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Search Results: 1 - 10 of 320548 matches for " Bogoslovskaya N. B. "
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FEATURES OF PATHOGENESIS OF GIBELLINA CEREALIS PASS. MICROMYCETES ON THE EARLY STAGES OF ONTOGENESIS OF WINTER WHEAT Особенности патогенеза микромицета Gibellina cerealis Pass. на ранних этапах онтогенеза озимой пшеницы
Gorkovenko V. S.,Bogoslovskaya N. B.
Polythematic Online Scientific Journal of Kuban State Agrarian University , 2013,
Abstract: The article discusses the features of the pathogenesis of micromycetes Gibellina cerealis Pass. on winter wheat
Оptimization of pharmacotherapy of osteopenia in children with chronic pyelonephritis
L.A. Osipova,S.I. Bogoslovskaya,T.V. Shelehova,N.E. Nikiforova
Saratov Journal of Medical Scientific Research , 2010,
Abstract: The purpose of present research wras definition of frequency of osteopenia development in children with chronic pyelonephritis and optimization of pharmacological correction of revealed disorders. 121 children with chronic pyelonephritis and normal glomerular filtration rate were included in the investigation. Mineral density of bone tissue, biochemical parameters of bone remodeling, cytokine profiles were examined. 3 varients of therapy were used. Control period lasted 12 months. Clinical predictors of osteopenia were indicated. The increased biochemical parameters of bone resorption, IL-6, IL-4, OPG were revealed in chidren with chronic pyelonephritis, the indices were higher in case of osteopenia. The article concluded that the most effective treatment scheme included the use of 3 medicines with different effects
BETA-ADRENORECEPTORS GENETIC POLYMORPHISM CONNECTION WITH BETA-BLOKER THERAPY EFFICACY IN PATIENTS WITH CARDIOVASCULAR DISORDERS
A.N. Levanov,I.V. Ignatyev,D.A. Sychev,S.I. Bogoslovskaya
Saratov Journal of Medical Scientific Research , 2009,
Abstract: At present it is obvious that genetic peculiarities of patients are the major reason for individual differences in pharmacological responses to (β-adrenoblockers. Furthermore ADRB1 gene polymorphism is responsible for the efficiency of (β-adrenoblockers. Thus, a real prospect exists for an individualized approach to administration of (β-adrenoblockers and selection of dosage based on patient’s genotype, which must undoubtedly increase efficiency of the administered therapy. Reviewfocuses on gene polymorphism responsible for (β-adrenoblockers pharmacodynamics and on the clinical significance of the polymorphism detection to individualize drug therapy based on patient’s genotype.
Schur Complement of con-s-k-EP Matrices  [PDF]
B. K. N. Muthugobal
Advances in Linear Algebra & Matrix Theory (ALAMT) , 2012, DOI: 10.4236/alamt.2012.21001
Abstract: Necessary and sufficient conditions for a schur complement of a con-s-k-EP matrix to be con-s-k-EP are determined. Further it is shown that in a con-s-k-EPr matrix, every secondary sub matrix of rank “r” is con-s-k-EPr. We have also discussed the way of expressing a matrix of rank r as a product of con-s-k-EPr matrices. Necessary and sufficient conditions for products of con-s-k-EPr partitioned matrices to be con-s-k-EPr are given.
The Role of Premenstrual Syndrome in the Causation of Arterial Hypertension in Women  [PDF]
B. N. Okeahialam
Open Journal of Obstetrics and Gynecology (OJOG) , 2014, DOI: 10.4236/ojog.2014.414113
Abstract: Introduction: Gender perspectives are gradually generating great interest in health matters. Hypertension is one illness where gender considerations are important. Advancements in knowledge of pathophysiology help in better understanding of diseases and improvements in treatment. Pre-menstrual syndrome has been reported to make hypertension less responsive to treatment. This work was therefore done to see if premenstrual syndrome contributed in some way to hypertension in women. Methodology: All female hypertensives consulting the author in a private specialized hypertension clinic were questioned using the University of Carlifornia at San Diego criteria with a view to determining if they suffered from pre-menstrual syndrome. The control status was also considered for each patient. Females who consulted over the same period and were not hypertensive served as controls. Result: Pre-menstrual syndrome was found to occur more in hypertensive women than normotensive controls; to a statistically significant extent (p < 0.05). Control tended to be poorer in hypertensives with pre-menstrual syndrome than those without. The difference however did not achieve statistical significance. Discussion: There is controversy surrounding the aetiology of pre-menstrual syndrome. However, each of the models albeit inconsistent is capable of initiating and sustaining hypertension. The result here shows that in women it is likely to be one of the many factors that could produce hypertension in those predisposed. Conclusion: Pre-menstrual syndrome should arouse suspicion of future hypertension, and should be sought in all female hypertensives. Its presence should evoke deliberate action to improve outcome or remove the need for pharmacotherapy, at least for some time.
Investigation Of Arterial Blood Pressure Level And Metabolic Indices In Patients With Arterial Hypertension At Pharmacotherapy With Antihypertensive Medicines Of Various Chemical Structure
T.V. Kurkina,A.A. Svistunov,S.I. Bogoslovskaya,V.A. Klochkov
Saratov Journal of Medical Scientific Research , 2009,
Abstract: The research goal is to carry on the comparative analysis of medicines of various chemical structure, Telmisar-tan and Bisoprolol, and to reveal their effect on the arterial blood pressure level and the indices of various metabolic processes in patients with arterial hypertension. 60 out-patients with arterial hypertension (stage II risk III) both males and females aged 33-55 have been under study taking Telmisartan and Bisoprolol for 3 months. While treating the patients the arterial blood pressure level control and biochemical investigations for determination the indices of metabolic processes have been carried out. The investigated medications have provided the decrease of systolic and diastolic arterial pressure parameters, the increase of concentration of total and ionized calcium, chlorine ions, urea and total bilirubin in blood plasma. Therapy with Telmisartan has shown more significant increase of potassium level in erythro-cytes, decrease of levels of natrium, glucose, glycolized hemoglobin and triglycerides and increased contents of alani-naminotransferase and aspartataminotransferase. The course of therapy with Bisoprolol has restored the normal level of magnesium in blood plasma, has not have any influence on carbohydrate and lipid metabolism, increased the level of alaninaminotransferase and significantly increased the contents of total and ionized calcium, urea and creatinine. 3-months therapy with Telmisartan and Bisoprolol has proved the decrease of systolic and diastolic arterial pressure in patients with arterial hypertension. The medications under study have had active and variable effects on metabolic indices
Pharmacodynamic and pharmacoeconomic aspects of application of antihypertensive preparations of various groups in patients with arterial hypertension
Kurkina T.V.,Svistunov А.А.,Bogoslovskaya S.I.,Klochkov V.A.
Saratov Journal of Medical Scientific Research , 2010,
Abstract: At the background of the therapy for 3 months with Perindopril, Telmisartan and Bisoprolol, the patients with arterial hypertension were noted to decrease systolic and diastolic arterial pressure. The preparations under investigation had different effects on electrolyte metabolism. Therapy with Telmisartan turned out to have the least effect on electrolyte metabolism. Microalbuminuria is a risk factor in patients with arterial hypertension and may influence on the basic blood electrolyte balance. Bisoprolol should be recommended as the most preferable therapy for arterial hypertension from the pharmacoeconomic point of view. In order to control morning systolic arterial pressure the preference should be given to Perindopril, while for controlling evening systolic arterial pressure the preference should be given to Telmisartan
Renal dysfunction and state of metabolic and hemodynamic factors in patients with arterial hypertension
Kurkina T.V.,Bogoslovskaya S.I.,Svistunov А.А.,Kodochigova A.L
Saratov Journal of Medical Scientific Research , 2011,
Abstract: The aim of the investigation is to carry out comparative evaluation of metabolic and hemodynamic indices in patients with arterial hypertension (AH) and renal dysfunction; to study the interrelation between arterial blood pressure level normalization and the presence or lack of microalbuminuria (MAU) in the morning urine portion of patients with AH after therapy with antihypertensive preparations (APs) of various groups. Methods. 121 persons have been investigated, 91 out — patients of both sexes, aged 33-55, with the diagnosis of arterial hypertension of stage II risk III, who have been taking Perindopril, Telmisartan and Bisoprolol for3 months. The control of arterial pressure level, biochemical analysis of metabolic indices and morning urine portion test for microalbuminuria has been carried out. Results. MAU has been revealed in 17,6% patients, occurring more frequently in men than in women. Microalbuminuria is accompanied by reliable decrease of total and ionized calcium and magnesium concentrations, an increase of potassium level in blood plasma, increase of cholesterol, triglycerides, glucose and levels. Patients with AH and renal dysfunction reliably demonstrate higher levels of systolic and diastolic arterial pressure in the morning and evening hours, their normalization effect after APs intake is significantly interconnected with MAU presence. Conclusion. In patients with AH and MAU the main risk factors of cardio-vascular diseases development are more expressed. Microalbuminuria is a risk factor in patients with arterial hypertension and may influence on the basic blood electrolyte balance. While carrying out antihypertensive therapy the presence of MAU should be taken into consideration
Determination of Azacitidine by Spectrophotometric Method  [PDF]
B. Ramachandra, N. Venkatasubba Naidu
Open Journal of Medicinal Chemistry (OJMC) , 2018, DOI: 10.4236/ojmc.2018.82002
Abstract: Simple, selective and sensitive spectrophotometric method has been developed for the determination of Azacitidine in pharmaceutical formulations and blood with MBTH (3-methyl-2-benzothiazolone hydrazone hydrochloride) reagent, at PH-4.0 which is extractable at 620 nm. Beer’s law is obeying in the concentration ranges 10 - 35 μg·ml-1 for formulations and 4 - 24 μg·ml-1 for blood sample. %R.S.D was found to be 0.0240%, 0.0610 and Recovery 99.82% 99.24% respectively. The method was completely validated and proven to be rugged. The interferences of the other ingredients and excipients were not observed. The repeatability and the performance of the proven method were conventional by point and interior proposition and through recovery studies.
Indoor Dust-Based Pollution Status and Risk Assessment for a Rural Town, Ebedei in Nigeria Hosting Gas Flare Facility  [PDF]
N. Boisa, B. U. Odagwe
Journal of Environmental Protection (JEP) , 2019, DOI: 10.4236/jep.2019.102012
Abstract: Recently, there has been series of petitions and protestations from petroleum production gas flare facility host communities in Nigeria about the degradation of their environment. This study was designed to conduct indoor dust related human health risk assessment for Cd, Pb, Mn and Ni. Deposited indoor dust samples were collected from sixteen (16) residential buildings distributed across the four quarters of Ebedei waterside town in Nigeria, within the vicinity of a petroleum production gas flare facility. The samples were digested and analysed for Cd, Pb, Mn and Ni concentrations using inductively coupled plasma mass spectrometry (ICP-MS). Contamination/pollution index (C/PI) and human health risk assessments were conducted. The concentration ranges of 1.2 - 14.9 mg/kg, 44.0 - 161.6 mg/kg and 221.3 - 752.0 mg/kg, and below detection to 29.8 mg/kg were recorded for Cd, Pb, Mn and Ni, respectively. C/PI analyses for metals in the indoor dusts investigated suggested Cd levels to be polluted and Pb levels to be slightly polluted, while Mn and Ni levels indicated contamination. Risk assessment studies indicated that children may be more at risk for all the three exposure pathways. Exposure through the ingestion pathway indicated the highest risk for both the adult and children population.
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