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Search Results: 1 - 10 of 504509 matches for " Bob W. N. J. Ursem "
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Nature’s Particulate Matter with and without Charge and Travelling  [PDF]
Bob W. N. J. Ursem
Open Journal of Biophysics (OJBIPHY) , 2016, DOI: 10.4236/ojbiphy.2016.63008
Abstract: Natures and anthropogenic particulates can travel long distances on wind flows, but negative electrical charge due to friction can increase dispersion. Models for calculations of distance travelling of biological particulate matter with and without charge are never been calculated in a theoretical approach. Nor do we realize the fact that we can calculate actual distances if we take the charge on particles in account. Particles that travel through the air encounter friction. Friction can be described in two ways; either in a smooth constant way through the air with its viscous forces, or in a turbulent chaotic eddies and vortices and other flow instabilities. In case of only viscous forces are to be concerned, it can be described as a lower Reynolds number than one, while in all other setting it always must be described by Reynolds numbers larger than or equal to one. This article describes the calculated effects on particles, either in a low Reynolds number and thus as a Navier-Stokes equation or Stokes’ Law or, in case of non-laminar and complex forces in an equal or higher Reynolds number according to the third Law of Newton. In addition some striking examples of particle travelling are given with evidence of natural particulate matter long distance dispersion.
Climate Shifts and the Role of Nano Structured Particles in the Atmosphere  [PDF]
Bob Ursem
Atmospheric and Climate Sciences (ACS) , 2016, DOI: 10.4236/acs.2016.61005
Abstract: A global net sum equilibrium in heat exchange is a fact and thus a global climate change doesn’t exist, but climate shifts in climate cells, especially in the northern temperate cell, do. The global climate has been ever since homeostatic, and has recuperated far huger climate impacts in the past. Current climate models need a drastically revision on the focus of carbon dioxide as main driver. Carbon dioxide and other carbon gasses do influence albedo patterns, but provide globally a homeostatic effect with a commonly accepted increase impact of 0.3 degrees Celsius. Carbon dioxide does not trigger the climate shifts, but is an indicator of exhaust of combustion processes that emit very small particles which drive these climate shifts. They are the fine dust and nano structured particles that cause the shifts of the climate in cells, as demonstrated in this article and results i.e. in more thunder and lightning, extreme weather, distinct droughts and precipitation patterns. The causes underlying these shifts are nano structured particles in the upper troposphere and lower stratosphere, especially largely produced and remain in the temperate climate northern hemisphere cell and get dispersed by jet streams and low and high pressure areas. However, because of electrical charge, caused by friction or due to anthropogenic negatively charged nano structured particle, emissions will travel up to the lower stratosphere and become neutralized at the electro sphere level, and they do also have a tendency to move to the Arctic. The southern hemisphere climate faces limited anthropogenic emissions, because only 10 percent of the world population can contribute with less pollutant providing activities, and hasn’t changed, but that could well be because it is equally influenced and driven, like the northern hemisphere, by the variation of sun activity in diverse cycles. The present problem is that we produce huge amounts of air borne nano structured particles from combustion processes that never exist before. The only nano particles known in nature are those who are limited produced from volcano eruptions and natural forest fires. The natural feedback systems that moderate climate shifts and influence global climate are: convection by cumulonimbus clouds, sea currents and vegetation adaptation. A novel ultra-fine dust electric reduction device (UFDRS-System), created by the author, diminishs to a size of less than 10 nano particles in diameter and thus prevents major electrical drift of nano structured particulates in the upper troposphere and lower
A Healthy Brain in a Healthy Body: Brain Network Correlates of Physical and Mental Fitness
Linda Douw, Dagmar Nieboer, Bob W. van Dijk, Cornelis J. Stam, Jos W. R. Twisk
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088202
Abstract: A healthy lifestyle is an important focus in today's society. The physical benefits of regular exercise are abundantly clear, but physical fitness is also associated with better cognitive performance. How these two factors together relate to characteristics of the brain is still incompletely understood. By applying mathematical concepts from ‘network theory’, insights in the organization and dynamics of brain functioning can be obtained. We test the hypothesis that neural network organization mediates the association between cardio respiratory fitness (i.e. VO2 max) and cognitive functioning. A healthy cohort was studied (n = 219, 113 women, age range 41–44 years). Subjects underwent resting-state eyes-closed magneto-encephalography (MEG). Five artifact-free epochs were analyzed and averaged in six frequency bands (delta-gamma). The phase lag index (PLI) was used as a measure of functional connectivity between all sensors. Modularity analysis was performed, and both within and between-module connectivity of each sensor was calculated. Subjects underwent a maximum oxygen uptake (VO2 max) measurement as an indicator of cardio respiratory fitness. All subjects were tested with a commonly used Dutch intelligence test. Intelligence quotient (IQ) was related to VO2 max. In addition, VO2 max was negatively associated with upper alpha and beta band modularity. Particularly increased intermodular connectivity in the beta band was associated with higher VO2 max and IQ, further indicating a benefit of more global network integration as opposed to local connections. Within-module connectivity showed a spatially varied pattern of correlation, while average connectivity did not show significant results. Mediation analysis was not significant. The occurrence of less modularity in the resting-state is associated with better cardio respiratory fitness, while having increased intermodular connectivity, as opposed to within-module connections, is related to better physical and mental fitness.
Thrombotic Occlusion of a Microvascular Anastomosis in a Resistance to Activated Protein C (APC) Patient with Incomplete Wound Healing after High Doses of Ascorbic Acid (Vitamin C)  [PDF]
Martijn P. J. Loonen, Bob De Frene, Bob Casaer
Modern Plastic Surgery (MPS) , 2012, DOI: 10.4236/mps.2012.23015
Abstract: A 45-year-old woman underwent a delayed breast reconstruction with a free Deep Inferior Epigastric Perforator Flap (DIEP flap) with total flap failure on the fourth postoperative day. Hematological investigation to exclude thrombofilia revealed a resistance to activated protein C (APC) with a factor V Leiden heterozygous mutation. The postoperative course was further complicated by delayed wound healing probably due to ascorbic acid (Vitamin C) related cytotoxic activity to fibroblasts. The surgeon must be aware of the use of preoperative nutritional supplement administration among patients. Future cost-effectiveness analyses should be made to warrant preoperative thrombophilia screening to prevent free flap failures.
Rapid and mobile determination of alcoholic strength in wine, beer and spirits using a flow-through infrared sensor
Dirk W Lachenmeier, Rolf Godelmann, Markus Steiner, Bob Ansay, Jürgen Weigel, Gunther Krieg
Chemistry Central Journal , 2010, DOI: 10.1186/1752-153x-4-5
Abstract: During method validation, the precision of the infrared sensor was found to be equal to or better than densimetric or FTIR methods. For example, the average repeatability, as determined in 6 different wine samples, was 0.05% vol and the relative standard deviation was below 0.2%. Accuracy was ensured by analyzing 260 different alcoholic beverages in comparison to densimetric or FTIR results. The correlation was linear over the entire range from alcohol-free beers up to high-proof spirits, and the results were in substantial agreement (R = 0.99981, p < 0.0001, RMSE = 0.279% vol). The applicability of the device was further proven for the analysis of wines during fermentation, and for the determination of unrecorded alcohol (i.e. non-commercial or illicit products).The flow-through infrared device is much easier to handle than typical reference procedures, while time-consuming sample preparation steps such as distillation are not necessary. Therefore, the alcoholic strength can be economically and quickly controlled (requiring less than 60 s per sample). The device also gives the opportunity for mobile on-site control in the context of labelling control of wine, beer and spirits, the process monitoring of fermentations, or the evaluation of unrecorded alcohols.The alcoholic strength expressed in percent by volume (% vol) is one of the oldest parameters for which quantitative analytical methods have been developed, and is still determined in businesses and laboratories around the world. The foundations for the determination of alcoholic strength were laid by Gay-Lussac by inventing not only a simple-to-use centesimal alcoholometer (i.e. a hydrometer with a '% vol' scale) but also by providing the theoretical background in his 1824 monograph 'l'alcoomètre centésimal' [1]. For this reason, the percentage by volume is also called the French or Gay-Lussac system. (American proof is equal to twice the percentage of volume (i.e. spirits that contain 50% vol are 100 proof) [2
A cross-sectional study of the nutritional status of community-dwelling people with idiopathic Parkinson's disease
Ahmed F Jaafar, William K Gray, Bob Porter, Elizabeth J Turnbull, Richard W Walker
BMC Neurology , 2010, DOI: 10.1186/1471-2377-10-124
Abstract: People diagnosed with idiopathic PD from within two PD prevalence study sites in North-East England were asked to participate in this study. Those who participated (n = 136) were assessed using a number of standard rating scales including Hoehn & Yahr stage and Unified Parkinson's Disease Rating Scale (UPDRS). Body mass index (BMI), mid-arm circumference (MAC), triceps skin fold thickness (TSF) and grip strength were recorded together with social and demographic information.BMI < 20 identified over 15% of the study group to have under-nutrition. The Malnutritional Universal Screening Tool (MUST) scoring system identified 23.5% of participants at medium or high risk of malnutrition. Low BMI, indicating under-nutrition, was associated with greater age and disease duration, lower MAC, TSF, mid-arm muscle circumference (MAMC), reduced grip strength and a report of unintentional weight loss. Problems increased with increasing age and disease duration and were greater in females.Under-nutrition is a problem for around 15% of community dwelling people with PD. All PD patients should be screened for under-nutrition; the MUST score is a useful early screening tool.Parkinson's disease (PD) is a progressive neurodegenerative disorder that has been shown to put individuals at increased risk of malnutrition and weight loss compared to age matched controls [1]. The nutritional problems associated with PD have been reviewed recently [2]. Previous studies have shown an increase in basal metabolic rate in PD patients, and this increase in energy expenditure has been implicated in the aetiology of weight loss in patients with PD [3-6]. Other possible causes of weight loss include, difficulty swallowing [7,8], inability to prepare food and handle it appropriately [9], gastrointestinal symptoms of the disease itself and drug side effects, such as dyskinesia [10,11].Using the mini nutritional assessment as a screening tool, a recent 3 year longitudinal study of 61 PD patients from a ref
Both Ligand- and Cell-Specific Parameters Control Ligand Agonism in a Kinetic Model of G Protein–Coupled Receptor Signaling
Tamara L Kinzer-Ursem,Jennifer J Linderman
PLOS Computational Biology , 2007, DOI: 10.1371/journal.pcbi.0030006
Abstract: G protein–coupled receptors (GPCRs) exist in multiple dynamic states (e.g., ligand-bound, inactive, G protein–coupled) that influence G protein activation and ultimately response generation. In quantitative models of GPCR signaling that incorporate these varied states, parameter values are often uncharacterized or varied over large ranges, making identification of important parameters and signaling outcomes difficult to intuit. Here we identify the ligand- and cell-specific parameters that are important determinants of cell-response behavior in a dynamic model of GPCR signaling using parameter variation and sensitivity analysis. The character of response (i.e., positive/neutral/inverse agonism) is, not surprisingly, significantly influenced by a ligand's ability to bias the receptor into an active conformation. We also find that several cell-specific parameters, including the ratio of active to inactive receptor species, the rate constant for G protein activation, and expression levels of receptors and G proteins also dramatically influence agonism. Expressing either receptor or G protein in numbers several fold above or below endogenous levels may result in system behavior inconsistent with that measured in endogenous systems. Finally, small variations in cell-specific parameters identified by sensitivity analysis as significant determinants of response behavior are found to change ligand-induced responses from positive to negative, a phenomenon termed protean agonism. Our findings offer an explanation for protean agonism reported in β2--adrenergic and α2A-adrenergic receptor systems.
The Yellowstone Permutation
David L. Applegate,Hans Havermann,Bob Selcoe,Vladimir Shevelev,N. J. A. Sloane,Reinhard Zumkeller
Mathematics , 2015,
Abstract: Define a sequence of positive integers by the rule that a(n) = n for 1 <= n <= 3, and for n >= 4, a(n) is the smallest number not already in the sequence which has a common factor with a(n-2) and is relatively prime to a(n-1). We show that this is a permutation of the positive integers. The remarkable graph of this sequence consists of runs of alternating even and odd numbers, interrupted by small downward spikes followed by large upward spikes, suggesting the eruption of geysers in Yellowstone National Park. On a larger scale the points appear to lie on infinitely many distinct curves. There are several unanswered questions concerning the locations of these spikes and the equations for these curves.
Naturopathic Care for Chronic Low Back Pain: A Randomized Trial
Orest Szczurko, Kieran Cooley, Jason W. Busse, Dugald Seely, Bob Bernhardt, Gordon H. Guyatt, Qi Zhou, Edward J. Mills
PLOS ONE , 2007, DOI: 10.1371/journal.pone.0000919
Abstract: Objective Chronic low back pain represents a substantial cost to employers through benefits coverage and days missed due to incapacity. We sought to explore the effectiveness of Naturopathic care on chronic low back pain. Methods This study was a randomized clinical trial. We randomized 75 postal employees with low back pain of longer than six weeks duration to receive Naturopathic care (n = 39) or standardized physiotherapy (n = 36) over a period of 12 weeks. The study was conducted in clinics on-site in postal outlets. Participants in the Naturopathic care group received dietary counseling, deep breathing relaxation techniques and acupuncture. The control intervention received education and instruction on physiotherapy exercises using an approved education booklet. We measured low back pain using the Oswestry disability questionnaire as the primary outcome measure, and quality of life using the SF-36 in addition to low back range of motion, weight loss, and Body Mass Index as secondary outcomes. Results Sixty-nine participants (92%) completed eight weeks or greater of the trial. Participants in the Naturopathic care group reported significantly lower back pain (?6.89, 95% CI. ?9.23 to ?3.54, p = <0.0001) as measured by the Oswestry questionnaire. Quality of life was also significantly improved in the group receiving Naturopathic care in all domains except for vitality. Differences for the aggregate physical component of the SF-36 was 8.47 (95% CI, 5.05 to 11.87, p = <0.0001) and for the aggregate mental component was 7.0 (95% CI, 2.25 to 11.75, p = 0.0045). All secondary outcomes were also significantly improved in the group receiving Naturopathic care: spinal flexion (p<0.0001), weight-loss (p = 0.0052) and Body Mass Index (?0.52, 95% CI, ?0.96 to ?0.08, p = 0.01). Conclusions Naturopathic care provided significantly greater improvement than physiotherapy advice for patients with chronic low back pain. Trial Registration Controlled-Trials.com ISRCTN41920953
The non-protein coding breast cancer susceptibility locus Mcs5a acts in a non-mammary cell-autonomous fashion through the immune system and modulates T-cell homeostasis and functions
Bart MG Smits, Deepak Sharma, David J Samuelson, Stephan Woditschka, Bob Mau, Jill D Haag, Michael N Gould
Breast Cancer Research , 2011, DOI: 10.1186/bcr2933
Abstract: We performed mammary carcinoma multiplicity studies with three mammary carcinoma-inducing treatments, namely 7,12-dimethylbenz(a)anthracene (DMBA) and N-nitroso-N-methylurea (NMU) carcinogenesis, and mammary ductal infusion of retrovirus expressing the activated HER2/neu oncogene. We used mammary gland and bone marrow transplantation assays to assess the target tissue of Mcs5a activity. We used immunophenotyping assays on well-defined congenic rat lines carrying susceptible and resistant Mcs5a alleles to identify changes in T-cell homeostasis and function associated with resistance.We show that Mcs5a acts beyond the initial step of mammary epithelial cell transformation, during early cancer progression. We show that Mcs5a controls susceptibility in a non-mammary cell-autonomous manner through the immune system. The resistant Mcs5a allele was found to be associated with an overabundance of gd T-cell receptor (TCR)+ T-cells as well as a CD62L (L-selectin)-high population of all T-cell classes. In contrast to in mammary carcinoma, gdTCR+ T-cells are the predominant T-cell type in the mammary gland and were found to be overabundant in the mammary epithelium of Mcs5a resistant congenic rats. Most of them simultaneously expressed the CD4, CD8, and CD161α markers. In cultured T-cells of Mcs5a resistant congenic rats we found increased mitogen-induced proliferation and production of Th1 cytokines IFNg, IL-2, and Tumor Necrosis Factor (TNF), but not Th2 cytokines IL-4 and IL-6, or Th17 cytokine IL-17 when compared with susceptible control rats.These data support a hypothesis that Mcs5a displays a non-mammary cell-autonomous mechanism of action to modulate breast cancer risk through the immune system. The resistant Mcs5a allele is associated with alterations in T-cell homeostasis and functions, and overabundance of γδTCR+ T-cells in carcinogen-exposed mammary epithelium.The genetic component of risk for most common forms of breast cancer defines it as a complex trait consisti
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