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Search Results: 1 - 10 of 163497 matches for " Bruno Luis Alves Louren?o "
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Virtual Screening and Molecular Docking for Arylalkylamine-N-Acetyltransferase (aaNAT) Inhibitors, a Key Enzyme of Aedes (Stegomyia) aegypti (L.) Metabolism  [PDF]
Bruno Luis Alves Loureno, Maicon Vinícius Araújo Santos Silva, Elisson Barros de Oliveira, Wagner Rodrigues de Assis Soares, Aristóteles Góes-Neto, Gesivaldo Santos, Bruno Silva Andrade
Computational Molecular Bioscience (CMB) , 2015, DOI: 10.4236/cmb.2015.53005
Abstract: Background: Dengue is a Neglected tropical disease (NTDs) with high incidence in Brazil. This disease is caused by Dengue virus and is transmitted by Aedes aegypti mosquito. The search for new approaches for controlling of this disease is the subject of numerous studies. The aaNAT is a key enzyme in the metabolism of A. aegypti and is crucial in the sclerotization process, as well as regulation of circadian rhythm and inactivation of neurotransmitters. Computational techniques applied to studies of biological systems become an effective weapon in the mapping and management of 3D data structures, giving direction and guidance of potential ligands that can form stable complexes with targets of interest, using a Molecular Docking approach. The present study was conducted by a virtual screening, followed by docking calculations, in order to find molecules that could inhibit aaNAT. In this study, we used available compounds in SAM database (Bioinformatics and Medicinal Chemistry Laboratory—Southwest Bahia State University, Jequié-Bahia, Brazil), PubChem and ZINC. Results: The result of dockings with selected ligands showed good energy affinities, presenting potential inhibitory interactions with the enzyme active site. Conclusions: The Coa-S-acetyl-tryptamine and 3-indoleacriloil-coenzyme-A showed the same binding energies -8.9 Kcal/Mol and were described as possible inhibitors of aaNAT.
Anestesia para amigdalectomia em crian?a portadora de síndrome de Klippel-Feil associada à síndrome de down: Relato de caso
Fernandes, Magda Loureno;Faria, Núbia Campos;Gon?alves, Thiago Ferreira;Santos, Bruno Holanda;
Revista Brasileira de Anestesiologia , 2010, DOI: 10.1590/S0034-70942010000300010
Abstract: background and objectives: craniofacial abnormalities present in klippel-feil syndrome (kfs) and down syndrome (ds) can hinder access to the airways. oropharyngeal surgeries also require special attention with the airways. the association of both syndromes in a patient scheduled for tonsillectomy is a rare condition that imposes challenges to the anesthetic-surgical treatment. the objective of this report was to discuss the approach of the airways and the risks of cervical manipulation in a patient with kfs and ds undergoing tonsillectomy. case report: this is a 5 years old child with diagnosis of kfs and ds and instability of the atlantoaxial joint who underwent tonsillectomy under general balanced anesthesia. ventilation under face mask and tracheal intubation were done with the neck in the neutral position. the perfect visualization of the epiglottis and vocal cords allowed tracheal intubation with conventional laryngoscopy. the surgery was also performed without cervical extension and without intercurrences. conclusions: although access to the airways can be easy, anatomical changes presuppose the presence of difficult airways in patients with kfs and ds. differentiated care and adequate resources are mandatory to avoid complications during approach of the airways. cervical manipulation should be avoided in the presence of instability of the atlantoaxial joint due to the risk of neurological damage.
Adriamycin-induced fetal hydronephrosis
Gon?alves, Anderson;Fran?a, Willy G.;Moraes, Suzana G.;Pereira, Luis A.V.;Sbragia, Loureno;
International braz j urol , 2004, DOI: 10.1590/S1677-55382004000600012
Abstract: introduction: at the end of pregnancy, the amniotic fluid (af) depends basically on renal function, corresponding to fetal urine. changes in af, especially oligohydramnios, are reported in association with fetal hydronephrosis (fh). the experimental model using adriamycin in pregnant female rats has a teratogenic effect and has been classically employed to study esophageal atresia. nevertheless, adriamycin promotes fh with high frequency as well. in the present study, using this animal model, we tried to identify the incidence and microscopic changes of fh, as well as its correlation with af weight. materials and methods: eight spreague-dawley pregnant female rats received adriamycin 2.2 mg/kg on the 8th and 9th gestational days (considering term gestation = 22 days). those fetuses that received adriamycin (adriamycin group) were compared with fetuses from 2 female rats (control group), which received 0.9% saline solution. on the 21.5 gestational day, the fetuses were collected by cesarean incision, sacrificed, and examined for macro and microscopic changes in kidneys and ureters. fetuses with bilateral hydronephrosis formed the hydronephrosis group. af weight was determined as well. results: hydronephrosis occurred in 70 (95%) of the 74 fetuses in the adriamycin group against none of the 21 fetuses from the control group. the amniotic fluid weight was increased in the adriamycin group in relation to the control group (p < 0.001). the histomorphometric study revealed dilation of the renal pelvis and reduction of renal parenchyma in the hydronephrosis group in relation to the control group. severe cortical atrophy, cortical tubular atrophy and medullar atrophy were observed in the hydronephrosis group. conclusions: slight renal lesions were in agreement with changes in af weight, since they suggest that there was production of urine with the maintenance of af.
Reten o de solu es de sulfatos por hidrogel de policrilamida = Retention of sulfhate solution by polierilamida hydrogel
Tedson Luis de Freitas Azevedo,Altair Bertonha,Paulo Sergio Loureno de Freitas,Antonio Carlos Andrade Gon?alves
Acta Scientiarum : Agronomy , 2006,
Abstract: A utiliza o de hidrogel na agricultura brasileira, principalmente na silvicultura e fruticultura, está cada dia mais consolidado pela capacidade que ele possui de armazenar e disponibilizar água para as plantas. Este trabalho teve por objetivo estudar a capacidade dereten o de solu o nutritiva pelo hidrogel quando submetido em diferentes solu es nutritivas de diferentes fertilizantes. Este estudo foi realizado no laboratório do Centro Técnico de Irriga o da Universidade Estadual de Maringá, Maringá, Estado do Paraná. Oexperimento constou de 26 tratamentos e 4 repeti es, disposto em um esquema fatorial (5 x 5) mais um tratamento testemunha comum a todos os tratamentos, em um delineamento inteiramente casualizado. Os resultados mostraram que tanto as condutividades elétricas quanto as diferentes solu es de sulfatos interferiram na capacidade de reten o de solu o nutritiva do hidrogel. The hydrogel use in the brazilian agriculture, mainly in the forestation, fruits field, and growth media, is being consolidated by its capacity of holding and release water (nutrient solution) to plants. This work aimed to study the holding capacity of nutrient solutions by hydrogel when submitted into differents solutions from sulphates. This study was conducted out the Irrigation Technical Center of Universidade Estadual de Maringá, Maringá, Paraná State. Itwas conducted in a 5 x 5 factorial way (with 26 treatments and 04 replications) and the randomized design. It was used as treatments 05 fertilizers sulphates base (ferrous sulphate, ammonium sulphate, zinc sulphate, copper sulphate, and magnesium sulphate) and 05 doses (0.4; 0.8; 1.2; 1.6, and 2.0 g to each 500 g of distilled water). The distilled water treatment and hydrogel were used as control treatment. The hydrogel was hydrated for 24 hours for a later measure of holding capacity of nutrient solution. We noticed that besidesthe electric conductivity of nutrient solution the different fertilizer interfered with the holding capacity of nutrient solution.
A weak constraint qualification for conic programs and a problem on duality gap
Bruno F. Loureno
Mathematics , 2015,
Abstract: We discuss a weak constraint qualification for conic linear programs and its applications for a few classes of cones. This constraint qualification is used to give a solution to a problem proposed by Shapiro and Z\v{a}linescu and show that if a closed convex cone is such that all its non-trivial faces are polyhedral and all the non-trivial exposed faces of its dual are polyhedral, then the duality gap is zero as long as the primal and dual problems are feasible. Moreover, the common optimal value must be attained at least at one of the sides. We also show an example of a cone that meets the requirements our theorem but is such that previously known results cannot be used to prove its good duality properties.
Family Organization in the Care of Pediatric Heart Transplant Patients: The Genogram as an Investigative Tool  [PDF]
Silvania Braga Ribeiro, Angela Maria Alves e Souza, Ana Ruth Macêdo Monteiro, Kiarelle Loureno Penaforte, Sarah Maria de Sousa Feitoza, Virna Ribeiro Feitosa Cestari, Flávia Paula Magalh?es Monteiro, Maria Gyslane Vasconcelos Sobral, Samila Torquato Araújo, Máguida Gomes da Silva, Mona Lisa Menezes Bruno, Islene Victor Barbosa, Isabelle Barbosa Pontes
Health (Health) , 2015, DOI: 10.4236/health.2015.711155
Abstract: This study aimed to describe structure, functionality and development of pediatric heart transplant families, from the understanding of the experienced chronic condition. A descriptive, exploratory study using a qualitative approach was developed in a hospital situated in a city of Northeast Brazil, in 2012. The study was conducted with three families, using the Calgary Family Assessment Model (CFAM). In addition to the genogram, an analysis of the children’s/adolescents’ family members was conducted at the time of interview. Two families were binuclear families and one was mononuclear. From the evaluation, it was possible to determine the care and support network of children and adolescents with heart transplants, as well as some difficulties faced by the investigated families. Nurses are important in this family context since the visualization of the family genogram can generate a change in the nursing care to each family.
Catalytic Properties of the Dioxomolybdenum Siloxide MoO2(OSiPh3)2 and its 2,2'-Bipyridine Adduct MoO2(OSiPh3)2(bpy)
Sofia M. Bruno,Bernardo Monteiro,Maria Salete Balula,Catarina Loureno,Anabela A. Valente,Martyn Pillinger,Paulo Ribeiro-Claro,Isabel S. Gon?alves
Molecules , 2006, DOI: 10.3390/11040298
Abstract: The tetrahedral triphenylsiloxy complex MoO2(OSiPh3)2 (1) and its Lewis baseadduct with 2,2'-bipyridine, MoO2(OSiPh3)2(bpy) (2), were prepared and characterised byIR/Raman spectroscopy, and thermogravimetric analysis. Both compounds catalyse theepoxidation of cis-cyclooctene at 55 oC using tert-butylhydroperoxide (t-BuOOH) isdecane as the oxidant, giving 1,2-epoxycyclooctane as the only product. The best resultswere obtained in the absence of a co-solvent (other than the decane) or in the presence of1,2-dichloroethane, while much lower activities were obtained when hexane oracetonitrile were added. With no co-solvent, catalyst 1 (initial activity 272 mol·molMo-1·h-1for a catalyst:substrate: oxidant molar ratio of 1:100:150) is much more active than 2(initial activity 12 mol·molMo–1·h–1). The initial reaction rates showed first orderdependence with respect to the initial concentration of olefin. With respect to the initialamount of oxidant, the rate order dependence for 1 (1.9) was higher than that for 2 (1.6).The dependence of the initial reaction rate on reaction temperature and initial amount ofcatalyst was also studied for both catalysts. The lower apparent activation energy of 1 (11kcal·mol–1) as compared with 2 (20 kcal·mol–1) is in accordance with the higher activity ofthe former.
Comportamento de clones de cana-de-a?úcar em rela??o a Diatraea saccharalis(Fabr., 1794)
Louren??o, André Luiz;Rossetto, Carlos Jorge;Germek, Emílio Bruno;Igue, Toshio;Rezende, Jorge Alberto Marques;Pereira, José Carlos Vila Nova Alves;
Bragantia , 1982, DOI: 10.1590/S0006-87051982000100015
Abstract: sixteen clones of sugarcane resistant to the sugarcane borer, d. saccharalis in houma, louisiana, usa, were introduced and tested in brazil against the same insect species. the sixteen introduced germplasm were cp57-614, cp62-258, cp66-491, cp70-321, cp70-330, cp71-321, tainan 2n = 96, us74-103, us76-9, us76-14, us76-15, us76-20, us76-22, us76-25, us76-26 e us76-34. these sixteen introductions plus 4 iac clones, namely 'iac50-134', 'iac52-150', 'iac71-1001' and 'iac1006', were planted on september 26, 1979, in ribeir?o preto, state of sao paulo, brazil. the experimental design used was a complete randomized block with 20 treatments and 10 replications. evaluation was made on september 9, 1980. twenty culms per plot were split lenghtwise and the numbers of internodes bored and not bored were registered. the variation of infestation among the clones was highly correlated with the diameter of the plants. the least infested germplasm was tainan 2n = 96 with a culm diameter of 1.03cm. the most infested, iac52-150 had a diameter of 2.83cm. the infestation (percentage of culms infested) was linearly correlated with the diameter (r2 = 0.91) and the intensity of infestation (percentage of internodes infested) was linearly correlated with the square of the diameter (r2 = 0.82). these results show the possibility of the use of thinner less infested clones introduced from usa as source of resistance to the sugarcane borer in brazilian breeding programs.
Papel do EEG em casos de suspeita ou diagnóstico de epilepsia
Dantas, Fábio Galv?o;Medeiros, Jovany Luis Alves;Nogueira, Bruno Noberto Felinto;Figueiredo, Ant?nio Ranniere de;
Journal of Epilepsy and Clinical Neurophysiology , 2005, DOI: 10.1590/S1676-26492005000200002
Abstract: introduction: since it was discovered, eeg has been used as an important auxiliary diagnostic method in neurology, especially in epilepsy. objective: to verify the value of eeg for supporting the diagnosis of epilepsy. method: we retrospectively analyzed 1015 pre-admission reports from an outpatient clinic of campina grande (pb) selecting the ones with suspected or confirmed epilepsy diagnosis. results: analyzing 259 eeg reports, which were in accordance with the methodology, we found abnormalities in 113 (43.6%). generalized discharges occurred in 30 (11.6%), focal discharges in 44 (17%) and multifocal discharges in 4 (1.5%). abnormal slow waves occurred in 19 (7.3%), being focal in 11 (4.2%) and diffuse in 8 (3.1%). background asymmetry occurred in 16 (6.2%). conclusion: eeg is important for supporting the diagnosis of epilepsy and our results were similar to other reports in the literature.
Potential impact of a presumed increase in the biting activity of dengue-virus-infected Aedes aegypti (Diptera: Culicidae) females on virus transmission dynamics
Luz, Paula Mendes;Lima-Camara, Tamara Nunes;Bruno, Rafaela Vieira;Castro, Márcia Gon?alves de;Sorgine, Marcos Henrique Ferreira;Loureno-de-Oliveira, Ricardo;Peixoto, Alexandre Afranio;
Memórias do Instituto Oswaldo Cruz , 2011, DOI: 10.1590/S0074-02762011000600017
Abstract: recently, we showed that infection with dengue virus increases the locomotor activity of aedes aegypti females. we speculate that the observed increased locomotor activity could potentially increase the chances of finding a suitable host and, as a consequence, the relative biting rate of infected mosquitoes. we used a mathematical model to investigate the impact of the increased locomotor activity by assuming that this activity translated into an increased biting rate for infected mosquitoes. the results show that the increased biting rate resulted in dengue outbreaks with greater numbers of primary and secondary infections and with more severe biennial epidemics.
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