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Search Results: 1 - 10 of 27415 matches for " Biya Nkizinkiko Robert "
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Multidrug-Resistant Tuberculosis Disease in North-Kivu Province, Democratic Republic of Congo  [PDF]
Biya Nkizinkiko Robert, Mashako Ruhanga Many
Journal of Tuberculosis Research (JTR) , 2019, DOI: 10.4236/jtr.2019.72006
Abstract: Introduction: The emergency of Mycobacterium tuberculosis resistant to the first line drug reduced access possibility to second line drugs for appropriate treatment and required for urgent action especially in le Democratic Republic of Congo (DRC), which counts among the highest tuberculosis (TB) burden countries in Africa. Objective: To present prevalence and describe multidrug-resistant tuberculosis cases in North-Kivu Province identified by using Genexpert technology. Methods: We conducted an observational prospective study on multidrug-resistant tuberculosis (MDR-TB) cases in North-Kivu Province, DRC from 2017 to 2018. All cases of MDR-TB identified by Genexpert MTB/ RIB were included in this series. Result: Of 15,544 tuberculosis cases registered during the study period, 19 cases of MDR-TB were identified. 57.9% was male, 89.5% was retreatment cases and 5.3% was coinfection HIV/TB cases. Conclusion: This new molecular technology diagnostic facilitates multidrug-resistance tuberculosis detection and improves the reporting of data lack.
Structural Basis and Selectivity of Tankyrase Inhibition by a Wnt Signaling Inhibitor WIKI4
Teemu Haikarainen, Harikanth Venkannagari, Mohit Narwal, Ezeogo Obaji, Hao-Wei Lee, Yves Nkizinkiko, Lari Lehti?
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0065404
Abstract: Recently a novel inhibitor of Wnt signaling was discovered. The compound, WIKI4, was found to act through tankyrase inhibition and regulate β-catenin levels in many cancer cell lines and human embryonic stem cells. Here we confirm that WIKI4 is a high potency tankyrase inhibitor and that it selectively inhibits tankyrases over other ARTD enzymes tested. The binding mode of the compound to tankyrase 2 was determined by protein X-ray crystallography to 2.4 ? resolution. The structure revealed a novel binding mode to the adenosine subsite of the donor NAD+ binding groove of the catalytic domain. Our results form a structural basis for further development of potent and selective tankyrase inhibitors based on the WIKI4 scaffold.
Short Communication - Hospital-Based Mortality in Federal Capital Territory Hospitals-Nigeria, 2005 - 2008
N Preacely, O Biya, S Gidado, H Ayanleke, M Kida, M Akhimien, A Abubakar, I Kurmi, I Ajayi, P Nguku, H Akpan
Pan African Medical Journal , 2012,
Abstract: Background: Cause-specific mortality data are important to monitor trends in mortality over time. Medical records provide reliable documentation of the causes of deaths occurring in hospitals. This study describes all causes of mortality reported at hospitals in the Federal Capital Territory (FCT) of Nigeria. Methods: Deaths reported in 15 secondary and tertiary FCT hospitals occurring from January 1, 2005 and December 31, 2008 were identified by a retrospective review of hospital records conducted by the Nigeria Field Epidemiology and Laboratory Program (NFELTP). Data extracted from the records included sociodemographics, geographic area of residence and underlying cause-of-death information. Results: A total of 4,623 deaths occurred in the hospitals. Overall, the top five causes of death reported were: HIV 951 (21%), road traffic accidents 422 (9%), malaria 264 (6%), septicemia 206 (5%), and hypertension 194 (4%). The median age at death was 30 years (range: 0-100); 888 (20%) of deaths were among those less than one year of age. Among children < 1 year, low birth weight and infections were responsible for the highest proportion 131 (15%) of reported mortality. Conclusion: Many of the leading causes of mortality identified in this study are preventable. Infant mortality is a large public health problem in FCT hospitals. Although these findings are not representative of all FCT deaths, they may be used to quantify mortality in that occurs in FCT hospitals. These data combined with other mortality surveillance data can provide evidence to inform policy on public health strategies and interventions for the FCT.
Introduction to a Requirements Engineering Framework for Aeronautics  [PDF]
Robert Abo
Journal of Software Engineering and Applications (JSEA) , 2010, DOI: 10.4236/jsea.2010.39105
Abstract: This paper introduces a framework to produce and to manage quality requirements of embedded aeronautical systems, called the ‘Requirements Engineering Framework’ (REF). It aims at making the management of the requirement lifecycle easier, from the specification of the purchaser’s needs, to their implementation in the final products, and also their verification, while controlling costs. REF is based on the main standards of aeronautics, in particular RTCA DO-254, and RTCA DO-178B standards. An implementation of REF, using the IBM Rational DOORS and IBM Rational Change tools, is also presented in this paper.
Pricing Options in Jump Diffusion Models Using Mellin Transforms  [PDF]
Robert Frontczak
Journal of Mathematical Finance (JMF) , 2013, DOI: 10.4236/jmf.2013.33037

This paper is concerned with the valuation of options in jump diffusion models. The partial integro-differential equation (PIDE) inherent in the pricing problem is solved by using the Mellin integral transform. The solution is a single integral expression independent of the distribution of the jump size. We also derive analytical expressions for the Greeks. The results are implemented and compared to other approaches.

Australia’s Out-Dated Concern over Fishing Threatens Wise Marine Conservation and Ecologically Sustainable Seafood Supply  [PDF]
Robert Kearney
Open Journal of Marine Science (OJMS) , 2013, DOI: 10.4236/ojms.2013.32006

Seafood plays an important role in human nutrition and its increased consumption is actively recommended for sustenance and health benefits in both developing and developed countries. In parallel to this, the public receives confusing advice as to what seafood is sustainably produced and is frequently misled about the environmental impacts of fishing, especially in locations such as Australia where contemporary fishery management has a conservation and sustainability focus. It is recognised globally that Australia’s traditional fishery management driven by strict sustainability and biodiversity regulations, has achieved impressive results in managing both fish stocks and the effects of fishing on marine environments. Despite this, continued pressure from non-government organisations (NGOs) and a perpetuation of the misuse of management terms such as overfished is used to promote the misguided need for ever increasing fishing restrictions, most obviously in protected areas. This paper questions the motives of some NGOs and governments in Australia in pursuing additional restrictions on fishing which are mostly unnecessary and disproportionate to the sustainability requirements of other sources of food. This is done within the context of the global need for sustainable seafood supply and the need for effective marine conservation that addresses all threats to marine ecosystems in proportion to the magnitude of each threat.

Wearable and wireless accelerometer systems for monitoring Parkinson’s disease patients—A perspective review  [PDF]
Robert LeMoyne
Advances in Parkinson's Disease (APD) , 2013, DOI: 10.4236/apd.2013.24021
Abstract: Parkinson’s disease is a growing medical concern as societies, such as the United States of America, become progressively aged. Therapy strategies exist for the amelioration of Parkinson’s disease symptoms, and the quantification of attributes, such as hand tremor, can provide valuable feedback. Wearable and wireless accelerometer systems for monitoring Parkinson’s disease patients have been progressively advanced over the course of the past half-decade. In particular, wireless accelerometer nodes and smartphones, such as the iPhone, hold promise for optimizing therapy strategy by providing convenient quantified feedback. This perspective review addresses the current advances in wearable and wireless accelerometer systems for monitoring Parkinson’s disease patients and forecasts for the near future.
A Study of Lateralized Cognitive Processes in Upper-Division Electrical Engineering Students’: Correlating Written Language Functions with Analytical Reasoning in Microelectronics  [PDF]
Robert Melendy
World Journal of Engineering and Technology (WJET) , 2014, DOI: 10.4236/wjet.2014.22008
Abstract: The human brain is asymmetrical in function, with each of its two hemispheres being somewhat responsible for distinct cognitive and motor tasks, to include writing. It stands to reason that engineering students who have established entrance into their upper-division programs will have demonstrated cognitive proficiency in math and logical operations, abstract and analytical reasoning and language usage, to include writing. In this study the question was asked: is there a correlation between an upper-division electrical engineering students’ analytical reasoning ability and their descriptive writing ability? Descriptive writing is taken here to mean a students’ ability to identify key physical aspects of a mathematical model and to express—in words—a concise and well-balanced description that demonstrates a deep conceptual understanding of the model. This includes more than a description of the variables or the particular application to an engineering problem; it includes a demonstrated recognition of the basic physics that govern the model, certain limitations (idealizations) inherent in the model, and an understanding of how to make practical experimental measurements to verify the governing physics in the model. A student at this level may demonstrate proficiency in their analytical reasoning skills and hence be capable of correctly solving a given problem. However, this does not guarantee that the same student is skilled in associating equations with their physical meaning on a deep conceptual level or in understanding physical limitations of the equation. Consequently, such a student may demonstrate difficulty in mapping their comprehension of the model into written language that demonstrates a sound conceptual understanding of the governing physics. The findings represent a sample of two independent class sections of Electrical and Computer Engineering junior’s first course in Microe-lectronic Devices and Circuits during fall semesters 2012 and 2013 at a private mid-size university in NW Oregon. A total of three exams were administered to each of the 2012/2013 groups. Correlations between exam scores that students achieved on their descriptive writing of microelectronics phenomena and their analytical problem-solving abilities were examined and found to be quite significant.
Foilized pouches can prevent the transmission of HIV from mother to child using multi-drug therapies  [PDF]
Robert Malkin
Journal of Biomedical Science and Engineering (JBiSE) , 2014, DOI: 10.4236/jbise.2014.71007
Abstract: Children can become HIV positive (HIV+) from their mother during home birth. If the infant ingests antiretroviral (ARV), medications immediately after birth, the risk of transmission can be dramatically reduced. We have previously proposed the use of foilized, polyethylene-lined pouches to store ARV’s. Using the pouch, the mother receives the medication at an antenatal care visit, months before delivery, and if she delivers at home, tears open the pouch and drips the medication into her child’s mouth. In this work, we extend the use of the pouch to store a modern ARV, Lamivudine (3TC), often used in multi-drug regimens. Under laboratory conditions, pouches were filled with 3TC and stored at 25?C/60% relative humidity (RH) for twelve months. We found that the 3TC was stable throughout the year (maximum 5.6% of labeled concentration change). The preservatives were somewhat degraded by the act of repackaging the medicine, but sufficient preservatives remained to maintain the medication. The same impurities were identified in the 3TC stored in the pouches and the samples removed from the bottles indicating that the pouches do not introduce new impurities (impurities that are not already introduced by the bottle). We conclude that the pouch can preserve this modern ARV for up to twelve months.
Valuation of Mineral Resources in Selected Financial and Accounting Systems  [PDF]
Robert Uberman
Natural Resources (NR) , 2014, DOI: 10.4236/nr.2014.59045
The paper presents reviews of fundamental issues regarding valuation methodologies of mineral deposits: 1) recommended by mineral industry standards; 2) used for disclosures in financial statements and 3) adopted in national statistics. A discussion of historical developments of various regulations is supplemented by characteristics of key valuation methods. Differences and similarities are analysed and compared to current practices. A special attention is given to certain distinctive issues which are not shared by most of other types of assets like inclusion of decommissioning and rehabilitation costs or consequences of long duration of investment phase.
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