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Search Results: 1 - 10 of 182 matches for " Bordin "
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Photochemical and photobiological properties of furocoumarins and homologues drugs
F. Bordin
International Journal of Photoenergy , 1999, DOI: 10.1155/s1110662x9900001x
Abstract: Furocoumarins are natural photosensitizing drugs used in PUVA photochemotherapy and in photopheresis. Their therapeutic effectiveness is connected to the lesions they induce to various cell components, membranes, ribosomes, mitochondria, and in particular to DNA, damaged by formation of monofunctional adducts and of inter-strand cross-links (ISC). ISC represent a severe damage, mainly correlated to the main side effects observed in photochemotherapy, skin phototoxicity and genotoxicity. Searching for new monofunctional derivatives, two tetramethylfuroquinolinones, 1,4,6,8-tetramethyl-2H-furo[2,3-h]quinolin-2- one (FQ) and 4,6,8,9-tetramethyl-2H-furo[2,3-h]-quinolin-2-one (HFQ) were studied. Both compounds are very active; however while FQ produced many chromosomal aberrations and strong skin erythemas, HFQ practically did not induce such side effects. FQ and HFQ formed high levels of monoadducts but no ISC in DNA, but both provoked many DNA-protein cross-links (DPC). FQ induced these lesions by a biphotonic reaction: at first a furan-side monoadduct is formed, which is then converted into a DPC; thus the FQ molecule seemed to form the bridge between DNA and proteins. HFQ formed DPC by a single step (DPC at zero length, like UVC). For these features, HFQ appears to be the first molecule belonging to a new class of active but not phototoxic drugs for photomedicine.
The Literary Utopias of Cultural Communities, 1790-1910. Eds. Marguérite Corporaal and Evert Jan van Leeuwen.
Elisa Bordin
European Journal of American Studies , 2011, DOI: 10.4000/ejas.8861
Abstract: “Utopia,” from the combination of the Greek diminutive plural of topos, that is “place,” and the pun between the two prefixes ou, “non-,” and eu, “good,” is a term that is not-so-often used in the twenty-first century. It rather reminds us of bygone centuries, when scientists, philosophers, publishers or writers had time to dream and discuss of possible societies, and were not forced to face the disillusionments of a post-modern and a post-industrial society in which scholars are more and mo...
Anemia hemolítica auto-imune e outras manifesta??es imunes da leucemia linfocítica cr?nica
Bordin, José O.;
Revista Brasileira de Hematologia e Hemoterapia , 2005, DOI: 10.1590/S1516-84842005000400008
Abstract: chronic lymphocytic leukemia (cll) is frequently associated with autoimmune diseases directed against hematopoietic cells, including autoimmune hemolytic anemia (aiha), immune thrombocytopenic purpura (itp), pure red cell aplasia (prca), and immune neutropenia. cll represents the diagnosis in up to 15% of the patients with aiha, and in 50% of the patients with aiha secondary to malignancy. itp occurs in 2% and prca in about 1% of all cll patients. prednisone is the first-line treatment for immune cytopenia related to cll. about 60% of patients relapse when treatment is stopped therefore splenectomy, intravenous immunoglobulin, or cyclosporine are reasonable second-line treatments. although the data on pathophysiology are very limited, it appears that the autoimmune mechanisms are related to the activity of the leukemic b lymphocytes that act as aberrant antigen-presenting cells, and are effective in processing and presenting proteins derived from red cells or platelets to auto-reactive th cells. th cells specific for certain auto-antigens escape from control mechanisms and when activated may initiate auto-immune disease. patients with aiha secondary to cll should not receive fludarabine because there is an increased frequency of severe and fatal aiha in patients treated with purine nucleoside analogues. patients who are more immunosuppressed due to several previous treatments are at higher risk for developing this auto-immune complication.
The Modification of EOQ Model under the Spare Parts Discrete Demand: A Case Study of Slow Moving Items
Sakon Wongmongkolrit,Bordin Rassameethes
Lecture Notes in Engineering and Computer Science , 2011,
Abstract:
Waterlike Features, Liquid-Crystal Phase and Self-Assembly in Janus Dumbbells
José Rafael Bordin
Physics , 2015,
Abstract: We use Molecular Dynamics simulations to explore the properties of dimmeric Janus nanoparticles. The nanoparticles are modeled as dumbbells. One kind of monomer interacts by a Lennard-Jones potential, while the other specie of monomer interacts though a two length scale potential. This specific two length scale potential do not present waterlike anomalies in bulk. However, our results shows that, when combined in a dimmer, the Janus nanoparticle will have waterlike anomalies. The self-assembly properties were also explored. We observe several kinds of micelles, and a liquid-crystal phase. This results indicates that is possible to create Janus nanoparticles with waterlike features using monomers without anomalous behavior. The anomalies and structures are explained with the two length scale potential characteristics.
Assessment and Professors’ Competence in Italian Higher Music Education between Tradition and New Goals  [PDF]
Tiziana Rossi, Anna Maria Bordin, Dario De Cicco
Creative Education (CE) , 2014, DOI: 10.4236/ce.2014.514153
Abstract:

Assessment of learning and the allocation of credits according to the European Credit Transfer and Accumulation System is no longer an educational tool which concerns professors, but it has become a statutory duty that sees conservatories of music part of a network of relationships. This study highlights the situation of Higher Music Education in Italy: we will consider the assessment models in their context of use and on the basis of ideal values that support them; we will examine the famous case of Giuseppe Verdi, rejected in its entrance exam to the Conservatory of Milan, which represents, paradoxically, the weaknesses of the assessment system, providing a historical perspective; we will propose an examination of the practical and legal aspects of the national assessment system; finally, we will offer an example of good practice that shows how to contextualize some important aspects of this problem.

Pacto pela saúde no Brasil: uma análise descritiva da progress?o dos indicadores de saúde bucal
Bordin, Danielle;Fadel, Cristina Berger;
Revista de Odontologia da UNESP , 2012, DOI: 10.1590/S1807-25772012000500002
Abstract: introduction: since the implementation of the health care system (sus) in brazil, many and constants are the attempts to extend the tactics which induce the optimization of the health public service. in this perspective of strategic progress about the actions and health public service in brazil, it′s released the pact for health - consolidations of sus and approve the operational guidelines attached to it. objective: to analyze and interpret the temporal evolution of oral health indicators, consolidated into the pact for health considering the five major brazilian regions. method: the analysis description of data collected on the banks of the unified health system (datasus) from 2008 to 2010, was realized, through oral health indicators like the indicator 41 - population estimated coverage of oral health teams in the family health strategy and indicator 42 - average of the collective action supervised brushing, available in the pact. result: the 41 indicator showed a gradual development over the period studied, although slow and uneven among the brazilian regions. with regard to the indicator 42, it`s shown oscillations in their benchmarks during the period analyzed, as well as the disparate regions analyzed. conclusion: many are the reasons that may lead to understanding these results, as the profile of the public health provision and population size of the municipalities that make up the different regions are still aspects that relate to the fragility of the public management and the lack of human resources policy.
Observa??es sobre Stomatopoda Squilla brasiliensis Calman, 1917 na plataforma continental do Rio Grande do Sul
Tommasi, Luiz Roberto;Bordin, Gilda;
Boletim do Instituto Oceanográfico , 1987, DOI: 10.1590/S0373-55241987000100005
Abstract: the distribution of squilla brasiliensis caiman, 1917 (crustacea stomatopoda) is by the first time discussed in the continental plataform in the region of rio grande do sul state, in relationship with depth, temperature and salinity. apparently the distribution of that species is more related to salinity than to depth and temperature, and specially to the water mass of subtropical origin. the largest densities were found between 84 and 128 m depth.
Observa??es sobre stomatopoda Squilla brasiliensis calman, 1917 na plataforma continental do Rio Grande do Sul
Tommasi, Luiz Roberto;Bordin, Gilda;
Brazilian Journal of Oceanography , 1987, DOI: 10.1590/S1679-87591987000100005
Abstract: the distribution of squilla brasiliensis caiman, 1917 (crustacea stomatopoda) is by the first time discussed in the continental plataform in the region of rio grande do sul state, in relationship with depth, temperature and salinity. apparently the distribution of that species is more related to salinity than to depth and temperature, and specially to the water mass of subtropical origin. the largest densities were found between 84 and 128 m depth.
Novas ocorrências de antóceros e hepáticas para o Estado do Rio Grande do Sul, Brasil
Bordin, Ju?ara;Yano, Olga;
Brazilian Journal of Botany , 2009, DOI: 10.1590/S0100-84042009000200002
Abstract: twenty two taxa (1 hornwort and 21 liverworts) were identified with new records to rio grande do sul state. eight families and 15 genera belong to marchantiophyta and one genus and one family belong to anthocerotophyta. the most representative families are lejeuneaceae, aneuraceae and metzgeriaceae. neesioscyphus argillaceus (nees) grolle and lejeunea cancellata nees & mont. were cited for new sites. all species are illustrated and geographic distributions are presented.
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