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Search Results: 1 - 10 of 106143 matches for " Bo?i?-Miljkovi? Ivana "
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Foreign trade competitiveness of the Balkan countries under the conditions of globalization
Medjunarodni Problemi , 2012, DOI: 10.2298/medjp1201067b
Abstract: The development of international trade on the world scale under the conditions of globalization, more than ever in the economic history has given prominence to the issues of given countries’ competitiveness and foreign trade companies. Competitiveness in foreign trade is a complex category affected by the factors of both economic and non-economic nature. With the increase of the degree of liberalization of foreign trade globally, competitiveness represents a very important factor that the results in this particular trade depend on and, consequently, realization of the developmental and stabilization objectives in the progress of trade. The Balkan countries are making efforts, through diverse forms of regional economic networking and economic cooperation, to define their competitiveness in foreign trade in such a way so as to ensure its higher level. The actions of this kind should change their relatively unfavorable position in international trade and improve the state in their foreign trade balance as well as balance of payments. In doing this, they encounter numerous problems of economic and non-economic nature, namely those that still condition their low competitiveness in foreign trade.
T cells cooperate with palmitic acid in induction of beta cell apoptosis
Tamara Cvjeti?anin, Ivana Stojanovi?, Gordana Timotijevi?, Stanislava Sto?i?-Gruji?i, Djordje Miljkovi
BMC Immunology , 2009, DOI: 10.1186/1471-2172-10-29
Abstract: Rat pancreatic islets or insulinoma cells (RIN) were co-cultivated with concanavalin A (ConA)-stimulated rat lymph node cells (LNC), or they were treated with cell-free supernatants (Sn) obtained from ConA-stimulated spleen cells or from activated CD3+ cells, in the absence or presence of palmitic acid (PA). ConA-stimulated LNC or Sn and PA cooperated in inducing caspase-3-dependent RIN cell apoptosis. The observed effect of PA and Sn on RIN cell viability was mediated by p38 mitogen-activated protein kinase (MAPK)-signaling and was achieved through auto-destructive nitric oxide (NO) production. The cooperative effect of Sn was mimicked with the combination of interleukin-1β, interleukin-2, interleukin-6, interleukin-17, interferon-γ and tumor necrosis factor-α.These results imply that stimulated T cells produce cytokines that cooperate with saturated free fatty acids in beta cell destruction during diabetes pathogenesis.Diabetes mellitus is a common name for a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion and/or action. Hyperglycemia and other related metabolic disturbances can lead to serious damage to various systems of the body, especially nerves and blood vessels. Statistical data show that the excess global mortality attributable to diabetes in the year 2000 was 5.2% of all deaths [1], while its prevalence for all age-groups worldwide was expected to increase from 2.8% in 2000 to 4.4% in 2030 [2]. The most frequent forms of diabetes mellitus are type 2 diabetes (T2D) and type 1 diabetes (T1D).T2D is classically considered to be a metabolic disease characterized by insulin resistance and additional disorders, such as pancreatic beta cell dysfunction and decrease in beta cell mass, which intensively contribute to the disease course [3,4]. One major reason for insulin resistance in T2D is obesity [4,5], which is associated with high glucose and free fatty acid levels circulating throughout the body affectin
Ochratoxin A 'in vitro' biosynthesis by the Aspergillus ochraceus E'G isolate
Bo?arov-Stan?i? Aleksandra S.,Miljkovi? Aleksandra D.,Resanovi? Radmila M.,Ne?i? Ksenija D.
Zbornik Matice Srpske za Prirodne Nauke , 2009, DOI: 10.2298/zmspn0917069b
Abstract: This paper deals with the biosynthetic capacity for ochratoxin A (OTA) production by Aspergillus ochraceus E'G isolate derived from A. ochraceus CBS 108.08 strain, during 2007. Preliminary analysis of fungal potential for the production of OTA were performed according to the modified method of Filtenborg et al. (1983). Toxin production was tested in the following liquid media: (i) glucose-peptone-yeast extract broth (GPY - pH 5.6), (ii) potato-dextrose broth (PDB - pH 6.9), (iii) yeast extract-sucrose broth (YES - pH 6.5), and (iv) YES broth supplemented with 0.23 mg/l ZnSO4 x 5 H2O (YESZn - pH 6.5) after stationary and submerged cultivation. Dynamics of OTA biosynthesis was tested after the cultivation of A. ochraceus E'G on natural solid substrates, such as wet sterilized rice, corn and wheat grain. Cultivations were performed during different time periods (ranging from four days to few weeks) at different temperatures (ranging from 21°C to 30°C). The presence of OTA was determined as follows: (i) in liquid media according to the method of Balzer et al. (1978) modified by Bo arov-Stan i et al. (2003), and (ii) in the solid substrates according to the Serbian official methods for sampling and analyzing of fodder (Official Gazette of SFRY, No. 15/87). After the cultivation of A. ochraceus E'G isolate in liquid media, the highest yield of OTA (6.4 mg/l) was obtained after submerged cultivation in PDB (4 days, 128 rpm, 21-23°C). In the case of cultivation on solid substrates, the highest amount of OTA (800.0 mg/kg of dry matter) was recorded after several week long cultivation on wheat grain at 30±1°C.
Ivana Mileti?,Ivor Jeftimijades,Bo?ena Bona?i,Kristijan Zanki
Ribarstvo : Croatian Journal of Fisheries , 2008,
Abstract: The main task of this paper is to describe digestive tract of bluefin tuna, with special focus on the liver. The samples for the research on tuna digestive tract where taken on the tuna farm Sardina d.d. Postira. The investigation were done on 22 samples (necropsy and photography of organs, Canon digital camera), 30 samples liver of unfatted tuna, 30 samples liver of fatted tuna and 20 histologic samples of liver before and after fattening. The quality of nutrition directly affects the differences of longitudinal and latitudinal values of the hepatosomatic index and the histology of liver of fatted and unfitted fish. Intensive, lipid–rich nutrition increases the quantity of the fat stored in liver therefore causing higher hepatosomatic index in fatted tuna. Histologic examination of fatted tuna indicates a beginning of hepatocytes degeneration with vacuolization of the cell and decentralized nuclei. Lack of eosinophilic granules in cytoplasm of hepatocytes indicates the cell’s inability of doing enzymatic activity, respectively its dysfunction.
Early continuous dialysis in acute glyphosate-surfactant poisoning
Kne?evi? Violeta,Boi? Du?an,Budo?an Ivana,?eli? Dejan
Srpski Arhiv za Celokupno Lekarstvo , 2012, DOI: 10.2298/sarh1210648k
Abstract: Introduction. Treating severe acute glyphosate-surfactant poisoning requires intensive therapy including dialysis. Cases of hemoperfusion and hemodialysis use in renal failure induced by herbicide ingestion have been reported in the current medical literature. We present a case report of successful patient treatment with continuous venovenous hemodiafiltration in acute glyphosate-surfactant poisoning. Case Outline. A 36-year-old male patient attempted suicide by drinking approximately 300 ml of glyphosate-surfactant about an hour before coming to our Clinic. On admittance the patient was somnolent, normotensive, acidotic and hyperkalemic. Six hours after poison ingestion there was no positive response to symptomatic and supportive therapy measures. The patient became hypotensive, hypoxic with oliguric acute renal failure, so that post-dilution continuous veno-venous hemodiafiltration was started. During the treatment the patient became hemodinamically stabile, diuresis was established along with electrolyte and acid-base status correction and a gradual decrease of blood urea nitrogen and creatinine levels. After a single 27.5-hour treatment, clinical condition and renal function parameters did not require further dialysis. Complete recovery of renal function was achieved on the fifth day. Conclusion. Early introduction of continuous veno-venous hemodiafiltration with other intensive therapy measures led to complete recovery in a hemodinamically instable patient.
The most frequent causes of ischemic stroke in young adults
Jovi?evi? Mirjana,Divjak Ivana,Slankamenac Petar,Boi? Ksenija
Medicinski Pregled , 2011, DOI: 10.2298/mpns1106331j
Abstract: Introduction. Pathogenesis of ischemic stroke in young adults is heterogeneous, thus making differential diagnosis very broad. Material and methods. The study comprised 60 ischemic stroke patients of both sexes aged 15-45 years who were treated at the Department of Neurology of the Clinical Centre of Vojvodina. Information about sex and age, detailed history, risk factors for ischemic stroke were obtained for all patients who underwent neurological examination as well. Diagnostic procedures applied in all patients included brain computed tomography and/or magnetic resonance imaging, routine laboratory tests, Doppler imaging of extra and endocranial blood vessels and coagulation tests. Contrast and/ or transesophageal echocardiography, immunological blood assays, magnetic resonance angiography and/or computed tomography angiography and/or conventional angiography, immunological tests, assessment of levels of natural coagulation inhibitors, toxicological examination, etc. were performed in selected patients. Results. Causes of ischemic stroke were determined according to the Trial of ORG 10172 in Acute Stroke Treatment criteria. The most frequent were the so called other causes of ischemic stroke, which were found in 26.7% patients. The second most frequent cause was cardiac embolisation, found in 25%. The cause of ischemic stroke remained undetermined in 21.7% of all patients. Conclusion. Aetiology of ischemic stroke in young adults is diverse and demands thorough diagnostic evaluation.
Urine-based testing for Chlamydia trachomatis among young adults in a population-based survey in Croatia: Feasibility and prevalence
Ivana Boi?evi?, Ivana Grgi?, Snje?ana ?idovec-Lepej, Jurja-Ivana ?akalo, Sanja Belak-Kova?evi?, Aleksandar ?tulhofer, Josip Begovac
BMC Public Health , 2011, DOI: 10.1186/1471-2458-11-230
Abstract: We sampled participants using a nationally representative, multi-stage stratified probability sample of young men and women. Detection of C trachomatis DNA in urine samples was performed by using a real-time PCR assay COBAS? TaqMan? CT Test, v2.0.Overall, 1005 young adults participated in the behavioural part of the survey, and 27.9% men and 37.5% women who were sexually experienced agreed to provide urine samples for testing on C trachomatis. Using multivariate analysis, women were significantly more likely to provide urine samples than men (aOR = 1.53, 95% CI 1.14-2.06) as were those who reported no condom use at last intercourse (aOR = 1.95, 95% CI 1.44-2.62). Prevalence of C trachomatis infection among those who were sexually experienced was 7.3% in men and 5.3% in women.Population-based surveys that use probabilistic sampling are a feasible way to obtain population estimates of C trachomatis prevalence among young adults in Croatia, but it is challenging to obtain an adequate response rate. The prevalence of C trachomatis among young adults in Croatia found in this study was higher than that found in other European countries with similar survey response rates.Chlamydia trachomatis is the most common bacterial sexually transmitted infection (STI) in Croatia. In 2008, 11 cases of Neisseria gonorrhoeae, 31 cases of syphilis and 553 cases of genital C trachomatis infection were reported [1]. However, those figures are based on case reporting, and are believed to substantially underestimate true incidence. C trachomatis case rates in Croatia ranged from 7.04/100,000 in 1999 to 9.11/100,000 in 2007, compared to 3.99/100,000 to 10.04/100,000 in Slovenia, and 96.32/100,000 to 200.26/100,000 in the United Kingdom [1]. In Croatia, as in the other countries of Eastern Europe, there is a lack of data on prevalence of C trachomatis in the general population, including young adults [2]. The focus of STI surveillance in Eastern Europe has been mainly on universal case reporti
Concentrations of veterinary drug residues in milk from individual farms in Croatia
Nina Biland?i,Bo?ica Solomun Kolanovi?,Ivana Varenina,Zorica Jurkovi?
Mljekarstvo , 2011,
Abstract: A total of 119 raw milk samples collected at individual small milk-producing facilities and collection tanks of milk routes from five counties of east and north continental Croatia were examined for chloramphenicol, sulfonamides, tetracyclines, gentamicin, streptomycin, dihydrostreptomycin, flumequine and enrofloxacin from January to March of 2011. Immunoassay methods used for drug determination were validated according to the guidelines laid down by European Commission Decision 2002/657/EC. Data indicated that the methods are appropriate for the detection of antibiotics measured. Measured mean values (μg L-1) of antibiotics were: 0.005 for chloramphenicol, 3.67 for sulfonamides, 2.83 for tetracyclines, 1.10 for gentamicin, 2.64 for streptomycin, 7.67 for dihydrostreptomycin, 10.4 for flumequine and 4.11 for enrofloxacin. None of samples analyzed showed the presence of veterinary drug residues above the maximum residues levels (MRLs) established by European Union and Croatian legislation. The calculated estimated daily intakes (EDIs) for the average daily milk consumption of 300 mL for an adult in Croatia for examined antibiotics showed levels 20 to 1640 times lower than the values of acceptable daily intakes (ADIs) fixed by European Medicines Agency and World Health Organization. This suggested that toxicological risk associated with the consumption of analysed milk could not be considered a public health issue with regards to these veterinary drugs.
Treatment of Stercoral Peritonitis Caused by Colorectal Carcinoma
Ivana ?or?evi?,Goran Stanojevi?,Dragoslav Miljkovi,Aleksandar Bogi?evi?
Acta Facultatis Medicae Naissensis , 2011,
Abstract: Stercoral peritonitis (SP) caused by perforation of the colon due to colorectal carcinoma (CRC) represents one of the most difficult types of peritoneal inflammation with complex clinical presentation. The aim of the study was to establish the frequency of CRC as a cause of stercoral peritonitis, type of treatment, postoperative complicatins, length of hospital stay and mortality among our patients. Retrospectively, two groups of patients were analyzed. Group A - the patients treated in the period from January 1, 2001 to December 31, 2006, and group B - the patients treated from January 1, 1995 to December 31, 2001. Surgical approach was different in those groups since we have accepted new strategies in the treatment of colonic perforations caused by CRC from 2000.Group A included 56 operated patients, median age 62.9, and in most of the cases (35.71%) SP was caused by carcinoma of the left colon. Group B involved 65 operated patients, median age 60.5, where most of SP cases were also caused by the cancer of the left colon (38.46%).In both groups, there was a similar number of minor complications (wound infection, peristomal abscess, personal irritation of the skin, stomal necrosis) - 34 in group A and 39 in group B. Thirty different major complications were recorded in group A (wound dehiscence, anastomotic leakage, intraabdominal abscess, fistula formation, and stomal retraction) opposed to 63 in group B. The higher percentage of complications in group B affected higher mortality rate (60%), opposed to mortality rate of 30% in group A. By applying new strategies in the treatment of stercoral peritonitis caused by CRC in the recent years, we have managed to reduce the rate of postoperative complications and mortality as well as hospital stay among these patients.
Dry olive leaf extract (DOLE) down-regulates the progression of experimental immune-mediated diabetes by modulation of cytokine profile in the draining lymph nodes
Saksida Tamara,Miljkovi? D.,Dekanski Dragana,Stojanovi? Ivana
Archives of Biological Sciences , 2011, DOI: 10.2298/abs1102289s
Abstract: We have recently demonstrated the beneficial effects of dry olive leaf extract (DOLE) in two preclinical models of type 1 diabetes. Here we analyze the potential mechanisms underlying diabetes amelioration at the level of lymph node drainage. Treatment of C57BL/6 mice with DOLE during induction of diabetes with multiple low doses of streptozotocin (MLD-SZ) modulated cytokine expression and production in pancreatic lymph node cells, thereby changing the balance between potentially pathogenic and down-regulating cytokines. These results support the immunoregulatory potential of DOLE which takes place at the level of lymph node drainage and preserves the target tissue from autoimmune attack.
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