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Search Results: 1 - 10 of 8333 matches for " Bruno; Cipriano "
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Tumor do estroma gastrointestinal em idade pediátrica Gastrointestinal stromal tumor in children
Paulo Freire,Francisco Portela,Bruno Gra?a,Maria Augusta Cipriano
Jornal Português de Gastrenterologia , 2012,
Abstract: Os tumores do estroma gastrointestinal (GIST) s o os mais frequentes tumores mesenquimatosos do tubo digestivo, surgem geralmente após os 40 anos e s o excepcionais na idade pediátrica. Os autores apresentam o caso de uma doente de 14 anos, admitida por anemia microcítica sintomática. A endoscopia digestiva alta revelou volumosa forma o submucosa gástrica, tendo os estudos histológico e imunohistoquímico (c-Kit) estabelecido o diagnóstico de GIST. O estudo genético dirigido às muta es dos genes c-Kit e PDGFRA mostrou a ausência de ambas (tumor wild-type). O estadiamento imagiológico evidenciou a existência de adenopatias peri-tumorais e de metastiza o hepática. Após ressec o cirúrgica do tumor primitivo, iniciou-se terapêutica com imatinib, substituída posteriormente por sunitinib devido a progress o da doen a. Após 18 meses de tratamento com este fármaco apresenta doen a estabilizada mas sem regress o. Quando comparados com os GIST no adulto, os GIST em idade pediátrica encerram múltiplas particularidades. Com base no caso clínico exposto, os autores salientam essas singularidades e as suas implica es práticas Gastrointestinal stromal tumors (GIST) are the most frequent mesenchymal tumors in the digestive tract. Usually, they develop after the fourth decade of life and are particularly unusual in paediatric age. The authors present the case of a 14-year old female patient admitted for symptomatic microcytic anemia. Upper gastrointestinal endoscopy showed a large gastric submucosal tumor. A diagnosis of GIST was made by histological and immunohistochemical (c-Kit) tests. Genetic assessment of c-Kit and PDGFRA mutations revealed the absence of both (wild-type tumor). The imagiologic staging showed peritumoral adenopathy and hepatic metastization. After surgical resection of the primitive tumor, imatinib therapy was started and later on replaced by sunitinib, due to disease progression. After 18 months of therapy with this drug the disease is stable but without regression. When compared with GIST in adults, paediatric GISTs have multiple specificities. Based on the clinical case described below, the authors highlight these specific characteristics and their clinical implications
La ense?anza de la modelación matemática en ingeniería
Cruz,Cipriano;
Revista de la Facultad de Ingeniería Universidad Central de Venezuela , 2010,
Abstract: the essential goals of mathematical education are: (1) find coherent explanations on how people learn maths, and (2) generate efficient teaching-learning proposals to satisfy the goals stated in the curriculum. this article addresses the way to consider various fundamentals in maths teaching. the idea is to focus the design of teaching experiences aimed at developing engineering students in contextual mathmodelling. this is regarded not only as a process of bidirectional work among contextual activities and mathematics content structures, but also towards the development of the student?s necessary skills to obtain a first approximation to the ?design method,? understood as the habitual work of an engineer. conceptual aspects such as mathmodelling, contextualization, and design in engineering, and relation issues among these concepts are taken into account. the study presents some analysis and various procedures related to the design of teaching experiences that take into account contents, development of mathematical and strategic thinking, both oriented to the use of the mathmodelling design.
Saúde e Doen a em Portugal
Cipriano Justo
Análise Social , 2005,
Abstract:
Entry time statistics to different shrinking sets
Italo Cipriano
Mathematics , 2015,
Abstract: We consider $\psi$-mixing dynamical systems $(\mathcal{X},T,B,\mu)$ and we find conditions on families of sets $\{\mathcal{U}_n\subset \mathcal{X}:n\in\mathbb{N}\}$ so that $\mu(\mathcal{U}_n)\tau_n$ tends in law to an exponential random variable, where $\tau_n$ is the entry time to $\mathcal{U}_n.$
Tumor do estroma gastrointestinal em idade pediátrica
Freire,Paulo; Portela,Francisco; Gra?a,Bruno; Cipriano,Maria Augusta; Urbano,Marta; Furtado,Emanuel; Lapa,Paula; Duque,Gabriela; Andrade,Paulo; Sofia,Carlos;
Jornal Português de Gastrenterologia , 2012,
Abstract: gastrointestinal stromal tumors (gist) are the most frequent mesenchymal tumors in the digestive tract. usually, they develop after the fourth decade of life and are particularly unusual in paediatric age. the authors present the case of a 14-year old female patient admitted for symptomatic microcytic anemia. upper gastrointestinal endoscopy showed a large gastric submucosal tumor. a diagnosis of gist was made by histological and immunohistochemical (c-kit) tests. genetic assessment of c-kit and pdgfra mutations revealed the absence of both (wild-type tumor). the imagiologic staging showed peritumoral adenopathy and hepatic metastization. after surgical resection of the primitive tumor, imatinib therapy was started and later on replaced by sunitinib, due to disease progression. after 18 months of therapy with this drug the disease is stable but without regression. when compared with gist in adults, paediatric gists have multiple specificities. based on the clinical case described below, the authors highlight these specific characteristics and their clinical implications
Oseltamivir compounding in the hospital pharmacy during the (H1N1) influenza pandemic
Marin, Márcia Lúcia de Mário;Oliveira, Bruno Barbosa do Carmo;Cipriano, Sonia Lucena;Suslik, Carlos Alberto;Faintuch, Joel;
Clinics , 2010, DOI: 10.1590/S1807-59322010001100004
Abstract: aims: pandemics impose large demands on the health care system. the supply of appropriate chemotherapeutic agents, namely oseltamivir solution, presented a serious challenge in the recent influenza pandemic. this study reports on the rational series of pharmacotechnical steps that were followed to appropriately handle bulk oseltamivir powder to meet the increased demand. methods: during a six-week period in august and september of 2009, a task force was created in the central pharmacy of hospital das clínicas to convert imported oseltamivir phosphate into ready-to-use solution for utilization by physicians and public health authorities. the protocol included dissolution, physico-chemical tests and the bottling of a liquid microdose formulation for emergency room and outpatient dispensing with adequate quality control during all phases. results: the successful production routine was based on a specially designed flowchart according to which a batch of 33210 g of oseltamivir powder was converted into 32175 solution units during the aforementioned period with a net loss of only 2.6%. the end products were bottles containing 50 ml of 15 mg/ml oseltamivir solution. the measured concentration was stable and accurate (97.5% - 102.0% of the nominal value). the drug was prescribed as both a prophylactic and therapeutic agent. discussion: hospital pharmacies are conventionally engaged in the manipulation of medical prescriptions and specialty drugs. they are generally responsible for only small-scale equipment used for manufacturing and quality-control procedures. the compounding of oseltamivir was a unique effort dictated by exceptional circumstances. conclusion: the shortage of oseltamivir solution for clinical use was solved by emergency operationalization of a semi-industrial process in which bulk powder was converted into practical vials for prompt delivery.
MODEL BASED PREDICTIVE CONTROL OF A ROUGHER FLOTATION CIRCUIT CONSIDERING GRADE ESTIMATION IN INTERMEDIATE CELLS
ROJAS,DANIEL; CIPRIANO,ALDO;
DYNA , 2011,
Abstract: effective control of rougher flotation is important because a small increase in recovery results in a significant economic benefit. although many flotation control strategies have been proposed and implemented over the years, none of them incorporate concentrate grade measurements at intermediate cells because these data are not usually available. on the other hand, there is much research on characterizing concentrate froth on the cell surface by image processing in order to extract information on froth color, bubble size, and speed that can then be used for developing expert control strategies, and some works have shown the possibility of estimating the concentrate grade. this work presents two multivariable model based predictive control (mpc) strategies for a rougher circuit. the first strategy is based only on general tailings and concentrate grade measurements while the second one includes, beside these data, the intermediate cell grade estimates. both strategies are compared with a fixed control strategy. simulation tests show that the recovery can increase by 1.7%, compared to the fixed control strategy.
La apropiación social de la ciencia: nuevas formas
Barrio Alonso,Cipriano;
Revista iberoamericana de ciencia tecnolog?-a y sociedad , 2008,
Abstract: the appearance of new forms of generation of scientific and technological knowledge, named cooperative development, allows to redefine the role of citizens with reference to the science and technology system, and to think about the social appropriation of science as a problem of redistribution of knowledge.
UNA PROPUESTA DE PRáCTICUM EN LA FORMACIóN INICIAL DEL MAESTRO ESPECIALISTA EN EDUCACIóN FíSICA
Cipriano Romero Cerezo
ágora para la Educación Física y el Deporte , 2003,
Abstract: : This paper describes the design of the subject Prácticum within the Faculty of Education (University of Granada). Our approach tries to empower future teachers to work in changing educative contexts. Central in this approach is the analysis of personal practises, theories and attitudes. The paper sumarises the plan (aims, methodology, organization, strategies, etc.) that guides our experience.Resumen: En este artículo exponemos el programa de Prácticum de la Facultad de Ciencias de la Educación de la Universidad de Granada. Nos apoyamos en un modelo de indagación que intentan desarrollar la capacidad docente para actuar en los diversos contextos educativos. El análisis, la reflexión sobre la práctica y sus propias teorías y actitudes son elementos centrales de este modelo. Presentamos las actividades, organización metodológica y estrategias de formación docente con las que desarrollamos la experiencia.
Educación Física: Perspectivas y líneas de investigación en el campo del currículo y la Formación del profesorado
Cipriano Romero Cerezo
PROFESORADO , 2007,
Abstract:
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