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Search Results: 1 - 10 of 8605 matches for " Bruno Rinaldi "
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Performance evaluation of positive regulators for population control
Simona Muratori,Sergio Rinaldi,Bruno Trinchera
Modeling, Identification and Control , 1989, DOI: 10.4173/mic.1989.3.1
Abstract: This paper deals with real time control of age-structured populations described by Leslie models with positive inputs. The classical industrial and pole-assignment regulators are adapted to this class of positive systems and their performance is evaluated through simulation. The influence of noise on cost and robustness of the controlled system and the role of the information structure are discussed in some detail.
Genome wide analysis of the bovine mucin genes and their gastrointestinal transcription profile
Prisca R Hoorens, Manuela Rinaldi, Robert W Li, Bruno Goddeeris, Edwin Claerebout, Jozef Vercruysse, Peter Geldhof
BMC Genomics , 2011, DOI: 10.1186/1471-2164-12-140
Abstract: Nine bovine membrane-associated mucins (MUC1, MUC3A, MUC4, MUC12, MUC13, MUC15, MUC16, MUC20 and MUC21) and six secreted mucins (MUC2, MUC5AC, MUC5B, MUC6, MUC7 and MUC19) were identified in the bovine genome. No homologues could be identified for MUC3B, MUC8 and MUC17. In general, domain architecture of the membrane-associated mucins was found to be similar between humans and cattle, while the protein architecture of the gel-forming mucins appeared to be less conserved. Further analysis of the genomic organization indicated that the previously reported bovine submaxillary mucin (BSM) may be part of a larger gene encoding for MUC19. Analysis of the transcription profile showed that the secreted mucins were transcribed from the abomasum onwards, whereas the membrane associated mucins MUC1 and MUC20 were transcribed throughout the whole GI tract. In contrast to humans, MUC5B transcript was found in both the small and large intestine, but was absent in oesophageal tissue.This study provides the first characterization of the mucin gene family in cattle and their transcriptional regulation in the GI tract. The data presented in this paper will allow further studies of these proteins in the physiology of the GI tract in ruminants and their interactions with pathogens.Mucins (MUC) are heavily O-glycosylated proteins that cover all mucosal surfaces. They play an important protective role as they form a physical, chemical and immunological barrier between the environment and the organism. Mucins can be largely divided into 2 structurally different families: the secreted and the membrane (cell surface)-associated mucins [1-4]. In humans, 7 members in the family of the secreted mucins have been identified, which can be further subdivided into gel-forming mucins (MUC2, MUC5AC, MUC5B, MUC6, MUC19) and non-gel-forming mucins (MUC7, MUC8) [5-7]. The membrane-associated mucins, on the other hand, count 11 members (MUC1, MUC3A, MUC3B, MUC4, MUC12, MUC13, MUC15, MUC16, MUC17, MUC20 a
Hospital discharge planning and continuity of care for aged people in an Italian local health unit: does the care-home model reduce hospital readmission and mortality rates?
Gianfranco Damiani, Bruno Federico, Antonella Venditti, Lorella Sicuro, Silvia Rinaldi, Franco Cirio, Cristiana Pregno, Walter Ricciardi
BMC Health Services Research , 2009, DOI: 10.1186/1472-6963-9-22
Abstract: In a retrospective observational cohort study a sample of 380 subjects aged 64 years and over was examined. Participants were discharged from the hospital S.Giovanni Bosco in Turin, Italy from March 1st, 2005 to February 28th, 2006. Of these subjects, 107 received routine discharge care while 273 patients were referred to care-home (among them, 99 received a long-term care intervention (LTCI) afterwards while 174 did not). Data was gathered from various administrative and electronic databases. Cox regression models were used to evaluate factors associated with mortality and hospital readmission.When socio-demographic factors, underlying disease and disability were taken into account, DPCH decreased mortality rates only if it was followed by a LTCI: compared to routine care, the Hazard Ratio (HR) of death was 0.36 (95% Confidence Interval (CI): 0.20 – 0.66) and 1.15 (95%CI: 0.77 – 1.74) for DPCH followed by LTCI and DPCH not followed by LTCI, respectively. On the other hand, readmission rates did not significantly differ among DPCH and routine care, irrespective of the implementation of a LTCI: HRs of hospital readmission were 1.01 (95%CI: 0.48 – 2.24) and 1.18 (95%CI: 0.71 – 1.96), respectively.The use of DPCH after hospital discharge reduced mortality rates, but only when it was followed by a long-term health care plan, thus ensuring continuity of care for elderly participants.Intermediate care is aimed to facilitate transition from hospital to home when the objectives of care are not primarily medical: patients are discharged earlier, and hospital length of stay is decreased [1]. In line with the principle of 'care closer to home', intermediate care services should generally be provided in community-based settings, in the patient's home, or they may be provided in discrete step-down facilities on acute hospital sites [2].The need for effective discharge planning for elderly patients is becoming increasingly important due to the rising number of elderly people requ
Accuracy of Specific BIVA for the Assessment of Body Composition in the United States Population
Roberto Buffa, Bruno Saragat, Stefano Cabras, Andrea C. Rinaldi, Elisabetta Marini
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0058533
Abstract: Background Bioelectrical impedance vector analysis (BIVA) is a technique for the assessment of hydration and nutritional status, used in the clinical practice. Specific BIVA is an analytical variant, recently proposed for the Italian elderly population, that adjusts bioelectrical values for body geometry. Objective Evaluating the accuracy of specific BIVA in the adult U.S. population, compared to the ‘classic’ BIVA procedure, using DXA as the reference technique, in order to obtain an interpretative model of body composition. Design A cross-sectional sample of 1590 adult individuals (836 men and 754 women, 21–49 years old) derived from the NHANES 2003–2004 was considered. Classic and specific BIVA were applied. The sensitivity and specificity in recognizing individuals below the 5th and above the 95th percentiles of percent fat (FMDXA%) and extracellular/intracellular water (ECW/ICW) ratio were evaluated by receiver operating characteristic (ROC) curves. Classic and specific BIVA results were compared by a probit multiple-regression. Results Specific BIVA was significantly more accurate than classic BIVA in evaluating FMDXA% (ROC areas: 0.84–0.92 and 0.49–0.61 respectively; p = 0.002). The evaluation of ECW/ICW was accurate (ROC areas between 0.83 and 0.96) and similarly performed by the two procedures (p = 0.829). The accuracy of specific BIVA was similar in the two sexes (p = 0.144) and in FMDXA% and ECW/ICW (p = 0.869). Conclusions Specific BIVA showed to be an accurate technique. The tolerance ellipses of specific BIVA can be used for evaluating FM% and ECW/ICW in the U.S. adult population.
Incentive or Habit Learning in Amphibians?
Rubén N. Muzio, Virginia Pistone Creydt, Mariana Iurman, Mauro A. Rinaldi, Bruno Sirani, Mauricio R. Papini
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0025798
Abstract: Toads (Rhinella arenarum) received training with a novel incentive procedure involving access to solutions of different NaCl concentrations. In Experiment 1, instrumental behavior and weight variation data confirmed that such solutions yield incentive values ranging from appetitive (deionized water, DW, leading to weight gain), to neutral (300 mM slightly hypertonic solution, leading to no net weight gain or loss), and aversive (800 mM highly hypertonic solution leading to weight loss). In Experiment 2, a downshift from DW to a 300 mM solution or an upshift from a 300 mM solution to DW led to a gradual adjustment in instrumental behavior. In Experiment 3, extinction was similar after acquisition with access to only DW or with a random mixture of DW and 300 mM. In Experiment 4, a downshift from DW to 225, 212, or 200 mM solutions led again to gradual adjustments. These findings add to a growing body of comparative evidence suggesting that amphibians adjust to incentive shifts on the basis of habit formation and reorganization.
Artroplastia total do quadril n?o cimentada em pacientes com artrite reumatóide
Rabello, Bruno Tavares;Cabral, Fernando Pina;Freitas, Emílio;Penedo, Jorge;Cury, Marco Bernardo;Rinaldi, Eduardo Regado;Peixoto, Louren?o;
Revista Brasileira de Ortopedia , 2008, DOI: 10.1590/S0102-36162008000800004
Abstract: objective: to analyze clinical, functional, and radiographic results of uncemented total hip arthroplasties in patients with rheumatoid arthritis. methods: retrospective study of 24 patients (28 hips) with rheumatoid arthritis submitted to total hip arthroplasty, using uncemented femoral prosthesis secur fit osteonics?, with minimum follow-up of two years. the patients were clinically evaluated using the merle d'aubigné criteria and the engh criteria in radiographic evaluation. results: mean follow-up time was 5.6 years (two years to eight years and 11 months). clinically, good and excellent results were observed in 22 patients, with emphasis on pain relief. no case of loosening was seen. two cases had complications: one patient had deep venous thrombosis (dvt), confirmed by doppler, and one case of fracture during surgery, distal to the calcar bone, treated with cerclage, with no repercussion in the quality of clinical and radiographic results of this patient. conclusion: after a mean follow-up of 5.6 years, results show that uncemented total hip arthroplasty may be a satisfactory option in coxoarthroses of patients with rheumatoid arthritis.
Treatises and Ars construendi: Teaching’s Method Theory and Practice of Critical History’s Application Based on Teacher-Student Relationships  [PDF]
Carlos Alberto Cacciavillani, Simona Rinaldi
Open Journal of Social Sciences (JSS) , 2016, DOI: 10.4236/jss.2016.49016
Abstract: The topic of this lecture is the results’ description obtained during many years of teaching. We shall illustrate how students use the same analytical techniques to study two different aspects: 1) Architectural Treatises are first studied separately and then in a comparative way. The purpose of this graphic analysis is to reach a new interpretation of them through the realization of original graphics; 2) The Roman Ars construendi: architectural techniques and buildings’ typologies used by the Romans are investigated in the archaeological sites, where the reading of buildings’ stratification in different historical periods becomes an important teaching tool.
Yaws: A Second (and Maybe Last?) Chance for Eradication
Andrea Rinaldi
PLOS Neglected Tropical Diseases , 2008, DOI: 10.1371/journal.pntd.0000275
Abstract:
The Global Campaign to Eliminate Leprosy
Andrea Rinaldi
PLOS Medicine , 2005, DOI: 10.1371/journal.pmed.0020341
Abstract:
Counting tillers
Andrea Rinaldi
Genome Biology , 2003, DOI: 10.1186/gb-spotlight-20030410-02
Abstract: Li et al. screened rice plant collections for mutants with altered tiller numbers. Genetic analysis with reciprocal crosses between tiller mutants and wild-type plants revealed that mutants possess a recessive mutation in a single locus, termed Monoculm 1 (MOC1). The MOC1 gene was then mapped to the long arm of chromosome 6, and encoded a nuclear-localized protein of 441 amino-acid residues. Tiller mutants transformed with up to three copies of the MOC1 gene produced 2-3 fold more tillers than wild-type plants, confirming the role of the gene in branching control. High-tillering transformed plants were also observed to be shorter than wild-type plants, indicating that MOC1 affects both rice tillering and plant height - another economically important trait.Although MOC1 seems to be a key regulator of rice tillering, this is expected to be a complex process which involves the finely-tuned expression of many genes. The identification of the other parties is likely to benefit from the recent completion of several drafts of the rice genome, produced by the International Rice Genome Sequencing Project and other sequencing programs.
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