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Search Results: 1 - 10 of 2637 matches for " Brajendra Mishra "
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Epidemiological Investigation on Rabies Deaths in Berasia Block, Bhopal
Mishra Brajendra
National Journal of Community Medicine , 2012,
Abstract: Background: In rural area of a community block, four rabies deaths within 19 days following exposure, in spite of receiving Post exposure Prophylactic vaccination warranted epidemiological investigation and situational analysis to take up remedial measures if any. Methodology: A detailed epidemiological study was planed. The component of the study included eco-geographical evaluation of the study area by visit, post exposure clinic-epidemiological evaluation of survivors by clinical examination and interview, verbal autopsy from the kith and kin of the four dead cases, enquiries on practice of standard protocol by health providers an health seeking behaviour of the cases/families involved through interview and immunological analysis for measuring the titers of antirabies antibodies in sera of some patients following exposure/vaccination. All the 36 cases bitten by rabid Jackal were contacted and interviewed. Family contacts of all four who died were also interviewed. Block Medical Officer of the area was also interviewed. Result: It was found that man made alterations in eco- geographical features were leading to increase in exposure risks to sylvatic rabies. It was found that standard protocol for Post Exposure Prophylaxis was not in practice and health providers and other related agencies needed reorientation on conduct of post exposure prophylaxis. It was found that population living in high risk zone needs to be educated on immediate care to be taken after exposure and modify their own health seeking behaviour by not visiting the quacks.
Chemical Enrichment of Nickel Sulfide  [PDF]
Vladimir Luganov, Brajendra Mishra, Saule Baimakhanova, Rinat Akpanbayev
International Journal of Nonferrous Metallurgy (IJNM) , 2016, DOI: 10.4236/ijnm.2016.51001
Abstract:

The availability of polymetallic ores is getting leaner in grade and is larger but inferior in volumes than in the past, making the extraction of copper, nickel and other non-ferrous metals metallurgically more difficult to produce. The standard technologies, including enrichment and concentration, do not provide methods for obtaining monometallic concentrates and high extraction of metals into the commercial product. Pyrometallurgical processing of large volumes of poor raw materials is not economical and is complicated from the technological point of view. Conditions of chemical enrichment of poor natural materials have been studied with the use of technology of salt exchange leaching. The main impurity in sulfide ores of nonferrous metals is iron present in the forms of pyrite and pyrrhotite and the properties of chemical enrichment for nickel in pyrite concentrates has been investigated in this work. On the basis of thermodynamic analysis carried out with the use of Potential-pH Pourbaix’s Diagrams, it has been established that, with the use of nickel salt, it is possible to leach iron sulfides from ores. Based on the study of the mechanism and kinetics of the process of dissolution of iron sulfides with nickel salts, it was established that during the dissolution, the chemical composition and thermodynamic characteristics of the dissolved iron sulfides change—the residues from leaching are enriched with iron sulfides that are rich in sulfur and also result with elemental sulfur formation. Enrichment of leaching residues with sulfide iron with increased sulfur content and formation on the surface of nickel sulfide leads to increase of diffusional resistances and the process is limited by the velocity of mass transfer. To increase the velocity of the process and completeness of the reaction, it is necessary to activate the process, in particular, by grinding the solid phase.

Electrochemical Method for Producing Valuable Sulfur Compounds from Waste Materials  [PDF]
Abduali Baeshov, Begzat Myrzabekov, Arman Makhanbetov, Brajendra Mishra, Omirserik Baigenzhenov, Vladimir Luganov
International Journal of Nonferrous Metallurgy (IJNM) , 2017, DOI: 10.4236/ijnm.2017.62002
Abstract: Method and mechanism for the formation of sulfur compounds during the process of sulfur electrochemical dissolution has been studied, including a technique for the production of composite sulfur-graphite electrode. Along with these, a 3D design is presented in the unit that was used to perform electrolytic reduction, using composite sulfur-graphite electrode. For the first time, a study was carried out for the simultaneous reactions of electroreduction and electrooxidation of sulfur at the sulfur-graphite electrode in sulfurous environment in the same electrolytic bath, with separate electrode spaces. Influences of current density, acid concentration and electrolyte temperature were studied, and it was demonstrated that sulfur is reduced in cathode chamber with formation of hydrogen sulfide gas, and is oxidized in the anode chamber with formation of sulfite and sulfate ions. It has been shown that the methods we propose can be used to produce important sulfur compounds through electrochemical dissolution of specially designed sulfur-graphite electrode.
Electrochemical Behavior of Titanium and Its Alloys as Dental Implants in Normal Saline
Rahul Bhola,Shaily M. Bhola,Brajendra Mishra,David L. Olson
Advances in Physical Chemistry , 2009, DOI: 10.1155/2009/574359
Abstract: The electrochemical behavior of pure titanium and titanium alloys in a simulated body fluid (normal saline solution) has been tested, and the results have been reported. The significance of the results for dental use has been discussed. The tests also serve as a screening test for the best alloy system for more comprehensive long-term investigations.
Electrochemical Evaluation of Wrought Titanium -15 Molybdenum Alloy for Dental Implant Applications in Phosphate Buffer Saline
Bhola,Rahul; Bhola,Shaily M.; Mishra,Brajendra; Olson,David L.;
Portugaliae Electrochimica Acta , 2010,
Abstract: ti-15mo alloy has been evaluated for its electrochemical behavior in phosphate buffer saline solution at the physiological temperature of 37 oc. a two time constant model of a duplex oxide layer has been used to assess the corrosion behavior of the ti-15mo alloy-solution interface using electrochemical impedance spectroscopy (eis). interfacial characteristics of the inner barrier layer and the outer porous layer have been studied to understand the role of the alloy as an implant. ti-15mo alloy shows a very high barrier layer resistance and a tendency to resist localized corrosion.
Electrochemical Evaluation of Wrought Titanium -15 Molybdenum Alloy for Dental Implant Applications in Phosphate Buffer Saline
Rahul Bhola,Shaily M. Bhola,Brajendra Mishra,David L. Olson
Portugaliae Electrochimica Acta , 2010,
Abstract: Ti-15Mo alloy has been evaluated for its electrochemical behavior in phosphate buffer saline solution at the physiological temperature of 37 oC. A two time constant model of a duplex oxide layer has been used to assess the corrosion behavior of the Ti-15Mo alloy-solution interface using electrochemical impedance spectroscopy (EIS). Interfacial characteristics of the inner barrier layer and the outer porous layer have been studied to understand the role of the alloy as an implant. Ti-15Mo alloy shows a very high barrier layer resistance and a tendency to resist localized corrosion.
Corrosion Response of Ti6Al4V and Ti15Mo Dental Implant Alloys in the Presence of Listerine Oral Rinse
Rahul Bhola,Charu Chandra,Faisal M. Alabbas,Sukumar Kundu,Brajendra Mishra,David L. Olson
International Journal of Corrosion , 2013, DOI: 10.1155/2013/739841
Abstract: The influence of a commonly used antibacterial mouth rinse, Listerine, on the corrosion behavior of one of the commonly used titanium alloys Ti6Al4V (two-phase structure, i.e., α and β) and a newer Ti15Mo (single β phase) in normal saline solution has been investigated using electrochemical techniques. Interfacial electrochemical changes occurring at the oxide-solution interface have been analysed using EIS circuit modeling. Listerine acts as a corrosion inhibitor for Ti15Mo alloy and a corrosion promoter for Ti6Al4V alloy. 1. Introduction Listerine is a commonly used mouth rinse with antiplaque, anticaries, and antibacterial properties. It is used in several dental applications following periodontal procedures and routine oral prophylaxis. It was awarded the American Dental Association’s seal of recognition in 1987 for its clinical efficacy in plaque control and gingival improvement [1]. Listerine antiseptic, developed by Warner-Lambert, was the first over-the-counter mouth rinse [2]. Listerine contains different essential oils, which are phenolics such as thymol, eucalyptol, menthol, and methyl salicylate and are known to retard plaque buildup and reduce gingivitis [3–10]. Thymol, eucalyptol, and menthol are known to possess proven antibacterial activity and are found in thyme (Thymus vulgaris), eucalyptus (Eucalyptus globulus), and peppermint (Mentha piperita), respectively. Methyl salicylate has anti-inflammatory activity and is found in meadowsweet (Filipendula ulmaria) and willow (Salix spp.) [2]. The effect of Listerine on plaque was ascribed to its bactericidal properties related to the alteration of bacterial cell wall, which has been well documented in vitro and in vivo [11–15]. A newly inserted prosthesis and various surrounding tissues may get exposed to Listerine from minutes to days, depending upon the therapy performed and the local and systemic patient factors. It is thus important to understand the effect of Listerine on the electrochemical and corrosion behavior of titanium alloys in order to predict treatment prognosis. Cestarolli et al. [16] have compared the effect of mouthwashes including Listerine and a simulated body fluid on the corrosion behavior of an Fe-Cr-Ni alloy. The corrosion resistance of this alloy was the highest in the presence of Listerine mouthwash. However, the present study simulates the use of Listerine as an oral prophylactic rinse, in other words, the condition when the concentration of saliva gets altered due to the presence of Listerine in the mouth. The effect of this normal saline-Listerine solution has,
VALIDATION AND PROCESS DEVELOPMENT: A REVIEW
Rajpoot Brajendra singh
International Research Journal of Pharmacy , 2011,
Abstract: Total Quality Management and specifications according to regulatory guidelines involved in pharmaceutical production has a great impact significantly on the quality of the products. The validation protocol includes inventory control and equipment inspections in the preliminary steps and in-process controls in the subsequent steps. Process controls are mandatory in good manufacturing practices (GMP). The purpose of setting validation parameters is to monitor the on-line and off-line performance of the manufacturing process, and hence, validate it1,2. Thus validation is an integral part of quality assurance. This review critically evaluates the need for pharmaceutical validation, the various approaches and steps involved, and other pertinent considerations.
METHOD DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD IN THE DETECTION OF EFAVIRENZ IN BULK DRUG AND TABLET FORMULATION
Brajendra singh Rajpoot
International Research Journal of Pharmacy , 2012,
Abstract: A simple, highly sensitive, isocratic reversed phase high performance liquid chromatography (RP-HPLC) was developed for the determination of efavirenz in the bulk drug and tablet dosage forms. Elution medium consisting of a mixture of methanol and water in the ratio of (89:11, v/v) at flow rate 1ml/min was employed in this study. The retention time of efavirenz was found 2.58 min. The calibration curves were linear with regression coefficient (r2) of 0.9999. The proposed method was extensively validated for linearity, range, accuracy, precision and specificity. The proposed method is sensitive, specific and was successfully applied for the estimation of efavirenz in pharmaceutical formulations (bulk drug and tablet).
METHOD DEVELOPMENT AND VALIDATION OF RP- HPLC IN THE APPLICATION OF IN-VITRO DISSOLUTION STUDY OF EMTRICITABINE IN BULK DRUG AND TABLET FORMULATION
Rajpoot Brajendra singh,Rajpoot Neha
International Research Journal of Pharmacy , 2012,
Abstract: A new RP-HPLC method was developed for the determination of Emtricitabine in the bulk drug and tablet dosage forms and it was applied for the in vitro drug dissolution studies. Isocratic elution mode with a mixture of methanol and water in the ratio of (89:11) was selected as the mobile phase with a C18 column (250 x 4.6mm, 5μ ) for separation. This mixture was found to be appropriate allowing good elution for the Emtricitabine at retention time 2.72 minute at flow rate of 1 ml/min and detection wavelength at 272nm. The linearity was found in the concentration range of Emtricitabine 5-100 μ g/ml. The liquid chromatography method was extensively validated for linearity, range, accuracy, precision (intermediate precision, repeatability) and specificity. All these analytical validation parameters were observed and the %RSD was determined which indicates the useful of RP-HPLC method for determination of Emtricitabine in the bulk drug & tablets dosage form.
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