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Search Results: 1 - 10 of 18807 matches for " Brase Jan Christoph "
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Two new cases of anti-Ca (anti-ARHGAP26/GRAF) autoantibody-associated cerebellar ataxia
Jarius Sven,Martínez-García Pedro,Hernandez Adelaida León,Brase Jan Christoph
Journal of Neuroinflammation , 2013, DOI: 10.1186/1742-2094-10-7
Abstract: Recently, we discovered a novel serum and cerebrospinal fluid (CSF) autoantibody (anti-Ca) to Purkinje cells in a patient with autoimmune cerebellar ataxia (ACA) and identified the RhoGTPase-activating protein 26 (ARHGAP26; alternative designations include GTPase regulator associated with focal adhesion kinase pp125, GRAF, and oligophrenin-1-like protein, OPHN1L) as the target antigen. Here, we report on two new cases of ARHGAP26 autoantibody-positive ACA that were first diagnosed after publication of the index case study. While the index patient developed ACA following an episode of respiratory infection with still no evidence for malignancy 52 months after onset, neurological symptoms heralded ovarian cancer in one of the patients described here. Our finding of anti-Ca/anti-ARHGAP26 antibodies in two additional patients supports a role of autoimmunity against ARHGAP26 in the pathogenesis of ACA. Moreover, the finding of ovarian cancer in one of our patients suggests that anti-Ca/anti-ARHGAP26-positive ACA might be of paraneoplastic aetiology in some cases. In conclusion, testing for anti-Ca/anti-ARHGAP26 should be included in the diagnostic work-up of patients with ACA, and an underlying tumour should be considered in patients presenting with anti-Ca/ARHGAP26 antibody-positive ACA.
From High-Throughput Microarray-Based Screening to Clinical Application: The Development of a Second Generation Multigene Test for Breast Cancer Prognosis
Jan C. Brase,Ralf Kronenwett,Christoph Petry,Carsten Denkert,Marcus Schmidt
Microarrays , 2013, DOI: 10.3390/microarrays2030243
Abstract: Several multigene tests have been developed for breast cancer patients to predict the individual risk of recurrence. Most of the first generation tests rely on proliferation-associated genes and are commonly carried out in central reference laboratories. Here, we describe the development of a second generation multigene assay, the EndoPredict test, a prognostic multigene expression test for estrogen receptor (ER) positive, human epidermal growth factor receptor (HER2) negative (ER+/HER2?) breast cancer patients. The EndoPredict gene signature was initially established in a large high-throughput microarray-based screening study. The key steps for biomarker identification are discussed in detail, in comparison to the establishment of other multigene signatures. After biomarker selection, genes and algorithms were transferred to a diagnostic platform (reverse transcription quantitative PCR (RT-qPCR)) to allow for assaying formalin-fixed, paraffin-embedded (FFPE) samples. A comprehensive analytical validation was performed and a prospective proficiency testing study with seven pathological laboratories finally proved that EndoPredict can be reliably used in the decentralized setting. Three independent large clinical validation studies (n = 2,257) demonstrated that EndoPredict offers independent prognostic information beyond current clinicopathological parameters and clinical guidelines. The review article summarizes several important steps that should be considered for the development process of a second generation multigene test and offers a means for transferring a microarray signature from the research laboratory to clinical practice.
DataCite and linked data DataCite and linked data
Jan Brase
JLIS.it , 2013, DOI: 10.4403/jlis.it-5493
Abstract: Science is global, it needs global standards, global workflows and is a cooperation of global players. But science is carried out locally by local scientists that are part of local infrastructures with local funders. DataCite is an international consortium, founded in 2009 of currently 17 institutions from 12 countries worldwide. Its mission is to allow a better re-use and citation of data sets. Over 1 million datasets have been registered with a DOI name as a persistent identifier, so they can be published as independent scientific objects to allow stabile citation of data. Citable data sets can be crosslinked from journal articles, their usage and citations can be measured therefore helping scientists gain credit for making their data available. DataCite offers a central metadata repository with additional linked data service for persistent access to RDF metadata. Science is global, it needs global standards, global workflows and is a cooperation of global players. But science is carried out locally by local scientists that are part of local infrastructures with local funders. DataCite is an international consortium, founded in 2009 of currently 17 institutions from 12 countries worldwide. Its mission is to allow a better re-use and citation of data sets. Over 1 million datasets have been registered with a DOI name as a persistent identifier, so they can be published as independent scientific objects to allow stabile citation of data. Citable data sets can be crosslinked from journal articles, their usage and citations can be measured therefore helping scientists gain credit for making their data available. DataCite offers a central metadata repository with additional linked data service for persistent access to RDF metadata.
Inferring Metadata for a Semantic Web Peer-to-Peer Environment
Jan Brase,Mark Painter
Educational Technology & Society , 2004,
Abstract: Learning Objects Metadata (LOM) aims at describing educational resources in order to allow better reusability and retrieval. In this article we show how additional inference rules allows us to derive additional metadata from existing ones. Additionally, using these rules as integrity constraints helps us to define the constraints on LOM elements, thus taking an important step toward a complete axiomatization of LOM metadata (with the goal of transforming the LOM definitions from a simple syntactical description into a complete ontology). We will use RDF metadata descriptions and Prolog as an inference language. We show how these rules can be applied for the extensions of course metadata using an existing test bed with several courses. Based on the Edutella peer-to-peer architecture we can easily make RDF metadata accessible to a whole community using Edutella peers that manage RDF metadata. By processing inference rules we can achieve better search results.
Serum microRNAs as non-invasive biomarkers for cancer
Jan C Brase, Daniela Wuttig, Ruprecht Kuner, Holger Sültmann
Molecular Cancer , 2010, DOI: 10.1186/1476-4598-9-306
Abstract: In this review, we discuss recent findings indicating that circulating microRNAs are useful as non-invasive biomarkers for different tumor types. Additionally, we summarize the knowledge about the mechanism of microRNA release and the putative functional roles of circulating microRNAs. Although several challenges remain to be addressed, circulating microRNAs have the potential to be useful for the diagnosis and prognosis of cancer diseases.One of the major challenges in cancer research is the identification of stable biomarkers, which can be routinely measured in easily accessible samples. Over many decades it has been shown that cell-free DNA and RNA is present in serum and other body fluids and that these circulating nucleic acids may represent potential biomarkers (reviewed in [1-3]). One decade ago, microRNAs (miRNAs) were discovered as a novel class of evolutionarily conserved small (18 - 24 nucleotides) non-coding RNA molecules, which are important regulators of gene expression [4,5]. By targeting the 3' untranslated region (UTR) of mRNA transcripts, miRNAs influence RNA stability and translational efficiency via degradation or protein translation inhibition, respectively [4,6-9]. Thus, alterations in miRNA-expression can affect crucial biological processes in cancer development and progression, such as proliferation, differentiation and apoptosis [10,11]. For example, the well-described let 7 miRNA family is evolutionary conserved from C. elegans to humans and has been shown to directly target the human RAS oncogenes [12]. In humans, significantly reduced expression of let-7 family members has been found in various cancers including lung, colon, ovarian, and gastric cancer, as well as leiomyoma and melanoma [13]. Its decreased expression is associated with a significantly shorter survival of lung cancer patients and promotes the colony forming ability of lung cancer cells in vitro [14]. miRNA 221 and miRNA 222 are located on chromosome X, and have been report
德国国家科技图书馆的发展思考与实践
jan,brase,uwe,rosemann,irina,sens,顾立平
图书情报工作 , 2013,
Abstract: ?简介科研数据应用的新发展以及科研数据权益管理的新挑战。描述德国国家科技图书馆的可扩展架构以及其中的科研数据入口网站getinfo、永久性识别服务doi、全球性数据引用服务datacite等的实践成果,并讨论培养数据馆员的需求。这些服务可以增强对非文本资源的检索、标识数字数据资源、促使科研数据得到正式引用以及提升图书馆价值。
Varicocele and a Vascular Tumor in the Testis
Christoph Kraft,Jan Janzen
Case Reports in Urology , 2013, DOI: 10.1155/2013/896142
Abstract: A 50-year-old man presented a rare morphological constellation: a left-sided varicocele (stage 3) and a vascular rich Sertoli cell tumor. 1. Introduction It is well known that varicocele leads to circulatory disturbances, testicular atrophy (shrinking), seminiferous tubule sclerosis, vessels degenerative changes, and abnormalities of Leydig, Sertoli, and germ cells [1, 2]. We have observed a high-grade varicocele in association with a testicular vascular tumor. 2. Case Presentation A 50-year-old man came to the urologist and presented a painful mass in the left scrotum. Clinically, a high-grade varicocele (stage 3) and a low testicular volume were found (Figure 1). Furthermore, a tumor in the upper pole area of the left testicle was observed. All tumor markers were negative; there were no symptoms of a renal cell carcinoma or nutcracker syndrome. Because of the low testicular volume, a left inguinal orchiectomy without intraoperative histopathological diagnosis (frozen section) was performed. Figure 1: Tumor (red circle) and high-grade varicocele in sonography. Macroscopically, an abnormal dilation of the plexus pampiniformis and vessel mass measuring 50?mm in diameter were found. Left testicle measured ?mm, and a ?mm grey white solid tumor was seen (Figures 2 and 3). Rete testis, epididymis, and spermatic cord were inconspiciuous. Figure 2: Macroscopic aspects of the benign testicular tumor. Figure 3: Vascular testicular tumor, measuring 12?mm in diameter. Microscopically, abnormal venous vessels in the plexus pampiniformis characterised by a severe leiomyomatous hyperplasia with incorporated nerve fibers were found. The lumen of the veins varied between 15 and 25?mm. Venous valves were absent. The testicular tumor had two microscopic patterns: (i)vascular pattern in 70% of the tumor area: thick-wall vessels with CD34 expression and epithelioid cells, (ii)tubular pattern in 30% of the tumor area: hyalinised Sertoli cells with cytokeratin 18 expression (Figures 4 and 5).Overall, a low proliferation rate (1 Mitosis/10 HPF), MIB1 (Ki67) in 3–5% of the tumor cells were detected; neither lymph nor hemangiosis carcinomatosa were observed. Adjacent testicular parenchyma showed a complete and arrested spermatogenesis, and a testicular intraepithelial neoplasia was excluded by immunohistochemistry (PLAP negative). We propose to classify this non-malignant tumor as a vascular rich Sertoli cell tumor of the testis. Figure 4: Microscopic aspects: benign vascular tumor and testicular parenchyma. Figure 5: Microscopic aspects: Sertoli cells (a) and vascular
On rate optimal local estimation in nonparametric instrumental regression
Christoph Breunig,Jan Johannes
Mathematics , 2009,
Abstract: We consider the problem of estimating the value of a linear functional in nonparametric instrumental regression, where in the presence of an instrument W a response Y is modeled in dependence of an endogenous explanatory variable Z. The proposed estimator is based on dimension reduction and additional thresholding. The minimax optimal rate of convergence of the estimator is derived assuming that the structural function and the representer of the linear functional belong to some ellipsoids which are in a certain sense linked to the conditional expectation operator of Z given W. We illustrate these results by considering classical smoothness assumptions.
Adaptive estimation of functionals in nonparametric instrumental regression
Christoph Breunig,Jan Johannes
Statistics , 2011,
Abstract: We consider the problem of estimating the value l({\phi}) of a linear functional, where the structural function {\phi} models a nonparametric relationship in presence of instrumental variables. We propose a plug-in estimator which is based on a dimension reduction technique and additional thresholding. It is shown that this estimator is consistent and can attain the minimax optimal rate of convergence under additional regularity conditions. This, however, requires an optimal choice of the dimension parameter m depending on certain characteristics of the structural function {\phi} and the joint distribution of the regressor and the instrument, which are unknown in practice. We propose a fully data driven choice of m which combines model selection and Lepski's method. We show that the adaptive estimator attains the optimal rate of convergence up to a logarithmic factor. The theory in this paper is illustrated by considering classical smoothness assumptions and we discuss examples such as pointwise estimation or estimation of averages of the structural function {\phi}.
The (In)flexibility of Evolved Frequency Representations for Statistical Reasoning: Cognitive Styles and Brief Prompts Do Not Influence Bayesian Inference
进化频率表征对统计推理(非)灵活性的影响:认知风格和简要提示不影响贝叶斯推理

Gary L Brase,
Gary
,L. ,Brase

心理学报 , 2007,
Abstract: What happens when format manipulations improve Bayesian reasoning? One view is that naturally sampled frequencies help induce a privileged representational system that is relatively specific in its operation. A contrasting view is that naturally sampled frequencies are but one way to induce a more general process of appreciating nested set relationships. This later view implies that fairly brief and immediate interventions (e.g., simple directives) should produce improvement, whereas the former view implies that more extensive interventions and/or more insightful understanding are necessary for improvement. The present research indicates that neither brief and immediate interventions nor pre-existing representational biases or representational flexibility facilitate performance. Some evidence emerged, on the other hand, that frequentist problem interpretation can improve statistical reasoning performance and increase confidence in responses at times. These results support the privileged representational system view.
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