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Search Results: 1 - 10 of 193510 matches for " Bueno Nadjanara D. "
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O transplante de medula óssea alogênico e autogênico na leucemia mielóide aguda: análise de 80 pacientes
Bueno Nadjanara D.
Revista Brasileira de Hematologia e Hemoterapia , 2003,
Abstract:
Bussulfano e melfalano como regime de condicionamento para o transplante autogênico de células-tronco hematopoéticas na leucemia mielóide aguda em primeira remiss?o completa
Bueno, Nadjanara D.;Dulley, Frederico L.;Saboya, Rosaura;Amigo Filho, José U.;Piron-Ruiz, Lílian;Sturaro, Daniel;Chamone, Dalton A. F.;
Revista Brasileira de Hematologia e Hemoterapia , 2008, DOI: 10.1590/S1516-84842008000500005
Abstract: twenty-two consecutive patients with acute myeloid leukemia in first complete remission submitted to autologous hematopoietic stem cells transplantation conditioned with busulfan and melphalan were evaluated between 1993 and 2006. the overall survival, according to the kaplan-meier curve, was 57.5% at 36 months, with a "plateau" at 20 months after transplant. factors such as gender, french-american-british (fab) classification of acute myeloid leukemia, induction therapy, intensive consolidation, remission after the first cycle of induction and source of cells had no impact on survival. one patient with poor prognosis before the procedure died a year after transplantation. nine patients died, eight by relapse and one because of bleeding. death before 100 days occurred for two patients, one due to relapse and the other bleeding caused by refractory thrombocytopenia related to the procedure. in conclusion, the conditioning regiment with busulfan and melphalan is a valid option compared to the other conditioning regimens, with an excellent overall survival.
O transplante de medula óssea na leucemia mielóide aguda: análise de 80 pacientes transplantados no complexo do Hospital das Clínicas da Faculdade de Medicina da Universidade de S?o Paulo
Bueno, Nadjanara D.;Saboya, Rosaura;Martins, Maria Cristina;Silva, Roberto L.;Chamone, Dalton A. F.;Rocha, Isamara F.;Sturaro, Daniel;Dulley, Frederico L.;
Revista Brasileira de Hematologia e Hemoterapia , 2004, DOI: 10.1590/S1516-84842004000200004
Abstract: the patients records of eighty consecutive patients with acute myeloid leukemia (aml) submitted to allogeneic (allo bmt) and autologous (auto bmt) bone marrow transplantation (bmt) between 1989 and 2001 were assessed. forty percent were alive in the end of the study; 37.9% of allogeneic patients and 45.4% of autologous. factors such as gender, the french-american-british aml classification, induction treatment, number of infused cells and the conditioning regiment did not have any impact in survival. patients with aml from m1 to m4, and who were consolidated with high doses of arabinoside had better a survival rate (p=0.0148). patients in their first complete remission also had better survival both with allogeneic and autologous bmt, with respective survival rates of 52.6% and 69.2%. acute graft-versus-host disease (gvhd) had an impact when it was compared the absence, grade i/ii with iii/iv giving a p-value of 0.0285. infection was the most frequent cause of death in allogeneic bmt. in autologous bmt relapse was the principal cause of death. toxicity related to the procedure occurred in 38.9% of patients who died in allogeneic bmt and 16.7% in autologous bmt. in univariant cox analyses for prognostic factors, the disease status and acute gvhd were significant, but this significance was lost in the multiple variant analyses (p-value = 0.069).
Estudo retrospectivo do tratamento de leucemia mielóide aguda com o transplante de medula óssea: a experiência brasileira
Hamerschlak, Nelson;Barton, Débora;Pasquini, Ricardo;Sarquis, Yana N.;Ferreira, Eurípedes;Moreira, Frederico R.;Colturato, Vergilio A. R.;Souza, Carmino A.;Voltarelli, Júlio;Piron-Ruiz, Lilian;Setúbal, Daniela C.;Zanichelli, Maria A.;Castro, Cláudio G. de;Bueno, Nadjanara D.;Seber, Adriana;Rotolo, Marco A.;Silla, Lucia M. R.;Bittencourt, Henrique;Souza, Mair P.;Vigorito, Afonso C.;Brandalise, Silvia R.;Maiolino, Angelo;Nucci, Márcio;Coelho, érika;Ostronoff, Maurício;Sim?es, Belinda;Ruiz, Milton A.;
Revista Brasileira de Hematologia e Hemoterapia , 2006, DOI: 10.1590/S1516-84842006000100005
Abstract: data from the international bone marrow transplant registry (ibmtr) contribute for the improvement of bone marrow transplant (bmt) worldwide. we studied the brazilian experience in bmt for aml to compare this with international data. we performed a retrospective study by sending questionnaires to 16 bmt centers regarding clinical and treatment variables. statistical analyses concerning autologous bmt (autobmt) and allogeneic bmt (allobmt) were performed using the kaplan-meier method and the log-rank test. all p-values were two-tailed. we collected data from 731 patients (205 autobmt and 526 allobmt). median overall survival (os) for autobmt patients was longer than allobmt patients (1035 vs. 466 days, p=0.0012). allobmt stem cell source (scs): 73% bone marrow stem cell (bmsc), 23% peripheral blood stem cells (pbsc) and 4% umbilical cord blood. among the autobmt patients, the scs was 63% pbsc, 22% bmsc and 15% both. the scs did not impact on os. there was no difference in os between different fab classifications in the allobmt group, but in the autobmt the m3 patients had longer survival. as expected, the main cause of mortality among autobmt patients was related to disease relapse (60%), while in the allobmt, to infection (38%). in both groups we found longer os in first complete remission (1cr) compared to second (2cr) and other (p<0.0001), and longer os in de novo aml than in secondary. in the allobmt group we found more patients with advanced disease (60%), while in the autobmt group, we found more m3 patients (24%), which could explain the difference in os. most of our results are in accordance with ibmtr data. one should consider the fact that this is a retrospective study and our findings should be analysed with caution.
Busulfan and melphalan as conditioning regimen for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia in first complete remission
Bueno, Nadjanara Dorna;Dulley, Frederico Luiz;Saboya, Rosaura;Amigo Filho, José Ulysses;Coracin, Fabio Luiz;Chamone, Dalton de Alencar Fischer;
Revista Brasileira de Hematologia e Hemoterapia , 2011, DOI: 10.5581/1516-8484.20110050
Abstract: background: allogeneic hematopoietic stem cell transplantation with hla-identical donors has been established for the treatment of acute myeloid leukemia patients for over 30 years with a cure rate of 50% to 60%. objectives: to analyze the overall survival of patients and identify factors that influence the outcomes of this type of transplant in patients in 1st complete remission who received a busulfan and melphalan combination as conditioning regimen. methods: twenty-five consecutive patients with acute myeloid leukemia were enrolled between 2003 and 2008. the median age was 34 years old (range: 16 - 57 years). all patients received cyclosporine and methotrexate for prophylaxis against graft-versus-host disease. median neutrophil engraftment time was 16 days (range: 7 - 22 days) and 17 days (range: 7 - 46 days) for platelets. sinusoidal obstructive syndrome was observed in three patients, seven had grade ii acute graft-versus-host disease and one extensive chronic graft-versus-host disease. results: the overall survival by the kaplan-meier method was 48% after 36 months with a plateau at 36 months after transplantation. intensive consolidation with high-dose arabinoside resulted in an improved survival (p-value = 0.0001), as did grade ii acute graft-versus-host disease (p-value = 0.0377) and mild chronic graft-versus-host disease (p-value < 0.0001). thirteen patients died, five due to infection within 100 days of transplant, two due to hemorrhages, one to infection and graftversus-host disease and three relapses followed by renal failure (one) and infection (two). the cause of death could not be determined for two patients. conclusion: the busulfan and melphalan conditioning regimen is as good as other conditioning regimens providing an excellent survival rate.
Determinates do grau de envolvimento na atividade exportadora e suas implica??es nas exporta??es brasileiras de carne de frango
Bueno, Ynaiá Masse;Aguiar, Danilo R. D.;
Gest?o & Produ??o , 2004, DOI: 10.1590/S0104-530X2004000200007
Abstract: this paper analyzes the factors determining the degree of engagement in export activities and verifies their implications in the performance of brazil's chicken exports. the exporters were first divided into groups by cluster analysis, after which the companies in each group were classified, according to their performance, as more successful or less successful. the results indicated that the company's international experience, its relations with foreign markets, and its competitive approach toward its competitors are the main determinants of its success, for they exert a positive influence on the choice of international marketing strategies that lead to improved performance. surprisingly, however, the company's degree of internationalization, the manager's international focus and his expertise in relations with foreign markets did not directly affect the choice of international marketing strategies producing a satisfactory performance. no evidence was found that the size of the business influenced its export performance.
Tratamiento interdisciplinario de periodontitis agresiva localizada: reporte de un Caso
Bueno Rossy,LA; Rodríguez Salaberry,D;
Revista clínica de periodoncia, implantología y rehabilitación oral , 2010, DOI: 10.4067/S0719-01072010000200006
Abstract: the patients with located agressive periodontitis (pal) generally have functionals and esthetics alterations so their treatment noy only should be focused on periodontitis infection. the case we present is about a 38 years old, professional, caucasian woman with located agressive periodontitis which is concerned to her esthetic. she was assisted by a interdisciplinary team formed by dental hygienist, periodontist, maxillofacial surgeon, orthodontist and prosthodontist.
Tratamiento interdisciplinario de periodontitis agresiva localizada: reporte de un Caso Interdisciplinary treatment of localizad agressive periodontitis: a case report
LA Bueno Rossy,D Rodríguez Salaberry
Revista Clínica de Periodoncia, Implantología y Rehabilitación Oral , 2010,
Abstract: Los pacientes con Periodontitis Agresiva Localizada (PAL) presentan generalmente alteraciones funcionales y estéticas, por lo cual su tratamiento no sólo debe estar enfocado al cuadro infeccioso de periodontitis. Se presenta el caso de una paciente de 38 a os de edad, profesional, caucásica, de sexo femenino con PAL, cuyo motivo de consulta fue mejorar su estética. El equipo interdisciplinario que la asistió se integró por Higienista Dental, Periodoncista, Cirujano Maxilofacial, Ortodoncista y Prostodoncista. The patients with located agressive periodontitis (PAL) generally have functionals and esthetics alterations so their treatment noy only should be focused on periodontitis infection. The case we present is about a 38 years old, professional, caucasian woman with located agressive periodontitis which is concerned to her esthetic. She was assisted by a interdisciplinary team formed by dental hygienist, periodontist, maxillofacial surgeon, orthodontist and prosthodontist.
Scientific Theories, Models and the Semantic Approach
Décio Krause,Otávio Bueno
Principia : an International Journal of Epistemology , 2007,
Abstract: According to the semantic view, a theory is characterized by a class of models. In this paper, we examine critically some of the assumptions that underlie this approach. First, we recall that models are models of something. Thus we cannot leave completely aside the axiomatization of the theories under consideration, nor can we ignore the metamathematics used to elaborate these models, for changes in the metamathematics often impose restrictions on the resulting models. Second, based on a parallel between van Fraassen’s modal interpretation of quantum mechanics and Skolem’s relativism regarding set-theoretic concepts, we introduce a distinction between relative and absolute concepts in the context of the models of a scientific theory. And we discuss the significance of that distinction. Finally, by focusing on contemporary particle physics, we raise the question: since there is no general accepted unification of the parts of the standard model (namely, QED and QCD), we have no theory, in the usual sense of the term. This poses a difficulty: if there is no theory, how can we speak of its models? What are the latter models of? We conclude by noting that it is unclear that the semantic view can be applied to contemporary physical theories.
Liposomal daunorubicin and dexamethasone as a treatment for multiple myeloma: the DD Protocol
Dulley, Frederico Luiz;Saboya, Rosaura;Hungria, Vania Tietsche de Moraes;Bueno, Nadjanara Dorna;Mello, Fernando Gomes de;Frota, Maria Tereza;Chiattone, Carlos Sergio;Barros, José Carlos;Mori, Nair Sumie;Sturaro, Daniel;Macedo, Maria Cristina Martins de Almeida;Silva, Roberto Luiz da;Melo, Leila Maria Magalh?es Pessoa de;Souza, Cármino Antonio;
Sao Paulo Medical Journal , 2005, DOI: 10.1590/S1516-31802005000600003
Abstract: context and objective: liposomal daunorubicin has been used to treat hematological malignancies, including multiple myeloma (mm). the goal was to evaluate efficacy, side-effects and toxicity of liposomal daunorubicin and dexamethasone ("dd protocol"). design and setting: prospective study at sírio-libanês, s?o camilo, brasil and alem?o oswaldo cruz hospitals. methods: twenty consecutive patients with active mm received four cycles of liposomal daunorubicin intravenously for two hours (25-30 mg/m2/day) on three consecutive days per month, with oral dexamethasone (10 mg every six hours) on four consecutive days three times a month. results: the male/female ratio was 1:1 and median age 60. nine patients were stage iia, ten iiia and one iiib. the median from diagnosis to starting dd was 13 months. all patients received four cycles, except one. fifteen had already received chemotherapy before dd. responses of > 50% reduction in serum monoclonal paraprotein were observed in six patients after first cycle (30%), six after second (30%) and four after third (20%), while four (20%) did not obtain this. initially, 17 patients (85%) had anemia: 12 (70%) achieved correction. progressive disease was observed in three patients (15%), while one had minimal response, four (20%) partial and 12 (60%) complete. hematological toxicity was acceptable: three patients (15%) had neutrophils < 1,000/mm3; none had thrombocytopenia. gastrointestinal toxicity was mild: nausea (10%), anorexia (15%) and no vomiting. conclusions: this treatment has mild toxicity and good response rate. it may therefore be feasible before autologous bone marrow transplantation.
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