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Search Results: 1 - 10 of 125 matches for " Borut Poljsak "
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Adaptive Response, Evidence of Cross-Resistance and Its Potential Clinical Use
Irina Milisav,Borut Poljsak,Du?an ?uput
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms130910771
Abstract: Organisms and their cells are constantly exposed to environmental fluctuations. Among them are stressors, which can induce macromolecular damage that exceeds a set threshold, independent of the underlying cause. Stress responses are mechanisms used by organisms to adapt to and overcome stress stimuli. Different stressors or different intensities of stress trigger different cellular responses, namely induce cell repair mechanisms, induce cell responses that result in temporary adaptation to some stressors, induce autophagy or trigger cell death. Studies have reported life-prolonging effects of a wide variety of so-called stressors, such as oxidants, heat shock, some phytochemicals, ischemia, exercise and dietary energy restriction, hypergravity, etc. These stress responses, which result in enhanced defense and repair and even cross-resistance against multiple stressors, may have clinical use and will be discussed, while the emphasis will be on the effects/cross-effects of oxidants.
Sleeping on an Anti-Wrinkle Pillow Reduces Facial Wrinkles: Results from an Anatomical Study  [PDF]
Borut Poljsak, Aleksandar Godic, Rok Fink, Martina Oder, Tomaz Lampe, Raja Dahmane
Forensic Medicine and Anatomy Research (FMAR) , 2015, DOI: 10.4236/fmar.2015.32010
Abstract: Background: A special pillow was designed to redistribute mechanical stress during sleeping in order to slow down the formation of facial skin wrinkles. Objective: To investigate whether sleeping on a specially designed pillow reduces facial skin wrinkles. Participants and Methods: A 28-day pilot study was carried out in which fifteen healthy female volunteers aged 23 - 55 years (mean age 35. 6 ± 8.5) slept on an antiwrinkle pillow. Evaluation of facial wrinkles was conducted before commencing the study (T0), following at 14 days (T14), and at 28 days (T28) when the study ended. Wrinkle density was assessed by computerized analysis of 2D images of participants’ faces. Results: A statistically significant decrease in wrinkle density was detected while smiling around both eyes, around the right eye in a relaxed facial expression, on average in all observed facial areas, around the left periorbital area in participants who predominantly slept on their left side of the body, but not on the frontal area. Limitations: A 3D camera could be used to better visualize and analyze wrinkle density. Conclusions: Sleeping on the specially designed pillow reduces facial wrinkles.
The Neglected Importance of Sleep on the Formation and Aggravation of Facial Wrinkles and Their Prevention  [PDF]
Borut Poljsak, Aleksandar Godic, Andrej Starc, Raja Dahmane
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2016, DOI: 10.4236/jcdsa.2016.63012
Abstract: The duration of sleep and the position of the face while resting on a pillow have a negative impact on the facial skin appearance and may lead to the formation of sleep wrinkles. Sleep lines occur when there is repetitive, long-term tension on the facial skin, which pushes or pulls the skin in a direction that is perpendicular to the direction of the muscles of the face. These lines tend to be more vertically oriented than expression lines and can be found on the forehead, around the eyebrows, the eyes, the cheeks, the chin, and the nasolabial folds. Our studies revealed that the average reduction of wrinkles in total investigated area of the face (expressed as the density of wrinkle per surface skin) was approximately 12% after 28 days of sleep on a specially-designed pillow. The specially designed anti-wrinkle pillows eliminate the pressure on the cheeks, the eyes and the mouth during sleep. Many such pillows have been designed to reduce the aging process and to encourage users to sleep in specific positions. Evidence supporting the claim that a special pillow prevents wrinkles was presented. Nevertheless, prolonged human studies are required to further elucidate the role of sleeping on appearance of facial wrinkles.
Strategies for Reducing or Preventing the Generation of Oxidative Stress
B. Poljsak
Oxidative Medicine and Cellular Longevity , 2011, DOI: 10.1155/2011/194586
Abstract: The reduction of oxidative stress could be achieved in three levels: by lowering exposure to environmental pollutants with oxidizing properties, by increasing levels of endogenous and exogenous antioxidants, or by lowering the generation of oxidative stress by stabilizing mitochondrial energy production and efficiency. Endogenous oxidative stress could be influenced in two ways: by prevention of ROS formation or by quenching of ROS with antioxidants. However, the results of epidemiological studies where people were treated with synthetic antioxidants are inconclusive and contradictory. Recent evidence suggests that antioxidant supplements (although highly recommended by the pharmaceutical industry and taken by many individuals) do not offer sufficient protection against oxidative stress, oxidative damage or increase the lifespan. The key to the future success of decreasing oxidative-stress-induced damage should thus be the suppression of oxidative damage without disrupting the wellintegrated antioxidant defense network. Approach to neutralize free radicals with antioxidants should be changed into prevention of free radical formation. Thus, this paper addresses oxidative stress and strategies to reduce it with the focus on nutritional and psychosocial interventions of oxidative stress prevention, that is, methods to stabilize mitochondria structure and energy efficiency, or approaches which would increase endogenous antioxidative protection and repair systems.
Strategies for Reducing or Preventing the Generation of Oxidative Stress
B. Poljsak
Oxidative Medicine and Cellular Longevity , 2011, DOI: 10.1155/2011/194586
Abstract: The reduction of oxidative stress could be achieved in three levels: by lowering exposure to environmental pollutants with oxidizing properties, by increasing levels of endogenous and exogenous antioxidants, or by lowering the generation of oxidative stress by stabilizing mitochondrial energy production and efficiency. Endogenous oxidative stress could be influenced in two ways: by prevention of ROS formation or by quenching of ROS with antioxidants. However, the results of epidemiological studies where people were treated with synthetic antioxidants are inconclusive and contradictory. Recent evidence suggests that antioxidant supplements (although highly recommended by the pharmaceutical industry and taken by many individuals) do not offer sufficient protection against oxidative stress, oxidative damage or increase the lifespan. The key to the future success of decreasing oxidative-stress-induced damage should thus be the suppression of oxidative damage without disrupting the wellintegrated antioxidant defense network. Approach to neutralize free radicals with antioxidants should be changed into prevention of free radical formation. Thus, this paper addresses oxidative stress and strategies to reduce it with the focus on nutritional and psychosocial interventions of oxidative stress prevention, that is, methods to stabilize mitochondria structure and energy efficiency, or approaches which would increase endogenous antioxidative protection and repair systems. 1. Introduction High levels of reactive oxygen species (ROS), compared to antioxidant defenses, are considered to play a major role in diverse chronic age-related diseases and aging. The cells of all present aerobic organisms produce the majority of chemical energy by consuming oxygen in their mitochondria. Mitochondria are thus the main site of intracellular oxygen consumption and the main source of ROS formation [1–3]. Mitochondrial ROS sources are represented by the electron transport chain and the nitric oxide synthase reaction. Nonmitochondrial sources of ROS include environmental pollutants, pollutants in food, radiation, or they are the by-products of other metabolic processes in organisms. Majority of free radicals are generated inside the cell rather than coming from the environment [1, 4, 5]. Sources of , the one electron reduction product of molecular oxygen, include NAD(P)H oxidases (NOX), xanthine oxidase (XO), mitochondria, and uncoupled nitric oxide synthase (NOS). Additionally, peroxynitrite and nitroxidative stress have also been implicated in various aspects of nitrooxidative
The Neglected Significance of “Antioxidative Stress”
B. Poljsak,I. Milisav
Oxidative Medicine and Cellular Longevity , 2012, DOI: 10.1155/2012/480895
Abstract: Oxidative stress arises when there is a marked imbalance between the production and removal of reactive oxygen species (ROS) in favor of the prooxidant balance, leading to potential oxidative damage. ROSs were considered traditionally to be only a toxic byproduct of aerobic metabolism. However, recently, it has become apparent that ROS might control many different physiological processes such as induction of stress response, pathogen defense, and systemic signaling. Thus, the imbalance of the increased antioxidant potential, the so-called antioxidative stress, should be as dangerous as well. Here, we synthesize increasing evidence on “antioxidative stress-induced” beneficial versus harmful roles on health, disease, and aging processes. Oxidative stress is not necessarily an un-wanted situation, since its consequences may be beneficial for many physiological reactions in cells. On the other hand, there are potentially harmful effects of “antioxidative stress,” especially in the cases of overconsumption of synthetic antioxidants. Antioxidants can neutralize ROS and decrease oxidative stress; however, this is not always beneficial in regard to disease formation or progression (of, e.g., cancer) or for delaying aging.
Irradiation of regionally advanced carcinoma of the penis
Borut Kragelj
Radiology and Oncology , 2009, DOI: 10.2478/v10019-009-0002-3
Abstract: Background. Penile cancer patients with inoperable groin metastases as well as patients with residual or recurrent groin tumours after inguinal lymphadenectomy are frequently considered for radiation treatment. Methods. A retrospective study of 12 patients with regionally advanced penile carcinoma treated with radiotherapy in the period 1995-2003 was done. Acute and chronic treatment-related complications were observed. Results. All patients (8/8) with the tumours palpable at the beginning of radiotherapy and two patients (2/4) with microscopic post-lymphadenectomy tumour residue died from the disease. The death occurred 4-24 months after starting radiotherapy. Median survival was 8 months. Locoregional control could only be achieved in patients irradiated for microscopic post-lymphadenectomy tumour residue (4/4). Conclusions. A timely and accurate diagnosis of regional disease spread and immediate lymphadenectomy are of vital importance. Radiotherapy should be applied soon after surgery as postoperative treatment of regional metastases that are at risk to recur - recurrences following lymphadenectomy could not be salvaged by radiotherapy.
An application of the Sakai's theorem to the characterization of H*-algebras
Borut Zalar
International Journal of Mathematics and Mathematical Sciences , 1995, DOI: 10.1155/s0161171295000408
Abstract: The well-known Sakai's theorem, which states that every derivation acting on a von Neumann algebra is inner, is ,used to obtain a new elegant proof of the Saworotnow's characterization theorem for associative H*-algebras via two-sided H*-algebras. This proof completely avoids structure theory.
World corporate loan markets for raising new capital - does distance still matter: Are financial assets priced locally or globally?
Vojinovi? Borut
Economic Annals , 2006, DOI: 10.2298/eka0668031v
Abstract: Though the paper focuses on pricing, as the background I provide some evidence about loan flows across markets in the form of borrowers’ and lenders’ propensity to issue outside their natural home market. The data show that borrowers stay home when they can and that they tend to issue in Europe when they must issue abroad. That is, borrowers domiciled in one of the major markets (Europe, U.S., and Asia) almost always issue in that market, whereas borrowers in more remote locations usually issue in the European market. For example, borrowers from Latin America are overwhelmingly issuing in Europe rather than in the U.S. market.
Wocheinite - Bauxite from Bohinj
Borut Razinger
Geologija , 1997,
Abstract:
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