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Search Results: 1 - 10 of 56 matches for " Bouchra Oumokhtar "
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Legionaires’ disease: Modalities, diagnosis and therapeutic
Bouchra Oumokhtar,Samira El Fakir
Technologies de Laboratoire , 2009,
Abstract: Infection with Legionella spp. is an important cause of community and hospital acquired pneumonia, occurring both sporadically and in outbreaks. The Legionaires’ disease affects primarily adults and more specifically fragile people such as elderly adult, patients affected by chronic respiratory diseases, diabetics and immunodeficient people. The contamination with legionellosis is mainly through respiratory tract, inhalation of contaminated water diffused in air. It is mainly transmitted by humidifying cooling systems and water network. The legionellosis is expressed by grip profile accompanied with fever and coughing. Others symptoms such as muscular pain, anorexia, digestive and neurological disorder might occur. The diagnosis of legionellosis is achieved by investigating the urinary antigen. But this test detects only Legionella pneumophila serogoup 1. The PCR allows fast diagnosis. However, this technique is not yet normalized. The legionellosis is mostly treated using suitable antibiotherapy. Macrolides and fluoroquinolones are the most widely used drugs in treatment.This review summarizes the available information regarding the microbiology, clinical presentation, diagnosis and treatment of Legionaires’ disease.
Microbial analysis of raw ground beef marketed in Fez (Morocco)
Oumokhtar bouchra,Berrada Halima,Ameur Najia,El Fakir Samira
Technologies de Laboratoire , 2008,
Abstract: The ground meat is highly perishable product. This foodstuff constitutes a potential risk for the consumer since it is mostly consumed while insufficiently cooked. The aim of the present study was to evaluate the bacterial quality of ground beef marketed in Fes. Forty samples of ground meat were collected randomly from butcheries during three months in Fez (Morocco). The samples were analyzed for the presence and counts of various bacteria. Results indicated that faecal coliforms and Escherichia coli were particularly high in all the samples analysed. The coagulase-positive Staphylococcus and anaerobic sulphite-reducing charges were not homogeneous. When Salmonella, and Shigella were detected respectively in 17,5 % and 2,5% of the ground beef samples. The ground beef samples contained 80% of bacteria above the maximum limits established by the Moroccan regulatory standards. These high levels of microbial contamination and occurrence of pathogenic bacteria reflect the poor hygienic quality of ground beef production and transport conditions.
Identification of an extracellular infection-induced glyceraldehyde-3-phosphate dehydrogenase of the phytopathogenic proteobacterium Pseudomonas syringae pv tomato DC3000  [PDF]
Bouchra Elkhalfi, Aurelio Serrano, Abdelaziz Soukri
Advances in Bioscience and Biotechnology (ABB) , 2014, DOI: 10.4236/abb.2014.53026

According to molecular biology, genomic and proteomic data, the phytopathogenic gamma-proteobacterium Pseudomonas syringae pv. tomato DC3000 produces a number of proteins that may promote infection and draw nutrients from plants. Remarkably, P. syringae DC3000 strain possesses three paralogous gap genes encoding glyceraldehyde-3-phosphate dehydrogenase (GAPDH) enzymes with different predicted molecular sizes and metabolic functions. As GAPDH was shown to be a virulence factor in other microbial pathogens, in the current study, we analyzed the expression levels of each paralogous gap gene by realtime PCR to understand the actual impact of their protein products on P. syringae virulence. We found that all of them were strongly induced during the infection process. Nevertheless, proteomic analysis of culture supernatants revealed that only Class I GAPDH1 encoded by the gap1 gene was identified as an extracellular protein in infective cells. These results strongly suggest that this GAPDH should play a role in the infective process, including its well-know enzymatic function in the glycolytic metabolic pathway.

Investment Sensitivity to Stock Prices and Analyst Coverage  [PDF]
Ahmed Marhfor, Rachid Ghilal, Bouchra M’Zali
American Journal of Industrial and Business Management (AJIBM) , 2015, DOI: 10.4236/ajibm.2015.53010
Abstract: This study examines whether more analyst coverage mitigates the informational risk borne by small investors. Using the investment-price sensitivity as a proxy for stock price informativeness, we find evidence that analysts do not specialize in the production of firm-specific information and substitute for other corporate governance mechanisms. Our results suggest that analysts are out-siders who have less access to firm-level information. The main findings are robust to many aspects of our methodology.
The Monitoring Role of Financial Analysts: An International Evidence  [PDF]
Ahmed Marhfor, Rachid Ghilal, Bouchra M’Zali
American Journal of Industrial and Business Management (AJIBM) , 2015, DOI: 10.4236/ajibm.2015.55027
Abstract: This study investigates whether high analyst coverage improves the quality of reported accounting numbers. Using conservatism in financial reporting as a proxy for the quality of reported earnings, we find evidence that analysts’ activities are not positively associated with accounting conservatism. The findings indicate that firms choose less conservative accounting methods when they are covered by more analysts. They are consistent with the notion that analysts’ activities do not substitute for other corporate governance mechanisms.
A Multi-Dimensional Analysis of Corporate Social Responsibility: Different Signals in Different Industries  [PDF]
Homayoon Shalchian, Kais Bouslah, Bouchra M’Zali
Journal of Financial Risk Management (JFRM) , 2015, DOI: 10.4236/jfrm.2015.42009
Abstract: This study investigates the relation between individual dimensions of corporate social responsibility (CSR) and financial performance in different industries. Using Kinder, Lydenberg and Domini (KLD) social ratings, we find that investors seem to be more sensitive to the dimension “Environment” in mining and manufacturing sectors while they seem to be more sensitive to the dimension “Employees’ welfare” in the service industry. Our results also suggest that investors perceive an additional financial risk from firm’s irresponsible behavior and consequently, they are more pre-occupied by eventual losses caused by firms’ social irresponsibility than by potential financial gains from corporate social performance.
A Multi-Dimensional Analysis of Corporate Social Responsibility: The Liquidity Risk Factor  [PDF]
Homayoon Shalchian, Bouchra M’Zali, Hager Tebini
Journal of Financial Risk Management (JFRM) , 2018, DOI: 10.4236/jfrm.2018.73016
Abstract: This study is an extension to Shalchian et al. (2015) and investigates the effect of the “liquidity” risk factor on the performance of socially responsible investments in different industries and based on different dimensions of corporate social responsibility. Using Pastor and Stambault’s liquidity risk factor, we find that in the mining industry and based on the dimensions of “environment”, “employees’ relations” and “community involvement”, socially responsible investments are relatively less exposed to the liquidity risk factor. Our results also suggest that compared to conventional investments in the manufacturing and service industries, socially responsible investment’s performance is more sensitive to the liquidity risk factor.
Substrate integrated waveguide power divider, circulator and coupler in [10-15] GHz band
Bouchra Rahali Mohammed Feham
Computer Science , 2014,
Abstract: The Substrate Integrated Waveguide (SIW) technology is an attractive approach for the design of high performance microwave and millimeter wave components, as it combines the advantages of planar technology, such as low fabrication costs, with the low loss inherent to the waveguide solution. In this study, a substrate integrated waveguide power divider, circulator and coupler are conceived and optimized in [10-15] GHz band by Ansoft HFSS code. Thus, results of this modeling are presented, discussed and allow to integrate these devices in planar circuits.
Study of glyceraldehyde-3-phosphate dehydrogenase expression in the tumor process of: Breast, cervix and prostate cancers  [PDF]
Bouchra Elkhalfi, Nezha Senhaji, Hakima Benomar, Abdelaziz Soukri
Advances in Biological Chemistry (ABC) , 2012, DOI: 10.4236/abc.2012.24041
Abstract: W Tumor proliferation of cancer cells requires a high intake of oxygen by angiogenesis. Deep cancer cells suffer from asphyxia and meet their energy needs through the enzymes of glycolysis. The anti-angio- genesis approach has been recognized for therapeutic purposes, but the deep cancers, difficult to reach by this therapy, could be targeted by inhibiting an enzyme of the glycolytic cycle. Our work focused on the study of the expression of GAPDH, a key enzyme of glycolysis, in cervix, breast and prostate tumors, for two approaches: Fundamental and targeted therapeutics. 60 samples, taken at the Anatomopathology laboratory of the Pasteur Institute of Morocco, were examined histologically and immunohistochemically, demonstrating the expression and cellular localization of GAPDH. The three organs have shown an overex-pression of GAPDH in tumor tissues. At the cellular level, the localization of GAPDH in cancer tissue is diffuse but mostly nuclear whereas it remains focused at the membrane and/or the cytoplasm in benign tumor tissues. From these results we could assume that GAPDH is involved in the cancer process and draws attention to a possible new nuclear role that could be either specific to one form or different isoforms of GAPDH enzyme.
Antibacterial activity of plant methanolic extracts on a field isolate of Pseudomonas syringae pvtomato from the Casablanca region (Morocco)  [PDF]
Bouchra Elkhalfi, Abderrazak Essari, Aurelio Serrano, Abdelaziz Soukri
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.47A2001
Abstract: A bacterial field isolate recovered from infected tomato plants in a green-house at Sidi Rehal, a region near Casablanca city (Morocco), was identified as the gammaproteobacterium Pseudomonas syringae pv. tomato DC3000 strain, the causal agent of bacterial speck. The bacterial isolate was characterized by morphological, biochemical and molecular biological tests, its growth curves carried out in various culture media, and its phytopathogenicity verified by infection tests. A screening was performed to evaluate the antibacterial activity of methanolic extracts of 12 selected Moroccan plants against the P. syringae pv. tomato DC3000 isolate, and Agar-well diffusion and Broth microdilution methods were used to determine minimum inhibitory and minimum bactericidal concentrations. Among the methanolic extracts tested, only those of Nigella sativa, Geranuim robertianum, Aizoon canariense and Rubia peregrine showed clear inhibitory and bactericidal activities, although the highest values were achieved with N. sativa, a plant used in Morocco as a spice, condiment and medicinal treatment.
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