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Search Results: 1 - 10 of 601 matches for " Bob Ursem "
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Climate Shifts and the Role of Nano Structured Particles in the Atmosphere  [PDF]
Bob Ursem
Atmospheric and Climate Sciences (ACS) , 2016, DOI: 10.4236/acs.2016.61005
Abstract: A global net sum equilibrium in heat exchange is a fact and thus a global climate change doesn’t exist, but climate shifts in climate cells, especially in the northern temperate cell, do. The global climate has been ever since homeostatic, and has recuperated far huger climate impacts in the past. Current climate models need a drastically revision on the focus of carbon dioxide as main driver. Carbon dioxide and other carbon gasses do influence albedo patterns, but provide globally a homeostatic effect with a commonly accepted increase impact of 0.3 degrees Celsius. Carbon dioxide does not trigger the climate shifts, but is an indicator of exhaust of combustion processes that emit very small particles which drive these climate shifts. They are the fine dust and nano structured particles that cause the shifts of the climate in cells, as demonstrated in this article and results i.e. in more thunder and lightning, extreme weather, distinct droughts and precipitation patterns. The causes underlying these shifts are nano structured particles in the upper troposphere and lower stratosphere, especially largely produced and remain in the temperate climate northern hemisphere cell and get dispersed by jet streams and low and high pressure areas. However, because of electrical charge, caused by friction or due to anthropogenic negatively charged nano structured particle, emissions will travel up to the lower stratosphere and become neutralized at the electro sphere level, and they do also have a tendency to move to the Arctic. The southern hemisphere climate faces limited anthropogenic emissions, because only 10 percent of the world population can contribute with less pollutant providing activities, and hasn’t changed, but that could well be because it is equally influenced and driven, like the northern hemisphere, by the variation of sun activity in diverse cycles. The present problem is that we produce huge amounts of air borne nano structured particles from combustion processes that never exist before. The only nano particles known in nature are those who are limited produced from volcano eruptions and natural forest fires. The natural feedback systems that moderate climate shifts and influence global climate are: convection by cumulonimbus clouds, sea currents and vegetation adaptation. A novel ultra-fine dust electric reduction device (UFDRS-System), created by the author, diminishs to a size of less than 10 nano particles in diameter and thus prevents major electrical drift of nano structured particulates in the upper troposphere and lower
Nature’s Particulate Matter with and without Charge and Travelling  [PDF]
Bob W. N. J. Ursem
Open Journal of Biophysics (OJBIPHY) , 2016, DOI: 10.4236/ojbiphy.2016.63008
Abstract: Natures and anthropogenic particulates can travel long distances on wind flows, but negative electrical charge due to friction can increase dispersion. Models for calculations of distance travelling of biological particulate matter with and without charge are never been calculated in a theoretical approach. Nor do we realize the fact that we can calculate actual distances if we take the charge on particles in account. Particles that travel through the air encounter friction. Friction can be described in two ways; either in a smooth constant way through the air with its viscous forces, or in a turbulent chaotic eddies and vortices and other flow instabilities. In case of only viscous forces are to be concerned, it can be described as a lower Reynolds number than one, while in all other setting it always must be described by Reynolds numbers larger than or equal to one. This article describes the calculated effects on particles, either in a low Reynolds number and thus as a Navier-Stokes equation or Stokes’ Law or, in case of non-laminar and complex forces in an equal or higher Reynolds number according to the third Law of Newton. In addition some striking examples of particle travelling are given with evidence of natural particulate matter long distance dispersion.
About the Causes of the Koror Bridge Collapse  [PDF]
Corneliu Bob
Open Journal of Safety Science and Technology (OJSST) , 2014, DOI: 10.4236/ojsst.2014.42013
Abstract:
This paper has been prepared from basic works published, mainly, after 2008 when the collapse investigation was made available. The main contributions of the paper are: a proper model for the deflections at mid-span of the bridge, the state of stress in elastic and post elastic stage for same phases of behavior, the stage of cracked of the top of cantilever beams, the repair effect on the structure of Koror Bridge, the probabilistic evaluation. The present study is based on well known and simple engineer tools: the one-dimensional beam-type was analyzed.
Source Code Comparison of DOS and CP/M  [PDF]
Bob Zeidman
Journal of Computer and Communications (JCC) , 2016, DOI: 10.4236/jcc.2016.412001
Abstract: In a previous paper [1], I compared DOS from Microsoft and CP/M from Digital Research Inc. (DRI) to determine whether the original DOS source code had been copied from CP/M source code as had been rumored for many years [2] [3]. At the time, the source code for CP/M was publicly available but the source code for DOS was not. My comparison was limited to the comparison of the DOS 1.11 binary code and the source code for CP/M 2.0 from 1981. Since that time, the Computer History Museum in Mountain View, California received the source code for DOS 2.0 from Microsoft and was given permission to make it public. The museum also received the source code for DOS 1.1 from Tim Paterson, the developer who was originally contracted by Microsoft to write DOS. In this paper, I perform a further analysis using the newly accessible source code and determine that no code was copied. I further conclude that the commands were not copied but that a substantial number of the system calls were copied.
The Scientific Evidence That “Intent” Is Vital for Healthcare  [PDF]
Bob Johnson
Open Journal of Philosophy (OJPP) , 2017, DOI: 10.4236/ojpp.2017.74022
Abstract: THINKING cannot occur without electrons, a point philosophically, scientifically and irrefutably confirmed for all, by the Electroencephalogram (EEG). However for 100 years, electrons and their ilk have scrupulously obeyed the Uncertainty Principle. Probability rules. The way human beings reason is by concluding that if event B is seen to follow cause A, it will do so again tomorrow—electrons don’t even support this today. Hume’s critique of causality which Kant failed to refute, gains traction from Quantum Mechanics. Despite needing to insert the word “probably” into every human reasoning, healthcare demonstrates an element of unexpected stability. The label “intent” is expanded to cover this anomaly, endeavouring to highlight how living cells cope with the impact of this unknowability, this Uncertainty. Mental health follows suit, though here the uncertainty comes additionally from “blockage” of the frontal lobes consequent upon trauma/terror. The collapse of today’s psychiatry is pathognomonic, and medically solipsistic. The role of “intent”, and its close relative, consent, are offered as remedies, not only for mental disease, relabelled here “social defeat”, but also for the global disease of violence, culminating in the biggest health threat of them all, thermonuclear war.
The Sociology of Knowledge, Citizenship and the Purification of Politics  [PDF]
Jed Donoghue, Bob White
Sociology Mind (SM) , 2013, DOI: 10.4236/sm.2013.31003
Abstract:

We reinterpret citizenship using Mannheim’s classical sociology of knowledge and through a more recent variant on them in Latour’s argument that “we have never been modern” (Latour, 1991). On that basis, we understand citizenship as a recursive effect of disputes over belonging and membership (Isin, 2002), where those disputes entail the three forms of political rationality or “thought styles” which Mannheim and Latour variously suggested: the linearly individual rationality of liberalism; dialectically collective socialism; and culturally collective conservatism. Marshall defines citizenship as a “status bestowed on those who are full members of a community” (Marshall, 1973). He presents an image of evolutionary progress, from civil to political rights and finally to the social form, in Britain. We argue that Marshall was entangled in evolutionary and teleological images of citizenship. We reinterpret citizenship using Mannheim’s classical sociology of knowledge. We suggest that sociologies of knowledge allow a re-reading of “citizenship” that can accommodate conceptual difficulties. Mannheim called into question the “progress” implied or stated in theories of “stages”. He stressed instead the continuing interaction between different ways of knowing social reality, or between what he called “thought styles”. We apply Mannheim to “citizenship” in order to lift two “purifications”, so that humanity is both natural and political.

The Impact of Computer Mediated Communication (CMC) on Productivity and Efficiency in Organizations: A Case Study of an Electrical Company in Trinidad and Tobago  [PDF]
Kenrick Bob, Prahalad Sooknanan
Advances in Journalism and Communication (AJC) , 2014, DOI: 10.4236/ajc.2014.22005
Abstract: This study investigates how computer mediated communication (CMC) and the electronic mailing system in particular have impacted on productivity and efficiency not to mention interpersonal interaction and increased use of technology in the organization. An electricity company was chosen for the case study since it had achieved approximately 78% computerization and networking of its office staff. Following the judgemental sampling technique to identify the organization, random sampling was used to select a sample size of 100 respondents. A questionnaire survey with sixteen items was self-administered over a one-week period. The results showed that 73% of the respondents agreed that CMC enhanced their overall productivity and efficiency while 27% differed. However, while the findings revealed that the introduction of CMC increased its use as a whole, it impacted negatively on interpersonal relationships among respondents.
Thrombotic Occlusion of a Microvascular Anastomosis in a Resistance to Activated Protein C (APC) Patient with Incomplete Wound Healing after High Doses of Ascorbic Acid (Vitamin C)  [PDF]
Martijn P. J. Loonen, Bob De Frene, Bob Casaer
Modern Plastic Surgery (MPS) , 2012, DOI: 10.4236/mps.2012.23015
Abstract: A 45-year-old woman underwent a delayed breast reconstruction with a free Deep Inferior Epigastric Perforator Flap (DIEP flap) with total flap failure on the fourth postoperative day. Hematological investigation to exclude thrombofilia revealed a resistance to activated protein C (APC) with a factor V Leiden heterozygous mutation. The postoperative course was further complicated by delayed wound healing probably due to ascorbic acid (Vitamin C) related cytotoxic activity to fibroblasts. The surgeon must be aware of the use of preoperative nutritional supplement administration among patients. Future cost-effectiveness analyses should be made to warrant preoperative thrombophilia screening to prevent free flap failures.
Both Ligand- and Cell-Specific Parameters Control Ligand Agonism in a Kinetic Model of G Protein–Coupled Receptor Signaling
Tamara L Kinzer-Ursem,Jennifer J Linderman
PLOS Computational Biology , 2007, DOI: 10.1371/journal.pcbi.0030006
Abstract: G protein–coupled receptors (GPCRs) exist in multiple dynamic states (e.g., ligand-bound, inactive, G protein–coupled) that influence G protein activation and ultimately response generation. In quantitative models of GPCR signaling that incorporate these varied states, parameter values are often uncharacterized or varied over large ranges, making identification of important parameters and signaling outcomes difficult to intuit. Here we identify the ligand- and cell-specific parameters that are important determinants of cell-response behavior in a dynamic model of GPCR signaling using parameter variation and sensitivity analysis. The character of response (i.e., positive/neutral/inverse agonism) is, not surprisingly, significantly influenced by a ligand's ability to bias the receptor into an active conformation. We also find that several cell-specific parameters, including the ratio of active to inactive receptor species, the rate constant for G protein activation, and expression levels of receptors and G proteins also dramatically influence agonism. Expressing either receptor or G protein in numbers several fold above or below endogenous levels may result in system behavior inconsistent with that measured in endogenous systems. Finally, small variations in cell-specific parameters identified by sensitivity analysis as significant determinants of response behavior are found to change ligand-induced responses from positive to negative, a phenomenon termed protean agonism. Our findings offer an explanation for protean agonism reported in β2--adrenergic and α2A-adrenergic receptor systems.
Combinatorial Gene Regulation Using Auto-Regulation
Rutger Hermsen ,Bas Ursem,Pieter Rein ten Wolde
PLOS Computational Biology , 2010, DOI: 10.1371/journal.pcbi.1000813
Abstract: As many as 59% of the transcription factors in Escherichia coli regulate the transcription rate of their own genes. This suggests that auto-regulation has one or more important functions. Here, one possible function is studied. Often the transcription rate of an auto-regulator is also controlled by additional transcription factors. In these cases, the way the expression of the auto-regulator responds to changes in the concentrations of the “input” regulators (the response function) is obviously affected by the auto-regulation. We suggest that, conversely, auto-regulation may be used to optimize this response function. To test this hypothesis, we use an evolutionary algorithm and a chemical–physical model of transcription regulation to design model cis-regulatory constructs with predefined response functions. In these simulations, auto-regulation can evolve if this provides a functional benefit. When selecting for a series of elementary response functions—Boolean logic gates and linear responses—the cis-regulatory regions resulting from the simulations indeed often exploit auto-regulation. Surprisingly, the resulting constructs use auto-activation rather than auto-repression. Several design principles show up repeatedly in the simulation results. They demonstrate how auto-activation can be used to generate sharp, switch-like activation and repression circuits and how linearly decreasing response functions can be obtained. Auto-repression, on the other hand, resulted only when a high response speed or a suppression of intrinsic noise was also selected for. The results suggest that, while auto-repression may primarily be valuable to improve the dynamical properties of regulatory circuits, auto-activation is likely to evolve even when selection acts on the shape of response function only.
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