). Although, the broilers weight gain and feed efficiency were significantly higher in the VWFP 3.5% (p<0.05) group throughout the entirety of the test period, no statistically significant differences were noted between the control group and other treatment groups. Triglyceride in the blood, total cholesterol and LDL-C were significantly lower in the VWFP treatment groups than in the control group (p<0.05). The blood lipid reduction rate ranged from 5.32-10.63% for triglycerides from 9.23-2.62% for total cholesterol and from 44.67-53.81% for LDL-C in the VWFP treatment groups relative to the control group. The abdominal fat weight ratio was reduced significantly in the VWFP treatment groups (p<0.05) compared with the control group with a reduction rate range of 17.67-21.68%. Broiler carcass weight, carcass rate and breast muscle, skin and thigh muscle weights against carcass weight were significantly higher in the VWFP 3.5% treatment group and a statistically significant difference was noted between the control group and other treatment groups (p<0.05). Enteropathogenic E. coli and Salmonella were lower in the VWFP treatment groups than in the control group whereas the beneficial bacteria Bifidobacteria were significantly higher in the VWFP treatment groups than in the control group (p<0.05).
Polymyxin B Alleviates Angiotensin II-Induced Stress Fiber Formation and Cellular Hypertrophy  [PDF]
Kwang-Seok Oh, Jeong Hyun Lee, Byung Koo Oh, Jihye Mun, Byung Kil Park, Byung Ho Lee
Pharmacology & Pharmacy (PP) , 2014, DOI: 10.4236/pp.2014.59101

Polymyxin B is widely used antibiotic in the clinic for resistant Gram-negative infections. In addition, polymyxin B-immobilized hemoperfusion cartridge has been used for endotoxin removal therapy in patients with septic shock. The aim of this study was to investigate the anti-fibrotic and anti-cellular hypertrophic effects of polymyxin B, and further to explore its possible mechanism. Polymyxin B (3, 10 μM) significantly inhibited stress fiber formation induced by angiotensin II (Ang II) in rat heart-derived H9c2 cells. Furthermore, polymyxin B (1 - 10 μM) showed a potent inhibitory effect on Ang II-induced cellular hypertrophy in H9c2 cells. Under the mechanism study, the inhibitory activities of polymyxin B against kinases involved in cellular hypertrophy such as AKT1, CAMK, GRK5, GSK3β, MLCK, PKC, PKD2, AMPK, ROCK2, p70S6K, SGK1were evaluated. Polymyxin B possesses a potent G protein related kinase 5 (GKR5) inhibitory activity with IC50 value of 1.1 μM, and has an ATP non-competitive inhibitory mode. Taken together, these results indicate that polymyxin B alleviates Ang II-induced stress fiber formation and cellular hypertrophy, and propose that one mechanism underlying these effects involves inhibition of the GRK5 pathway.

Short Communication—A Novel Sample Preparation Method That Enables Ultrathin Sectioning of Urea-Formaldehyde Resin for Imaging by Transmission Electron Microscopy  [PDF]
Adya P. Singh, Arif Nuryawan, Byung- Dae Park
Microscopy Research (MR) , 2013, DOI: 10.4236/mr.2013.11001
Abstract: Urea-formaldehyde (UF) resin is widely used as an adhesive for the manufacture of a range of wood and fiber based products. Although the microstructure of this resin has been examined at high resolution by field-emission scanning electron microscopy and atomic force microscopy, transmission electron microscopy (TEM) has thus far not been used, perhaps because of difficulties in ultrathin sectioning this resin in cured (polymerized) state. In the technical note presented here, a novel sample preparation method is described which enabled us to examine the microstructural morphology of UF resin by transmission electron microscopy in ultrathin sections, revealing the presence of spherical particles within the resin. Our initial attempt to ultrathin section the resin directly was not successful as it was too brittle to trim blocks for sectioning. Then, we developed a sample preparation technique that involved impregnation ofPinus radiatawood tissues with the UF resin, and then embedding of resin impregnated wood tissues with Spurr’s low viscosity embedding medium, which has been widely employed in plant and wood ultrastructure work. The TEM images illustrated and the information on the microstructural morphology of the UF resin presented are based on this novel sample preparation approach.
Balancing false discovery and false negative rates in selection of differentially expressed genes in microarrays
Byung S Park, Motomi Mori
Open Access Bioinformatics , 2010, DOI: http://dx.doi.org/10.2147/OAB.S7181
Abstract: alancing false discovery and false negative rates in selection of differentially expressed genes in microarrays Methodology (3439) Total Article Views Authors: Byung S Park, Motomi Mori Published Date February 2010 Volume 2010:2 Pages 1 - 9 DOI: http://dx.doi.org/10.2147/OAB.S7181 Byung S Park1,2,3, Motomi Mori1,2,3 1Division of Biostatistics, Department of Public Health and Preventive Medicine, 2Biostatistics Shared Resource, Knight Cancer Institute, 3Biostatistics and Design Program, Oregon Clinical and Translational Science Institute, Oregon Health and Science University, Portland, OR, USA Abstract: Genome-wide mRNA expression profiling using microarrays is widely available today, yet analysis and interpretation of the resulting high dimensional data continue to be a challenge for biomedical scientists. In a typical microarray experiment, the number of biological samples is quite modest compared with the number of genes on a microarray, and a probability of falsely declaring differential expression is unacceptably high without any adjustment for multiple comparisons. However, a stringent multiple comparison procedure can lead to an unacceptably high false negative rate, potentially missing a large fraction of truly differentially expressed genes. In this paper we propose a new “balancing factor score” (BFS) method for identifying a set of differentially expressed genes. The BFS method combines a traditional P value criterion with any other informative factors (referred to as balancing factors) that may help to identify differentially expressed genes. We evaluate the performance of the BFS method when the observed fold change is used as a balancing factor in a simulation study and show that the BFS method can substantially reduce the false negative rate while maintaining a reasonable false discovery rate.
On the structure of braid groups on complexes
Byung Hee An,Hyo Won Park
Mathematics , 2015,
Abstract: We consider the braid groups $\mathbf{B}_n(X)$ on finite simplicial complexes $X$, which are generalizations of those on both manifolds and graphs that have been studied already by many authors. We figure out the relationships between geometric decompositions for $X$ and their effects on braid groups, and provide an algorithmic way to compute the group presentations for $\mathbf{B}_n(X)$ with the aid of them. As applications, we give complete criteria for both the surface embeddability and planarity for $X$, which are the torsion-freeness of the braid group $\mathbf{B}_n(X)$ and its abelianization $H_1(\mathbf{B}_n(X))$, respectively.
Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types
Seongwon Cha,Imhoi Koo,Byung L. Park,Sangkyun Jeong,Sun M. Choi,Kil S. Kim,Hyoung D. Shin,Jong Y. Kim
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1093/ecam/nep162
Abstract: Sasang constitutional medicine (SCM), a Korean tailored medicine, categorizes human beings into four types through states of physiological imbalances and responsiveness to herbal medicine. One SCM type susceptible to obesity seems sensitive to energy intake due to an imbalance toward preserving energy. Common variants of fat mass and obesity associated (FTO) and melanocortin 4 receptor (MC4R) genes have been associated with increased body mass index (BMI) by affecting energy intake. Here, we statistically examined the association of FTO and MC4R polymorphisms with BMI in two populations with 1370 Koreans before and after SCM typing, and with the lowering of BMI in 538 individuals who underwent a 1-month lifestyle intervention. The increased BMI replicated the association with FTO haplotypes (effect size ? 1.1 kg/m2) and MC4R variants (effect size ? 0.64 kg/m2). After the lifestyle intervention, the carriers of the haplotype represented by the minor allele of rs1075440 had a tendency to lose more waist-to-hip ratio (0.76%) than non-carriers. The constitutional discrepancy for the accumulation of body mass by the effects of FTO and/or MC4R variants seemed to reflect the physique differences shown in each group of SCM constitutional types. In conclusion, FTO and MC4R polymorphisms appear to play an important role in weight gain, while only FTO variants play a role in weight loss after lifestyle intervention. Different trends were observed among individuals of SCM types, especially for weight gain. Therefore, classification of individuals based on physiological imbalance would offer a good genetic stratification system in assessing the effects of obesity genes.
A high-throughput de novo sequencing approach for shotgun proteomics using high-resolution tandem mass spectrometry
Chongle Pan, Byung H Park, William H McDonald, Patricia A Carey, Jillian F Banfield, Nathan C VerBerkmoes, Robert L Hettich, Nagiza F Samatova
BMC Bioinformatics , 2010, DOI: 10.1186/1471-2105-11-118
Abstract: In this study, a new de novo sequencing algorithm, called Vonode, has been developed specifically for analysis of such high-resolution tandem mass spectra. To fully exploit the high mass accuracy of these spectra, a unique scoring system is proposed to evaluate sequence tags based primarily on mass accuracy information of fragment ions. Consensus sequence tags were inferred for 11,422 spectra with an average peptide length of 5.5 residues from a total of 40,297 input spectra acquired in a 24-hour proteomics measurement of Rhodopseudomonas palustris. The accuracy of inferred consensus sequence tags was 84%. According to our comparison, the performance of Vonode was shown to be superior to the PepNovo v2.0 algorithm, in terms of the number of de novo sequenced spectra and the sequencing accuracy.Here, we improved de novo sequencing performance by developing a new algorithm specifically for high-resolution tandem mass spectral data. The Vonode algorithm is freely available for download at http://compbio.ornl.gov/Vonode webcite.Tandem mass spectrometry (MS/MS) has become an important method for characterizing complex protein mixtures. Since the emergence of this high-throughput technology, two complementary data analysis approaches have been pursued: a database searching approach and a de novo sequencing approach. The former identifies peptide sequences from a protein database by matching their predicted tandem mass spectra to measured tandem mass spectra; whereas the latter infers partial or complete peptide sequences directly from measured tandem mass spectra. Due to its high identification accuracy and the rapid expansion of genomic sequence data, the database searching approach, enabled by popular algorithms such as Sequest [1] and Mascot [2], is routinely used in current proteomics workflows. In contrast, although many de novo algorithms have been developed [3-14], they have not been widely used in high-throughput proteomics workflows. A high-throughput de novo seq
HIV-1 Envelope Glycoprotein Resistance to Monoclonal Antibody 2G12 Is Subject-Specific and Context-Dependent in Macaques and Humans
Delphine C. Malherbe, Rogier W. Sanders, Marit J. van Gils, Byung Park, Michelle M. Gomes, Hanneke Schuitemaker, Susan Barnett, Nancy L. Haigwood
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0075277
Abstract: HIV-1 Envelope (Env) protein is the sole target of neutralizing antibodies (NAbs) that arise during infection to neutralize autologous variants. Under this immune pressure, HIV escape variants are continuously selected and over the course of infection Env becomes more neutralization resistant. Many common alterations are known to affect sensitivity to NAbs, including residues encoding potential N-linked glycosylation sites (PNGS). Knowledge of Env motifs associated with neutralization resistance is valuable for the design of an effective Env-based vaccine so we characterized Envs isolated longitudinally from a SHIVSF162P4 infected macaque for sensitivity to neutralizing monoclonal antibodies (MAbs) B12, 2G12, 4E10 and 2F5. The early Env, isolated from plasma at day 56 after infection, was the most sensitive and the late Env, from day 670, was the most resistant to MAbs. We identified four PNGS in these Envs that accumulated over time at positions 130, 139, 160 and 397. We determined that removal of these PNGS significantly increased neutralization sensitivity to 2G12, and conversely, we identified mutations by in silico analyses that contributed resistance to 2G12 neutralization. In order to expand our understanding of these PNGS, we analyzed Envs from clade B HIV-infected human subjects and identified additional glycan and amino acid changes that could affect neutralization by 2G12 in a context-dependent manner. Taken together, these in vitro and in silico analyses of clade B Envs revealed that 2G12 resistance is achieved by previously unrecognized PNGS substitutions in a context-dependent manner and by subject-specific pathways.
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