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Search Results: 1 - 10 of 21732 matches for " Bum-Soo Kim "
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Laparoscopic resection of an adrenal pseudocyst mimicking a retroperitoneal mucinous cystic neoplasm
Bum-Soo Kim, Sun-Hyung Joo, Sung-Il Choi, Jeong-Yoon Song
World Journal of Gastroenterology , 2009,
Abstract: Adrenal pseudocysts are rare cystic masses that arise within the adrenal gland and are usually non-functional and asymptomatic. Adrenal pseudocysts consist of a fibrous wall without a cellular lining. We report a patient with a 9 cm, left-sided suprarenal cystic mass who presented with abdominal discomfort of 2 years’ duration. A 38-year-old woman was referred to our service for evaluation of abdominal discomfort and gastrointestinal symptoms. Routine laboratory tests were within normal limits. An abdominal computed tomography scan showed a 9 cm × 8 cm × 8 cm well-defined cystic lesion displacing the left kidney. Magnetic resonance imaging showed a cystic lesion with low signal intensity on the T1-weighted image and high signal intensity on the T2-weighted image. A laparoscopic left adrenalectomy was performed to diagnose the lesion. The final pathology showed an adrenal pseudocyst without a cellular lining. The patient had no postoperative complications and she was discharged four days after surgery.
Treatment outcome of maxillary sinus cancer
Hye Sung Won,Sang Hoon Chun,Bum-soo Kim,So Ryoung Chung
Rare Tumors , 2009, DOI: 10.4081/rt.2009.e36
Abstract: The standard treatment in the early stage of maxillary sinus cancer is surgical resection followed by postoperative radiation therapy. However, for locally advanced maxillary sinus cancer, a multimodality treatment approach is strongly recommended to improve the survival rate and quality of life of the patient. We determined the treatment outcomes of induction chemotherapy, concurrent chemoradiation therapy, and surgical resection for locally advanced maxillary sinus cancer. Forty-four patients with locally advanced maxillary sinus cancer, who had been treated between January 1990 and April 2008 at Kangnam St. Mary's Hospital, were retrospectively analyzed. The objective response rates were 70%, 53%, and 57% in the intra-arterial induction chemotherapy, intravenous induction chemotherapy, and concurrent chemoradiation therapy groups, respectively. The orbital preservation rates were 83%, 100%, and 75% in the intra-arterial induction chemotherapy, intravenous induction chemotherapy, and surgical resection groups, respectively. In seven of nine patients in whom the orbit could be preserved after induction chemotherapy, the primary tumors were removed completely. However, although the orbits were preserved in three patients who underwent surgical resection as a primary treatment, all three cases were confirmed to be incomplete resections. We found that active induction chemotherapy for locally advanced cancer of the maxillary sinus increased the possibility of complete resection with orbital preservation as well as tumor down-staging.
Carcinoma in situ arising in a tubulovillous adenoma of the distal common bile duct: A case report
Bum-Soo Kim, Sun-Hyung Joo, Kwang-Ro Joo
World Journal of Gastroenterology , 2008,
Abstract: Tubulovillous adenomas are common in the colon and rectum, but are rare in the common bile duct. Biliary adenomas may produce obstructive jaundice, which can be easily confused with a malignant neoplasm or stone. We report a case of a carcinoma in situ arising in a tubulovillous adenoma of the distal common bile duct causing obstructive jaundice. A 55-year-old male presented with a 10-d history of pruritus and progressive jaundice. Abdominal sonography and computed tomography showed a mass in the distal common bile duct. Endoscopic retrograde cholangiopancreatography showed luminal narrowing of the bile duct due to a polypoid mass. Positron emission tomography demonstrated no abnormal uptake. It was thought that this mass was a malignant tumor, thus a pylorus-preserving panceaticoduodenectomy was performed. The final pathology showed a tubulovillous adenoma with carcinoma in situ of the distal common bile duct. At follow-up 8 mo later, endoscopy showed multiple polyps in the rectum, colon and stomach. The polyps were removed by endoscopic mucosal resection and shown to be tubular adenomas with high grade dysplasia. Biliary adenomas require careful follow-up for early detection of recurrence and malignant transformation.
Linear Detrending Subsequence Matching in Time-Series Databases
Myeong-Seon Gil,Yang-Sae Moon,Bum-Soo Kim
Computer Science , 2010, DOI: 10.1587/transinf.E94.D.917
Abstract: Each time-series has its own linear trend, the directionality of a timeseries, and removing the linear trend is crucial to get the more intuitive matching results. Supporting the linear detrending in subsequence matching is a challenging problem due to a huge number of possible subsequences. In this paper we define this problem the linear detrending subsequence matching and propose its efficient index-based solution. To this end, we first present a notion of LD-windows (LD means linear detrending), which is obtained as follows: we eliminate the linear trend from a subsequence rather than each window itself and obtain LD-windows by dividing the subsequence into windows. Using the LD-windows we then present a lower bounding theorem for the index-based matching solution and formally prove its correctness. Based on the lower bounding theorem, we next propose the index building and subsequence matching algorithms for linear detrending subsequence matching.We finally show the superiority of our index-based solution through extensive experiments.
The leukoaraiosis is more prevalent in the large artery atherosclerosis stroke subtype among Korean patients with ischemic stroke
Seung-Jae Lee, Joong-Seok Kim, Kwang-Soo Lee, Jae-Young An, Woojun Kim, Yeong-In Kim, Bum-Soo Kim, So-Lyung Jung
BMC Neurology , 2008, DOI: 10.1186/1471-2377-8-31
Abstract: There were 594 patients included in this study that were classified as large artery disease, lacune and cardioembolic stroke. For large-artery disease, the analysis focused on the intracranial or extracranial location of the stenosis, and the multiplicity of the stenotic lesions. Leukoaraiosis grading was performed according to the Atherosclerosis Risk in Communities Study.There was a significant association between leukoaraiosis and the stroke subtypes; the large-artery-disease group had a higher prevalence of leukoaraiosis than did the other groups (55.4% in the large-artery-disease group, 30.3% in the lacunar group and 14.3% in the cardioembolic group, P = 0.016 by chi-square test). On the multivariate linear regression analysis, age, the presence of hypertension, previous stroke and stroke subtype were independently associated with the presence of leukoaraiosis. In the sub analysis of the large-artery-disease group, the leukoaraiosis had a tendency to be more prevalent in the mixed and intracranial stenosis group than did the extracranial stenosis group (45.5% in the mixed group, 40.3% in the intracranial group and 26.9% in the extracranial group, P = 0.08 by chi-square test).The association of leukoaraiosis with large-artery disease in this study might be due to the relatively high prevalence of intracranial occlusive lesions in Korean stroke patients compared to other ethnic groups.The term leukoaraiosis (LA) refers to lesions of altered signal intensity on computed tomography (CT) and magnetic resonance imaging (MRI) in the periventricular and subcortical white matter. LA is found during the normal aging process, and in the patients with cerebrovascular disease. It also constitutes the core pathology of Binswanger's disease, a type of vascular dementia. The association of LA with lacunar infarcts rather than territorial infarcts is well documented [1-7]. However, most prior studies have been based on CT findings, not MRI, and reported from western countries.I
Predicting incident fatty liver using simple cardio-metabolic risk factors at baseline
Ki-Chul Sung, Bum-Soo Kim, Yong-Kyun Cho, Dong-il Park, Sookyoung Woo, Seonwoo Kim, Sarah H Wild, Christopher D Byrne
BMC Gastroenterology , 2012, DOI: 10.1186/1471-230x-12-84
Abstract: 2589 people with absence of fatty liver on ultrasound examination at baseline were re-examined after a mean of 4.4?years in a Korean occupational cohort study. Multi-variable logistic regression analyses were used to identify baseline factors that were independently associated with incident fatty liver at follow up. The diagnostic performance of thresholds of these baseline factors to identify people with incident fatty liver at follow-up was assessed using receiver operating characteristic (ROC) curves.430 incident cases of fatty liver were identified. Several factors were independently associated with incident fatty liver: increased triglyceride (per mmol/l increase) OR 1.378 [95%CIs 1.179, 1.611], p?<?0.0001; glucose (per mmol/l increase) OR 1.215 [95%CIs 1.042, 1.416], p?=?0.013; waist (per cm increase) OR 1.078 [95%CIs 1.057, 1.099], p?<?0.001; ALT (per IU/L increase) OR 1.009 [95%CIs 1.002, 1.017], p?=?0.016; and platelets (per 1x109/L increase) OR 1.004 [1.001, 1.006], p?=?0.001; were each independently associated with incident fatty liver. Binary thresholds of the five factors were applied and the area under the ROC curve for incident fatty liver was 0.75 (95%CI 0.72–0.78) for the combination of all five factors above these thresholds.Simple risk factors that overlap considerably with risk factors for type 2 diabetes allow identification of people at high risk of incident fatty liver at who use of hepatic imaging could be targeted.
Relationship between Insulin Resistance and Coronary Artery Calcium in Young Men and Women
Ki-Chul Sung, Jin-Ho Choi, Hyeon-Cheol Gwon, Seung-Hyuk Choi, Bum-Soo Kim, Hyon Joo Kwag, Sun H. Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0053316
Abstract: Background The gender disparity in cardiovascular disease (CVD) risk is greatest between young men and women. However, the causes of that are not fully understood. The objective of this study was to evaluate the relationship between insulin resistance and the presence of coronary artery calcium (CAC) to identify risk factors that may predispose young men and women to CVD. Methodology/Principal Findings Insulin resistance and CVD risk factors were examined in 8682 Korean men and 1829 women aged 30–45 years old. Insulin resistance was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR), and CAC was measured using computed tomography. Women were less likely to be insulin resistant (upper quartile of HOMA-IR, 18% vs. 27%, p<0.001) and had a lower prevalence of CAC (1.6% vs. 6.4%, p<0.001). Even when equally insulin resistant men and women were compared, women continued to have lower prevalence of CAC (3.1% vs. 7.2%, p = 0.004) and a more favorable CVD risk profile. Finally, after adjustment for traditional CVD risk factors, insulin resistance remained an independent predictor of CAC only in men (p = 0.03). Conclusions/Significance Young women have a lower risk for CVD and a lower CAC prevalence compared with men. This favorable CVD risk profile in women appears to occur regardless of insulin sensitivity. Unlike men, insulin resistance was not a predictor of CAC in women in this cohort. Therefore, insulin resistance has less impact on CVD risk and CAC in young women compared with men, and insulin resistance alone does not explain the gender disparity in CVD risk that is observed at an early age.
Crystal Structures of the Tetratricopeptide Repeat Domains of Kinesin Light Chains: Insight into Cargo Recognition Mechanisms
Haizhong Zhu, Han Youl Lee, Yufeng Tong, Bum-Soo Hong, Kyung-Phil Kim, Yang Shen, Kyung Jik Lim, Farrell Mackenzie, Wolfram Tempel, Hee-Won Park
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0033943
Abstract: Kinesin-1 transports various cargos along the axon by interacting with the cargos through its light chain subunit. Kinesin light chains (KLC) utilize its tetratricopeptide repeat (TPR) domain to interact with over 10 different cargos. Despite a high sequence identity between their TPR domains (87%), KLC1 and KLC2 isoforms exhibit differential binding properties towards some cargos. We determined the structures of human KLC1 and KLC2 tetratricopeptide repeat (TPR) domains using X-ray crystallography and investigated the different mechanisms by which KLCs interact with their cargos. Using isothermal titration calorimetry, we attributed the specific interaction between KLC1 and JNK-interacting protein 1 (JIP1) cargo to residue N343 in the fourth TRP repeat. Structurally, the N343 residue is adjacent to other asparagines and lysines, creating a positively charged polar patch within the groove of the TPR domain. Whereas, KLC2 with the corresponding residue S328 did not interact with JIP1. Based on these finding, we propose that N343 of KLC1 can form “a carboxylate clamp” with its neighboring asparagine to interact with JIP1, similar to that of HSP70/HSP90 organizing protein-1's (HOP1) interaction with heat shock proteins. For the binding of cargos shared by KLC1 and KLC2, we propose a different site located within the groove but not involving N343. We further propose a third binding site on KLC1 which involves a stretch of polar residues along the inter-TPR loops that may form a network of hydrogen bonds to JIP3 and JIP4. Together, these results provide structural insights into possible mechanisms of interaction between KLC TPR domains and various cargo proteins.
A System for Improving the Management of the Lesion and Test Images of Patients  [PDF]
Sung-Bum Cho, Kyung-Won Jin, Jong-Soon Kim, Soo-Jin Huh, Segyeong Joo
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.510B035
Abstract:

Nowadays, almost every hospital utilizes picture archiving and communications system (PACS) and electronic medical record (EMR) system to manage patient’s data digitally. However, patient’s pictures taken by nurses or physicians to monitor lesions or various test results are not managed well in general. Although for some disease, these pictures provide meaningful information in diagnosis and treatment. In this paper, we propose a management system for these images to improve the accessibility and storability. To manage the images efficiently, the proposed methods utilized the PACS system in the hospital. After sending the image data of each patient to a local monitoring computer, the patient’s information, such as, name, age, male, and registration number were attached on the image. This file was then converted to a DICOM (digital imaging and communications in medicine) files and transferred to the PACS Server. The proposed system promises easy and convenient access on the images of lesions and various test results of patients to support fast and appropriate treatment.

Isolation and Characterization of Canine Amniotic Membrane-Derived Multipotent Stem Cells
Sang-Bum Park, Min-Soo Seo, Hyung-Sik Kim, Kyung-Sun Kang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044693
Abstract: Recent studies have shown that amniotic membrane tissue is a rich source of stem cells in humans. In clinical applications, the amniotic membrane tissue had therapeutic effects on wound healing and corneal surface reconstruction. Here, we successfully isolated and identified multipotent stem cells (MSCs) from canine amniotic membrane tissue. We cultured the canine amniotic membrane-derived multipotent stem cells (cAM-MSCs) in low glucose DMEM medium. cAM-MSCs have a fibroblast-like shape and adhere to tissue culture plastic. We characterized the immunophenotype of cAM-MSCs by flow cytometry and measured cell proliferation by the cumulative population doubling level (CPDL). We performed differentiation studies for the detection of trilineage multipotent ability, under the appropriate culture conditions. Taken together, our results show that cAM-MSCs could be a rich source of stem cells in dogs. Furthermore, cAM-MSCs may be useful as a cell therapy application for veterinary regenerative medicine.
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