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Search Results: 1 - 10 of 14468 matches for " Bui Thi Minh Hao "
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Sexual Health and Men Who Have Sex with Men in Vietnam: An Integrated Approach to Preventive Health Care
Le Minh Giang,Vu Duc Viet,Bui Thi Minh Hao
Advances in Preventive Medicine , 2012, DOI: 10.1155/2012/796192
Abstract: Background. While HIV infection among men who have sex with men (MSM) in Vietnam has received increasing attention, most studies focus on HIV knowledge and established risk factors such as injection drug use. This paper proposes to address HIV risk among MSM from an integrated approach to preventive care that takes into account syndemic conditions such as substance use, mental health, and stigma, the latter of which prevents MSM from accessing health services. Method. Current studies related to MSM in Vietnam from 2000 onwards, gathered from peer-reviewed as well as non-peer-reviewed sources, were examined. Results. HIV and STI prevalence among MSM varied significantly by location, and yet HIV prevalence has increased significantly over the past few years. Most studies have focused on sexual risk behaviors, paying little attention to the broad spectrum of sexual health, including noninjecting drug use, heavy alcohol consumption, high rates of mental health distress and anxiety, and stigma. Conclusion. Future research and interventions targeting MSM in Vietnam should address their vulnerability to HIV from an integrated approach that pays attention to both sexual health and syndemic conditions. 1. Introduction Research studies have shown that men who have sex with men (MSM) have unique health-care needs and that interventions focusing on this group should address these needs [1, 2]. MSM have been significantly affected by HIV epidemics all over the world. Research on MSM has found that the epidemics are reemerging in many wealthy countries and that many developing countries are paying more attention to the HIV epidemic among MSM [3]. A critical study on MSM in developing countries showed that the possibility of MSM being HIV infected was much higher than that of the general population [4]. In Asia, an association between HIV infection and drug use, including both injection and noninjection use, has been found [5]. However, non-injection drug use has been an increasingly important risk factor for HIV infection among MSM, whereas injecting drug use is thought to have a limited impact on the spread of HIV among this group [6]. Recreational drug use, especially the use of ecstasy and methamphetamines and alcohol use, is becoming increasingly common and is an important factors contributing to unprotected receptive anal intercourse [5, 7, 8]. The impact of substance use and myriad syndemic conditions has resulted in an alarming increase in HIV infection in Southeast Asia [9]. There are a number of studies on HIV infection among MSM in Vietnam, yet
Treatment 2.0 Pilot in Vietnam—Early Progress and Challenges  [PDF]
Duc Duong Bui, Fabio Mesquita, Thi Nhan Do, Masaya Kato, Thi Thuy Van Nguyen, Thi Minh Thu Nguyen, Adrienne Poon
World Journal of AIDS (WJA) , 2012, DOI: 10.4236/wja.2012.22009
Abstract: Announced in 2010 at the International AIDS Conference in Vienna and pioneered by the Joint United Nations Programme on HIV/AIDS (UNAIDS) and the World Health Organization's (WHO) leadership at the global level, Treatment 2.0 is a new approach to the HIV response that encourages innovation, efficiency, and sustainability. Building upon WHO and UNAIDS' \"3 by 5\" Initiative, Treatment 2.0 focuses upon scale-up and universal access of life-saving ART treatment through strategic investments and innovations in five priority pillars that include: 1) Optimize drug regimens, 2) Provide point-of-care (POC) and other simplified diagnostic and monitoring tools, 3) Reduce costs, 4) Adapt service delivery, and 5) Mobilize communities [1-3]. The Treatment 2.0 approach is in line with UNAIDS' 2011-2015 Strategy: Getting to Zero with the vision of, \"Zero New infections; Zero discrimination; and Zero AIDS-related deaths\", and as well as the four strategic directions for the health sector response outlined under WHO's Global Health Sector Strategy on HIV/AIDS 2011-2015 [4,5]. At the Sixty-fourth World Health Assembly (WHA) in May 2011, it was formally announced that Vietnam has taken the leadership to pilot Treatment 2.0 in two of its provinces, with support from both the WHO and UNAIDS country offices [6,7]. Given that Vietnam is one of the few countries with a concentrated epidemic to pilot Treatment 2.0, the outcomes and experiences of this initiative can provide valuable insight to other countries who may consider implementation. The objectives of this article are therefore to: 1) Describe the early process for translating Treatment 2.0 concept in Vietnam's context; and 2) Highlight early progress and challenges.
Aetiologies of Central Nervous System Infection in Viet Nam: A Prospective Provincial Hospital-Based Descriptive Surveillance Study
Nghia Ho Dang Trung, Tu Le Thi Phuong, Marcel Wolbers, Hoang Nguyen Van Minh, Vinh Nguyen Thanh, Minh Pham Van, Nga Tran Vu Thieu, Tan Le Van, Diep To Song, Phuong Le Thi, Thao Nguyen Thi Phuong, Cong Bui Van, Vu Tang, Tuan Hoang Ngoc Anh, Dong Nguyen, Tien Phan Trung, Lien Nguyen Thi Nam, Hao Tran Kiem, Tam Nguyen Thi Thanh, James Campbell, Maxine Caws, Jeremy Day, Menno D. de Jong, Chau Nguyen Van Vinh, H. Rogier Van Doorn, Hien Tran Tinh, Jeremy Farrar, Constance Schultsz, the VIZIONS CNS Infection Network
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0037825
Abstract: Background Infectious diseases of the central nervous system (CNS) remain common and life-threatening, especially in developing countries. Knowledge of the aetiological agents responsible for these infections is essential to guide empiric therapy and develop a rational public health policy. To date most data has come from patients admitted to tertiary referral hospitals in Asia and there is limited aetiological data at the provincial hospital level where most patients are seen. Methods We conducted a prospective Provincial Hospital-based descriptive surveillance study in adults and children at thirteen hospitals in central and southern Viet Nam between August 2007– April 2010. The pathogens of CNS infection were confirmed in CSF and blood samples by using classical microbiology, molecular diagnostics and serology. Results We recruited 1241 patients with clinically suspected infection of the CNS. An aetiological agent was identified in 640/1241 (52%) of the patients. The most common pathogens were Streptococcus suis serotype 2 in patients older than 14 years of age (147/617, 24%) and Japanese encephalitis virus in patients less than 14 years old (142/624, 23%). Mycobacterium tuberculosis was confirmed in 34/617 (6%) adult patients and 11/624 (2%) paediatric patients. The acute case fatality rate (CFR) during hospital admission was 73/617 (12%) in adults and to 42/624 (7%) in children. Conclusions Zoonotic bacterial and viral pathogens are the most common causes of CNS infection in adults and children in Viet Nam.
Extended Hartree-Fock study of the single-particle potential: the nuclear symmetry energy, nucleon effective mass, and folding model of the nucleon optical potential
Doan Thi Loan,Bui Minh Loc,Dao T. Khoa
Physics , 2015,
Abstract: The nucleon mean-field potential has been thoroughly investigated in an extended Hartree-Fock (HF) calculation of nuclear matter (NM) using the CDM3Y3 and CDM3Y6 density dependent versions of the M3Y interaction. The single-particle (s/p) energies of nucleons in NM are determined according to the Hugenholtz-van Hove theorem, which gives rise naturally to a rearrangement term (RT) of the s/p potential at the Fermi momentum. Using the RT obtained exactly at the different NM densities and neutron-proton asymmetries, a consistent method is suggested to take into account effectively the momentum dependence of the RT of the s/p potential within the standard HF scheme. To obtain a realistic momentum dependence of the nucleon optical potential (OP), the high-momentum part of the s/p potential was accurately readjusted to reproduce the observed energy dependence of the nucleon OP over a wide range of energies. The impact of the RT and momentum dependence of the s/p potential on the density dependence of the nuclear symmetry energy and nucleon effective mass has been studied in details. The high-momentum tail of the s/p potential was found to have a sizable effect on the slope of the symmetry energy and the neutron-proton effective mass splitting at supranuclear densities of the NM. Based on a local density approximation, the folding model of the nucleon OP of finite nuclei has been extended to take into account consistently the RT and momentum dependence of the nucleon OP in the same mean-field manner, and successfully applied to study the elastic neutron scattering on the lead target at the energies around the Fermi energy.
Structure of Fucoidan from Brown Seaweed Turbinaria ornata as Studied by Electrospray Ionization Mass Spectrometry (ESIMS) and Small Angle X-ray Scattering (SAXS) Techniques
Thuy Thi Thu Thanh,Van Thi Thanh Tran,Yoshiaki Yuguchi,Ly Minh Bui,Tai Tien Nguyen
Marine Drugs , 2013, DOI: 10.3390/md11072431
Abstract: The purpose of this study is to elucidate both the chemical and conformational structure of an unfractionated fucoidan extracted from brown seaweed Turbinaria ornata collected at Nha-trang bay, Vietnam. Electrospray ionization mass spectrometry (ESI-MS) was used for determining the chemical structure and small angle X-ray scattering (SAXS) provided conformational of the structure at the molecular level. The results showed that the fucoidan has a sulfate content of 25.6% and is mainly composed of fucose and galactose residues (Fuc:Gal ≈ 3:1). ESIMS analysis suggested that the fucoidan has a backbone of 3-linked α-l-Fucp residues with branches, →4)-Galp(1→ at C-4 of the fucan chain. Sulfate groups are attached mostly at C-2 and sometimes at C-4 of both fucose and galactose residues. A molecular model of the fucoidan was built based on obtained chemical structure and scattering curves estimated from molecular model and observed SAXS measurement were fitted. The results indicated that fucoidan under study has a rod-like bulky chain conformation.
The Effect of Polyvinylpyrrolidone on the Optical Properties of the Ni-Doped ZnS Nanocrystalline Thin Films Synthesized by Chemical Method
Tran Minh Thi,Le Van Tinh,Bui Hong Van,Pham Van Ben,Vu Quoc Trung
Journal of Nanomaterials , 2012, DOI: 10.1155/2012/528047
Abstract: We report the optical properties of polyvinyl-pyrrolidone (PVP) and the influence of PVP concentration on the photoluminescence spectra of the PVP (PL) coated ZnS : Ni nanocrystalline thin films synthesized by the wet chemical method and spin-coating. PL spectra of samples were clearly showed that the 520 nm luminescence peak position of samples remains unchanged, but their peak intensity changes with PVP concentration. The PVP polymer is emissive with peak maximum at 394 nm with the exciting wavelength of 325 nm. The photoluminescence exciting (PLE) spectrum of PVP recorded at 394 nm emission shows peak maximum at 332 nm. This excitation band is attributed to the electronic transitions in PVP molecular orbitals. The absorption edges of the PVP-coated ZnS : Ni0.3% samples that were shifted towards shorter wavelength with increasing of PVP concentration can be explained by the absorption of PVP in range of 350 nm to 400 nm. While the PVP coating does not affect the microstructure of ZnS : Ni nanomaterial, the analyzed results of the PL, PLE, and time-resolved PL spectra and luminescence decay curves of the PVP and PVP-coated ZnS : Ni samples allow to explain the energy transition process from surface PVP molecules to the Ni2
Evolutionary Trajectory of White Spot Syndrome Virus (WSSV) Genome Shrinkage during Spread in Asia
Mark P. Zwart,Bui Thi Minh Dieu,Lia Hemerik,Just M. Vlak
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0013400
Abstract: White spot syndrome virus (WSSV) is the sole member of the novel Nimaviridae family, and the source of major economic problems in shrimp aquaculture. WSSV appears to have rapidly spread worldwide after the first reported outbreak in the early 1990s. Genomic deletions of various sizes occur at two loci in the WSSV genome, the ORF14/15 and ORF23/24 variable regions, and these have been used as molecular markers to study patterns of viral spread over space and time. We describe the dynamics underlying the process of WSSV genome shrinkage using empirical data and a simple mathematical model.
Absorption and Radiation Transitions in Configuration of Mn-Doped ZnS Nanoparticles Synthesized by a Hydrothermal Method
Bui Hong Van,Pham Van Ben,Tran Minh Thi,Hoang Nam Nhat
Journal of Materials , 2013, DOI: 10.1155/2013/716452
Abstract: The Mn-doped ZnS nanoparticles with Mn content of 0–15?mol% were synthesized by a hydrothermal method from the solutions Zn(CH3COO)2 0.1?M, Mn(CH3COO)2 0.01?M, and Na2S2O3 0.1?M at 220°C for 15?h. These nanoparticles presented the cubic structure with average particle size about 16?nm. The yellow-orange photoluminescence (PL) band at 586?nm was attributed to the radiation transition of the electrons in 3d5 unfilled shell of Mn2+ ions [4T1(4G)-6A1(6S)] in ZnS matrix. The photoluminescence excitation (PLE) spectra monitored at the yellow-orange band, the absorption spectra also showed the near band edge absorption of 336–349?nm and the characteristic absorption bands of Mn2+(3d5) ions at 392, 430, 463, 468, 492, and 530?nm. These bands should be attributed to the absorption transitions of 3d5 electrons from the ground state 6A1(6S) to the excited states 4E(4D), 4T2(4D), 4A1(4G)-4E(4G), 4T2(4G), and 4T1(4G) of Mn2+ ions. The intensity of PL band and absorption bands of Mn2+(3d5) ions also increased with the Mn content from 0.1 to 9?mol%, but their peak positions were almost unchanged. The PLE spectra showed clearly the energy level splitting of Mn2+ ions in ZnS crystal field and allowed for the calculation of the splitting width between the excited states 4A1(4G), 4E(4G) about of 229?cm?1 (28.6?meV), and the Racah parameters ?cm?1, ?cm?1 , and the crystal field strength ?cm?1. The PL spectra with different excitation wavelengths corresponding to absorption transition bands of the PLE spectra allow for the discussion of the indirect and direct excitation mechanisms of Mn2+(3d5) ions in the ZnS crystal. 1. Introduction In the Mn-doped A2B6 semiconductor crystals such as ZnS, ZnSe, and CdTe the energy levels 6S, 4G, 4P, and 4D of Mn2+ ions with a 3d5 unfilled electronic shell (called the Mn2+(3d5) configuration) are splitted into the multiple levels 6A1(6S), 4T1(4G), 4T2(4G), 4E(4G), 4A1(4G), 4T2(4D), and 4E(4D) under the crystal field of the host matrix. The splitting of these energy levels has been studied both theoretically and experimentally [1–7]. Tanabe and Sugano have calculated the energy levels of Mn2+(3d5) configuration in the octahedral crystal field and obtained the energy levels diagram representing the dependence of the ratio on (which corresponds with [4]), where is the energy of the terms of the free Mn2+(3d5) ions, is the crystal field splitting energy, and are the Racah parameters characterizing the interaction between the 3d5 electrons of Mn2+ ions, and is the crystal field strength. Fazzio and coworkers have calculated the energy structure
QSAR Modeling on Benzo[c]phenanthridine Analogues as Topoisomerase I Inhibitors and Anti-cancer Agents
Khac-Minh Thai,Quang-Huynh Bui,Thanh-Dao Tran,Thi-Ngoc-Phuong Huynh
Molecules , 2012, DOI: 10.3390/molecules17055690
Abstract: Benzo[c]phenanthridine (BCP) derivatives were identified as topoisomerase I (TOP-I) targeting agents with pronounced antitumor activity. In this study, hologram-QSAR, 2D-QSAR and 3D-QSAR models were developed for BCPs on topoisomerase I inbibitory activity and cytotoxicity against seven tumor cell lines including RPMI8402, CPT-K5, P388, CPT45, KB3-1, KBV-1and KBH5.0. The hologram, 2D, and 3D-QSAR models were obtained with the square of correlation coefficient R2 = 0.58 ? 0.77, the square of the crossvalidation coefficient q2 = 0.41 ? 0.60 as well as the external set’s square of predictive correlation coefficient r2 = 0.51 ? 0.80. Moreover, the assessment method based on reliability test with confidence level of 95% was used to validate the predictive power of QSAR models and to prevent over-fitting phenomenon of classical QSAR models. Our QSAR model could be applied to design new analogues of BCPs with higher antitumor and topoisomerase I inhibitory activity.
HIV-Associated TB in An Giang Province, Vietnam, 2001–2004: Epidemiology and TB Treatment Outcomes
Trinh Thanh Thuy, N. Sarita Shah, Mai Hoang Anh, Do Trong Nghia, Duong Thom, Truong Linh, Dinh Ngoc Sy, Bui Duc Duong, Luu Thi Minh Chau, Phung Thi Phuong Mai, Charles D. Wells, Kayla F. Laserson, Jay K. Varma
PLOS ONE , 2007, DOI: 10.1371/journal.pone.0000507
Abstract: Background Mortality is high in HIV-infected TB patients, but few studies from Southeast Asia have documented the benefits of interventions, such as co-trimoxazole (CTX), in reducing mortality during TB treatment. To help guide policy in Vietnam, we studied the epidemiology of HIV-associated TB in one province and examined factors associated with outcomes, including the impact of CTX use. Methodology/Principal Findings We retrospectively abstracted data for all HIV-infected persons diagnosed with TB from 2001–2004 in An Giang, a province in southern Vietnam in which TB patients receive HIV counseling and testing. We used standard WHO definitions to classify TB treatment outcomes. We conducted multivariate analysis to identify risk factors for the composite outcome of death, default, or treatment failure during TB treatment. From 2001–2004, 637 HIV-infected TB patients were diagnosed in An Giang. Of these, 501 (79%) were male, 321 (50%) were aged 25–34 years, and the most common self-reported HIV risk factor was sex with a commercial sex worker in 221 (35%). TB was classified as smear-positive in 531 (83%). During TB treatment, 167 (26%) patients died, 9 (1%) defaulted, and 6 (1%) failed treatment. Of 454 patients who took CTX, 116 (26%) had an unsuccessful outcome compared with 33 (70%) of 47 patients who did not take CTX (relative risk, 0.4; 95% confidence interval [CI], 0.3–0.5). Adjusting for male sex, rural residence, TB smear status and disease location, and the occurrence of adverse events during TB treatment in multivariate analysis, the benefit of CTX persisted (adjusted odds ratio for unsuccessful outcome 0.1; CI, 0.1–0.3). Conclusions/Significance In An Giang, Vietnam, HIV-associated TB was associated with poor TB treatment outcomes. Outcomes were significantly better in those taking CTX. This finding suggests that Vietnam should consider applying WHO recommendations to prescribe CTX to all HIV-infected TB patients.
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