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Search Results: 1 - 10 of 31037 matches for " Biyun Z.; "
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The Accounting Analysis of the Intangible Cultural Heritage Enterprises’ Brand Value—Take the Chinese Medicine Industry as an Example  [PDF]
Biyun Lin
American Journal of Industrial and Business Management (AJIBM) , 2018, DOI: 10.4236/ajibm.2018.87115
Abstract: Intangible cultural heritage enterprises have geographical, cultural and technical characteristics. Different from other general enterprises, its brand has a profound traditional cultural intrinsic. Therefore, when companies undertake greater responsibility to protect and inherit it, they should also consider how to use and develop resources to increase their brand value. The article quantitatively calculated and analyzed the brand value of an enterprise based on an accounting perspective. Taking the Chinese medicine industry as an example, the article selected the financial data of three brands, namely Tong Ren Tang, Dong E-Ejiao, and Yunnan Baiyao, as the calculation basis. We use the improved “Interbrand assessment model” to identify existing weaknesses in the relatively weak brand companies and find common and individual problems, such as low levels of management, difficulty in cost control, small profit margins, and easily damaged brand images. Finally, we will provide countermeasures to enhance the brand value of intangible cultural heritage companies from increasing effective investment, effectively controlling costs, increasing profits through innovation, and strengthening cooperation with various organizations of society.
Development and Validation of an Adsorptive Method for Aluminium Determination in Fluids Used in Renal Dialysis
Quirós,Miriam B.; Wu,Biyun Z.;
Portugaliae Electrochimica Acta , 2005,
Abstract: it was developed and validated an analytical methodology able to quantify aluminium in haemodialysis fluids, based on the reaction of aluminium with cupferrron (ammonium salt of n-nitroso phenyl hydroxyl amina), on the adsorption of the complex on a hanging drop mercury electrode, and on the measurement of the reduction current of the complex. parameter validation was done using square wave voltammetry for accumulation potential, time of accumulation, frequency, pulse amplitude, equilibrium time, cupferron concentration, optimum ph. performance parameters of the method were established: detection limit, quantification limit, reliability, lineal interval for the calibration curves. the method was applied to haemodialysis mineralized fluids, being done the quantification of the aluminium presented.
Desarrollo y Validación de un Método Adsortivo para la Determinación de Aluminio en Fluidos Usados en Diálisis Renal Development and Validation of an Adsorptive Method for Aluminium Determination in Fluids Used in Renal Dialysis
Miriam B. Quirós,Biyun Z. Wu
Portugaliae Electrochimica Acta , 2005,
Abstract: Se desarrolló y validó una metodología apta para cuantificar aluminio en fluidos utilizados en hemodiálisis renal, basada en la reacción de Al con cupferrón (sal de amonio de la N- nitroso fenil hidroxil amina), y en la adsorción sobre un electrodo de gota de Hg, la desorción y la medida de la corriente producida por la reducción del complejo. Para lograr este objetivo se realizó la validación de parámetros para voltamperometría de onda cuadrada (SWV): potencial de acumulación, tiempo de acumulación, frecuencia, amplitud de pulso, tiempo de equilibrio, concentración de cupferron, pH óptimo. Se determinaron también los parámetros de desempe o del método, veracidad, ámbito lineal, límite de detección, y límite de cuantificación. Se aplicó el método a fluidos de hemodiálisis mineralizados siendo éste adecuado para la cuantificación de aluminio. It was developed and validated an analytical methodology able to quantify aluminium in haemodialysis fluids, based on the reaction of aluminium with cupferrron (ammonium salt of N-nitroso phenyl hydroxyl amina), on the adsorption of the complex on a hanging drop mercury electrode, and on the measurement of the reduction current of the complex. Parameter validation was done using square wave voltammetry for accumulation potential, time of accumulation, frequency, pulse amplitude, equilibrium time, cupferron concentration, optimum pH. Performance parameters of the method were established: detection limit, quantification limit, reliability, lineal interval for the calibration curves. The method was applied to haemodialysis mineralized fluids, being done the quantification of the aluminium presented.
Research on Improving the Talent Incentive Mechanism of Artificial Intelligence Industry in China  [PDF]
Biyun Lin, Qingjun Meng, Changzheng Zhang
Open Journal of Social Sciences (JSS) , 2018, DOI: 10.4236/jss.2018.64012
Abstract:
Under the double drives of national attention and market demand, the artificial intelligence industry in China has developed rapidly in recent years. However, the problem lacking artificial intelligence talents is very prominent which should not be ignored. The loss of them is closely related to the imperfect incentive mechanism. Therefore, in order to better improve the talent incentive mechanism and help enterprises retain talented people, research will provide effective countermeasures mainly from two angles, government and enterprise. For example, the government should strengthen the planning of the talent incentive system; the company ought to vigorously promote the property rights incentive program and etc.
Ascorbic Acid Biosynthesis and Brackish Water Acclimation in the Euryhaline Freshwater White-Rimmed Stingray, Himantura signifer
Samuel Z. H. Wong, Biyun Ching, You R. Chng, Wai P. Wong, Shit F. Chew, Yuen K. Ip
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0066691
Abstract: L-gulono-γ-lactone oxidase (Gulo) catalyzes the last step of ascorbic acid biosynthesis, which occurs in the kidney of elasmobranchs. This study aimed to clone and sequence gulonolactone oxidase (gulo) from the kidney of the euryhaline freshwater stingray, Himantura signifer, and to determine the effects of acclimation from freshwater to brackish water (salinity 20) on its renal gulo mRNA expression and Gulo activity. We also examined the effects of brackish water acclimation on concentrations of ascorbate, dehydroascorbate and ascorbate + dehydroascorbate in the kidney, brain and gill. The complete cDNA coding sequence of gulo from the kidney of H. signifer contained 1323 bp coding for 440 amino acids. The expression of gulo was kidney-specific, and renal gulo expression decreased significantly by 67% and 50% in fish acclimated to brackish water for 1 day and 6 days, respectively. There was also a significant decrease in renal Gulo activity after 6 days of acclimation to brackish water. Hence, brackish water acclimation led to a decrease in the ascorbic acid synthetic capacity in the kidney of H. signifer. However, there were significant increases in concentrations of ascorbate and ascorbate + dehydroascorbate in the gills (after 1 or 6 days), and a significant increase in the concentration of ascorbate and a significant decrease in the concentration of dehydroascorbate in the brain (after 1 day) of fish acclimated to brackish water. Taken together, our results indicate that H. signifer might experience greater salinity-induced oxidative stress in freshwater than in brackish water, possibly related to its short history of freshwater invasion. These results also suggest for the first time a possible relationship between the successful invasion of the freshwater environment by some euryhaline marine elasmobranchs and the ability of these elasmobranchs to increase the capacity of ascorbic acid synthesis in response to hyposalinity stress.
Multi-Effect Evaporation Coupled with MVR Heat Pump Thermal Integration Distillation for Separating Salt Containing Methanol Wastewater  [PDF]
Deming Yang, Yifan Yin, Zhengguang Wang, Biyun Zhu, Qiang Gu
Energy and Power Engineering (EPE) , 2017, DOI: 10.4236/epe.2017.912048
Abstract: Due to the high energy consumption for separation of salt containing methanol wastewater, in this work, the multi-effect evaporation coupled with mechanical vapor recompression (MVR) heat pump and thermal integration technologies were raised for the first time. The ELECNRTL thermodynamic model is used to simulate and optimize the evaporation rectification process. Energy consumption and total annual cost (TAC) are taken as objective functions. The results show that multi-effect evaporation coupled with conventional distillation process can save energy consumption and TAC by 44.12% and 39.14%. The multi-effect evaporation coupled with distillation process based on MVR heat pump technology can save energy consumption and TAC by 55.27% and 47.49%, which is super to three-effect evaporation coupled with conventional distillation process. The three-effect evaporation coupled with MVR heat integration process can save energy consumption and TAC by 81.32% and 58.55%, which is more economical than other processes. It can be clearly seen that three-effect evaporation coupled with MVR heat integration process is more competitive to deal with the salt containing methanol wastewater.
MiR-122 Inhibits Cell Proliferation and Tumorigenesis of Breast Cancer by Targeting IGF1R
Biyun Wang, Hong Wang, Ziang Yang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0047053
Abstract: miRNAs are emerging as critical regulators in carcinogenesis and tumor progression. Recently, microRNA-122 (miR-122) has been proved to play an important role in hepatocellular carcinoma, but its functions in the context of breast cancer (BC) remain unknown. In this study, we report that miR-122 is commonly downregulated in BC specimens and BC cell lines with important functional consequences. Overexpression of miR-122 not only dramatically suppressed cell proliferation, colony formation by inducing G1-phase cell-cycle arrest in vitro, but also reduced tumorigenicity in vivo. We then screened and identified a novel miR-122 target, insulin-like growth factor 1 receptor (IGF1R), and it was further confirmed by luciferase assay. Overexpression of miR-122 would specifically and markedly reduce its expression. Similar to the restoring miR-122 expression, IGF1R downregulation suppressed cell growth and cell-cycle progression, whereas IGF1R overexpression rescued the suppressive effect of miR-122. To identify the mechanisms, we investigated the Akt/mTOR/p70S6K pathway and found that the expression of Akt, mTOR and p70S6K were suppressed, whereas re-expression of IGF1R which did not contain the 3′UTR totally reversed the inhibition of Akt/mTOR/p70S6K signal pathway profile. We also identified a novel, putative miR-122 target gene, PI3CG, a member of PI3K family, which further suggests miR-122 may be a key regulator of the PI3K/Akt pathway. In clinical specimens, IGF1R was widely overexpressed and its mRNA levels were inversely correlated with miR-122 expression. Taken together, our results demonstrate that miR-122 functions as a tumor suppressor and plays an important role in inhibiting the tumorigenesis through targeting IGF1R and regulating PI3K/Akt/mTOR/p70S6K pathway. Given these, miR-122 may serve as a novel therapeutic or diagnostic/prognostic-target for treating BC.
Shortwave Radiation and Sea Surface Temperature Variations over East and West Tropical Pacific Ocean  [PDF]
Yongxin Huang, Biyun Guo, Mantravadi Venkata Subrahmanyam
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104839
Abstract:
Shortwave radiation (SWR) is having direct impact on sea surface temperature (SST). In this paper the relation between SWR and SST has been over east and west Pacific Ocean. TAO/TRITON buoy data have been used for this study. It is well known that El Nino phenomenon is related to SST anomalies and warmer temperatures can observe over eastern Pacific Ocean (EP) leading to strong El Nino. The relation between eastern and western Pacific Ocean (WP) SST, SWR has been checked and presented. Monthly data have been used to find out the relation and the annual variation of SWR and SST during the El Nino and La Nina events are discussed.
Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices Analysis (CoMSIA) Studies on α1A-Adrenergic Receptor Antagonists Based on Pharmacophore Molecular Alignment
Xin Zhao,Minsheng Chen,Biyun Huang,Hong Ji,Mu Yuan
International Journal of Molecular Sciences , 2011, DOI: 10.3390/ijms12107022
Abstract: The α 1A-adrenergic receptor (α 1A-AR) antagonist is useful in treating benign prostatic hyperplasia, lower urinary tract symptoms, and cardiac arrhythmia. Three-dimensional quantitative structure-activity relationship (3D-QSAR) studies were performed on a set of α 1A-AR antagonists of N-aryl and N-nitrogen class. Statistically significant models constructed from comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) were established based on a training set of 32 ligands using pharmacophore-based molecular alignment. The leave-one-out cross-validation correlation coefficients were q 2 CoMFA = 0.840 and q 2 CoMSIA = 0.840. The high correlation between the cross-validated/predicted and experimental activities of a test set of 12 ligands revealed that the CoMFA and CoMSIA models were robust ( r2pred /CoMFA = 0.694; r2pred /CoMSIA = 0.671). The generated models suggested that electrostatic, hydrophobic, and hydrogen bonding interactions play important roles between ligands and receptors in the active site. Our study serves as a guide for further experimental investigations on the synthesis of new compounds. Structural modifications based on the present 3D-QSAR results may lead to the discovery of other α 1A-AR antagonists.
The Pharmacological NF-κB Inhibitor BAY11-7082 Induces Cell Apoptosis and Inhibits the Migration of Human Uveal Melanoma Cells
Shuiqing Hu,Qingqiong Luo,Biyun Cun,Dan Hu,Shengfang Ge,Xianqun Fan,Fuxiang Chen
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms131215653
Abstract: Uveal melanomas are highly metastatic and have high rate of recurrence due to the lack of effective systemic therapy. The identification of important survival pathways in uveal melanomas provides novel therapeutic targets for effective treatment. In the present study, we found that the NF-κB signaling pathway was constitutively and highly activated in uveal melanoma cells. Treatment with the pharmacological NF-κB specific inhibitor BAY11-7082 markedly decreased the nuclear translocation of NF-κB. In a dose-dependent setting, BAY11-7082 inhibited the proliferation and growth of uveal melanoma cells by inducing apoptosis without effect on cell cycle. The migration capacity of uveal melanoma cells was also significantly suppressed by BAY11-7082 treatment. Mechanistically, BAY11-7082 increased the activity of caspase 3 and reduced the expression of anti-apoptotic protein Bcl-2, but did not influence the expression of pro-apoptotic protein Bax. Furthermore, BAY11-7082 induced uveal melanoma cell apoptosis and inhibited xenograft tumor growth in vivo. Collectively, the present study identified NF-κB as an important survival signal for uveal melanoma cells and suggested that administration of specific NF-κB inhibitor BAY11-7082 could serve as an effective treatment for patients with uveal melanoma.
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