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Search Results: 1 - 10 of 7199 matches for " Boato Francesco "
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Absence of IL-1β positively affects neurological outcome, lesion development and axonal plasticity after spinal cord injury
Boato Francesco,Rosenberger Karen,Nelissen Sofie,Geboes Lies
Journal of Neuroinflammation , 2013, DOI: 10.1186/1742-2094-10-6
Abstract: Precise crosstalk between the nervous and immune systems is important for neuroprotection and axon plasticity after injury. Recently, we demonstrated that IL-1β acts as a potent inducer of neurite outgrowth from organotypic brain slices in vitro, suggesting a potential function of IL-1β in axonal plasticity. Here, we have investigated the effects of IL-1β on axon plasticity during glial scar formation and on functional recovery in a mouse model of spinal cord compression injury (SCI). We used an IL-1β deficiency model (IL-1βKO mice) and administered recombinant IL-1β. In contrast to our hypothesis, the histological analysis revealed a significantly increased lesion width and a reduced number of corticospinal tract fibers caudal to the lesion center after local application of recombinant IL-1β. Consistently, the treatment significantly worsened the neurological outcome after SCI in mice compared with PBS controls. In contrast, the absence of IL-1β in IL-1βKO mice significantly improved recovery from SCI compared with wildtype mice. Histological analysis revealed a smaller lesion size, reduced lesion width and greatly decreased astrogliosis in the white matter, while the number of corticospinal tract fibers increased significantly 5 mm caudal to the lesion in IL-1βKO mice relative to controls. Our study for the first time characterizes the detrimental effects of IL-1β not only on lesion development (in terms of size and glia activation), but also on the plasticity of central nervous system axons after injury.
Interleukin-1 beta and neurotrophin-3 synergistically promote neurite growth in vitro
Francesco Boato, Daniel Hechler, Karen Rosenberger, Doreen Lüdecke, Eva M Peters, Robert Nitsch, Sven Hendrix
Journal of Neuroinflammation , 2011, DOI: 10.1186/1742-2094-8-183
Abstract: Interleukin-1 beta (IL-1β) is a member of the IL-1 family of cytokines which have potent pro-inflammatory properties. It is produced in the periphery mainly by monocytes and is a strong activator of the host immune response to both injury and infection [1,2]. In the central nervous system (CNS) IL-1β is primarily produced by microglia and invading monocytes/macrophages, but other types of resident cells of the nervous system, including neurons and astrocytes, are also capable of its production [3]. It is generally believed that inflammatory processes stimulated by pro-inflammatory cytokines and particularly by IL-1β, are rather detrimental and can aggravate the primary damage caused by infection of the CNS. This has been suggested by various in vivo studies, in line with its enhanced expression in the brain after damage or in neurodegenerative diseases, including Alzheimer's disease (AD). Consistently, IL-1 deficient mice display reduced neuronal loss and infarct volumes after ischemic brain damage [4] and direct application of the recombinant cytokine results in an enhanced infarct volume [5]. In traumatic brain injury, antibodies against IL-1β reduce the loss of hippocampal neurons [6]. Consistently, in a mouse model of AD, an inhibitor of pro-inflammatory cytokine production suppressed neuroinflammation leading to a restoration of hippocampal synaptic dysfunction markers [7]. In AD it has also been demonstrated that members of the IL-1 family are associated with an increased risk of contracting the disease [8].The findings in various in vitro models suggest a rather elaborated mechanism. In culture, IL-1β demonstrated neurotoxic effects towards hippocampal neurons exposed to high concentrations (500 ng/ml) combined with long-term exposure (three days). However, no effect was observed in lower concentrations following short-term exposure (one day) [9]. In other in vitro models, IL-1β has even been seen to display beneficial effects towards neuronal survival in the
Robert Lepage: anatomia di un regista
Giulio Boato
Antropologia e Teatro : Rivista di Studi , 2012, DOI: 10.6092/issn.2039-2281/2641
Abstract: – IT Robert Lepage è uno dei registi più rilevanti del panorama teatrale internazionale contemporaneo. L’articolo cerca di fornire una sintetica analisi della poetica del regista soffermandosi in particolar modo sulle nozioni di “montaggio” e di “immagine” al fine di definire il rapporto tra tecnologia e linguaggio in teatro. L’analisi di due spettacoli di Lepage presentati in occasione del Napoli Teatro Festival Italia (edizioni 2010 e 2011) alimenta la riflessione teorica che si snoda seguendo una metafora anatomica: analizzare separatamente (sezionando come il chirurgo) le varie componenti narrative e formali del modus operandi lepagiano permette di comprendere più agevolmente l’architettura organica dell’insieme – FR Robert Lepage est un des metteurs en scène les plus remarqués de la scène théatrale internationale contemporaine. L’article cherche à fournir une analyse synthétique de l’art poétique du metteur en scène en se concentrant en particulier sur les notions de montage et image afin d’en définir le rapport entre technologie et langage au théatre. L’analyse de deux spectacles de Lepage présentés pendant le Napoli Teatro Festival Italia (éditions 2010 et 2011) alimente la réflexion théorique qui se développe selon une métaphore anatomique : à la manière d'un chirurgien disséquant un corps, on analysera séparément les différentes composantes narratives et formelles utilisées par Lepage afin de comprendre plus facilement l’architecture organique de l’ensemble. – EN Robert Lepage is one of the most significant directors on the international and contemporary theatre scene. The article tries to provide a synthetic analysis of the director’s work: focusing on the notions of “editing” and “image”, it defines the relation between technology and language in theatre. The analysis of two pieces of theatre presented at the Napoli Teatro Festival Italia (editions 2010 and 2011) feeds the theoretical reflection which follows an “anatomic” metaphor. As the surgeon dissects, we will analyse the different narrative and formal components to understand the organic architecture of Lepage’s theatre.
Genetics of a Reenactment in Jan Fabre’s Work
Giulio Boato
Revista Brasileira de Estudos da Presen?a , 2013,
Abstract: This article proposes a selective path through the process of recreation of two spectacles by Jan Fabre: This is theatre like it was to be expected and foreseen (1982) and The power of theatrical madness(1984). The author – who followed closely the work of the company from April to July 2012 – focuses on the small differences between the two versions of the works, analysing the modalities and reasons of the changes. The dissertation examines the work of the director and the performers, at the same time as it questions the notions of theatrical genetics and reenactment.
Archeologia e storia del cantiere di costruzione
Mannoni, Tiziano,Boato, Anna
Arqueología de la Arquitectura , 2002,
Abstract: The history of architecture, for more than two centuries, has tried to understand the buildings using written sources, reaching in this way an outstanding specialisation.The very most recent building archaeology is trying to make the built heritage itself speak about its history, even that of the construction site.The archaeological data (stratigraphic sequences, archaeological dating, materials and building techniques), put in dialogue with the archaeometric data (natural watches; characteristics, provenience and preciousness of the materials) and following the rules of the “cultura materiale” - material culture - (empirical way of doing apprehension and transmission), allow us to begin the study of the builders choices, their possibilities and their motivations (archaeological critic). At this point, the research makes a real qualitative and quantitative jump if we read again, with an archaeological eye, all the written data coming from tenders, public permissions, construction site computations and from the ancient estimations and appraisals. La storia dell’architettura per più di duecento anni ha cercato di capire la costruzione attraverso le fonti scritte, raggiungendo in ciò una notevole specializzazione. La assai più recente archeologia dell’architettura sta cercando di far parlare il costruito stesso sulla sua storia, ivi compresa quella del cantiere di costruzione. I dati archeologici (sequenze stratigrafiche, datazioni archeologiche, materiali e tecniche costruttive), fatti dialogare con i dati archeometrici (orologi naturali, provenienze, caratteristiche e rarità dei materiali), secondo le regole della cultura materiale (apprendimento e trasmissione del saper fare empirico), permettono di affrontare la conoscenza delle scelte effettuate dai costruttori, le loro possibilità e le loro motivazioni (critica archeologica). E’ a questo punto che la ricerca fa un vero salto di qualità e di quantità se si rileggono con l’occhio dell’archeologo i dati scritti provenienti dai contratti di costruzione, dai permessi pubblici, dalla contabilità del cantiere e dalle stime e perizie delle opere compiute.
Annals of Geophysics , 1951, DOI: 10.4401/ag-5932
Abstract: .
Joint Watermarking and Encryption of Color Images in the Fibonacci-Haar Domain
Federica Battisti,Michela Cancellaro,Giulia Boato,Marco Carli
EURASIP Journal on Advances in Signal Processing , 2009, DOI: 10.1155/2009/938515
Abstract: A novel method for watermarking and ciphering color images, based on the joint use of a key-dependent wavelet transform with a secure cryptographic scheme, is presented. The system allows to watermark encrypted data without requiring the knowledge of the original data and also to cipher watermarked data without damaging the embedded signal. Since different areas of the proposed transform domain are used for encryption and watermarking, the extraction of the hidden information can be performed without deciphering the cover data and it is also possible to decipher watermarked data without removing the watermark. Experimental results show the effectiveness of the proposed scheme.
N-methyl-D-aspartate (NMDA) mediates vascular relaxation via nitric oxide (NO) in rats but not in mice  [PDF]
Francesco Crespi
Advances in Bioscience and Biotechnology (ABB) , 2010, DOI: 10.4236/abb.2010.14045
Abstract: Amperometric studies have indicated that substance P as well as NMDA stimulates release of NO in rat aortic rings. These data have been confirmed by functional observations of vaso-relaxant action of NMDA within noradrenaline pre-contracted aortic rings, supporting the presence of NMDA receptor in rat aortic rings. It is known that the enzyme endothelial NO synthase (eNOS) mediates vasodilatation not only in rats, but also in C57BL6 mice aortic ring, indicating that in this blood vessel NO is the endogenous endothelium-derived vasodilator. In this work, amperometry together with specifically nitrites insensitive micro-biosensors have been applied to examine the effect of NMDA and substance P upon NO release in rat and in two strains of mice aortic rings. The electrochemical data monitored demonstrate that NMDA mediates vascular relaxation via NO in rats but not in mice. These results are supported by functional data, therefore they suggest that NMDA receptors are “not responding” within these experimental conditions in mice aortic rings.
Theoretical modeling of airways pressure waveform for dual-controlled ventilation with physiological pattern and linear respiratory mechanics  [PDF]
Francesco Montecchia
Journal of Biomedical Science and Engineering (JBiSE) , 2011, DOI: 10.4236/jbise.2011.44042
Abstract: The present paper describes the theoretical treatment performed for the geometrical optimization of advanced and improved-shape waveforms as airways pressure excitation for controlled breathings in dual-controlled ventilation applied to anaesthetized or severe brain injured patients, the respiratory mechanics of which can be assumed linear. Advanced means insensitive to patient breathing activity as well as to ventilator settings while improved-shape intends in comparison to conventional square waveform for a progressive approaching towards physiological transpulmonary pressure and respiratory airflow waveforms. Such functional features along with the best ventilation control for the specific therapeutic requirements of each patient can be achieved through the implementation of both diagnostic and compensation procedures effectively carried out by the Advance Lung Ventilation System (ALVS) already successfully tested for square waveform as airways pressure excitation. Triangular and trapezoidal waveforms have been considered as airways pressure excitation. The results shows that the latter fits completely the requirements for a physiological pattern of endoalveolar pressure and respiratory airflow waveforms, while the former exhibits a lower physiological behaviour but it is anyhow periodically recommended for performing adequately the powerful diagnostic procedure.
Is a Divergent Central Serotonergic Activity Responsible for Either Despair or Learning Behavior in Intact Wistar or Sprague-Dawley CD Rats, Respectively? A Concomitant Behavioral and Electrochemical Analysis  [PDF]
Francesco Crespi
Psychology (PSYCH) , 2010, DOI: 10.4236/psych.2010.13028
Abstract: Behavioral observations combined with electrochemical analysis have been performed in Wistar or Sprague-Dawley CD rats in the attempt to clarify earlier controversial behavioral reports. In particular, these rats were submitted to FST and to repeated Forced Swimming (rFS, during 4 days). In parallel, voltammetric in vivo analysis of serotonin (5-HT) levels in platelet-rich plasma (PRP) collected daily from these animals was also performed as it is known that peripheral 5-HT levels monitored in rat PRP mirror cerebral 5-HT contents. Thus, combined behavioral-voltammetric studies allow deducing changes of central 5-HT levels that could be correlated to FST or rFS, with the advantage of non invasive analysis of central neurotransmitter activities in intact behaving animals. In particular, combined beha-vioral-voltammetric results suggest that “behavioral despair” is the process interesting Wistar rats when submitted to FST or rFS while “learning to be immobile” is the process involving Sprague-Dawley CD rats.
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