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Search Results: 1 - 10 of 249106 matches for " Br?ndbo Per "
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IQ as a moderator of outcome in severity of children’s mental health status after treatment in outpatient clinics
Mathiassen B?rge,Brndbo Per,Waterloo Knut,Martinussen Monica
Child and Adolescent Psychiatry and Mental Health , 2012, DOI: 10.1186/1753-2000-6-22
Abstract: Background Psychotherapy is an effective treatment for mental health disorders, but even with the most efficacious treatment, many patients do not experience improvement. Moderator analysis can identify the conditions under which treatment is effective or whether there are factors that can attenuate the effects of treatment. Methods In this study, linear mixed model analysis was used to examine whether the Full Scale IQ (FSIQ), Performance IQ (PIQ) and Verbal IQ (VIQ) on the Wechsler Intelligence Scale for Children – Third Edition, moderated outcomes in general functioning and symptom load. A total of 132 patients treated at three outpatient child and adolescent mental health services (CAMHS) were assessed at three different time points. The Children’s Global Assessment Scale (CGAS) and the Health of the Nation Outcome Scales for Children and Adolescents (HoNOSCA) were used to measure the severity of impairments in general functioning and symptom load. IQ was assessed at the start of treatment. Results Moderator analysis revealed that the FSIQ × time interaction predicted changes in CGAS scores (p < .01), and that the PIQ × time interaction predicted changes in HoNOSCA scores (p < .05). The slopes and intercepts in HoNOSCA scores covaried negatively and significantly (p < .05). The same pattern was not detected for the CGAS scores (p = .08). Conclusions FISQ and PIQ moderated change in general functioning and symptom load, respectively. This implies that patients with higher IQ scores had a steeper improvement slope than those with lower scores. The patients with the highest initial symptom loads showed the greatest improvement, this pattern was not found in the improvement of general functioning.
The strengths and difficulties questionnaire as a screening instrument for norwegian child and adolescent mental health services, application of UK scoring algorithms
Brndbo Per,Mathiassen B?rge,Martinussen Monica,Heiervang Einar
Child and Adolescent Psychiatry and Mental Health , 2011, DOI: 10.1186/1753-2000-5-32
Abstract: Background The use of screening instruments can reduce waiting lists and increase treatment capacity. The aim of this study was to examine the usefulness of the Strengths and Difficulties Questionnaire (SDQ) with the original UK scoring algorithms, when used as a screening instrument to detect mental health disorders among patients in the Norwegian Child and Adolescent Mental Health Services (CAMHS) North Study. Methods A total of 286 outpatients, aged 5 to 18 years, from the CAMHS North Study were assigned diagnoses based on a Development and Well-Being Assessment (DAWBA). The main diagnostic groups (emotional, hyperactivity, conduct and other disorders) were then compared to the SDQ scoring algorithms using two dichotomisation levels: 'possible' and 'probable' levels. Sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio (ORD) were calculated. Results Sensitivity for the diagnostic categories included was 0.47-0.85 ('probable' dichotomisation level) and 0.81-1.00 ('possible' dichotomisation level). Specificity was 0.52-0.87 ('probable' level) and 0.24-0.58 ('possible' level). The discriminative ability, as measured by ORD, was in the interval for potentially useful tests for hyperactivity disorders and conduct disorders when dichotomised on the 'possible' level. Conclusions The usefulness of the SDQ UK-based scoring algorithms in detecting mental health disorders among patients in the CAMHS North Study is only partly supported in the present study. They seem best suited to identify children and adolescents who do not require further psychiatric evaluation, although this as well is problematic from a clinical point of view.
Recurrent Respiratory Papillomatosis: HPV Genotypes and Risk of High-Grade Laryngeal Neoplasia
Turid Omland, Kathrine A. Lie, Harriet Akre, Lars Erik Sandlie, Peter Jebsen, Leiv Sandvik, Dag Andre Nymoen, Davit Bzhalava, Joakim Dillner, Kjell Brndbo
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0099114
Abstract: Patients with recurrent respiratory papillomatosis (RRP) in Norway treated between 1987 and 2009 were recruited to this cohort study. They were followed from disease onset and data recorded until January 2012. Here, we describe the distribution of human papillomavirus (HPV) genotypes, the prevalence of multiple HPV infections, and the risk of high-grade laryngeal neoplasia and respiratory tract invasive carcinoma in a large cohort of patients with RRP. We also examined whether HPV genotype, gender, age or clinical course are risk factors for this development. Clinical records and histological specimens were reviewed. Using formalin-fixed paraffin-embedded biopsies, HPV genotyping were performed by quantitative polymerase chain reaction assays identifying 15 HPV types. HPV-negative specimens were analyzed by metagenomic sequencing. Paraffin blocks were available in 224/238 patients. The DNA quality was approved in 221/224 cases. HPV DNA was detected in 207/221 patients and all were HPV 6 or HPV 11 positive, comprising HPV 6 in 133/207, HPV 11 in 40/207 cases and HPV 6/11 in 15/207 cases. Co-infection with one or two high-risk HPV types together with HPV 6 or HPV 11 was present in 19/207 patients. Metagenomic sequencing of 14 HPV-negative specimens revealed HPV 8 in one case. In total, 39/221 patients developed high-grade laryngeal neoplasia. 8/221 patients developed carcinoma of the respiratory tract (six patients with laryngeal carcinoma and two patients with lung carcinoma). High-grade laryngeal neoplasias were found more frequently in HPV-negative versus HPV-positive patients, (RR = 2.35, 95% CI 1.1, 4.99), as well as respiratory tract carcinomas (RR = 48, 95% CI 10.72, 214.91). In summary, the majority of RRP were associated with HPV 6 and/or 11. HPV-negative RRP biopsies occurred more frequently in adult-onset patients, and were associated with an increased risk of laryngeal neoplasia and carcinoma in the respiratory tract.
High Frequency Production of Doubled Haploid Rapeseed Plants by Direct Colchicine Treatment of Isolated Microspores

ZHOU Wei-jun,HAGBERG Per,<br>周伟军,HAGBERG Per
浙江大学学报(农业与生命科学版) , 2000,
Abstract: Techniques for microspore culture of Brassica napus have been improved rapidly, and embryogenesis has been achieved in a wide range of genotypes. Plants regenerated from microspore-derived embryoids can be haploid, diploid or polyploid. From rapeseed microspore culture it is reported that 70%-90% of regenerated plants are haploid. The usual methods of chromosome doubling involve soaking roots (most common) or whole plants in a colchicine solution, or culturing plantlets in colchicine-containing medium in the greenhouse. Other alternatives are injecting colchicine into the secondary buds or applying colchicine-soaked cotton plugs to axillary buds.
Efficient Production of Doubled Haploid Plants through Microspore Culture in Brassica napus

ZHOU Wei-jun,HAGBERG Per,<br>周伟军,HAGBERG Per
浙江大学学报(农业与生命科学版) , 2000,
Abstract: Since haploid embryoids were first obtained from microspore culture of Brassica napus there has been a rapid progress in the application of this technique in genetic studies and breeding utilization of rapeseed.The relative simplicity of the culture protocol and high-frequency recovery of doubled haploid plants makes microspore culture a potentially powerful technique for varietal development.Nevertheless, there are still some obstacles in the efficient use of this technique such as recalcitrant genotypes, secondary embryogenesis of embryoids, and the lack of efficient chromosome doubling.The present experiment is attempted to improve the production efficiency of doubled haploid rapeseed plants.
Chinese life cycle impact assessment factors
YANG Jian,|xin,Per H Nielsen,<br>YANG Jian-xin,Per H. Nielsen
环境科学学报(英文版) , 2001,
Abstract: The methodological basis and procedures for determination of Chinese normalization references and weighting factors according to the EDIP\|method is described. According to Chinese industrial development intensity and population density, China was divided into three regions and the normalization references for each region were calculated on the basis of an inventory of all of the region's environmental emissions in 1990. The normalization reference was determined as the total environmental impact potential for the area in question in 1990 (EP(j) 90 ) divided by the population. The weighting factor was determined as the normalization reference (ER(j) 90 ) divided by society's target contribution in the year 2000 based on Chinese political reduction plans, ER(j) T2000 . This paper presents and discuss results obtained for eight different environmental impact categories relevant for China: global warming, stratospheric ozone depletion, acidification, nutrient enrichment, photochemical ozone formation and generation of bulk waste, hazardous waste and slag and ashes.
A Qualitative Study of Individual and Organizational Learning through Physiotherapists’ Participation in a Research Project  [PDF]
Petra Dannapfel, Anneli Peolsson, Per Per Nilsen
International Journal of Clinical Medicine (IJCM) , 2014, DOI: 10.4236/ijcm.2014.59071

The need for evidence-based practice has been recognized by physiotherapy organizations over the past decades. Earlier studies have documented facilitators and barriers that affect the use and implementation of evidence-based practice. Less is known about what kind of interventions might be useful to implement evidence-based practice. This study explores what physiotherapists learn through participation in a research project relevant to their professional development towards achieving a more evidence-based physiotherapy practice. To what extent this learning was transferred to colleagues for organizational learning is also examined. This study was set in Sweden, where health care is publicly funded. Patients do not need a referral from a physician to consult a physiotherapist. Eleven interviews were conducted with physiotherapists who had participated in a randomized, controlled, multicenter, physiotherapy intervention investigating neck-specific exercise for patients with whiplash disorder. Gadamer’s hermeneutics was used to analyze the data. The physiotherapists described a range of learning experiences from their project participation, including instrumental learning (the concrete application of knowledge to achieve changes in practice) and conceptual learning (changes in knowledge, understanding or attitudes). The research project enabled the physiotherapists to develop new treatment techniques for broader application and extend their competence in techniques already known (instrumental learning). The physiotherapists believed that project participation enhanced their overall competence as physiotherapists, increased their job motivation and strengthened their self-confidence and self-efficacy (conceptual learning). Physiotherapists’ participation in the research project yielded many individual learning experiences, fostered positive attitudes to research and was conducive to achieving a more research-informed physiotherapy practice. Participation was associated with a deeper understanding of the challenges involved in conducting research. The transfer from individual learning to the wider organization in terms of organizational learning was limited.

On a senary cubic form
Valentin Blomer,J?rg Brüdern,Per Salberger
Mathematics , 2012, DOI: 10.1112/plms/pdt043
Abstract: A strong form of the Manin-Peyre conjecture with a power saving error term is proved for a certain cubic fourfold.
An Exceptional Generalization of the Poisson Distribution  [PDF]
Per-Erik Hagmark
Open Journal of Statistics (OJS) , 2012, DOI: 10.4236/ojs.2012.23039
Abstract: A new two-parameter count distribution is derived starting with probabilistic arguments around the gamma function and the digamma function. This model is a generalization of the Poisson model with a noteworthy assortment of qualities. For example, the mean is the main model parameter; any possible non-trivial variance or zero probability can be attained by changing the other model parameter; and all distributions are visually natural-shaped. Thus, exact modeling to any degree of over/under-dispersion or zero-inflation/deflation is possible.
Long Term Effects of Radiation-Induced Osteonecrosis of the Pelvis Caused Complete Failure of Total Hip Arthroplasty  [PDF]
Tigist Wodaje, Per Wretenberg
Surgical Science (SS) , 2012, DOI: 10.4236/ss.2012.37074
Abstract: This case report describe severe osteonecrosis of the pelvis more than 30 years after radiation due to ovarian cancer. As orthopedic surgeon it is important to ask about previous radiation to the pelvis in case of total hip arthroplasty and also to perform CT in unclear cases.
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