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Search Results: 1 - 10 of 215316 matches for " Brian L.; "
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PRESTO: Rapid calculation of order statistic distributions and multiple-testing adjusted P-values via permutation for one and two-stage genetic association studies
Brian L Browning
BMC Bioinformatics , 2008, DOI: 10.1186/1471-2105-9-309
Abstract: PRESTO is an order of magnitude faster than other existing permutation testing software, and can analyze a large genome-wide association study (500 K markers, 5 K individuals, 1 K permutations) in approximately one hour of computing time. PRESTO has several unique features that are useful in a wide range of studies: it reports empirical null distributions for the top-ranked statistics (i.e. order statistics), it performs user-specified combinations of allelic and genotypic tests, it performs stratified analysis when sampled individuals are from multiple populations and each individual's population of origin is specified, and it determines significance levels for one and two-stage genotyping designs. PRESTO is designed for case-control studies, but can also be applied to trio data (parents and affected offspring) if transmitted parental alleles are coded as case alleles and untransmitted parental alleles are coded as control alleles.PRESTO is a platform-independent software package that performs fast and flexible permutation testing for genetic association studies. The PRESTO executable file, Java source code, example data, and documentation are freely available at http://www.stat.auckland.ac.nz/~browning/presto/presto.html webcite.Permutation testing is often described as the gold-standard for determining statistical significance when performing multiple correlated tests for genetic association. Permutation testing can be applied to both case-control studies and trio studies (parents and affected offspring). In permutation testing, the case/control status of the individuals (for case-control studies) or the transmitted/untransmitted status of the parental chromosomes (for trio studies) are randomly permuted. The maximum test statistic, maximized over all tests for all markers, is calculated for the original affection/transmission status and for each permuted affection/transmission status. If k out of P permutations have a maximum test statistic greater than the maxi
(Miscege)nación en O Corti o
BrianL. Price
Trans : Revue de Littérature Générale et Comparée , 2008,
Abstract: écrit un an après la proclamantion d’indépendance du Brésil, O Corti o de Aluísio Azevedo dépeint la composition démographique du pays avec un sens du détail naturaliste et examine les dangers potentiels de la miscégénation pour la nouvelle république. Influencé par les théories racistes européennes, Azevedo et ses contemporains craignaient que le mélange des races ne fin t par diluer les ascendances européennes qui devaient servir de base à la nouvelle société. Dans le roman, le corti o - une sorte de bourgade prolétarienne qui proliférait à la fin du XIX siècle- fonctionne comme un laboratoire où les différents éléments raciaux de la société convergent, s’entretissent et se détruisent. Le présent essai examine le contexte historique dans lequel ce roman a été rédigé et centre son regard critique sur les deux principales liaisons amoureuses. Dans les deux cas, un homme européen s’unit avec une femme de race inférieur et il paye un prix moral élevé ; dans les deux cas, l’homme perd la pureté que l’auteur attend de la nation nouvelle. En fin de comptes, et contrairement à ce qu’Azevedo espérait, le Brésil métis triomphe sur la colonie européenne et se transforme en corti o. Written a year after the proclamation of Brazilian independence, O Corti o by Aluisio Azevedo depicts the demographic composition of the country with a naturalistic sense of detail and examines the possible dangers of miscegenation in the new republic. Influenced by racist European theories, Azevedo and his contemporaries feared that the mixing of races would eventually result in diluting the European ancestries which had to be the base of the new society. In the novel, the corti o - a kind of small proletarian town which abounded in the 19th century - works as a laboratory where the different racial elements converge, entangle and destroy each other. The present essay examines the historical context during which that novel was written and its critical eye focuses on the two main love affairs. In both, a European man marries (has a love relationship with) a woman of inferior race and pays a high moral price for that. In both, the man loses the purity which the author expects from the new nation. Eventually contrary to what Azevedo expected, mixed-race Brazil triumphs over the European colony and turns into a corti o . Escrito el a o después de realizarse la independencia brasile a, O Corti o de Aluísio Azevedo retrata con detalle naturalista la composición demográfica del país y examina los potenciales maleficios de la miscegenación para la nueva república. Bajo las influencias de teor
Extended-therapy duration for chronic hepatitis C, genotype 1: The long and the short of it
Brian L Pearlman
World Journal of Gastroenterology , 2008,
Abstract: With pegylated interferon and ribavirin, more than half of all chronically-infected hepatitis C patients can achieve a sustained virologic response; however, patients with genotype 1 infections and those with other poor prognostic factors have relatively inferior treatment response rates. Since new therapies are still years away from approval, it is incumbent upon providers to maximize the therapeutic efficacy of today’s treatment. The later the virus is undetectable in serum during treatment, the less likely it will be eradicated. Patients with a delayed or slow virologic response to therapy (at least a 2-log10 decrease in baseline hepatitis C RNA yet detectable viremia at 12 wk of therapy and undetectable virus 12 wk subsequently) may, therefore, benefit from an extended therapy course beyond one of standard duration. Although higher rates of treatment discontinuation may plague this approach, 72 wk of treatment for genotype 1-infected slow-responders may improve response rates and diminish relapse rates relative to those of 48 wk. Based on data from both viral kinetic and clinical studies, therapy prolongation in slow responders may be a reasonable strategy to improve response rates in these treatment-refractory patients.
TEI Texts that Play Nicely: Lessons from the MONK Project
Brian L. Pytlik Zillig
Journal of the Chicago Colloquium on Digital Humanities and Computer Science , 2011,
Abstract: Text curation, like most human endeavors, requires tools. A technique developed for the MONK Project, schema harvesting, provides a useful platform for facilitating the digital conversion and curation of text corpora. The author describes Abbot, an XSLT-based application that has had success in converting various Text Creation Partnership collections, and others, during and after MONK.
Fin de la Preuve de la Conjecture du Jacobien en dimension 2
Jo?l Brian?on
Mathematics , 2005,
Abstract: This paper has been withdrawn by the author. Indeed, the identity Jac(F\_j,Psi)=Psi^s in part 2.2. has to be proved.
Examination of Sexually Dimorphic Behavior on the Novel-Image Novel-Location Recognition Memory Test  [PDF]
Brian J. Piper, Alia L. Yasen, Jeremy K. Miller
Journal of Behavioral and Brain Science (JBBS) , 2011, DOI: 10.4236/jbbs.2011.13018
Abstract: Objectives: Sex differences in object location memory favoring females appear to be a replicable phenomenon but may also depend on the task demands. This investigation evaluated if females outperformed males at both a short (immediate) and long (half-hour) interval between the learn and test condition using a recently developed version of the Novel-Image Novel-Location (NINL) test (Piper et al. 2011, Physiology & Behavior, 103, 513 - 522). Methods: Young-adults (N = 184) completed a standardized handedness inventory and the NINL. Results: Participants assigned to the Immediate and Delayed conditions did not differ in age, sex, or handedness. The NINL total score was higher among females at the Immediate, but not Delayed, interval. However, within the Delayed condition, females excelled at correctly identifying the unchanged items with a similar pattern for the Novel-Location (NL) scale. Conclusion: These findings are consistent with the view that sexually dimorphic performance favoring females in neurocognitive function can also extend to tasks that have a spatial component.
Microsurgical Reconstruction of Large, Locally Advanced Cutaneous Malignancy of the Head and Neck
Joseph L. Hill,Brian Rinker
International Journal of Surgical Oncology , 2011, DOI: 10.1155/2011/415219
Abstract: Large, locally advanced cutaneous malignancy of the head and neck region is rare. However, when present, they impart a significant reconstructive challenge. These cancers have a tendency to invade peripheral tissues covering a large surface area as well as expose deeper structures such as skull, dura, orbit, and sinus after resection. Complicating the reconstructive dilemma is the high incidence of individuals who have undergone previous surgery in the region as well as adjuvant radiation therapy, which may preclude the use of local flaps or skin graft. Free tissue transfer provides a reconstructive surgeon the ability to provide well-vascularized tissue with adequate volume not limited by arc of rotation. 1. Background Skin cancer is the most common type of cancer in fair skinned individuals [1]. Basal cell carcinoma is the most common type of skin cancer, affecting approximately 2 million Americans per year [2]. Basal cell carcinoma is followed closely in incidence by squamous cell carcinoma, which accounts for 20% of all skin cancers, with approximately 700,000 new cases identified per year [2, 3]. Basal cell and squamous cell cancers are more common in sun-exposed areas of the body, including the head and neck region [3, 4]. Other less common types of cutaneous malignancy in the head and neck region include melanoma, Merkel cell carcinoma, sebaceous carcinoma, eccrine carcinoma, and dermatofibrosarcoma protuberans. The head and neck region is a well-visualized region of the body. Skin cancers in this region are usually easily identifiable with patients typically presenting early in the clinical course of the disease [5]. These skin cancers are amenable to simple resection followed by reconstruction with a skin graft, local flap, or healing by secondary intention [5, 6]. Most patients heal uneventfully with good restoration of function and appearance [5, 6]. Occasionally, however, patients with skin cancers present much later in the clinical course of the disease [7]. These types of cancers have been described as “advanced,” “massive,” “complex,” “gigantic,” and “horrifying [7].” The main reasons that patients present with such extensive tumors are failure of primary treatment and patient neglect [7]. 2. Reconstructive Dilemma Fortunately, these types of advanced skin cancers are rare [6, 8]. As an example, the incidence of giant basal cell carcinomas (>5?cm diameter) is less than 1% of all basal cell carcinomas [8]. Despite their infrequent presentation, defects following resection of large cutaneous malignancies present a marked reconstructive
A Revision of Male Ants of the Malagasy Amblyoponinae (Hymenoptera: Formicidae) with Resurrections of the Genera Stigmatomma and Xymmer
Masashi Yoshimura, Brian L. Fisher
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0033325
Abstract: In a male-based revision of ants of the subfamily Amblyoponinae from the Southwest Indian Ocean islands (SWIO: Comoros, Madagascar, Mauritius, Mayotte, Reunion, and Seychelles), we explore and reconsider male morphological characters that distinguish genera within the group. Our investigation redefines Amblyopone Erichson sensu Brown (1960), here referred to as Amblyopone sensu lato, into three genera: Xymmer Santschi stat. rev., Amblyopone sensu stricto, Stigmatomma Roger stat. rev. All species names under Amblyopone s. l. reassign into Xymmer and Amblyopone s. s., which are small, well-defined genera, and Stigmatomma, a large group with a generic delimitation that still needs further refinement. Based on a study of male mandible characters and our scenario for mandibular evolution of the worker caste within Amblyopone s. l, we conclude that Amblyopone s. s. nests outside of XMAS (Xymmer+Mystrium+Adetomyrma+Stigmatomma) clade. The following names are transferred from Amblyopone s. l. to Xymmer as comb. rev.: muticus. The following names are transferred from Amblyopone s. l. to Stigmatomma as comb. rev.: amblyops, armigerum, bellii, bierigi, bruni, celata, chilense, denticulatum, elongatum, emeryi, feae, impressifrons, luzonicum, minuta, normandi, oregonense, pallipes, quadratum, reclinatum, rothneyi, santschii, saundersi, silvestrii, zwaluwenburgi; as comb. nov.: agostii, annae, besucheti, boltoni, caliginosum, cleae, crenatum, degeneratum, egregium, electrinum, eminia, exiguum, falcatum, ferrugineum, fulvidum, gaetulicum, gingivalis, glauerti, gnoma, gracile, groehni, heraldoi, lucidum, lurilabes, monrosi, mystriops, noonadan, octodentatum, ophthalmicum, orizabanum, papuanum, pertinax, pluto, punctulatum, rubiginoum, sakaii, smithi, trigonignathum, trilobum, wilsoni, zaojun, and testaceum. A male-based key to the genera of Malagasy amblyoponine ants, their diagnoses, and a discussion of the evolution of the morphological character of males in the subfamily are given, and the distinguishing characters of each are illustrated. In addition, our results predict that Paraprionopelta belongs in the XMAS clade and that Concoctio should have males with two mandibular teeth.
Temporally Dissociated, Trait-Specific Modifications Underlie Phenotypic Polyphenism in Spea multiplicata Tadpoles, Which Suggests Modularity
Brian L. Storz,Joseph Travis
The Scientific World Journal , 2007, DOI: 10.1100/tsw.2007.159
Embedding Communication Skills for Future Financial Planners
L. Celeste Rossetto,Brian Murphy
Australasian Accounting Business and Finance Journal , 2010,
Abstract: Financial planners need to have solid knowledge of a range of financial concepts and be adeptcommunicators. Australian universities comprehensively ground students in the necessary contentknowledge for their future careers, however, scant attention is paid to the indispensable communication skillsthat students will need when they enter the professional arena. Students need to accumulate financialplanning knowledge but they also have to interact with clients and peers in a business where they willnegotiate a professional identity for themselves that will serve their specific expertise. It takes time to developthese skills and to assume a professional identity. The focus of our paper is how to engender this persona atthe same time as the students acquire their knowledge. We focus on strategies and activities that were used toembed professional communication skills within a financial planning subject in a regional university throughexperiential learning and authentic tasks.
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