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Search Results: 1 - 10 of 1187 matches for " Britta Hardy "
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New era in cancer immunotherapy: Twenty years to the discovery of monoclonal antibodies harnessing the immune system to eradicate tumors  [PDF]
Britta Hardy, Annat Raiter
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.44A005

The better understanding of the mechanism in which the immune system responds to the developing cancer provided the outcome in a new era in cancer immunotherapy. The tumor suppressive effect on the immune system is caused by negative T cell receptor signaling that abrogate immunity against the cancer cells. Novel monoclonal antibodies that target co-inhibitory receptors on T cells block the tumor induced inhibition of the immune system and enable the immune system to eradicate the tumors. The development of such antibodies started twenty years ago by the preparation of a monoclonal antibody termed BAT. A single administration of the antibody to tumor bearing mice resulted in striking anti tumor activity that was mediated by the lymphocytes. These studies provided a basis for the new era of cancer immunotherapy. The present review summarizes twenty years to the discovery of monoclonal antibodies harnessing the immune system to eradicate tumors.

Euler-Lagrange Elasticity: Differential Equations for Elasticity without Stress or Strain  [PDF]
H. H. Hardy
Journal of Applied Mathematics and Physics (JAMP) , 2013, DOI: 10.4236/jamp.2013.17004

Differential equations to describe elasticity are derived without the use of stress or strain. The points within the body are the independent parameters instead of strain and surface forces replace stress tensors. These differential equations are a continuous analytical model that can then be solved using any of the standard techniques of differential equations. Although the equations do not require the definition stress or strain, these quantities can be calculated as dependent parameters. This approach to elasticity is simple, which avoids the need for multiple definitions of stress and strain, and provides a simple experimental procedure to find scalar representations of material properties in terms of the energy of deformation. The derived differential equations describe both infinitesimal and finite deformations.

Euler-Lagrange Elasticity with Dynamics  [PDF]
H. H. Hardy
Journal of Applied Mathematics and Physics (JAMP) , 2014, DOI: 10.4236/jamp.2014.213138
Abstract: The equations of Euler-Lagrange elasticity describe elastic deformations without reference to stress or strain. These equations as previously published are applicable only to quasi-static deformations. This paper extends these equations to include time dependent deformations. To accomplish this, an appropriate Lagrangian is defined and an extrema of the integral of this Lagrangian over the original material volume and time is found. The result is a set of Euler equations for the dynamics of elastic materials without stress or strain, which are appropriate for both finite and infinitesimal deformations of both isotropic and anisotropic materials. Finally, the resulting equations are shown to be no more than Newton's Laws applied to each infinitesimal volume of the material.
Linear Algebra Provides a Basis for Elasticity without Stress or Strain  [PDF]
H. H. Hardy
Soft (Soft) , 2015, DOI: 10.4236/soft.2015.43003
Abstract: Linear algebra provides insights into the description of elasticity without stress or strain. Classical descriptions of elasticity usually begin with defining stress and strain and the constitutive equations of the material that relate these to each other. Elasticity without stress or strain begins with the positions of the points and the energy of deformation. The energy of deformation as a function of the positions of the points within the material provides the material properties for the model. A discrete or continuous model of the deformation can be constructed by minimizing the total energy of deformation. As presented, this approach is limited to hyper-elastic materials, but is appropriate for infinitesimal and finite deformations, isotropic and anisotropic materials, as well as quasi-static and dynamic responses.
Franchising: An adequate Business Model for the "Proactive University"? A Public-Private Perspective on German HE
Leusing, Britta;
Sinéctica , 2011,
Abstract: public higher education institutions (heis) are experiencing circumstantial changes due to increasing financial pressure, higher autonomy and diversified actors on an increasingly challenging "market". these changes have led to forms of "entrepreneurial behavior" in public heis, such as franchising arrangements, which have become prominent in the context of internationalization and the export of study programs. over the last decade, a growing number of franchising arrangements on an intrastate level can be observed between public universities as franchisors and private, non-state recognized heis as franchisees in the german he sector. the german situation is of special interest because the he system is traditionally state-run and emphasizes the university as a prestige and sound institution. students pay almost no tuition fees for a public university degree except those students enrolled in a franchise model, where the fees are about 9 times higher. special organizational structures like intermediary stock companies and either the lack of or not commonly interpreted regulatory instruments lead to critical discussions of these models. the most crucial assumptions are that financial motives dominate decision making rather than pedagogical considerations and that public services are exploited to mask the interests of individuals. although these presumptions cannot be rejected through the empirical results of case study analyses, the opportunities of such strategic alliances are not to be underestimated. with adequate external and internal quality assurance mechanisms, franchising models can be used to strengthen the market position of public universities through a higher number of students and an extended portfolio of products and services. additionally, he programs can be offered more flexibly in regions with minimal he infrastructure and / or with programs particularly designed for "non-traditional students".
The body in medical imaging between reality and construction
Britta Schinzel
Poiesis & Praxis , 2006, DOI: 10.1007/s10202-006-0025-4
Abstract: Bild gebende Verfahren in der Medizin haben Einsichten in den lebenden K rper verschafft, die vorher ohne invasive Eingriffe nicht m glich waren. Mit diesen Methoden hat eine Revolution in medizinischer Diagnose und biomedizinischer Forschung eingesetzt. Dabei treten andererseits problematische Effekte auf, insbesondere durch die hoch konstruktiven Eigenschaften der Bildproduktion, die komplizierte physikalische und physiologische Effekte ausnutzen. Die Bilderzeugung verwendet komplizierte Kombinationen von Technik und mathematischen und algorithmischen L sungen. Dazu werden Eigenschaften der menschlichen Kognition und des visuellen Systems für die Konstruktion von Unterscheidbarkeit ausgenutzt. Kein Wunder, dass die Visualisierungen des K rpers auch Effekte vorzeigen, die keine physiologischen Korrelate im menschlichen K rper haben. Dessen ungeachtet werden diese Bilder h ufig als eineindeutige Abbildungen des K rpers gesehen. Das hat Folgen, beispielsweise für ihren Gebrauch als Standardisierungsinstanzen. Diese führen zu Definitionen des normierten gesunden K rpers, versus von Krankheit oder Pathologien, von M nnlichkeit versus Weiblichkeit, von rassischen Unterscheidungen etc. Dazu werden Determinismen insinuiert, die in Widerspruch zur Plastizit t und Variabilit t des Gehirns stehen, die sowohl zeitlich wie r umlich, inter- und intra-individuell enorm gro sind.
Rezension zu: Kreowski, Hans-J rg [Hrsg.] (2009): Informatik und Gesellschaft
Britta Schinzel
Libreas : Library Ideas , 2012,
Der Einsatz archivierter Forschungsdaten in der qualitativen Methodenausbildung – Konzept und Evaluation eines Pilotmodells für forschungsnahes Lernen The Use of Archived Research Data in the Training of Qualitative Research Methods—Concept and Evaluation of a Pilot Model for Learning that is Closely Linked to Research El uso de datos de investigación archivados en la capacitación de métodos de in
Britta Stiefel
Forum : Qualitative Social Research , 2007,
Abstract: Die digitale Archivierung qualitativer Forschungsdaten bietet zusammen mit dem Fortschritt softwaregestützter Datenanalyse die Chance zur Wiederverwendung der Daten für eine forschungsnahe Ausbildung in der qualitativen Sozialforschung. Archivierte Daten k nnen als Demonstrations- und Analysematerialien genutzt werden und damit zu einem besseren Verst ndnis qualitativer Forschungsmethodik verhelfen. Für die forschungsnahe Methodenausbildung kann die Verwendung des Konzepts des "Blended Learning", das Pr senzlehre mit Elementen des E-Learning verknüpft, von Vorteil sein. Es gew hrleistet sowohl die fachliche Anleitung durch eine Lehrperson als auch eigenst ndige forschungspraktische Anwendungen durch die Lernenden. Der Artikel stellt das Konzept und Evaluationsergebnisse eines Lehr-Lernmodells vor, welches das Archiv für Lebenslaufforschung (ALLF) der Graduate School of Social Sciences (GSSS) an der Universit t Bremen für die Nutzung archivierter Interviewdaten in der qualitativen Methodenausbildung entwickelte. Das Pilotmodell, dessen inhaltlicher Schwerpunkt auf der Auswertungsmethode des problemzentrierten Interviews liegt, orientiert sich am Konzept des Blended Learning. Die Erprobung und Evaluation in der Lehr-Lernpraxis erfolgte im Rahmen einer Pilotveranstaltung des mobileCampus-Projekts im Studiengang Psychologie der Universit t Bremen. Das Lehr-Lernmodell für forschungsnahes Lernen des Archivs für Lebenslaufforschung soll im Rahmen der Debatte "Lehren und Lernen der Methoden qualitativer Sozialforschung" (http://www.qualitative-research.net/fqs/fqs-d/debate-4-d.htm) zur Diskussion gestellt werden. Au erdem soll mit dem Artikel selbst ein Beitrag zur Debatte geleistet werden. URN: urn:nbn:de:0114-fqs0703152 Digital archiving of qualitative research data together with the progress made in software-based data analysis provides the opportunity to re-use data for a training scheme that is closely related to research in the qualitative social sciences. Archived data can be used as material for demonstration and analysis and can thus facilitate a deeper insight into qualitative research methodology. The use of the concept of "blended learning" linking face-to-face teaching with elements of e-learning can be of advantage for the training of methods that is closely related to research. It ensures both professional tutoring by a teacher and independent research work by the students. The article presents the concept and the evaluation results of a training and learning model the Life-Course-Archive of the Graduate School of Social Sciences (GSSS) at the Uni
EU-project The European Library (TEL) sucessfully finished
Britta Woldering
Knji?nica : Revija za Podro?je Bibliotekarstva in Informacijske Znanosti , 2004,
Universit tslehrgang "Patientensicherheit und Qualit t im Gesundheitssystem": Ein berufsbegleitender Universit tslehrgang für verantwortliche Positionen im Gesundheitswesen [Patient Safety and Healthcare Quality (MSc): an advanced postgraduate program for personnel with positions of responsibility in the health care sector]
Bookhagen, Britta
GMS Zeitschrift für Medizinische Ausbildung , 2011, DOI: 10.3205/zma000732
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